COURSE SYLLABUS GENETICS PCB 3063-RVC

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COURSE SYLLABUS

GENETICS

PCB 3063
-
RVC











General Information

PROFESSOR INFORMATION

Instructor:

Helena Schmidtmayerova, PhD



Phone:

(305) 919
-
4135

Office Hours:
By appointment




E
-
mail:

hschmid@fiu.edu

T
echnical Problems:

(305) 348
-
3630




online@fiu.edu





COURSE DESCRIPTION

This course
will
discuss

the principles of genetics and its applications
to the study of
biological
functions
at the molecular, cellular,
organ
ism
, and population

level.
We will primarily focus on the
principles of heredit
y and the molecular mechanisms
by which genetic information is transferred.
During this course, y
ou
will
uncover the major concepts of genetics

and
make connections among
those
concepts so as to have better understanding of genetics.

This is an online
course

with
two on
-
campus
administered exams

(
m
idterm
and the final
)
.

COURSE PREREQUISITES

The prerequisite for the course is passing grade
(C or higher)
from General Biology I

I
n addition, all participants should be familiar with Blackboard Learn 9. To learn how to navigate and
utilize all of the tools, please click on the link below and go to
the Blackboard Learn Orientation
Course
link on the bottom of the page.

http://online.fiu.edu/futurestudents/practicecourse

Be aware that this online section requires two on
-
campus exams.


COURSE OBJECTIVES

After completing this course,
you

will be able to:




Define

the m
echanisms by which genetic information is transmitted to new cells in the
process of cell division

and gamete formation.




Identify and interpret the basic
Mendel’s
principles of heredity.



Explain the major extensions and modifications of Mendel’s principl
es of heredity.



Apply principles of heredity to
practical

problems and pr
edict
ions

of
genetic
crosses.



Recognize particularities of bacterial and viral genetics
.




Define and describe the molecular mechanisms by which genetic information is trans
mitted.



De
fine how gene expression is regulated



Recognize and interpret t
he outcomes of genetic mutation



De
termine practical applications
of molecular genetics.



Identify the genetic nature of cancer




Explain how gene pool of a population shapes
it and changes with

time
.

TECHNICAL REQUIREMENTS

All students should have access to a personal computer with internet access. You must have basic
computer skills as you will be required to navigate through the Blackboard, post discussions, save and
upload assignment files, a
nd participate at least once at weekly online meetings
organized via

Adobe
Connect.

In order to be able to view course content, you have to make sure
that you have Adobe Reader
Software plug
-
ins.

All technical requirements for the course are specified i
n the following page

http://online.fiu.edu/futurestudents/whatsrequired

LEARNING MATERIAL

Benjamin A. Pierce.
GENETICS: A Conceptual Approach
,

4
th

edition, W.H. Freeman and Company,
New Y
ork
.
You will need access to Genetics Portal
; an online site with many features that will help
you to master genetics. You will also have graded assignments from Genetics Portal. Genetics Portal
comes with an eBook.

You have following options:



Benjamin A
. Pierce
GENETICS: A Conceptual Approach 4
th

edition
,

Hard Cover + Genetics
Portal

order ISBN: 978
-
1
-
4292
-
9331
-
0



Benjamin A. Pierce
GENETICS: A Conceptual Approach 4
th

edition,
Paperback + Genetics
Porta
l order ISBN 978
-
1
-
4292
-
9531
-
4



Benjamin A. Pierce
GEN
ETICS: A Conceptual Approach 4
th

edition,
Loose
-
leaf

+ Genetics
Portal order ISBN 978
-
1
-
4292
-
9293
-
1



Access to Genetics Portal

without printed textbook
(
http://courses.bfwpub.com/pierce4e.php
).


The t
extbook is your basic reference
book;

Genetics Portal is
required resource, which will provide
you with helpful animations, videos, news feeds, and end of the chapter practice tests. In

addition,
there will be required
and

recommended readings posted perio
dically throughout the semester.

POLICIES

Please review the FIU policies (link provided below) with essential information.
http://online.fiu.edu/app/webroot/html/wct_
files/policies_and_resources/

EXPECTATIONS OF THE COURSE

Expectations for an online g
enetic
s course are the same as for an in
-
class course.
During this

semester
you have to master major concepts of genetics, develop and apply critical thinking to recogni
ze
connections among genetics concepts and
to
solve the application problems
. In addition,

since most of
the course work will be conducted online, you will have to possess
technical skills

allowing you to
complete required tasks
,
as well as
self
-
motivation

and self
-
discipline

to follow study calendar in
timely manner
.

Participants are expected to:


• Review
the
introductory information



Become

familiar with Blackboard
by
using Blackboard Learn O
rientation

• Take the practice quiz (located in
the Introd
uctory section
) to ens
ure compatibility of yo
ur



computer
wi
th Blackboard


• During the first week, introduce yourself to the clas
s posting a self introduction

to the




appropriate

discussion forum


• Review and follow the course calendar


• Revi
ew and study weekly assigned material


• Login to the course at least 3 times per week


• Complete Learning Curve and online quizzes by corresponding deadline


• Submit discussion post

by corresponding deadline


• Respond to discussion board

by set deadlin
es


• Submit the assignment
by
corresponding deadline


• Attend an online
conferencing

(Adobe Connect) at least once
per course duration


• Take
two on
-
campus

exams

The instructor will:


• Log in to the course a minimum of 2 times a week


• Hold online m
eetings via Adobe Connect once
every two

week
s


• Respond to questions posted on
the general d
iscussion
f
orum

if the response is required

within 72 hours.

Instructor response is
not required if

the pos
t

was answered/solved correctly

by other
students
.


• Grade quizzes and
assigned
activities
within
1
4

bus
iness days of the due

dates












Course Details

COURSE COMMUNICATION


An email communication between instructor and students will be used exclusively for private and
personal issues.


For all general questions and comments related to course content, organization, and course material,

communication will take place via the
general d
iscussion
f
orum

-

Genetics Cafe
. The same
applies to any specific question regarding the course material,

questions about the applications
problem and how to solve them, or any particular question on the assigned material
, quizzes, or tests.

This form of communication wil
l

benefit most of you by making

you think about the problem
s

posted by your fellow studen
ts.
Answ
er
ing posted questions/comments will enhance your
communication with other students
. In addition,
some of the students might not realize
depth of the

problem until they

see it on the discussion board. Altogether,
following
and actively engaging in
discussion forum
will not only enhance your class communication, but will also enhance you
knowledge.


Online conferencing via Adobe Connect will be held once
in every two weeks
. The primary purpose
of the online conference is to discuss
course
material
, assigned readings, and/or any additional
questions that may arise during the week
s
. This
is an optional activity that

will allow you to

have
face
-
to
-
face interactions with instructor and your fellow students.
I will summarize the most
important learning
objectives covered within two weeks and y
ou can bring any
course material
-
related questions and comments
to the online conference
.
I strongly recommend your
participation
.
I will record adobe connect sessions and make them available to those students who
c
ouldn’t attend only if there is at least 10 %
class participation.


Requirements for using Adobe Connect:


1. Disable any pop
-
up window blocker


2. You must have Adobe Flash Player installed on your computer


3. Use of headphone and microphone combination
with USB connection is highly

recommended
.


COURSE ASSESSMENT

Course grades will be assessed based on the
on
-
campus

tests, online quizzes, learning
-
curve,
assignment, and group
discussion.

In addition, at the end of each learning module

you will have s
elf
-
assessment quizzes, which will not be graded.

The purpose of self
-
assessment quizzes is to give you an
opportunity to review your understanding of the material covered in the module. I strongly encourage
you to take
them.

On
-
campus tests

There will be

2 on
-
campus

tests, midterm and the final exam.
You will have to take those two exams
either at FIU Biscayne Bay campus, North Miami, FL 33181
,
or make an appointment at
the
local
NCTA certified testing center

(
http://www.ncta
-
testing.org/cctc/find.php
).
Be aware that
NCTA
charges for exam time (
you can find individual fees at
the
NCTA
website
)
and

you

will be
fully
responsible for
those
charges
; FIU will not reimburse your expenses for NCTA testing
.


Each, midterm and the final,
is worth 200 points; 400 points from both tests will weight 40% of your
final grade. Both tests are
cumulative

and are designed to
test

your
understanding
of the
genetic
content covered up to the point of the exam
. They wi
ll
co
nsist

of
multiple choice questions

and true
-
false questions answered on computer
-
graded forms (Scantron). On the day of your exam, you are
responsible for bringing picture

identification
and
at least two pencils and an eraser
.

There will be no make
-
up tests unless circumstances beyond the student’s control arise and are
accompanied by the appropriate documentation:



Death of an immediate family member requires official bereavement statement
.



Student/immediate family member with acute/terminal ill
ness require an





official

hospital/clinic notification.


Traffic accident requires official accident report.



Jury duty requires county clerk summons.




Military duty.

Online quizzes


You will have

3

online quizzes worth 100 points each;
3
00 poi
nts from
all of them
will weight
3
0% of
your final grade. They are summative quizzes
designed to test your
understanding of the material

covered up to the point of the exam.
You will have two attempts for each quiz;
the highest score will
be recorded. Cons
equently, if your computer freezes, do not panic, you still have second chance to take
the quiz. However, questions will be randomly selected from the question pool for each individual
attempt.
There is no makeup or late policy.


Learning Curve

Learning

Curve is

a formative assessment activity that
will
guide

you

through a series of questions
catered to
your

in
dividual level of understanding. Learning Curve is an integral part of Genetics Portal.
You will have target points to reach in order to get 5 poi
nts for the assignment. You will have options,
either to answer the question if you know the answer, or request the hint
,

or open the appropriate book
chapter to find the answer.
You will have 20 assignments, each worth 5 points. You can accumulate
100 poi
nts from all of them.
To obtain the points, you have to complete learning curve before deadline.
If you miss deadline, you can still access it and learn by practicing, however, you will not receive
points for it. Access to Learning Curve is not limited, so

you can get back to it anytime you want to
rehearse or refresh your skills.

Assignment

You will have to complete one

assignment
that is worth
100 points
. The goal of the assignment is to
demonstrate your conceptu
al and critical thinking skills. You will
apply those skills to connect
genetic

concepts
to

everyday life problems and
create a presentation
based on provided genetic topics. Clear

instructions and rubric are provided in the folder where assignment appears. All assignments will be
submitted via Bl
ackboard
and directly linked to Turnitin
.

Late submission
guideline:

F
or
every
24 hours delay 10 points will be automatically deducted

from
your assignment
’s earned

total points
.

Consequently, if you submit the assignment 10 days after the
deadline, you wi
ll not earn any points for it.



Group discussions

You will have to participate in one group discussion forum, which will allow you to interact online
with your group members.
The groups will be created randomly. Within your group, you will have to
post

discussions and comment on discussion post of each member of your group.

Detailed instructions and rubric are provided in the appropriate week folder.
There is no makeup or
late policy.


G
RADING

ASSESSMENTS

NUMBER OF

POINTS

WEIGHT

On
-
site

tests

2

400

40%

Online quizzes

3

3
00

3
0%

Learning Curve

20

100

10%

Assignment

1

100

10%

Group Discussion

1

100

10
%

TOTAL


1000

100%


GRADING SCALE


A

93 %
-

100%






A
-

90 %
-

92.99 %






B+

88 %
-

89.99 %







B

83 %
-

87.99 %


B
-

80 %
-

82.99 %



C+

78 %
-

79.99 %





C

70 %
-

77.99 %


D

60 %
-

69.99 %


F

<60%


WEEKLY SCHEDULE AND OBJECTIVES


The week
runs from Monday to Monday


All weekly course work is due on
Monday
Morning

by 11:
00

a
m EST

_______________________________________________________________
___
____

Intro



Review how to get started

information


Enroll in Blackboard Learn Orientation Course


Take a practice quiz

__________________________________________________________________
____

WEEK 1

August 26
-



Ch

01
-

Introduction to Genetics

September
1


Ch 02
-

Cellular Reproduction



Tasks:

2 Learning Curves



Self
-
assessment quiz

At the end of this week you will be able to:


1.
Describe differences in genetic characteristics of prokaryotic and eukaryotic cells
.


2. Define basic features of prokaryoti
c cell reproduction
.


3.
Explain

how genetic information is apportioned during the course of eukaryotic cell



reproduction
.



4.
Compare and contrast

m
itosis and
m
eiosis
.


5. Identify processes unique to meiosis and their role in production of geneticall
y variable


progeny
.


_________________________________________________________________
_____

WEEK 2

September 2
-

8


Ch 03
-

Basic Principles of Heredity




Tasks:

Learning Curve


Self
-
assessment quiz

At the end of this week you will be able to:


1. Expla
in basic principles of heredity known as Mendel’s principl
es o
f heredity
.


2. Analyze and discuss Mendel’s contribution to the modern genetics
.



3. Solve genetic problems with mono and dihybrid crosses
.



4. Apply probability to predict outcome of genetic

crosses
.


5. Apply chi
-
square test and solve application problems
.

__________________________________________________________________
____

WEEK 3

September 9
-
15

Ch 04
-

Sex Determination and Sex
-
linked C
haracteristics


Ch 05
-

Extension
s

and
Modifications of

Basic Hereditary P
rinciples





Tasks:

2
Learning Curve
s




Self
-
assessment quiz




Assignment

At the end of this week you will be able to:


1. Explain
genetic determination

of sex
.


2
.

Discuss how
characteristics encoded by
genes located on
sex chromo
somes are inherited.


3.
Explain

distinct inheritance pattern of sex
-
linked characteristics in males and females
.



4. Identify factors acting at individual loci that can alter phonotypical ratios predicted by



Mendel’s principles of heredity
.



5. Solv
e genetic problems with extended and modified hereditary principles
.


___________________________________________________________________
___

WEEK 4

September 16
-
22

Ch 06
-

Pedigree A
nalysis
, Applications, and Genetic T
esting


Ch 07
-

Linkage and Recombinati
on




Tasks:

2 Learning Curves




Self
-
assessment

quiz




Quiz 1

At the end of this week you will be able to:


1.

Discuss three important techniques used by geneticists to investigate human genetic




characteristics
.



2. Explain how design of thes
e techniques can help to distinguish the effects of genes and


environment
.



3. Explain how the information generated with these techniques can be used in genetic




counseling and prenatal diagnosis
.


4.
Demonstrate how gene linkage and recombina
tion affects genetic inheritance
.


5. Predict the results of genetic crosses in which genes are linked
.



WEEK 5

September 23
-
29

C
h 08
-

Bacterial and Viral Genetic Systems





Tasks:

Learning Curve




Self
-
assessment quiz




Group Discussion

At the end o
f this week you will be able to:


1.
Define the genetic properties of bacteria and viruses
.



2. Explain mechanisms by which bacteria exchange and recombine their genes
.


3. Define the role of plasmids in bacterial resistance to antibiotics
.


4. Discuss t
he use of bacteria and viruses in
genetic research
.



5. Recognize and explain mechanisms by which RNA viruses, such as HIV and






influenza virus, avoid recognition and elimination by the host defense mechanisms

WEEK 6

September 30
-

Ch 10
-

DNA
:
The Chemical Nature of the Gene

October 6

Ch 11
-

Chromosome Structure
and Transposable Elements




Tasks:

2 Learning Curves




Self
-
assessment quiz

At the end of this week you will be able to:


1. Describe DNA structure
.



2
.
Explain how DNA encodes genet
ic information
.


3. Define relationship between DNA and genes
.


4. Discuss how the large amount of DNA
can

be

fold into a limited space of a cell nucleus
.


5. Describe structure of chromosomes
.



6. Classify different types of DNA sequences
in eukaryotes
.


7. Explain general features of transposable elements and the processes by which they move


from place to place
.



WEEK 7

October 7
-
13

Ch 12
-

DNA replication




Tasks:

Learning Curve




Self
-
assessment quiz




MIDTERM EXAM, Saturday, October 12

At the

end of this week you will be able to:


1.
Explain basic mechanisms of DNA replication
.


2. Identify and describe requirements of DNA replication
.


3. Explain differences between bacterial and eukaryotic DNA replication
.




WEEK 8

October 14
-

20

Ch 13
-

Tr
anscription




Ch 14
-

RNA
Molecules and RNA Processing




Tasks:

2 Learning Curves




Self
-
assessment quiz


At the end of this week you will be able to:


1.
Define how the pathway of genetic information transfers from DNA (genotype) to protein


(phen
otype)
.



2. Explain process of transcription
.



3. Identify similarities and differences between gene transcription and DNA replication
.


4. Summarize characteristics and role of different classes of RNA



5. Explain mechanisms and outcome of RNA modifica
tions in eukaryotes


6. Discuss RNA interference


WEEK 9

October 21
-

27

Ch 15
-

The
Genetic Code
and Translation




Tasks:

Learning Curve




Self
-
assessment quiz




Quiz 2

At the end of this week you will be able to:


1.
Explain what genetic code is.


2.
Identify the major characteristics of the genetic code.


3
. Describe the mechanism of translation in bacterial and eukaryotic cells


4
.
Define mRNA surveillance mechanisms



WEEK 10



October 28
-


Ch 16 and 17
-

Control of Gene Expression

November 3


Tas
ks:

2 Learning Curves




Self
-
assessment quiz




Assigned reading




Assignment due date

At the end of this week you will be able to:


1. Identify the levels at which gene expression is controlled.



2. Explain how gene expression is regulated in bacteri
a.


3. Describe the structure and function of
E. coli

lac

and
trp

operons.


4. Illustrate functions of antisense RNA and RNA regulatory sequences in bacterial gene



expression.


5. Explain basic principles of gene regulation in eukaryotes and compare

and contrast them to


those in bacteria.


6. Define the epigenetic effects on the eukaryotic gene expression


7. Evaluate the role of RNA interference in the eukaryotic gene expression


WEEK 11


November 4
-

10

Ch 18
-

Gene Mutations and DNA Repair




Tasks:

Learning Curve




Self
-
assessment quiz

At the end of this week you will be able to:


1. Identify the mechanisms leading to gene mutations
-

errors in genetic instructions.


2. Classify different types of mutations and explain their phenotypic ef
fects.


3. Identify different environmental factors causing mutations.


4. Discuss the role of DNA repair mechanisms.


WEEK 12

November 11
-

17

Ch 19
-

Molecular Genetic Analysis and Biotechnology




Tasks:

Learning Curve




Self
-
assessment quiz





At t
he end of this week you will be able to:


1. Assess molecular genetic techniques used in genetic engineering.


2. Explain how DNA can be isolated, altered, recombined, and placed back into cells.


3. Describe how recombinant DNA technology and other molec
ular techniques are being used


in different areas of industry, medicine, drug production, and court of law.



WEEK 13



November 18
-

24

Ch 23
-

Cancer Genetics




Tasks:

Learning Curve




Self
-
assessment quiz




Assigned reading




Quiz 3

At the end
of this week you will be able to:


1. Define the genetic nature of cancer.


2. Identify types of genes that can contribute to cancer development.


3. Compare and contrast physiological role of proto
-
oncogenes and tumor
-
suppressor genes.


4. Assess the ro
le that viruses play in some cancers.


5. Outline epigenetic changes associated with cancer.


WEEK 14

November 25
-

Ch 25
-

Population Genetics

December 1


Tasks:

Learning Curve




Self
-
assessment quiz

At the end of this week you will be able to:


1. Ex
plain what the gene pool of a population is and how it is defined.


2. Analyze genotypic and allelic frequencies in a population.


3. Recognize implications of Hardy
-
Weinberg law for the genetic structure of a population.


4. Explain natural selection.



WEEK 15



December 2
-

8


Review of genetic
concepts and applications for the final exam

FINAL EXAM, Saturday
, December 14