Bioinformatics' Lesson Plan - Bioinformatics Activity Bank

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1 Οκτ 2013 (πριν από 3 χρόνια και 11 μήνες)

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Bioinformati
cs’ Seminar Lesson Plan Number 2


Submitted by:

Chris Eurich


Course:

Biology, AP Biology, Anatomy & Physiology,
Biotechnology


Unit:

The Nervous System; Bioinformatics


Topic:

Exploring the Neuroscience of the Human Brain Using Bioinformatic T
ools


Background Information:
The field of neuroscience is rapidly growing and information generated from research
is
being made available electronically on
-
line
. To utilize this information in a meaningful way
bioinformatic

web
serv
ers

and relational data
bases are critical to anyone who wishes to examine information related to
their

are
a

of interest. One new site that has been developed is entitled
“Genes 2 Cognition”
. This is a media
-
rich site
containing information on Human Brain Disorders, Cognitive P
rocesses, Research Approaches, Protein
-
Protein
Interactions and an interactive 3
-
D Model of the Human Brain. Each of these areas also provides additional links to
bioservers (NCBI, OMIM, Estrez, PubMed, PDB, etc.) for further exploration.


Essential Quest
io
n:

What is the structure and function of the nervous system?


Key Question
: How do you use bioinformatic relational databases to explore biological molecules?


Cognitive Strategies
:

To begin this activity students will log on to the Genes 2 Cognition web
site at the following address:



http://www.g2conline.org


To become familiar with the website and its various components they should watch the tutorial by clicking the
Using G2C

located on the top menu bar.


Once
they are familiar with the general layout and operation of the site they should explore the
Bioinformatics

section by viewing the related subway lines for Genes, Biochemicals, Cells, Brain Anatomy and Cognition.

This is
located under the
Research Approach
es

heading.


Using the
Protein
-
Protein Interaction Database

students should select a molecule for further study. Using the
relational links
provided for various
bioinformatics’ programs
(OMIM, NCBI, Allen Brain Atlas, Ensemble,
Entrez, etc. )
they should
complete their worksheet with information on the molecule’s name, identification
number, species, chromosome number and locus, a description of its physiology along with identifying specific
regions of the brain where they interact. These regions should b
e explored using the
3
-
D
Brain

modeling

component of the website
.


Summarizing Strategy:

Students will record the results of their search in the appropriate section(s) of their
worksheet and answer the concluding questions.