Challenges and Opportunities in Geospatial Analysis of Environmental Exposures Analysis of Environmental Exposures

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11 Δεκ 2013 (πριν από 3 χρόνια και 7 μήνες)

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Challenges and Opportunities in Geospatial
Analysis of Environmental Exposures
Analysis of Environmental Exposures
DavidMBalshawPhD
David

M
.
Balshaw
,
Ph
.
D
.
Program Director
CenterforRiskandIntegratedSciences
Center

for

Risk

and

Integrated

Sciences
National Institute of Environmental Health Sciences
A Quick overview of Environmental Health and NIEHS
Other
Di
Genetic
Environmental
Hlh
Di
seases
V
ulnerability
Toxicants
H
ea
l
t
h
y
Diseased
Nutrition
Development
and Age
Nutrition
Behavior
Drugs
•The environmental contribution to ‘complex’ diseases
Willett, WC, (2002) Science 296:695-8
How do we use geospatial analysis in environmental health
today?
http://airnow.gov/
The NIEHS Strategic Plan (in draft form)
Next Steps in Exposure Science
The Exposome and Environment Wide Association Studies
Patel et al. PLoSOne, 2010
Rappaport and Smith (2010), Science,
330:460-461
NIH Genes, Environment and Health Initiative
ExposureBiology Program
Genes, Environment, and Health Initiative
GENETICS PROGRAM
EXPOSURE BIOLOGY
PROGRAM
PROGRAM
Identify genetic
variants
GXE
Develop technology
and biomarkers

GWA Studies

Data Analysis

Database

Function
Tli

Diet

Physical Activity

Environmental Exposures

PsychosocialStressand

Replication

Sequencing

T
rans
l
at
i
on
Psychosocial

Stress

and

Addictive Substances
NIH Genes, Environment and Health Initiative
ExposureBiology Program
New tools for characterizing the personal environment –in
s
p
ace and time
p
Pesticides
Ultrafine Particulate
Volatile Compounds Black Carbon
PhilAtiit
DietaryIntake
Both
Ph
ys
i
ca
l

A
c
ti
v
it
y
Dietary

Intake
Both
Physiological
Response to Stress
Ecological Momentary Assessment of
stress and the use of addictive
substances
A Wearable Chemical Sensor SystemA Wearable Chemical Sensor System
for Personal Ex
p
osure Assessmentfor Personal Ex
p
osure Assessment
p
p
Nongjian Tao, Arizona State
University
NIEHS -U01 ES016064-01
NIH Genes, Environment and Health Initiativ
e
Exposure Biology Program
•Selective detection of VOCs
(hydrocarbon and acid
vapors)
vapors)
•Sensitive: ppb -ppm
•Real-time: sec. –min.

SpatiallyResolved
Spatially

Resolved
•Wearable: cell phone size
•Cell phone based interface
NIH Genes, Environment and Health Initiative
ExposureBiology Program
Physical Activity Location Measurement System (PALMS) –Kevin Patrick, UCSD
My Air , My Health
Challenge
•Two-Phase Government
Challenge
Challenge
U.S. Department of Health and Human Services
U.S. Environmental Protection Agency
•Integrate wearable
sensors for air pollution
exposureand
exposure

and

physiological response
•Geocode/time stam
p
p
•Data integration,
analysis and telemetry

wwwchallengegov

www
.
challenge
.
gov
Major issues in geospatial analysis of personal environment
and effects on health

Validationofemergingtools

Validation

of

emerging

tools
•Development of Multi-component measures
•Analytical tools for assessing temporal and spatial
variation
S
•Data
S
haring and Privacy Protection
•Application in epidemiological setting
–definition of ‘normal’ and the variability of ‘normal’
–Untargeted associations of exposure and disease
THANKYOU!
THANK

YOU!