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25 Νοε 2013 (πριν από 3 χρόνια και 8 μήνες)

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SATHYABAMA UNIVERSITY

(Established under section 3 of UGC Act,1956)


Course & Branch : M.Tech
-

BIN

Title of the Paper :
Systems Biology and Metabolic Engineering

Max. Marks:80

Sub. Code :

SBIX5008

(2010)




Time : 3 Hours

Date :05/03/2012







Session :FN

______________________________________________________________________________________________________________________


PART
-

A (6 x 5 = 30)


Answer ALL the Questions

1.

What is
Flux balance analysis?


2.

Explain robustness and sensitivity of a model.


3.

Describe E
-
cell project.


4.

What is a scale free network in cell biology?


5.

Define Gene ontology and Reactome.


6.

What are the uses and applications of CellDesigner and PyBio
s?


7.

Give an example of a directed graph representing gene network.


8.

What is Quasispecies with respect to evolution?


PART


B


(5 x 10 = 50)

Answer ALL the Questions


7.

Explain the properties of a model in systems biology and give the
advantages of
computational modeling.

(or)

8.

How does differential gene expression help in the various
developmental stages of humans?


9.

How do you translate biochemical networks in linear algebra?
Explain in detail.

(or)

10.

Explain the control coefficients and the
elasticity coefficients of
metabolic control analysis along with their theorems.


11.

Explain three models of gene expression using stochastic
equations.

(or)

12.

How do you capture gene expression data and explain clustering
algorithms.


13.

Describe how
to predict the biological systems from optimality
principles.

(or)

14.

Explain DNA
-
Protein and Protein
-
Protein Interactions.


15.

Explain any five systems biology databases and tools.

(or)

16.

Write short notes on:

(a) Mathematica,

(b) Matlab