BioInformatics in Life Science Research - Adams Business Associates

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29 Σεπ 2013 (πριν από 4 χρόνια και 1 μήνα)

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Adams Business Associates. 3, Buckingham Place, Oxford Road, High Wycombe, Bucks. HP13 5HW.






BioInformatics in Life Science Research

CONTENTS

1. Introduction & Purpose 1



1.1 Position of Life Science Research 1
1.2 Integration of the “Omics” with Empirical Science 4
1.3 Drug Discovery and Genomics & Proteomics 9
1.4 Technologies & Analysis 16


2. Business Structure 23


2.1 Research Why there is a Need 23
2.2 How the Need is Met 28
2.3 Trends & Issues 36

3. Products, Services & Suppliers in BioInformatics 43

3.1 Product Segmentation by Application 43
3.2 Product Segmentation by Type 48


3.2.1 Process Analysis 52
3.2.2 Information Libraries & Data Bases 58
3.2.3 Data Mining & Search Platforms 61
3.2.4 Applications & Interpretative Platforms 67
3.2.5 BioInformatics Services 70


3.3 Suppliers & Commercial Development of the Industry 72
3.4 Profiles of Suppliers in the Industry 79


Adams Business Associates

3, Buckingham Place, Oxford Road, High Wycombe, Bucks. HP13 5HW
Tel: 44-[0]1494-465244 Email: aba@a-b-a.co.uk




Adams Business Associates. 3, Buckingham Place, Oxford Road, High Wycombe, Bucks. HP13 5HW.
4. End User Customers 94


4.1 Customer Segmentation 94
4.2 Life Science Research Customer Profiles 110
4.3 Pharmaceutical R&D Customer Profiles 118


5. Market Description & Dynamics 124

5.1 User Needs 124
5.2 Basis of Competition 128
5.3 Definition of Markets by Products and Regions 131
5.4 Key Trends 133
5.5 Regulatory Influences 135
5.6 Current & Future Market Quantification & Dynamics 138



6. Future Developments & Business Opportunities 151


6.1 Technology Developments 151
6.2 Segment Developments 155
6.3 Regional Developments 157
6.4 Regulatory & Political Developments 158
6.5 Strategic Options & Business Opportunities 159


7. Conclusion 161

7.1 Business Overview 161
7.2 Overall Market Dynamics 164
7.3 Market Sector Revenue, 2002 165
7.4 Strategic Issues 169








Adams Business Associates. 3, Buckingham Place, Oxford Road, High Wycombe, Bucks. HP13 5HW.

FIGURES

1. Introduction & Purpose 1

Figure 1. Life Sciences Bioactivity Cascade 3
Figure 2. Genomics & Proteomics Linkage 5
Figure 3. Technology & Analysis Shifts 6
Figure 4. Bioinformatics, Genomics & Proteomics and Drug Discovery Links 8
Figure 5. Drug Discovery Linkages 10
Figure 6. Pharmaceutical Drug Development – Attrition Rates 12
Figure 7. Pharmaceutical Drug Development – Attrition Rates Costs 12
Figure 8. Drug Discovery and Technologies 14
Figure 9. Drug Discovery Tools 15
Figure 10. BioInformatics Problems and Terms 17
Figure 11. Data Generation, Storage and Interpretation Pathways 20


2. Philosophy & Application of BioInformatics 23

Figure 12. Novartis Drug Discovery Process Changes 24
Figure 13. BioInformatics Needs & Technologies 26
Figure 14. New Life Science Industry Paradigm 30
Figure 15. BioInformatics – Planning & Recording Solutions 32
Figure 16. BioInformatics – Analysis Solutions 32
Figure 17. BioInformatics – Data & Information Storage Solutions 33

Figure 18. BioInformatics – Data Base Links & Mining Solutions 33
Figure 19. BioInformatics – Structural Analysis Solutions 34
Figure 20. BioInformatics – Modeling & Pathway Analysis Solutions 34
Figure 21. BioInformatics – Global Link Solutions 35
Figure 22. BioInformatics – Grid Computing Solutions 35
Figure 23. Non – Pharmaceutical Application of Genomics & Proteomics 37





Adams Business Associates. 3, Buckingham Place, Oxford Road, High Wycombe, Bucks. HP13 5HW.



3. Products & Services Used in Genomics / Proteomics & Drug Discovery 43

Figure 24. Application Areas for Life Science Research Reagents, Europe 1992 & 2002 47
Figure 25. Drug Discovery Products & BioInformatic Product Groups, 2002 49
Figure 26. Flow Diagram of BioInformatics Network System 51
Figure 27. Process Analysis BioInformatics Companies & Activites, 2003 54
Figure 28. Information Libraries & Databases, 2003 59

Figure 29. Data Mining & Search Platform Products, 2003 63
Figure 30. Application & Interpetative Platform Products, 2003 68
Figure 31. BioInformatics Services Suppliers, 2003 71
Figure 32. Commercial Origins & Strategies of BioInformatics Companies 73
Figure 33. Flow Diagram of BioInformatics Business Model 78



4. End User Customers 94

Figure 34. Life Science Research Market Segment Distribution, 2002 95
Figure 35. Biotechnology Revenues & Investment by Region, 2001 99
Figure 36. Japanese Biotechnology Companies, 2002 107
Figure 37. Biotechnology Market Dynamics for Selected European Countries 111
Figure 38. European Biotechnology Company Distribution by Country, 2002 113

Figure 39. Summary of Regional Clusters of Biotechnology Companies, Europe 114

Figure 40. Summary of Regional Clusters of Biotechnology Companies, USA 114
Figure 41. General Market Segment Uses for BioInformatic Product 116
Figure 42. Global Pharma Market Distibution, 2002 119
Figure 43. Origin of New Drugs Introduced Globally Between 1975 and 1994 119
Figure 44. Pharmaceutical Research & Development Segmentation by Function, 2001 122





Adams Business Associates. 3, Buckingham Place, Oxford Road, High Wycombe, Bucks. HP13 5HW.

5. Market Description & Dynamics 124

Figure 45. Segment Basis of Competition Element Weighting – BioInformatics, 2003 129
Figure 46. Product Categories, Groups & Classes, BioInformatics, 2003 132
Figure 47. Records Required by Predicate Rates for CFR Part 11, 2003 137
Figure 48. Records Subject to 21 CFR Part 11 & Technical Controls for Compliance, 2003 137
Figure 49. Genomics/Proteomics Product Categories – By Application, 2001 139
Figure 50. BioInformatics Market Announcement Selection, 2003 140
Figure 51. BioInformatics Products – Global Market Figures, 2002 & 2007 142
Figure 52. BioInformatics Products Regional Markets – Share & Growth, 2002 & 2007 142

Figure 53. European BioInformatics Country Distribution, 2002 143
Figure 54. BioInformatics Market by Product, 2002 145
Figure 55. BioInformatics Market by Product Category, 2007 145
Figure 56. BioInformatics Product Group Market, 2002 and 2007 146
Figure 57. BioInformatics Product Group – Market Shares & Growth, 2002 & 2007 147
Figure 58. BioInformatics Products Applications, 2002 and 2007 148
Figure 59. BioInformatics Products Applications – Share & Growth, 2002 & 2007 148
Figure 60. BioInformatics Products Distribution by Segment, 2002 and 2007 149
Figure 61. BioInformatics Products Distribution by Segment – Share & Growth, 2002 & 2007 150


6. Future Developments & Business Opportunities
151


Figure 62. New Technology Development in Life Science Research, 2003 152


7. Conclusion
213


Figure 63. S-Curve Model for BioInformatics Product Groups, 2002 163
Figure 64. BioInformatics Sector Market Position, 2002 165
Figure 65. BioInformatics Product & Services – Regional Shares 2002 - 2007 167
Figure 66. BioInformatics Product & Services – Segment Shares 2002 – 2007 167

Figure 67. BioInformatics Product & Services – Application Shares 2002 – 2007 168

Figure 68. BioInformatics Products & Serivces – Product Group Shares 2002 - 2007 168