BIO_304_2012_files/Lecture 31 annotated.pptx

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14 Δεκ 2012 (πριν από 4 χρόνια και 8 μήνες)

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What is the definition of proteomics
?




1.

The process of defining the complete set of
proteins encoded by a genome



2.

The harvesting of proteins from a cell to
determine their
ecomomic

value



3.

The manipulation of amino acid sequences in
proteins to alter their function



4.

The rational design of drugs based on
protein structure


The
use of computer and mathematics applications
to organize, share, and analyze data related to gene
structure, sequence and expression
is



1.

genomics



2.

transcriptomics






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4.

genetic engineering


An open reading frame (ORF) begins with a(n)
_______________ and ends with a(n)
_________________
.



1.

promoter; poly
-
A signal sequence






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3.

TATA box; start codon



4.

TATA box; stop codon



5.

transcription start site; poly
-
A tail


Homologous genes in different species that
are thought to have descended from a gene in
a common ancestor are
called



1.

paralogs



2.

pseudogenes



3.

gene duplications




4.

orthologs



5.

synologs


Dysfunctional relatives of genes that have lost
their protein
-
coding ability or are otherwise no
longer expressed in the cell are
called



1.

transposons



2.

antigenes




3.

pseudogenes



4.

minigenes



5.

nonsense genes


One method that is used to measure the
expression levels of large numbers of genes
simultaneously
is



1.

metagenomics



2.

whole
-
genome shotgun sequencing



3.

BLAST search



4.

2D gel electrophoresis






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BIO 304

Lecture 31

BLAST search to identify gene
sequences

Functional genomics

The Human Genome Project

Comparative genomics

Comparative genomics