Membership Criteria and Application - Oregon Health & Science ...

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Membership Application







mail: ______________
_______ Phone: _________________
___ Fax: __

____ Department: __________________ Institution: ____________


(if applicable)




Please describe your cancer
related primary research interest and any other research
interests related to cancer. Attach additional pages as necessary:

List "key" search words related to your primary research area:

Program Preference:


Cancer Biology


Hematologic Malignancies


Solid Tumors Studies


Prevention, Control, and Population



Please return application, NIH
formatted biographical sketch, NIH ot
her support, and your CV to:

Candi Adams

OHSU Knight Cancer Institute

3181 SW Sam Jackson Park Rd., CR 145

Portland, OR 97239


Mission Statement/Vision

The mission of the Knight Cancer Institute

at Oregon Health & Science University
(OHSU) is to
reduce the impact that cancer has on all of our lives by providing world class, patient
focused, comprehensive and coordinated clinical care; conducting groundbreaking research; and
training the next generation of oncology researchers and clinicians. To
duce cancer incidence,
morbidity and mortality
, we must bring together the energy and abilities of the talented and diverse
cancer researchers and clinicians
at OHSU and its affiliates.

Cancer Institute

aims to
nsure that no person will have
to travel out of
our region for
class care; m
aintain our leadership position in personalized cancer medicine
; and r
Oregon’s death rate from cancer to the lowest in the nation


The OHSU Knight Cancer Institute is:

a matrix cancer cen
ter at OHSU in Portland, Oregon

the only National Cancer Institute (NCI) designated cancer center between Sacramento and

one of the 63 NCI cancer centers nationwide

The institute has been an NCI
designated cancer center for 14 years and is comprised of four
scientific programs and eight core facilities. Among its more than 150 members are basic, clinical,
and population scientists who collaborate on ground
breaking tr
anslational research. The institute
is directed by Brian Druker, MD. Dr. Druker, member of the National Academy of Sciences and
recipient of both the
Charles F. Kettering Prize and the
Keio Medical Science Prize, has a top
priority: recruit and retain outs
tanding cancer researchers and clinicians to the institute, equip them
with the best resources, and support their efforts to target the underlying causes of cancer.

The OHSU Knight Cancer Institute recently received a $100 million gift from
Philip H. and
. The Nike founder's gift

the largest in the history of OHSU

is transformative as far as its
impact on allowing the cancer institute to achieve its ambitious goals.


Membership Requirements

welcomes applications for membership from individuals who have major cancer
related efforts in research, patient care, or education. The
rograms must fulfill
certain NCI criteria to receive approval for funding. They include: (a) evid
ence that membership
leads to intra

and inter
programmatic collaboration, (b) evidence of regular participation of
members in program
related meetings, (c) a significant publication record of program members,
and (d) evidence that the research activities
of members are either cancer focused or relevant to
the cancer problem. Physician members should be board certified if specialty (and subspecialty)
boards exist in their fields.

Eligible for membership are physicians involved in clinical or basic resear
ch, research scientists,
and education/outreach and prevention control specialists whose primary objective is to organize
and help accomplish the basic concept, mission, and goals of the
nstitute. The
nstitute oversees
all cancer related
activities on ca
mpus to: (1) encourage multidisciplinary patient care in order to
improve outcomes in patients with cancer, (2) maximize OHSU’s cancer
related research potential;
and (3) directly provide and indirectly enhance education about cancer in our institution and

in our
communities. By providing administrative and program support, laboratory space, support for core
laboratory facilities, pilot projects, and support for new faculty, the Cancer Institute facilitates
collaborative interactions across departmental lin
es in a way that that enhances patient care,
research, and education.

Research Programs

Institute membership is separated into four research programs. Each of these programs is broken
down into work (focus) groups. The programs and their work groups are
detailed below:

Program 1: Cancer Biology

Leaders: Matt Thayer, PhD and Rosalie Sears, PhD

The Cancer Biology program constitutes the foundation of basic science research of the institute.
The overall goal of the Cancer Biology
rogram is to investig
ate the underlying cellular and
molecular mechanisms involved in the development of cancer and in the regulation of both normal
and abnormal cell growth.
The scientific thrust of the program is in two related areas of
investigation: Carcinogenesis/Genetic
Instability and Signal Transduction.

Members of the
Carcinogenesis/Genetic Instability

group focus their studies around cell cycle control, the
regulation of apoptosis, and the relationship of these events to the development of genetic
instability and cancer. The members of the
Signal Transduction

group focus their studies around
general si
gnaling mechanisms of relevance to regulation of normal and cancer cell growth: the
integrated function of growth factors and their receptors, kinase
mediated signaling phenomena,
and the regulation of transcription that lies downstream of the aforemention
ed events. Because of
the seamless nature of cellular regulation that is relevant to the cancer problem, there is a great
deal of overlap between the research interests of the two groups.


Program 2: Hematologic Malignancies

Interim Leader: Mike Deining
er, MD, PhD

The main goal of the Hematologic Malignancies Program is to develop novel molecularly
approaches for the treatment and prevention of hematopoietic malignancies based on an
understanding of the molecular pathogenesis of these disorders
There are three focus groups
within the Hematologic Malignancies Program: Hematopoiesis, Molecular Leukemogenesis/
Lymphomagenesis, and HIV/AIDS.

Members of the

focus group study the events
that control proliferation, survival, and differen
tiation of hematopoietic stem cells and investigate
how hematologic malignancies evolve from molecular disorder of these cells. This also includes
studies of how perturbations of the hematopoietic microenvironment, genetic instability, or stem
cell damage
can lead to hematologic malignancies. The

focus group seeks to define and understand the molecular
defects that cause leukemias and lymphomas. By understanding precise causal mechanisms,
therapeutic agents can be de
veloped that specifically target the abnormality. This approach has
been validated by this program’s discovery and development of imatinib as a molecularly
agent for CML. The

focus group includes investigators with interests in the struct
ure and
function of HIV, with specific emphasis on the mechanism of viral infectivity, tissue tropism, and
targets of HIV for therapy, along with the mechanism of bone marrow suppression and
predisposition to malignancy caused by HIV infection and the mole
cular pathogenesis of Kaposi
sarcoma. The Hematologic Malignancies Program has provided a successful framework that
promotes interactions between basic scientists involved in hematological research and related
diseases and the clinicians treating these dis
orders. It also emphasizes translating laboratory
findings into the clinic and performing scientific studies in association with clinical trials to assist in
patient selection, understanding responses, and optimizing therapy.

Program 3: Solid Tumors

: Molly Kulesz
Martin, PhD

and Alan Sandler, MD

The primary goals of the Solid Tumors Program are to develop novel molecularly
approaches for prevention and treatment of malignancies arising from mucocutaneous, urogenital
and gut epithelia and mesenchymal tissues and to design and conduct translational clinical trials
based on findings in basic and/or population research studies. The Solid Tumors Program
researchers apply cellular, molecular biological, and genetic techni
ques to advance understanding
of molecular pathogenesis. Research in this program involves studies of normal and malignant
cells, as well as inherited diseases that predispose to the development of epithelial malignancies
by combined mechanisms of genetic
instability and microenvironmental perturbations.
There are
three focus groups within this program: Gastrointestinal Malignancies, Prostate Cancer,
and Other Solid Tumors.

Gastrointestinal Malignancies

group focuses on new methods for
screening, diagno
sis, prevention, and therapy of esophageal, pancreatic, and colorectal
malignancies, as well as characterizing mechanisms of resistance and developing new therapies
for patients with
Gastrointestinal Stromal Tumors (
GIST). The GI focus group meets weekly.
Prostate Cancer

group was formed approximately five years ago, and has developed a horizontally
integrated, multidepartmental, and translational group of scientists who conduct integrated


research in cancer biology, translational, clinical, and populat
ion science in ways that capitalize on
the organizational structure and shared resources of the OHSU Cancer Institute. This focus group
meets weekly and is highly interactive. The
Other Solid Tumors

group encompasses a variety of
cancer types, particularly

skin malignancies, breast cancer, gynecologic malignancies, and bone
and soft tissue sarcomas. Members of this group meet at least once weekly, having initiated a
highly successful campus
wide carcinogenesis journal club.
The program provides a successful

framework that promotes interactions between basic scientists involved in research on epithelial
cell survival, differentiation, and clonal evolution and clinicians treating these disorders who also
develop translational clinical trials.

Program 4: Cance
r Prevention, Control, and Population Studies

: Patty Carney, PhD

and Jeffery Fellows PhD

The Cancer Prevention, Control, and Population Studies Program aims to reduce cancer
incidence, morbidity, and mortality by identifying controllable risk f
actors, special high
risk target
groups, and molecular markers of risk and tumor aggressiveness. Using such knowledge, the
program members seek to develop and test interventional strategies, and, by the translation of
such knowledge into practice, to estab
lish new standards of care. A monthly Cancer Prevention
and Control Seminar Series serves to enhance collaborations internally and interprogrammatically,
with a particular emphasis on aiding junior investigators and trainees.
This program comprises
three f
ocus areas: (1) Survivorship and Symptom Management, (2) Surveillance and
Epidemiology, and (3) Underserved Populations.

Survivorship and Symptom Management

is focused on documenting and decreasing the short and long
term side effects of cancer
and its treatment. This focus group studies secondary and tertiary prevention in cancer patients
and survivors. The
Epidemiology and Surveillance group

uses the tradi
tional tools of epidemiology
to study causes of cancer: the work of this group aims to lead to interventions directed toward
primary cancer prevention. The third group is focused on
Underserved Populations
. The
has a particular connection to the
Native American population in the Pacific Northwest. Each year
numerous Native American researchers come to OHSU to be trained in cancer prevention and
control research. Rural Oregonians are also a special population that must navigate particular
to cancer treatment and services; the program is involved in designing outreach programs
to these groups. Program members in all three focus groups work with researchers in the other

programs to accomplish their work.


For Our Members

Cancer Institute provides shared resources that give ready access to state
technologies and also provides developmental support for new faculty startups and pilot projects.


Biostatistics Shared Resource

Director: Motomi Mo
ri, PhD


The primary goal of the Biostatistics Shared Resource (BSR) is to provide biostatistics support to
basic scientists, clinical researchers, and population scientists who are conducting cancer research
at OHSU. The BSR strives to enhance sc
ientific quality of research through tailored professional
consultation and collaboration at all phases of cancer research. The BSR encourages cancer
researchers to seek biostatistics consultation at the earliest stage possible and to work with a
tician as a collaborator and co


Grant submission and clinical protocol development

Study and experimental design

Sample size and power analysis

Statistical analysis plan

Development and implementation of statistical protocols for
throughput cores

Institutional clinical research support, including scientific review and data monitoring

Data analysis*

Manuscript preparation and review*

Training and education (e.g., software training)*

*denotes services that are performed on a fee
service basis.

Clinical Research Manag
ment Shared Resource

Bashi Ratterree, BSN, CCRP


To support
Cancer Institute investigators in conducting basic, clinical and epidemiological
research aimed at improving the lives of peop
le and families with cancer by applying innovative
strategies for cancer prevention, cancer treatment and support of cancer survivors


This resource provides centralized services for the initiation, conduct and quality assurance of
cancer related
clinical trials. The process of initiating trials includes management of the
ommittee (CRRC), which provides scientific review of all cancer related
protocols. The CRRC approved protocol, consent and supporting documents are then
submitted to


IRB. Assistance with budget development and negotiation, as well as study account management
is available. During conduct of the trial, Clinical Research Management (CRM) oncology certified
nurse researchers and experienced data managers use a

team approach to provide investigators
with all aspects of study coordination. The CRM maintains a database of all
nstitute clinical trials
and is responsible for preparing NCI summary reports for current trial accrual. This includes
tracking subject en
rollment on all cancer related studies conducted through OHSU. For
intervention studies enrollments need to be entered into the
nstitute database within 3
5 days after
consent signing or submitted to the CRM manager on the enrollment form listed under the Related
Documents section. For studies that do not include an intervention or do not require consent,
enrollment numbers are tra
cked on the annual continuing review. This includes gender, race and
ethnicity. Continuous safety and accrual monitoring is provided the CRRC. The Data Safety and
Monitoring Committee provides auditing for protocol compliance and adherence to IRB, NCI and

FDA regulations.

Flow Cytometry Shared Resource


Philip R. Streeter, PhD


Mandy Boyd, BS


The Flow Cytometry
esource (FCSR), which has operated as a core resource for
members since 1996, provides advanc
ed instrumentation, technical expertise, and technical
services to meet the needs of
nstitute members. The FCSR also provides training to
members in data interpretation, experiment design, and routine operation, offering these
investigators an a
dditional cost
saving option of doing some of the work themselves. Finally, this
resource saves valuable investigator time by analyzing specimens and preparing them, if needed.


FACS Calibur Analysis

LSR Analysis

FACS Analysis Training



*Costs per service hour are calculated with or without operator assistance

Gene Microarray Shared Resource

Director: Chris Harrington, PhD


The Gene Microarray Shared Resource (GMSR) operates as a full
service genemicroarray center
that p
rovides infrastructure and support for performing genearray experiments and managing and
analyzing microarray data. Specifically, we provide
nstitute members with: 1) expression profiling
services using high
density oligonucleotide

arrays; 2) advice and training on the use of microarrays
and analysis of microarray data; and 3) support in producing and identifying high quality RNA
samples for microarray analysis. A critical function of the Microarray core is to provide effective

warehousing and management capabilities that allow investigators to store, distribute and
share genomic data. To meet this goal the GMSR works closely with the Cancer Institute


Informatics Shared Resource in the development and ongoing support of a centra
l microarray
database and Web
based tools for project application, sample tracking, and data management. In
addition to expression profiling services, the GMSR provides genotyping and CGH
(comparativegenomehybridization) services using high density Affymet
rix SNP arrays.


Expression profiling

RNA quality assessment

Amplification and labeling o fRNA samples

Target/array processing

expression arrays

Data preparation/basic analysis. Online access to project data

Workshops, tutorials and support for
data interpretation and analysis

SNP genotyping

Restriction digest, amplification and labeling of DNA samples

Target/array processing

SNP arrays

Data preparation/basic analysis

Workshops, tutorials and support for data interpretation and analysis

In deve

Informatics Shared Resource


Shannon McWeeney, PhD


The primary goal of the Informatics Shared Resource (ISR) is to provide informatics support and
infrastructure to
nstitute administration and other shared resources. In
addition, the ISR will
provide informatics consulting and user support to basic scientists, clinical researchers and
population scientists who are conducting cancer research at OHSU.

Services and Resources

Computational Resources

SUN SunFire V880 with fou
r 900MHZ CPUs, 8GB memory, and 438GB local hard drives

Two SUN SunFire E3800s with four CPUs each at 900MHZ/8
MB cache and 4GB of

Two SUN SunFire

v440 with four 1.062GHz CPUs each web
application/data servers with
four 36GB hard disks and 8GB memory each

SUN Enterprise Server E450 with four 480MHz processors, 4GB memory, four 36GB
internal drives with a 327GB SUN StorEdge T3WG RAID system

SUN Ultra

80 statistical server with two 360MHz processors and 1GB memory

Available application software includes Statistical Analysis System, R, Splus, MatLab 6.5,
Oracle 8.1.7, Java, Perl, and others.


Informatics Seminar Series (co
hosted with
the GCRC Informatics Core) [monthly]

Software Training and Workshops


CBCIBM ADCSR Joint Group Meetings (Staff Professional Development) [weekly]


Pathology Shared Resource

Director: Christopher Corless, MD, PhD


The Cancer Pathology Shared Res
ource is a core facility that provides tissue banking and related
histology services to
investigators. The facility collects and stores samples of normal and
neoplastic human tissues from local hospitals. The nature and quality of all samples are

verified by
the director (a board
certified surgical pathologist) prior to their distribution. Relevant clinical and
demographic data are provided with the tissue samples as needed. The facility also handles
tissues from research animals and offers a full

range of histology techniques for evaluating tissues
of all types.


Histology: Including tissue processing and paraffin embedding, sectioning (cryostat or
embedded) to specified thickness, histochemical stains (including H&E, Trichrome,
Elastin, Reticulin, Giemsa, Luxol fast blue, Iron, Bacterial/Fungal).

Laser Capture Microscopy: The laboratory has a PIXCELL II laser capture microscope
(Arcturus Engineering) that can be used to microdissect small clusters of cells, or even
single cells,
for use in DNA, RNA or protein analyses. Cells can be dissected from either
cryostat or paraffin sections that have been stained.

Immunohistochemistry: The laboratory has an automated Dako immunostainer with a
capacity of 48 slides per run, supporting high
throughput staining. Services provided
include: testing and titering new antibodies, both monoclonal and polyclonal, optimization of
staining to enhance detection and reduce background, and double

and triple
stains using multiple chromagens.

sue Procurement & Storage: A growing collection of normal and neoplastic human
tissues is available to local investigators. The tissues are stored in several ways, each one
optimal for a particular use.

Proteomics Shared Resource

Director: Larry David, DM
D, PhD


This relatively new shared resource brings proteomic research techniques to bear on the cancer
problem at OHSU. While proteomics has been largely associated with protein identification by
mass spectrometry, the synergy of informatics tools and high
put analytical instrumentation
has revealed new opportunities in biomarker discovery and systems biology, both of which will play
a key role in future cancer research in the Institute. OHSU invested $1.9m in developing a campus
wide proteomics unit, a uni
t that serves as the Proteomics Shared Resource (PSR) of the
Under the direction of Dan Dorsa, OHSU Vice President for Research, a proteomics steering
committee was created to assist Dr. David in further enhancing the use of the Proteomics Shar
Research by the OHSU community. This committee, chaired by Dr. Peter Gillespie, is composed
of six members who actively use mass spectrometry and proteomics in their research. A formalized
cooperative agreement between the OHSU Proteomics
Shared R
ce and the proteomics


cores at the University of Oregon and Oregon State University is in process to share
instrumentation and expertise. This will greatly enhance the application of new proteomics
technologies in cancer research at OHSU and the other maj
or state universities in Oregon.


Economy protein ID by MALDI

Full service protein ID by MALDI

Full service protein ID by LC/MS/MS

MUDPIT or multidimensional protein identification

Mass determination of proteins or peptides (MALDI or ESI)

spot excision of gel plugs

Manual and automated sample preparation.

Additional services that will be offered in the next year include protein expression analysis
and mapping of post
translational modifications.

Shared Resource

irector: Lev Fedorov, PhD


The mission of the OHSU


Shared Resource is to assist investigators
achieving research objectives that concern the production of genetically engineered mice and the
management of the mouse colony size by cryopreservation of mouse germplasm. (Note: Originally,
the goal was to simpl
y freeze sperm as part of the cryopreservation laboratory, which was funded
by the “Oregon Opportunity” funding Initiative. However, while setting up this laboratory, it became
apparent that many PIs wanted to have trial data on reconstituting animals from

frozen sperm. The
laboratory is now set up for cryopreservation of both sperm and embryos, and to produce pre
implantation embryos for cryopreservation by IVF, similar to the model developed by the Jackson
Laboratory termed “Speed Cryo” to rapidly cryopre
serve large numbers of strains, particularly
induced mutant mice that are held on the C57BL/6 inbred background.)


Transgene Microinjection

Gene Targeting in ES cells

Chimera Construction by Blastocyst Injection

Rederivation of SPF Strains

Lentiviral Vector
mediated Transgenic Mice

Cryopreservation of Mouse Germplasm