book chapters

vainclamInternet και Εφαρμογές Web

14 Δεκ 2013 (πριν από 3 χρόνια και 3 μήνες)

181 εμφανίσεις

JIANJUN LI, P
H
.D.


Institute for Biological Sciences

National Research Council Canada

100 Sussex Drive, Ottawa, Ontario

Canada K1A 0R6

Tel, 613
-
990
-
0558

Fax, 613
-
952
-
9092

E
-
mail, jianjun.li@nrc
-
cnrc.gc.ca




DEGREE


Ph.D


Chemistry, Wuhan University, Chi
na

1990

MSc


Chemistry, Wuhan University, China

1986

BSc


Chemistry, Wuhan University, China

1983


PROFESSIONAL EXPERIENCE


2005
-


Head of Glycoanalysis Facility, Institute for Biological Sciences, NRCC

2007
-


Senior Research Officer, Institute for Biolo
gical Sciences, NRCC

2002
-
2007


Associate Research Officer, Institute for Biological Sciences, NRCC

1999
-
2002

Assistant Research Officer, Institute for Biological Sciences, NRCC

1997
-
1999

NSERC
Postdoctoral Fellow
, Institute for Biological Sciences, NRCC

1995
-
1997


Postdoctor
al Fellow
, Chemistry Department, University of Montreal

1993
-
1995

Associate Professor, Chemistry Department, Wuhan University

1990
-
1993

Lecturer, Chemistry Department, Wuhan University

1986
-
1987

Assistant Lecturer, Chemistry Department, Wuhan University



PROFESSIONAL SERVICES


Guest

p
rofessor
ship



May. 2008
-
present, Wuhan University, Wuhan, China



Oct. 2007
-
present,
Huazhong University of Science

and Technology,


Wuhan, China


Participation in National Committees

National
Executive Committee
Member of Analytical Division, Chemistry
Institute of
Canada (Jun. 2008


present)
.

Executive Committee of Ottawa, Chemistry Institute of Canada (Oct. 2006


present)
.

Chair of Executive Committee of Ottawa, Chemistry Institute of Canada (Oct. 2005


Sept. 2006)
.


Editorship


Member of
Editorial
B
oard

of

International Journal of Carbohydrate Chemistry


Membership

Member of
American Society for Mass Spectrometry


President
-
elected, Chinese American Society of Mass Spectrometrists (CASMS)



REFEREED JOURNAL PUBLICATIONS



1.

Zhang

J.,

Liu X.,

Bell

A.,

To

R.,

T Baral

T. N.,

Azizi

A.,

Li

J.,

Cass

B.,

Durocher

Y.
, Transient
expression and purification of chimeric heavy chain antibodies
, Protein
Expression and Purification
,
in press.


2.

Zhao Y. Y., Liu X, Boyd J. M., Qin F.,

Li J.
, Li X.
-
F., I
dentification o
f N
-
n
itrosamines in
t
reated
d
rinking
w
ater
u
sing
n
anoelectrospray
i
onization
h
igh
-
f
ield
a
symmetric

w
aveform
i
on
m
obility
s
pectrometry
with
q
uadrupole
t
ime
-
of
-
f
light
m
ass
s
pectrometry
,
J. Chromatogr
.

Sci
.
, Vol. 47, January 2009
.


3.

Yi W., Shen J., Zhou G.,
Li

J.
, Wang P. G.,
Bacterial homologue of human blood group A transferase
,
J. Am. Chem. Soc.

In press.


4.

Dzieciatkowska M, Liu X, Heikema AP, Houliston RS, van Belkum A, Schweda EK, Gilbert M,
Richards JC,
Li J.
, Rapid method for sensitive screening of oligos
accharide epitopes in the
lipooligosaccharide from
Campylobacter jejuni

strains isolated from Guillain
-
Barre syndrome and
Miller Fisher syndrome patients.
J Clin Microbiol.

46, 3429
-
3436 (2008)
.


5.

Liu X, Chan K, Chu I
.
K
.
,
Li J.
, Microwave
-
assisted nonspeci
fic proteolytic digestion and controlled
methylation for glycomics applications.
Carbohydr. Res
.
343, 2870
-
2877
(2008).


6.

Schweda E.K.H., Twelkmeyer B.,
Li J.
, Profiling structural elements of short
-
chain lipopolysaccharide
of non
-
typeable

Haemophilus influ
enzae

(invited review).
Innate Immun.

14,
199
-
211

(2008).


7.

Reid C.W, Stupak J., Chen M.M., Imperiali B.,
Li J.
*
, and Szymanski C.M.
*
, Affinity
-
capture tandem
mass spectrometric characterization of polyprenyl
-
linked oligosaccharides: a novel tool to study
p
rotein
N
-
glycosylation pathways.
Anal. Chem.

80, 5468
-
5475

(2008)


8.

Liu

X.
, Afonso

L.
, Altman

E.
, Johnson

S.
, Brown

L.
,
Li

J.
, O
-
acetylation of sialic acids in
N
-
glycans of
Atlantic salmon (
Salmo salar
) serum is altered by handling stress.
Proteomics
,
8,
28
49
-
28
57
(2008)

(feature article)


9.

Lundström S
.
L
.


,
Li J
.


, Månsson M
.
, Figueira M
.
, Leroy M
.
, Goldstein R
.
, Hood D
.
W
.
, Moxon E
.
R
.
,
Richards J
.
C
.
, Schweda E
.
K.
, Application of CE
-
ESI
-
MS and LC
-
ESI
-
MS
n

to profile glycoform
expression during
Haemophilus inf
luenzae

pathogenesis in the chinchilla model of experimental otitis
media.
Infect Immun.
76, 3255
-
3267

(2008)

(

shared first author)


10.

Altman E.,

Chandan

V.,
Larocque

S.
, Aubry

A.
, Logan

S.M.
, Vinogradov

E., and

Li
J.
, Effect of the
HP0159 ORF mutation on
the lipopolysaccharide structure and colonizing ability of
Helicobacter
pylori
,
FEMS Immun
.

Med
.

Microbiol
.
,
53, 204
-
213

(2008)


11.

Lundström

S.,
Li

J.
, Deadman M., Hood D., Moxon E. R., Schweda E.,
Structural analysis of the
lipopolysaccharide from non
-
typea
ble
Haemophilus influenzae

strain R2846
,
Biochemistry
,
47,
6025
-
6038

(2008)
.


12.

Dzieciatkowska M., Hood D.W, Schweda E.K.H, Moxon E.R.,

Richards J.C.,
Li J
.
, Characterization of
intact lipopolysaccharides from
Haemophilus influenzae

strain RM 118 using elect
rophoresis
-
assisted
open
-
tubular liquid chromatography
-
mass spectrometry,
Electrophoresis
,

29, 2171
-
2181

(2008)


13.

Kanipes M
.
I
.
, Tan X
.
, Akelaitis A
.
,
Li J
.
, Rockabrand D
.
, Guerry P
.
, Monteiro M
.
A.

Genetic
a
nalysis of
lipo
oligosaccharide
c
ore
b
iosynthesis in

Campylobacter jejuni

81
-
176.

J. Bacteriol
.
190, 1568
-
74

(2008)
.


14.

Male K.B.,
Li J.
, Bun C.C., Ng S.
-
C., Luong J., Synthesis and stability of fluorescent gold
nanoparticles by sodium borohydride in the presence of mono
-
6
-
deoxy
-
6
-
pyridinium
-

-
cyclodextrin
C
hloride.
J. Phys. Chem.

112, 443


451 (2008).


15.

Liu X.,

Ma L.,

Li J.

Recent developments in the enrichment of glycopeptides for glycoproteomics.
Anal. L
ett
.

41, 268
-

277
(2008)


16.

Wang Z, Liu X.,
Li J.

and Altman E., Structural characterization of the
O
-
cha
in polysaccharide of
Aeromonas caviae

ATCC 15468 lipopolysaccharide.
Carbohydr. Res.
343, 483
-
488

(2008)


17.

Fox K. L.,
Li J.
, Schweda E. K., Vitiazeva V., Makepeace K., Jennings M. P., Moxon E. R., Hood D.
W.,

Duplicate copies of
Lic
1 direct the addition of
multiple phosphocholine residues in the
lipopolysaccharide of
Haemophilus influenzae
,
Infect Immun
.
76, 588
-
600
(200
8
)


18.

Dzieciatkowska M., Brochu D., van Belkum A., Heikema A., Yuki, N., Houliston R. S., Richards J.C.
Gilbert M.,
Li J.
, Mass spectrometric
analysis of intact lipooligosaccharide: Direct evidence for
O
-
acetylated sialic acids and discovery of
O
-
linked glycine expressed by
Campylobacter jejuni
.
Biochemistry
, 46, 14704
-
14714 (2007).


19.

Bernatchez S., Gilbert M., Blanchard M. C., Karwaski M. F.,
Li

J.
, DeF
rees S., Wakarchuk W. W.
Variants of the

-
1,3
-
galactosyltransferase CgtB from the bacterium
Campylobacter jejuni

have
distinct acceptor specificities.
Glycobiology
.
17, 1333
-
1343
(
2007
)
.


20.

Lundstrom S. L., Twelkmeyer B., Sagemark M. K.,
Li J.
, Rich
ards J. C., Hood D. W., Moxon E. R,
Schweda E. K. Novel globoside
-
like oligosaccharide expression patterns in nontypeable
Haemophilus
influenzae

lipopolysaccharide.
FEBS J
. 274, 4886
-
4903 (2007)


21.

McNally D. J., Lamoureux M. P., Karlyshev A. V., Fiori L. M.
,
Li J.
, Thacker G., Coleman R. A., Khieu
N. H., Wren B. W., Brisson J. R., Jarrell H. C., Szymanski C. M. Commonality and biosynthesis of the
O
-
methyl phosphoramidate capsule modification in
Campylobacter jejuni
.
J Biol Chem.

282, 28566
-
28576 (2007)


22.

Houl
iston R.S., Koga M.,
Li J.
, Jarrell H.C., Richards J.C., Vitiazeva V., Schweda E.K.H., Yuki N.,
Michel Gilbert M., A
Haemophilus influenzae

s
train
a
ssociated with Fisher
s
yndrome
e
xpresses a
n
ovel
d
isialylated
g
anglioside
m
imic.
Biochemistry
, 46
, 8164
-
71 (
2007).


23.

Chandan V., Logan S.M., Aubry A., Hiratsuka K., Chow M., Stupak J.,
Li J.
, Altman E.,
Characterization of a waaF mutant of
Helicobacter pylori
strain 26695 provides evidence that an
extended lipopolysaccharide structure has a limited role in invasi
on of gastric cancer cells,
Biochem.
Cell Biol.
,
85, 582
-
590 (2007)
.


24.

Wang Z., Liu X., Dacanay A., Harrison B.A., Fast M., Colquhoun D.J., Lund V., Brown L.L.,
Li J.

Altman E. Carbohydrate analysis and serological classification of typical and atypical iso
lates of
Aeromonas salmonicida
: a rationale for the lipopolysaccharide
-
based classification of
A. salmonicida
,
Fish Shellfish Immunol.
, 23,1095
-
1106 (2007).


25.

Liu X., Li X., Chan K., Zou W., Pribil P., Li X., Sawyer M.B.,
Li J.
, "One
-
pot” methylation in gl
ycomics
application: Esterification of sialic acids and permanent charge construction.
Anal. Chem.
, 79, 3894
-
3900 (2007)


26.

Li J.
, Dzieciatkowska M., Hood D.W, Cox A.D., Schweda E.K.H, Moxon E.R., Richards J.C.,
Structural characterization of sialylated gly
coforms of
H. influenzae

by electrospray mass
spectrometry: fragmentation of protonated and sodiated
O
-
deacylated lipopolysaccharides.
Rapid
Commun. Mass Spectrom.

21, 952
-
960 (2007)


27.

Gilbert M., Mandrell R.E., Parker C.T.,
Li J.
, Vinogradov E., Structu
ral
a
nalysis of the
c
apsular
p
olysaccharide from
Campylobacter jejuni

RM1221.
ChemBioChem
, 8, 625
-
631 (2007)


28.

Liu Q.
-
D., Lu J., Ding J., Day M., Tao Y., Barrios P., Stupak J., Chan K.,
Li J.
, Chi Y., Monodisperse
s
tarburst
o
ligofluorene
-
f
unctionalized 4,4’
,4’’
-
t
ris(carbazol
-
9
-
yl)
-
triphenylamines: Their
s
ynthesis and
d
eep
-
b
lue
f
luorescence
p
roperties for
o
rganic
l
ight
-
e
mitting
d
iode
a
pplications.
Adv. Funct. Mater
.,
17, 1028
-
1036 (2007)


29.

Liu X., Zhao Y., Chan K., Hrudey S.E., Li X.
-
F.,
Li J.
, Analysis of nit
rosamines by capillary
electrospray
-
high
-
field asymmetric waveform ion mobility spectrometry
-
mass spectrometry with
programmed CV.
Electrophoresis
, 28, 1327
-
1334 (2007).


30.

Godschalk P
.
C
.
, Kuijf M
.
L
.
,
Li J
.
, St Michael F
.
, Ang C
.
W
.
, Jacobs B
.
C
.
, Karwaski M
.
F
.
, Brochu D
.
,
Moterassed A
.
, Endtz H
.
P
.
, van Belkum A
.
, Gilbert M., Structural characterization of
Campylobacter
jejuni

lipooligosaccharide outer cores associated with Guillain
-
Barre and Miller Fisher syndromes.
Infect Immun.

75, 1245
-
54 (2007).


31.

Li J.
, Ri
chards J.C., The application of capillary electrophoresis mass spectrometry to the
characterization of bacterial lipopolysaccharides,
Mass Spectrom. Rev.

26, 35
-
50 (2007).


32.

Fox K.L., Cox A.D., Gilbert M., Wakarchuk W.W.,
Li J.
, Makepeace K., Richards J.C.,

Moxon E.R.,
Hood D.W., Identification of a bifunctional lipopolysaccharide sialyltransferase in
Haemophilus
influenzae
: Incorporation of disialic acid
J. Bio. Chem.

281, 40024
-
40032 (2006).


33.

Wang Z.,
Li J.
, Altman E., Structural characterization of the
lipid A region of
Aeromonas salmonicida

subsp.
salmonicida

lipopolysaccharide.
Carbohydr Res
. 341, 2816
-
25 (2006).


34.

Liu X., McNally D.J., Nothaft H., Szymanski C.M., BrissonJ
-
R.,
Li J.

, A mass spectrometry
-
based
glycomics strategy for exploring
N
-
linked g
lycosylation in eukaryotes and bacteria.
Anal. Chem.

78,
6081
-
6087 (2006)


35.

Preston A, Petersen BO, Duus JO, Kubler
-
Kielb J, Ben
-
Menachem G,
Li J
, Vinogradov E., Complete
structures of
Bordetella bronchiseptica

and
Bordetella parapertussis

lipopolysaccharid
es.
J Biol
Chem.

281, 18135
-
44 (2006).


36.

Kimoto K., Koga M., Odaka M., Hirata K., Takahashi M.,
Li J.
, Gilbert M., Yuki N., Relationship of
bacterial strains to clinical syndromes of
Campylobacter
-
associated neuropathies,
Neurology

67,
1837
-
1843.


37.

McNally D
.J., Jarrell H.C., Knieu N.H.,
Li J.
, Vinogradov E., Whitfield D.M., Szymanski C.M., Brisson
J.
-
R., The HS:19 serotstrain of
Campylobacter jejuni

has a hyaluronic acid
-
type capsular
polysaccharide with a nonstoichiometric sorbose branch and
O
-
methyl phos
phoramidate group.
FEBS J.

273, 3975
-
3989 (2006).


38.

McNally D.J., Lamoureux M.,
Li J.
, Kelly J., Brisson J.
-
R., Szymanski C.M., Jarrell H.C., HR
-
MAS
NMR studies of
15
N
-
labeled cells confirm the structure of the
O
-
methyl phosphoramidate CPS
modification in
Campylobacter jejuni

and provide insight into its biosynthesis1
Can. J. Chem
. 84,
676

684 (2006)


39.

Houliston R.S., Endtz H.P., Yuki N.,
Li J.
, Jarrell J.C., Koga M., van Belkum A., Karwaski M.
-
F.,
Wakarchuk W.W., Gilbert M., Identification of a sialate
-
O
-
ac
etyltransferase from
Campylobacter
jejuni
: demonstration of direct transfer to the C
9

position of terminal α
-
2,8
-
linked sialic acid.
J. Biol.
Chem.
281,11480
-
11486 (2006).


40.

Vinogradov E., Sadovskaya I.,
Li J.
, Jabbouri S. Structural elucidation of the extracellular and cell
-
wall teichoic acids of
Staphylococcus aureus

MN8m, a biofilm formi
ng strain.
Carbohydr. Res.

341,
738
-
743 (2006)


41.

Godschalk P.C.R., Gilbert M., Jacobs B.C., Kramers T., Tio
-
Gillen A.P., Anga C.W., Van den Braak
N.,
Li J.
, Verbrugh H.A., Van Belkum A., Endtz H.P., Co
-
infection with two different
Campylobacter
jejuni

strai
ns in a patient with the Guillain

Barré syndrome,
Microbes Infect
. 8. 248
-
253

(2006)


42.

Koga M., Gilbert M., Takahashi M.,
Li J.
, Koichi S., Hirata K., Yuki N., Comprehensive analysis of
bacterial risk factors for developing Guillain
-
Barré syndrome after
Cam
pylobacter jejuni

enteritis,
J.
Infect. Dis
. 193, 547
-
555 (2006)


43.

Wang Z.,
Li J.
, Vinogradov E., Altman E., Structural studies of the core region of
Aeromonas
salmonicida

subsp.
salmonicida

lipopolysaccharide.
Carbohydr. Res.

341, 109
-
117 (2006).


44.

Yildirim

H. H.,
Li J.
, Richards J. C., Hood D. W., Moxon E. R., Schweda E. K. H., Complex
O
-
acetylation in non
-
typeable
Haemophilus influenzae

lipopolysaccharide: evidence for a novel site of
O
-
acetylation
Carbohydr. Res.

340, 2598
-
2611 (2005)


45.

McNally D.J., Jarr
ell H.C.,
Li J.
, Khieu N.H., Vinogradov E, Szymanski C.M., Brisson J.
-
R., The HS:1
serostrain of
Campylobacter jejuni

has a complex teichoic acid
-
like capsular polysaccharide with
nonstoichiometric fructofuranose branches and
O
-
methyl phosphoramidate group
s,
Eur. J.
Biochem.

272, 4407
-
4422 (2005)


46.

Li J.
, Koga M., Brochu D., Yuki N., Chan K., Gilbert G., Electrophoresis
-
assisted open
-
tubular liquid
chromatography / mass spectrometry for the analysis of lipooligosaccharide expressed by
Campylobacter jejuni
,
Electrophoresis
, 26, 3360
-
3368 (2005)


47.

Li J.
, Cox A.D., Hood D.W., Schweda E.K.H., Moxon E.R., Richards J.C., Electrophoretic and mass
spectrometric strategies for profiling bacterial lipopolysaccharides,
Mol. BioSyst.
, 1, 46
-
52 (2005)


48.

Li J.
, Wang Z., Alt
man E., In
-
source fragmentation and analysis of polysaccharides by capillary
electrophoresis
-

mass spectrometry,
Rapid Commun. Mass Spectrom.

19, 1305
-
1314 (2005)


49.

St. Michael F.,
Li J.
, Cox A.D., Structural analysis of the core oligosaccharide from
Paste
urella
multocida

strain X73,
Carbohydr. Res.

340, 1253
-
1257 (2005)


50.

Logan S.M., Altman E., Mykytczuk O., Brisson J.
-
R., Chandan V., St. Michael F., Masson A., Leclerc
S., Hiratsuka K., Smirnova N.,
Li J.
, Wu Y., Wakarchuk W.W., Novel biosynthetic functions

of
lipopolysaccharide rfaJ homologs from
Helicobacter pylori
,
Glycobiology

15, 721
-
733 (2005)


51.

St. Michael F., Vinogradov E.,
Li J.
, Cox A.D., Structural analysis of the lipopolysaccharide from
Pasteurella multocida

genome strain Pm70 and identification o
f the putative lipopolysaccharide
glycosyltransferases,
Glycobiology
, 15, 323
-
333 (2005)


52.

Yildirim H.H.,
Li J.
, Richards J.C., Hood D.W., Moxon E.R., Schweda E.K.H., An alternate pattern for
globoside oligosaccharide expression in
Haemophilus influenzae

li
popolysaccharide, Structural
diversity in nontypeable strain 1124,
Biochemistry
, 44, 5207
-
5224, (2005)


53.

St. Michael F.,
Li J.
, Howard M.D., A. Duncan J., Inzana T.J., Cox A.D., Structural analysis of the
oligosaccharide of
Histophilus somni

(
Haemophilus so
mnus
) strain 2336 and identification of several
lipooligosaccharide biosynthesis gene homologues,
Carbohydr. Res.

340, 665
-
672 (2005)


54.

Wang Z., Vinogradov E., Larocque S., Harrison B.A.,
Li J.
, Altman E., Structural and serological
characterization of the
O
-
chain polysaccharide of
Aeromonas salmonicida

strains A449, 80204 and
80204
-
1,
Carbohydr. Res.

340, 693
-
700 (2005)


55.

Koga M., Gilbert M.,
Li J.
, Koike S., Takahashi M., Furukawa K., Hirata K., Yuki N., Antecedent
infections in Fisher syndrome, a common pa
thogenesis of molecular mimicry.
Neurology
, 64, 1605
-
1611 (2005)


56.

Bernatchez S., Szymanski C.M., Ishiyama N.,
Li J.
, Jarrell H.C., Lau P.C., Berghuis A.M., Young
N.M., Wakarchuk W.W.,

A single bifunctional UDP
-
GlcNAc/Glc 4
-
epimerase supports the synthesis
of
three cell surface glycoconjugates in
Campylobacter jejuni
,
J. Biol. Chem.

280, 4792
-
4802 (2005).


57.

Karlyshev A.V., Champion O.L., Churcher C., Brisson J.
-
R., Jarrell H.C., Gilbert M., Brochu D., St.
Michael F.,
Li J.
, Wakarchuk W.W., Goodhead I., Sander
s M., Stevens K., White B., Parkhill J., Wren
B.W., Szymanski C.M., Analysis of
Campylobacter

jejuni

capsular loci reveals multiple mechanisms
or the generation of structural diversity and the ability to form complex eptoses,
Mol. Microbiol.

55,
90
-
103 (20
05)


58.

St. Michael F.,
Li J.
, Vinogradov E., Larocque S., Harper M., Cox A.D., Structural analysis of the
lipopolysaccharide of
Pasteurella multocida

strain VP161, identification of both Kdo
-
P and Kdo

Kdo
species in the lipopolysaccharide,
Carbohydr. Res.

34
0, 59
-
68 (2005)


59.

Vinogradov E., Paul C.J.,
Li J.
, Zhou Y., Lyle E.A., Tapping R.I., Kropinski A.M., Perry M.B., The
structure and biological characteristics of the
Spirochaeta aurantia

outer membrane glycolipid LGL
B
,
Eur. J. Biochem.

271, 4685
-
4695 (2004)


60.

Lu T.L., Chen C.S., Yang F.L., Fung J.M., Chen M.Y., Tsay S.S.,
Li J.
, Zou W., Wu S.H., Structure of
a major glycolipid from
Thermus oshimai

NTU
-
063,
Carbohydr. Res.

339, 2593
-
2598 (2004)


61.

Gilbert M., Godschalk P.C., Karwaski M.F., Ang C.W., van Belkum A.
,
Li J.
, Wakarchuk W.W., Endtz
H.P., Evidence for acquisition of the lipooligosaccharide biosynthesis locus in
Campylobacter jejuni

GB11, a strain isolated from a patient with Guillain
-
Barre syndrome, by horizontal exchange.
Infect
Immun
. 72, 1162
-
1165 (20
04).


62.

Wang Z., Larocque S., Vinogradov E., Brisson J.
-
R., Dacanay A., Greenwell M., Brown L.,
Li J.
,
Altman E., Structural studies of the capsular polysaccharide and lipopolysaccharide
O
-
antigen of
Aeromonas salmonicida

strain 80204
-
1 produced under
in
vitro

and
in vivo

growth conditions.
Eur. J.
Biochem.

271, 4507
-
4516 (2004)


63.

Godschalk P.C., Heikema, A.P., Gilbert M., Komagamine T., Ang C.W., Glerum J., Brochu D.,
Li J.
,
Yuki N., Jacobs B.C., van Belkum A., Endtz H.P. The crucial role of
Campylobacte
r jejuni

genes in
autoimmune antibody induction.
J. Clin. Invest
. 114, 1659
-
1665 (2004).


64.

St. Michael F., Brisson J.
-
R., Larocque S., Monteiro M.,
Li J.
, Jacques M., Perry M. B., Cox A. D.,
Structural analysis of the lipopolysaccharide derived core oligosa
ccharides of
Actinobacillus
pleuropneumoniae

serotypes 1, 2, 5a and the genome strain 5b,
Carbohydr. Res.

339,

1973
-
1984
(2004)


65.

Li J.
, Purves R. W., Richards J. C., Coupling capillary electrophoresis and high field asymmetric
waveform ion mobility spectro
metry (FAIMS) mass spectrometry for the analysis of complex
lipopolysaccharides,
Anal. Chem.
76, 4676
-
4683 (2004)


66.

Kaniuk N. A., Vinogradov E.,
Li J.
, Monteiro M. A., Whitfield C., Chromosomal and plasmid
-
encoded
enzymes are required for assembly of the R3
-
type core oligosaccharide in the lipopolysaccharide of
Escherichia coli

O157,H7,
J. Biol. Chem.

279, 31237
-
31250 (2004)


67.

Li J.
, Cox A.D., Hood D.W., Moxon E.R., Richards J.C., Application of capillary electrophoresis
-
electrospray mass spectrometry to the
separation and characterization of isomeric
lipopolysaccharides of
Neisseria meningitides
.
Electrophoresis
, 25, 2017
-
2025 (2004)


68.

Wright J.C., Hood D.W., Randle G.A., Makepeace K., Cox A.D.,
Li J
, Chalmers R., Richards J.C.,
Moxon E.R., lpt6, a gene requir
ed for addition of phosphoethanolamine to inner
-
core
lipopolysaccharide of
Neisseria meningitidis

and
Haemophilus influenzae
.
J. Bacteriol
. 186, 6970
-
6982 (2004).


69.

Hood D.W., Randle G., Cox A.D., Makepeace K.,
Li, J.
, Schweda, E.K.H., Richard, J.C., Moxo,
E.R.,
Biosynthesis of cryptic lipopolysaccharide glycoforms in
Haemophilus influenzae

involves a
mechanism similar to that required for
O
-
antigen synthesis.
J. Bacteriol
. 186, 7429
-
7439 (2004).


70.

Vinogradov E.,
Li J.
, Sadovskaya I., Jabbouri S., Helander I.
M., The structure of the carbohydrate
backbone of the lipopolysaccharide of
Pectinatus frising
ensis strain VTT E
-
79104,
Carbohydr. Res.

339, 1637
-
1642 (2004)


71.

Wakarchuk W.W., Schur M.J., St Michael F.,
Li J.
, Eichler E., Whitfield D., Characterization of t
he

-
1,2
-
N
-
acetyl
-
glucosaminyltransferase of
Neisseria gonorrhoeae
, a key control point in
lipooligosaccharride biosynthesis.
Glycobiology
. 14, 537
-
546 (2004)


72.

Sadovskaya I., Vinogradov E.,
Li J.
, Jabbouri S., Structural elucidation of the extracellular an
d cell
-
wall teichoic acids of
Staphylococcus epidermidis

RP62A, a reference biofilm
-
positive strain,
Carbohydr. Res.

339, 1467
-
1473 (2004)


73.

St Michael F., Vinogradov,E.,
Li J.
, Cox A. D., Structural analysis of the lipopolysaccharide from
Pasteurella multo
cida

genome strain Pm70 and identification of the putative lipopolysaccharide
glycosyltransferases.
Glycobiology
. 15, 323
-
333 (2004)


74.

St Michael F., Howard M.D.,
Li J.
, Duncan A.J., Inzana T.J., Cox, A.D., Structural analysis of the
lipooligosaccharide fro
m the commensal
Haemophilus somnus

genome strain 129Pt.
Carbohydr.
Res.

339, 529
-
35 (2004).


75.

Landerholm M.K.,
Li J.
, Richards J.C., Hood D.W., Moxon E.R., Schweda E. K. H., Characterization
of novel structural features in the lipopolysaccharide of nondisea
se associated nontypeable
Haemophilus

influenzae
,
Eur. J. Biochem
. 271, 941

953 (2004)


76.

Altman E., Smirnova N.,
Li J.
, Aubry A., Logan S.M.,
Occurrence of a nontypable
Helicobacter pylori

strain lacking Lewis blood group
O
-
antigens and DD
-
heptoglycan, Evid
ence for the role of the core

1,6
-
glucan chain in colonization.
Glycobiology
. 13, 777
-
783 (2003)


77.

Schweda E.K.H., Landerholm M.K.,
Li J.
, Moxon E.R., Richards J.C., Structural profiling of
lipopolysaccharide glycoforms expressed by non
-
typeable
Haemophilu
s influenzae
, phenotypic
similarities between NTHi strain 162 and the genome strain Rd.
Carbohydr. Res.

338, 2731
-
2744
(2003)


78.

Ram S., Cox A.D., Wright J.C., Vogel U., Getzlaff S., Boden R.,
Li J.
, Plested J.S., Meri S., Gulati S.,
Stein D.C., Richards J.C
., Moxon E.R., Rice P.A.,
Neisserial

lipooligosaccharide is a target for
complement component C4b. Inner core phosphoethanolamine residues define C4b linkage
specificity.
J. Biol. Chem.

278, 50853
-
50862. (2003).


79.

Cox A.D., Wright J.C.,
Li J.
, Hood D.W., Mo
xon E.R., Richards J.C., Phosphorylation of the lipid A
region of meningococcal lipopolysaccharide, identification of a family of transferases that add
phosphoethanolamine to lipopolysaccharide.
J. Bacteriol.

185, 3270
-
3277 (2003).


80.

Szymanski C.M., St. Mic
hael F., Jarrell H.C.,
Li J.
, Gilbert M., Larocque S., Brisson J.
-
R. Detection of
conserved
N
-
linked glycans and phase variable lipooligosaccharides and capsules from
campylobacter

cells by mass spectrometry and high resolution magic angle spinning NMR
spe
ctroscopy.
J. Biol. Chem
.

278, 24509
-
24520 (2003)


81.

Bouchet V.

, Hood D.W.

,
Li J.

, Brisson J.
-
R., Randle G.A., Martin A., Li Z., Goldstein R., Schweda
E.K.H., Pelton S.I., Richards J.C., Moxon E.R.,

Host
-
derived sialic acid is incorporated into
Haemophil
us influenzae

lipopolysaccharide and is a major virulence factor in experimental otitis
media.
Proc. Natl. Acad. Sci. USA
. 100, 8898
-
8903 (2003) (

shared first author
)


82.

Kneidinger B., O’Riordan K.,
Li J.
, Brisson J.
-
R., Lee J.C., Lam J.S., Three highly co
nserved proteins
catalyze the conversion of UDP
-
N
-
acetyl
-
D
-
glucosamine to precursors for the biosynthesis of O
-
antigen in
Pseudomonas aeruginosa

O11 and Capsule in
Staphylococcus aureus

Type 5.
Implications for the UDP
-
N
-
acetyl
-
L
-
fucosamine biosynthetic pa
thway.

J. Biol. Chem.

278, 3615
-
3627 (2003)


83.

St. Michael F., Szymanski C.M.,
Li J.
, Chan K.H., Khieu N.H., Larocque S., Wakarchuk W.W.,
Brisson J.
-
R., Monteiro M.A., The structures of the lipooligosaccharide and capsule polysaccharide of
Campylobacter jeju
ni

genome sequenced strain NCTC 11168,
Eur. J. Biochem.

269, 5119
-
5136
(2002)


84.

Bonneil E.,
Li J.
, Tremblay T.
-
L., Bergeron J.J., Thibault P., Integration of solid
-
phase extraction
membranes for sample multiplexing, Application to rapid protein identificati
on from gel
-
isolated
protein extract,
Electrophoresis
, 23, 3589
-
3598 (2002)


85.

Cox A. D.,
Li J.
, Brisson J.
-
R., Moxon E.R., Richards J.C., Structural analysis of the
lipopolysaccharide from
Neisseria meningitidis

strain BZ157
galE
, localisation of two
phosph
oethanolamine residues in inner core oliosaccharide,
Carbohydr. Res.
, 337, 1435
-
1444
(2002)


86.

Cox A.D.,
Li J.
, Richards J.C., Identification and localisation of glycine in the inner core
lipopolysaccharide of
Neisseria meningitidis
.
Eur. J. Biochem.
, 269,
4169
-

4175 (2002)


87.

Cox A.D., Hood D.W., Martin A., Makepeace K., Deadman M.E.,
Li J.
, Brisson J.
-
R., Moxon E.R.,
Richards J.C., Identification and structural characterization of a sialylated lacto
-
N
-
neotetraose
structure in the lipopolysaccharide of
Hae
mophilus influenzae
.
Eur. J. Biochem.
, 269, 4009
-

4019
(2002)


88.

Mansson M., Hood D.W.,
Li J
.
, Richards J.C., Moxon E.R., Schweda E.K.H.,
Structural analysis of
the lipopolysaccharide from nontypeable
Haemophilus influenzae

strain 1003,

Eur. J. Biochem.
, 2
69,
808
-
818 (2002)


89.

Li J.
, LeRiche T., Tremblay T.
-
L., Wang C., Bonneil E., Harrison D.J., Thibault P.,
Application of
microfluidic devices in proteomics research, Identification of trace
-
level protein digests and affinity
capture of target peptides.
Mol.

Cell. Proteomics
,
1, 157
-
168 (2002)


90.

Schweda E.K.H.,
Li J.
, Moxon E.R., Richards J.C., Structural analysis of lipopolysaccharide
oligosaccharide epitopes expressed by non
-
typeable

Haemophilus influenzae

strain 176.
Carbohydr.
Res.
, 337, 409
-
420 (2002)


91.

Li

J.
, Bauer S.H.J., Mansson M., Moxon E.R., Richards J.C., Schweda E.K.H., Glycine is a common
substituent of the inner core in
Haemophilus influenzae

lipopolysaccharide.
Glycobiology
, 11, 1009
-
1015 (2001).


92.

Li J.
, Tremblay T.
-
L., Wang C., Attiya S., Harris
on D.J., Thibault P., Integrated system for high
throughput protein identification using a microfabricated device coupled to capillary
electrophoresis/nanoelectrospray mass spectrometry.
Proteomics,

1, 975
-
986 (2001).


93.

Zou W.,
Li J.
, Larocque A., Jennings

H.J., Construction of multivalent sialyl Le
x

from the type Ia group
B
Streptococcus

capsular polysaccharide.
Carbohydr. Res.
, 332, 249
-
255 (2001).


94.

Deng Y., Henion J.,
Li J.
, Thibault P., Wang C., Harrison D.J., Chip
-
based capillary
electrophoresis/mass s
pectrometry
-

Determination of carnithines in human urine.
Anal. Chem.
, 73,
639
-
646 (2001).


95.

Wakarchuk W.W., Watson D., St. Michael F.,
Li J.
, Wu Y., Brisson J.
-
R., Young N.M., Gilbert M.,
Dependence of the Bi
-
functional nature of a sialyltransferase from

Neisseria meningitidis

on a single
amino acid substitution,
J. Biol. Chem.,

276, 12785
-
12790 (2001).


96.

Zhao X., Creuzene C., Bélanger M., Egbosimba E.,
Li J.
, Lam J.S., WbpO, a UDP
-
N
-
acetyl
-
D
-
galactosamine dehydrogenase from
Pseudomonas aeruginosa

serotype

O6.
J. Biol. Chem.,

275,
33252
-
33259 (2000).


97.

Creuzene C., Schurr M.,
Li J.
, Wakarchuk W.W., Lam J.S., FlaA1, a new bifunctional UDP
-
GlcNAc
C
6

dehydratase/C
4

reductase from
Helicobacter pylori
.
J. Biol. Chem.,

275, 34873
-
34880 (2000).


98.

Wang C., Oleschuk R
., Ouchen F.,
Li J.
, Thibault P., Harrison D.J., Integration of immobilized trypsin
bead beds for protein digestion within a microfluidic chip incorporating capillary electrophoresis
separations and an electrospray mass spectrometry interface.
Rapid Commun
. Mass Spectrom.,
14,1377
-
1383 (2000).


99.

Li J.
, Kelly J.F., Chernushevich I., Harrison J.D., Thibault P., Separation and identification of peptides
from gel
-
isolated membrane proteins using a microfabricated device for capillary
electrophoresis/nanoelectros
pray mass spectrometry,
Anal. Chem.,

72, 599
-
609 (2000).


100.

Li J.
, Wang C., Kelly J.F., Harrison D.J., Thibault P., Rapid and sensitive separation of trace level
protein digests using microfabricated devices coupled to a quadrupole/time
-
of
-
flight mass
spectr
ometer,
Electrophoresis,

21, 198
-
210 (1999).


101.

Li J.
, Waldron K.C., Effect of surfactant concentration on the determination of trans, trans
-
muconic acid in urine by cationic micellar electrokinetic chromatography with thermo
-
optical
absorbance detection.
J.

Liq. Chrom. Rel. Technol.,

22, 1919
-
1933 (1999)
.


102.

Li J.
, Waldron K.C., Estimation of the pH
-
independent binding constants of alanylphenylalanine
and leucylphenylalanine stereoisomers with

-
cyclodextrin in the presence of urea,
Electrophoresis
,
20, 171
-
1
79 (1999).


103.

Li J.
, Thibault P., Bings N.H., Skinner C.D., Wang C., Harrison D.J., Integration of
microfabricated devices to capillary electrophoresis
-
electrospray mass spectrometry using a low dead
volume connection, Application to rapid analysis of proteo
lytic digests,
Anal. Chem.
, 71, 3036
-
3045
(1999).


104.

Li J.
, Thibault P., Martin A., Richards J.C., Wakarchuk W.W., vander Wilp W., Development of
on
-
line preconcentration method for the analysis of pathogenic lipooligosaccharides using capillary
electrophore
sis
-
electrospray mass spectrometry, application to single colony
, J. Chromatogr. A
, 817,
325
-
336 (1998).


105.

Furtos
-
Matei A.,
Li J.
, Waldron K.C., micellar electrokinetic chromatographic study of the
interaction between enkephalin peptide analogies and charg
ed micelles,
J. Chromatogr. B
, 695, 39
-
47 (1997)


106.

Waldron K.C.,
Li J.
, Investigation of a pulsed
-
laser thermo
-
optical absorbance detector for the
determination of food preservatives separated by capillary electrophoresis,
J. Chromatogr. B
, 683,
47
-
54 (1
996).


107.

Huang, B.,
Li, J.
, Zhang, L., Cheng, J., On
-
line sensitive CL detection for capillary ion
electrophoresis,
Anal. Chem
., 68, 2366
-
2369 (1996).


108.

Xiong S.,
Li J.
, Cheng J., Multicomponent analysis of highly overlapped capillary electrophoretic
peaks u
sing multiwavelength charge
-
coupled device detection,
J. Liq. Chrom. Rel. Technol
., 19,
2129
-
2134 (1996).


109.

Xiong S.,
Li J.
, Cheng J., Multiwavelength fluorescence detection for purity analysis of
fluorescent agents using capillary electrophoresis with a c
harge
-
coupled device,
Anal. Chim. Acta
,
322, 187
-
194 (1996).


110.

Huang B.,
Li J.
, Cheng J., Construction of end
-
capillary chemiluminescence detection system for
capillary electrophoresis,
Chem. J. Chinese Universities
, 17, 528
-
530 (1996).


111.

Xiong S.,
Li J.
, Ch
eng J., Studies on the coupling technique between high performance capillary
electrophoresis and charge
-
coupled devices detector (VI). Laser induced fluorescence detection
setup and comparison with common light source setup,
Fenxi Kexue Xuebao
(Chinese Jou
rnal of
Analytical Sciences), 11(3), 12
-
15 (1995).


112.

Xiong S.,
Li J.
, Cheng J., Studies on the coupling technique between high performance capillary
electrophoresis and charge
-
coupled devices detector (IV). Monte Carlo simulation,
Fenxi Huaxue

(Chinese Jour
nal of Analytical Chemistry), 24, 19
-
22 (1996).


113.

Xiong S.,
Li J.
, Cheng J., Studies on the coupling technique between high performance capillary
electrophoresis and charge
-
coupled devices detector (III). Quantitative calculation methods,
Chem. J.
Chinese U
niversities
, 17, 38
-
42 (1996).


114.

Xiong S.,
Li J.
, Cheng J., Studies on the coupling technique between high performance capillary
electrophoresis and charge
-
coupled devices detector (II). Separation of fluorescent dye mixture,
Fenxi Huaxue

(Chinese Journal o
f Analytical Chemistry), 24, 54
-
56 (1996).


115.

Huang B.,
Li J.
, Cheng J., Highly sensitive chemiluminescence detection for capillary ion
analysis,

Chromatography
(Chinese), 13, 430
-
433 (1995).


116.

Xiong S.,
Li J.
, Cheng J., Studies on the coupling technique betw
een high performance capillary
electrophoresis and charge
-
coupled devices detector (I). A setup for multi
-
wavelength fluorescence
detection,
Chromatography
(Chinese), 13, 396
-
399 (1995).


117.

Xiong S.,
Li J.
, Cheng J., A new charge
-
coupled device array setup f
or highly sensitive
fluorescence detection,
Fenxi Huaxue

(Chinese Journal of Analytical Chemistry), 23, 356
-
358
(1995).


118.

Xiong S.,
Li J.
, Cheng J., Highly sensitive charge
-
coupled device fluorescence detection
--
studies
on the influence factors of Kalman fi
ltering,
Fenxi Kexue Xuebao
(Chinese Journal of Analytical
Sciences), 11(1), 3
-
7 (1995).


119.

Xiong S.,
Li J.
, Cheng J., Charge transfer device detectors and their application in analytical
chemistry,
Fenxi Huaxue

(Chinese Journal of Analytical Chemistry), 23,

960
-
963 (1995).


120.

Li J.
, Chen G., Zeng Y., Application of time
-
resolved, window and derivative techniques in
fluorimetric analysis of rare earths,
Spectroscopy and Spectra Analysis
(Chinese), 13 (3), 1
-
4
(1993).


121.

Li J.
, Chen G., Hu J., Zeng Y., The applica
tion of synergetic luminescence of Eu in time
-
resolved
fluoroimmunoassay,
Fresenius’ J. Anal. Chem
., 342, 552 (1992).


122.

Li J.
, Chen G., Zeng Y., Time resolved
-
window techniques and its application,
Chem. J. Chinese
Universities
, 13, 37
-
39 (1992).


123.

Chen G.,
Yang X.,
Li J.
, Hu J., Studies on Hardmard transform fluorimetry,
Chemical Research
in Chinese Universities
, 8, 27
-
30 (1992).


124.

Li J.
, Chen G., Zeng Y., Application of three
-
dimensional fluorimetry of rare earths,
Bulletin of
Analysis & Testing
(Chinese), 1
1 (3), 25
-
28 (1992).


125.

Li J.
, Chen G., Zeng Y., Studies on laser induced time
-
resolved fluorescence of rare earth
elements,
Metallurgical Analysis
(Chinese), 12 (6), 1
-
4 (1992).


126.

Li J.
, Chen G., Zeng Y., Determination of europium by laser induced
-
time resol
ved fluorimetry,
Anal. Lab.
(Chinese), 10 (3), 4
-
7 (1991).


127.

Li J.
, Chen G., Zeng Y., The application of three
-
dimensional fluorimetry in multicomponent
resolution,
Fenxi Huaxue

(Chinese Journal of Analytical Chemistry), 18, 726
-
730 (1990).


128.

Li J.
, Chen G.,

Zeng Y., The simultaneous determination of some rare
-
earth elements by laser
induced derivative fluorimetry,
Chem. J. Chinese Universities
, 11, 1310
-
1313 (1990).


129.

Li J.
, Chen G., Zeng Y., The application of synergetic luminescence system to time
-
resolved
fluoroimmunoassay,
Kexue Tongbao

(Chinese Journal of Science), 35, 1678 (1990).


130.

Li J.
, Chen G., Zeng Y., Simultaneous determination of some rare
-
earth elements by derivative
fluorimetry and use of Kalman filter,
Talanta
, 37, 809
-
813 (1990).


131.

Li J.
, Chen G
., Zeng Y., The simultaneous determination of Dy, Eu, Sm and Tb by laser induced
-
time resolved derivative fluorescence,
Fresenius’ J. Anal. Chem
., 336, 139
-
143 (1990).


132.

Li J.
, Luo Q., Zeng Y., Studies on derivative spectrophotometry (V) The theory of zero
crossing
method and its application,
Acta Chim. Sinica
, 46, 590
-
591 (1988).


133.

Li J.
, Luo Q., Zeng Y., The theoretical analysis of interferences of overlap bands in derivative
spectrophotometry and its application,
Chem. J. Chinese Universities
, 9, 337
-
339 (
1988).


134.

Li J.
, Luo Q., Zeng Y., The derivative spectrophotometric studies of trithylene
tetraaminehexaacetic acid (TTHA)
-

RE complexes and its applications,
Anal. Lab.,

(Chinese), 7, 13
-
16 (1988).


135.

Li J.
, Luo Q., Zeng Y., Studies on derivative spectrophot
ometry (III). Simultaneous determination
of micro lead and bismuth in tin by forth
-
derivative spectrophotometry,
Fenxi Huaxue

(Chinese
Journal of Analytical Chemistry), 8, 597
-
599 (1986).


BOOK CHAPTERS


1.

Li J.

and Altman E., Chapter 717: The application of

mass spectrometry to polysaccharide structure
analysis,
Comprehensive Natural Products Chemistry II
, edited by Mander L.N. and Liu H.
-
W.,
Elsevier, Oxford, UK. In press (2009)


2.

Wang C., Liu X., Hamula C.L.A., Li X.
-
F., and
Li J.
, Chapter 130: Mass spectro
metry analysis of
bacterial glycomes,
Comprehensive Natural Products Chemistry II
, edited by Mander L.N. and Liu
H.
-
W., Elsevier, Oxford, UK. In press (2009)


3.

Li J.
, Martin A., Cox A.D., Moxon E.R., Richards J.C., Thibault P., Mapping bacterial glycolipid
complexity using capillary electrophoresis and electrospray mass spectrometry,
Methods in
Enzymology, Mass spectrometry: Modified proteins and glycoconjugates.

edited by Burlingame,
A. L. Academic Press, San Diego, CA, pp369
-
397 (2005)


4.

Li J.
, Tremblay T.
-
L., Harrison D.J., Thibault P., Integrated system for rapid proteomics analyses
using microfluidic devices coupled to nanoelectrospray mass spectrometry,
Methods in Molecular
Biology, vol. 276, Capillary Electrophoresis of Proteins and Peptides
. edited by,

M. A. Strege
and A. L. Lagu, Humana Press, pp305
-
324 (2004)


5.

Thibault P.,
Li J.
, Martin A., Richards J.C., Hood D.W., Moxon E.R., Electrophoretic and mass
spectrometric strategies for the identification of lipopolysaccharides and immunodeterminants in
pat
hogenic strains of
Haemophilus influenzae
, application to clinical isolates,

Mass Spectrometry in
Biology and

Medicine
, edited by Burlingame A. L., Carr S. A. and Baldwin M. A., Humana Press,
pp439
-
462 (1998).


BOOK




Methods in Molecular Biology: Functiona
l Glycomics
. edited by Jianjun Li, Humana Press, in
preparation (2009)


PATENTS




Tang
T., Harrison

J.D., Bings N., Wang C., Ocvirk

G.,
Li

J.
, Skinner C., Thibault

P., Microfluidic
Devices Connected to Capillarie
s With Minimal Dead Volume, 2000 (WO 0022409, U.S. Patent No.
6,605,472).