Chapter 1. Scope of Bioinformatics - Weigang Qiu

tennisdoctorΒιοτεχνολογία

29 Σεπ 2013 (πριν από 3 χρόνια και 8 μήνες)

154 εμφανίσεις

Chapter 1.Scope of Bioinformatics
Weigang Qiu & Yözen Hernández
Department of Biological Sciences
Hunter College
BIOL 470/790 Bioinformatics Workshop,Summer 2010
Weigang Qiu & Yözen Hernández
Chapter 1.Scope of Bioinformatics
What is Bioinformatics
Definition
Bioinformatics – the new science at the interface of molecular
biology and computer science.
Enormity of Genetic Data
Genomes:All DNA sequences of a cell
Transcriptomes:e.g.,All mRNA of a normal vs.a cancer cell
Proteomes:All proteins in a cell
Meta-genomes:e.g.,All microbial DNAs in a human gut,a
drop of ocean water,one gram of soil
Weigang Qiu & Yözen Hernández
Chapter 1.Scope of Bioinformatics
What is Bioinformatics
Definition
Bioinformatics – the new science at the interface of molecular
biology and computer science.
Enormity of Genetic Data
Genomes:All DNA sequences of a cell
Transcriptomes:e.g.,All mRNA of a normal vs.a cancer cell
Proteomes:All proteins in a cell
Meta-genomes:e.g.,All microbial DNAs in a human gut,a
drop of ocean water,one gram of soil
Weigang Qiu & Yözen Hernández
Chapter 1.Scope of Bioinformatics
Major Bioinformatics Applications
Genome Annotation:Functions of most genes unknown
Protein Structure Prediction:Structures of most proteins
unknown
Systems Biology:Gene networks and protein interactions
mostly unknown
Biomarker Discovery:What genes are turned on/off in cancer
or other diseases?
Molecular Epidemiology:Tracking of infectious diseases
Fact
The Evolutionary/Related-by-Common-Descent Nature of
Biological Data
Weigang Qiu & Yözen Hernández
Chapter 1.Scope of Bioinformatics
Research in Dr Qiu’s Lab
Weigang Qiu & Yözen Hernández
Chapter 1.Scope of Bioinformatics
Dr Qiu’s Research
Weigang Qiu & Yözen Hernández
Chapter 1.Scope of Bioinformatics
Algorithms
Definition
Algorithm – A set of specific steps that describe how a problem can
be solved
Definition
Computer Programming – Implementing/Coding the step-by-step
instructions of an algorithm using a programming language
Corollary
“The benefit of using a computer is not to solve an insoluble
problem but to arrive at a solution more quickly and accurately
than a human can.”
Weigang Qiu & Yözen Hernández
Chapter 1.Scope of Bioinformatics
Algorithms
Definition
Algorithm – A set of specific steps that describe how a problem can
be solved
Definition
Computer Programming – Implementing/Coding the step-by-step
instructions of an algorithm using a programming language
Corollary
“The benefit of using a computer is not to solve an insoluble
problem but to arrive at a solution more quickly and accurately
than a human can.”
Weigang Qiu & Yözen Hernández
Chapter 1.Scope of Bioinformatics
Algorithms
Definition
Algorithm – A set of specific steps that describe how a problem can
be solved
Definition
Computer Programming – Implementing/Coding the step-by-step
instructions of an algorithm using a programming language
Corollary
“The benefit of using a computer is not to solve an insoluble
problem but to arrive at a solution more quickly and accurately
than a human can.”
Weigang Qiu & Yözen Hernández
Chapter 1.Scope of Bioinformatics