SUGUNA DEVI S

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SUGUNA DEVI S

Dr.
SUGUNA

DEVI


Official Address







Permanent Address

C/O Prof. Keun
W
oo Lee Ph.D,






Plot #2, Duraiswamy Nagar,

Dept of Biochemistry,







2
nd

St, Keelk
attalai,

Buildi
ng No.352, Room No.517,





Chennai

Gyeongsang National University,





India

900 Gazwa dong, Jinju 660 701






Mobile: +91
-
9444514781

South Korea








E
-
mail:
suguna.dv@gmail.com

Tel: +82
-
10
-
8904
-
258
3

E
-
mail
:
suguna.dv@gmail.com


Profile


To handle
the
scientific challenges and comments in a positive way and to set great heights in the
field of science by experimenting in a novel and hierarchical way.


Education




2011
-
2012

Doctor of Philosophy (Ph.D),

Gyeongsang National University,

Jinju,

South Korea



2002
-
2004

Master of Bio Informatics
(M.Sc) secured
5.84 out of 6

Bharathiar University,

Coimbatore
,

India.



1999


2002

Bachelor of Science in Chemistry
(B.Sc) secured (74%)

Ethiraj College for women,

Chennai
,

India
.

SUGUNA DEVI S

Research/Training
Experience
s




Period

Designation

Organization

Project

Aug 2008


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K

Technical Skills


Operating System

Windows 7/XP/NT/2000, UNIX, MS
-
DOS 6.2, Sun Solaris,
Red Hat Linux, IRIX

RDBMS

Oracle 7.3/8i

Languages/Frame Work

C, C++, Perl, Bioperl, Visual Basic, Python

Internet

HTML, XML

SQL

MYSQL

Others

ASP, MS
-
Office, Fox
-
Pro

Visualization Software

Rasmol, Rastop, Swiss PDB Viewer, Cn3D, VMD

Docking Software

HEX, Auto dock, Cerius2

Proprietary Packages

InsightII, Cerius2, Discover Studio, Catalyst, DOT,
SUGUNA DEVI S

GROMACS, Gaussian,
Pathway Studio

Others

Cytoscape,
Blast, Clustal X, Clus Pro, WhatIf server, Hyper
chem, Predict protein, DAMBE, EMBOSS, SYBYL,
GRASP, Pymol, Geno Cluster, TOPKAT, Catalyst, Open
Eye.


Awards and Honors




Won “
Y
oung
P
ioneer researcher award” Gyeongsang National University (2010)



Brain Korea 21 fellowship for studying Doctor of Philosophy




“Mani parisu award” Ethiraj College (2002
).


Lists of Publications


25.

C. Meganathan, S. Sakkiah, K. W. Lee,
Combined Chemical Feature Cased Assessment
and Bayesian Model Studies to Identify Potential Inhibitors for Factor Xa.

Medicinal
Chemistry Research (In Press)


24.

C. Meganathan,
S.Sakkiah
, K. W. Lee, Structure
-
based Pharmacophore Modeling and
Molecular Dynamic
s Simulations Approaches to Design Potent Inhibitor
for

InterLeukin
-
2
-
Inducuble T
-
cell Kinase. (In Press)


23.

S. Sakkiah
, S. Thangapandian, K. W. Lee, Pharmacophore modeling, molecular docking
and dynamics simulations approaches to identify new leads for
Aldo
se
reductase 2.
Journal of Molecular Modeling. (
In Press
)


22.

S. Sakkiah
, A. Baek, K. W. Lee, Pharmacophore Modeling and Molecular Dynamics
Simulation to Identify the critical chemical Features against Human Sirtuin2 Inhibitors.
Journal of Molecular
Structure. (In Press)


21.

P. Soundararajan,
S.Sakkiah
, Iyyakkannu Sivanesan, Keun Woo Lee, Byoung Ryoung
Jeong, Macromolecular Docking Simulation to Identify Binding Site of FGB1 for
Antifungal Compounds.
Bull. Korean Chem. Soc
. 2011 In Press
(*Contributed eq
ually)


SUGUNA DEVI S

20.

S. Hwang, S. Thangapandaian, Y. Lee,
S. Sakkiah
, S. John, K. W. Lee, Discovery and
Evaluation of Potential Sonic Hedgehog Signaling Pathway Inhibitors Using
Pharmacophore Modeling and Molecular Dynamics Simulations. Journal of
Bioinformatics and Co
mputational Biology. In Press


19.

S. Sakkiah
, S. Thangapandian, S. John, “Pharmacophore Based Virtual Screening,
Molecular Docking Studies To Design Potent Heat Shock Protein 90 Inhibitors”.
European Journal of Medicinal Chemistry

2001,
46:2937
-
2947
.


18.

Kh.
Dhanachandra Singh, Palani Kirubakaran, Shanthi Nagarajan,
S. Sakkiah
,
Karthikeyan Muthusamy, Devadasan Velmurugan, Jeyaraman Jeyakanthan, “Homology
modeling. Molecular dynamics, e
-
pharmacophore mapping and docking study of
Chikungunya virus nsP2 protease”
.
Journal of Molecular Modeling

In Press


17.

S. Thangapandian
1
,
S. John
1
,
S. Sakkiah
, Keun Woo Lee, “Discovery of Potential
Integrin VLA
-
4 Antagonists Using Pharmacophore Modeling, Virtual Screening and
Molecular Docking Studies”.
Chemical Biology and Drug
design

In Press


16.

S. Thangapandian
1
,
S. John
1
,
S. Sakkiah
, K.W. Lee, “Potential Virtual Lead
Identification in the Discovery of Renin Inhibitors: Application of Ligand and Structure
-
Based Pharmacophore Modeling Approaches”.
European Journal of Medicinal
Che
mistry

2011,
46:2469
-
2476
.



15.

S. Thangapandian
1
,
S. John
1
,
S. Sakkiah
, K.W. Lee, “Pharmacophore
-
based virtual
screening and Bayesianmodel for the identification of potential human leukotriene A4
hydrolase inhibitors”.
European Journal of Medicinal Chemistry

2011,
46:1593
-
1603
.


14.

M. Chandrasekaran
*
,
S. Sakkiah
*
, K.W. Lee, “Combined Ligand Based Pharmacophore
Modeling, Virtual Screening methods to Identify Critical Chemical Features of Novel
Potential Inhibitors for Phosphodiesterase
-
5”.
Journal of the Taiwan Institute of
Chemical Engineers )
In Press

(
*
Contributed equally)


13.

S. Thangapandian
1
, S. John
1
,
S. Sakkiah
, K.W. Lee, “Molecular Docking and
Pharmacophore Filtering in the Discovery of Dual
-
inhibitors for Human Leukotriene A4
Hydrolase and Leukotriene C4 Synthase”.
Journal of Chemical Information and
Modeling
2011,
51:33
-
44
.

(2011)

SUGUNA DEVI S


14.

S. John
1
, S. Thangapandian
1
,
S. Sakkiah
, K.W. Lee,

Discovery of Potential Pancreatic
Cholesterol Esterase Inhibitors Using Pharmacophore Modeling,

Virtual Screening and
Optimization Studies
”.

Journal of Enzyme Inhibition and Medicinal Chemistry

In Press



11.

S. John
1
, S. Thangapandian
1
,
S. Sakkiah
, K.W. Lee, “Potent BACE
-
1 Inhibitor Design
using Pharmacophore Modeling, In Silico Screening and Molecular

Docking Studies”.
BMC Bioinformatics

2011,
12(s1):S28
.


10.

S. Thangapandian
1
,
S. John
1
,
S. Sakkiah
, K.W. Lee, “Molecular Modeling Study on
Human Histamine H1 Receptor and Their Applications in Virtual Lead Identification for
Designing Novel Inverse Agonists”
.
Molecular Simulation

2011,
985:14
-
26
.


9.

S. Sakkiah
, S. Thangapandian,
S. John,
K.W. Lee, “Identification of Critical Chemical
Features for Aurora kinase
-
B Inhibitors using Hip
-
Hop, Virtual Screening and Molecular
Docking”.
Journal of Molecular Structure

2011,
32:201


207
.


8.

S. Thangapandian
1
,
S. John
1
,
S.Sakkiah

K.W.Lee, “Docking
-
Enabled Pharmacophore
Model for Histone Deacetylase 8 Inhibitors and Its Application in Anti
-
Cancer Drug
Discovery”.
Journal of Molecular Graphics and Modeling
2010,
29:382
-
395
.


7.

C. Meganathan
*
,
S. Sakkiah
*
, S. Thangapandian, N. Sundaraganesan, H.
-
H. Kim, Y.S.
Kim, K.W. Lee, “Pharmacophore Design for Anti
-
inflammatory Agent Targeting
Interleukin
-
2 Inducible Tyrosine Kinase (Itk)”.
Bull. Korean Chem. Soc.
2010,
31:3333
-

3340
(
*
Contributed equally)


6.

S. Thangapandian
1
,
S. John
1
,
S. Sakkiah
, K.W. Lee, “Ligand and Structure Based
Pharmacophore Modeling to Facilitate Novel Histone Deacetylase 8 Inhibitor Design”.
European Journal of Medicinal Chemistry

2010,
45:4409
-
4417
.


5.

S. John
1
,
S. Thangapandian
1
,
S. Sakkiah
, K. W. Lee, “Identification of Potent Virtual
Leads to Design Novel Indoleamine 2,3
-
Dioxygenase Inhibitors: Pharmacophore
Modeling and Molecular Docking Studies”.
European Journal of Medicinal Chemistry
2010
,
45:4004
-
4012
.



SUGUNA DEVI S

4.

S
. Sakkiah
,
S.
Thangapandian,
S.
John, Y. J. Kwon,
K. W. Lee
, “3D QSAR
Pharmacophore Based Virtual Screening and Molecular Docking for Identification of
Potential HSP90 Inhibitors”.
European Journal of Medicinal Chemistry

2010,
45:2132
-
2140

(This article was selected as the 4th hottest article from the all EJMC articles for
April to June 2010)


3.

S. Thangapandian, N. Krishnamoorthy, S. John,
S. Sakkiah
,
K. W. Lee
, “Pharmacophore
Modeling, Virtual Screening and Molecular Docking Studies for Ide
ntification of New
Inverse Agonists of Human Histamine H1 Receptor”.
Bull. Korean Chem. Soc.
2010,

31:52
-
58
.


2.

P. Gajendrarao, N. Krishnamoorthy,
S. Sakkiah
,
K. W. Lee
, “Molecular Modeling Study
on the Orphan Human Protein CYP4A22 for Identification of Pote
ntial Ligand Binding
Sites”.
Journal of Molecular Graphics and Modeling

2010,
28:524
-
532
.


1.

S. Sakkiah
, N. Krishnamoorthy, P. Gajendrarao,
S.
Thangapandian, Y. Lee, S. Kim, J.
-
K. Suh, H.
-
H. Kim,
K. W. Lee
, “Pharmacophore Mapping and Virtual Screening for
SI
RT1 Activators”.
Bull. Korean Chem. Soc
.
2009,
30:1152
-
1156
.



Manuscript under Review


1)

Ligand
-
based Pharmacophore Modeling and Bayesian Approaches: To Identify c
-
Src
Inhibitors.
(First Author)

2)

Introduction of Bayesian Model and Density Functional Theory Approach to Identify the
Novel Scaffolds for Sirtuin Activator.
(First Author)

3)

Molecular Modeling Study: Conformational Changes of Sirtuin 2 Due to Substrate and
Inhibitor Binding.
(First Author)

4)

Ligand Based Virtual Screening and Density Functional Theory: To identify the critical
chemical features of 11b
-
hydroxysteroid dehydrogenase type 1 inhibitor.
(First Author)

5)

Combined Molecular dynamics simulations, receptor based pharmacophore and its
app
lications to identify novel inhibitors for human sirtuin 2.
(First Author)


6)

Ligand based virtual screening and molecular docking studies to identify the critical
chemical features of potent cathepsin D inhibitors.
(First Author)


SUGUNA DEVI S

7)

Pharmacophore modeling and

molecular dynamics simulations studies to identify the
selective chemical features for Aurora kinase B and A inhibitors.
(First Author)


8)

Pharmacophore based molecular docking and density functional theory approach to
design potential butyrylcholinesterase

inhibitors.
(First Author)

9)

Pharmacophore design, Virtual Screening, Molecular Docking and Optimization
Approaches to Discover Thrombin Inhibitors.

(Second

Author)

10)

Ligand Based Pharmacophore Identification and Molecular Docking Studies for Grb2
Inhibitor.

(Co
-
first Author)

11)

Synthesis, docking, anti
-
tuberculosis and antimicrobial studies of some 3t
-
alky
-
2r, 6c
-
diarylpiperidin
-
4
-
one N
-
isonicotinoyl hydrazones.
(Second Author)

12)

Synthesis, docking, antituberculosis and antimicrobial studies of some 2, 6
-
diarylth
ian
-
4
-
one N
-
isonicotinoylhydrazones.
(Second Author)

13)

Synthesis, docking, antituberculosis and antimicrobial studies of some 2,4 diaryl
-
3
-
azabicyclo[3.3.1]
-
nonan
-
9
-
one N
-
isonicotinoylhydrazones.
(Second Author)


Conference attended/

Paper
presented




“Structure and Dynamics of Protein Networks” at European Molecular Biology Laboratory,
2011, Germany.




“Molecular Modeling and Inhibitor Design Study on Human Sirtuin Protein” has present
(
oral presentation
) in “Asia Pacific Bioinformatics Conference”
2010.




Participating in 9
th

“Asia Pacific Bioinformatics Conference” at Songdo Convensia, Incheon,
Korea, Jan. 11
-
14, 2011.




105
th

spring meeting of the Korean Chemical Society, Songdo Convensia, Incheon, Korea,
Apr. 29
-
30, 2010.




Bioinfo 2009, The 10
th

In
ternational conference, Haeundae Grand Hotel, Busan, Korea, Nov.
4
-
6, 2009.




103
rd

spring meeting of the Korean Chemical Society, COEX, Samsung City, Seoul, Korea,
Apr. 16
-
17, 2009.


SUGUNA DEVI S



The 9
th

International Conference of Korean Society for Bionformatics and
Systems Biology
(KSBSB), Chungbuk National University, (CBNU), Cheongju City, Korea, Nov. 13
-
14,
2008.




Participating in RABIOS workshop held at Sri Ramakrishna College of Art and Science for
women, Coimbatore.




Conducted MOTIF ’03 (National level Symposium) in Bharathiar University




Participating in 90
th

Indian Science Congress held at Jnana Bharathiar Campus, Bangalore
University, Bangalore.




Conducted MOTIF ’02 (State Level Symposium) in Bharathiar University




MLB (Medicinal Laboratory Techniques) Course in Loy
o
la Coll
e
ge.




PGDCA in Swathi Computer Center, Chennai.



References





Prof. Keun woo Lee Ph.D,


Dept of Biochemistry,

Building No.352, Room No.517,

Gyeongsang National University,

900 Gazwa



dong, Jinju 660 701

South Korea

Tel: +82
-
10
-
5804
-
2588

Email:
kwlee@gnu.ac.kr




Dr.Y.Kamalakar Rao,

Chief Scientific Officer,

Xcelris labs limited,

Nr.Parimal Crossing,

Ellisbridge,

Ahmedabad
-
380006


SUGUNA DEVI S



Mr.

Amit Kumar
S/O C


Radiation Biology and Health Science Division

Bhabha Atomic Research Center (BARC), Mumbai
-

400 087

Ph: +91
-
22
-
25590418,

Email:
amit_k@magnum.barc.ernet.in