lecture notes-introduction-2012 - College of Engineering ...

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20 Φεβ 2013 (πριν από 4 χρόνια και 7 μήνες)

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Welcome!

Introduction to Biochemical
Engineering


(
CHE 461.3/861.3)



Instructor

Dr. G. Kennell

Chemical and Biological Engineering

Research Area


Mathematical modeling of coupled electric
fields and ionic transport



Crevice corrosion



Lithium
-
ion cells with multi
-
dimensional
current distributions and non
-
homogenous
properties



Course Objectives

To provide a general understanding of



the basic concepts of


-

microbiology


-

biochemistry and genetics



To apply chemical engineering principles to


-

bioreactor analysis


-

downstream processing and



bioprocess optimization and control.

ChE 461

ChE

861

Assignments (4)

10

10

Quizzes (1
-
2)

10

10

Survey

5

-

Term project

-

10

Midterm

25

20

Final exam

50

50

Total Mark

100

100

Marking Scheme

The mark distribution is only approximate. Final grades will be assigned at the

discretion of the instructor subject to the University Council and College Regulations on

Examinations. Bonus marks may be allocated due to in
-
class participation.

Disclaimer:
Students should be aware of and follow the new

University of Saskatchewan Academic Honesty/Dishonesty definitions,

rules and procedures, and the Guidelines for Student Appeals in Academic Matters

that are available on the web at
www.usask.ca/honesty.



Notes

on the
class website





Check regularly the class website!




Text:

Shuler, M.L. and Kargi, F. Bioprocess
Engineering, Basic Concepts.


Second edition. 2002. Prentice
-
Hall Inc. (on
reserve in the Engineering Library)



Office hours
:

email, or drop by my office

http://www.engr.usask.ca/classes/CHE/461/index.html

Introduction of Biochemical
Engineering

What is Biochemical Engineering?

Definitions


Biochemical engineering:

has usually
meant the extension of chemical
engineering principles to systems using a
biological catalyst to bring about desired
chemical transformations.

Definitions


Biotechnology



-

Traditionally, implies the use or development of
methods of direct genetic manipulation for a
socially desirable product.



-

Broadly, “Commercial techniques that use
living organisms, or substances from those
organism, to make or modify a product…”

(Congress of the United States, 1984)


Definitions

Fermentation



-
Traditionally, defined as the process for the
production of alcohol or lactic acid from glucose.


-
Broadly, defined as “an enzymatically controlled
transformation of organic compound” (
Webster’s
New College Dictionary
)

Typical Bioprocess

Stock culture

Shake flask

Seed fermenter

Raw materials

Medium formulation

Sterilization

Computer control

Production fermenter

Air

Recovery

Purification

Products

Effluent treatment

Microorganism

cell preparation

Medium


preparation

Batch Fermenter

Biochemical Engineering History



5000 to 10,000 BC: yogurt, cheese and soy products,






wine and beer.




In early 20th century: pure bakers yeast were being




produced in tanks and sold.



In world war I: fermentation was used to produce





chemicals needed for war.



World War II: antibiotics production became on the




commercial scale.



1970s: recombinant DNA technology

Canadian Innovative Biotech
Companies

According to the survey of Statistics Canada
every two year:



532 innovative biotechnology firms in
Canada in 2005


9% increase from 496

in Canada in

2003


42% increase from

375

in

2001



87% increase from

282

firms in

1997.

Distribution of Biotech Companies

Regulation and organization

In pharmaceutical and biotechnology industry,



Primary concern: to produce a product of consistently
high quality in amounts to satisfy the medical needs of
the population.


Secondary concern: to reduce the manufacturing cost.


A future biochemical engineer needs to understand the
regulatory climate in which many bioprocess engineers
work.


U. S Food and Drug Administration (FDA) and its
equivalents in other countries