Hemostasis/Thrombosis Translational Investigator Training Program at Beth Israel Deaconess Medical Center/Harvard Medical School

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16 Νοε 2013 (πριν από 3 χρόνια και 7 μήνες)

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Hemostasis/Thrombosis
Translational Investigator Training Program

at Beth Israel Deaconess Medical Center
/Harvard Medical School



Program Overview


The goal of this program is to train physicians with a major interest in blood coagulation
,
thrombosis

and vascular biology. The program will integrate formal didactic training, research
skills development, and close mentorship by experienced faculty to facilitate the transition of
senior fellows to junior faculty and independent investigators. A particula
r focus will be on
training candidates to conduct patient
-
oriented research in the field of hemostasis and
thrombosis.


The program is targeted at junior clinician scientists to foster their transition from senior fellows
or entry
-
level faculty to indep
endently funded investigators. This program will provide one to two
years of salary support, which will afford senior fellows or junior faculty sufficient protected time
to generate the data required for a competitive NIH application (e.g., K23 mentored ph
ysician
-
scientist
, K08

or a first RO1). Enrollment into the program will be open to physicians with an
interest in
laboratory or
clinical research in hemostasis and thrombosis within
d
ivisions of
Hematology
-
Oncology, Pathology, Cardiology, or Pulmonary and

Critical Care.


Training Environment

The Division of Hemostasis and Thrombosis is located in the Center for Life Science at Beth
Israel Deaconess Medical Center

on the Harvard Medical School campus
. Neighboring
research facilities include Harvard Inst
itutes of Medicine

the New Research Building of Harvard
Medical School
, Brigham and Women’s Hospital, Children’s Hospital, and Dana Farber Cancer
Institute. Drs. Bruce and Barbara Furie are co
-
directors for the
Division of Hemostasis and
Thrombosis

and hav
e trained over
100

postdoctoral fellows in the field of hemostasis,
thrombosis and vascular biology. Faculty interests and expertise in hemostasis and thrombosis
are wide ranging and include subjects from basic biochemistry and structural biology to phase
III
clinical investigation. Numerous opportunities exist for translational investigation for junior
investigators interested in the field of hemostasis and thrombosis.



PROGRAM PLAN


Program Administration

The program is overseen by Dr. Kenneth Bauer who

will serve as the overall program director.
Given the translation
al

emphasis of this program, there will also be two associate directors to
provide focused mentoring in laboratory
-
based research (Dr. Bruce Furie) and clinical
investigation (Dr. Jeffrey Zw
icker).



Program Director:

Dr. Bauer
is a hematologist
-
oncologist with an international reputation in
the evaluation and management of patients with thrombotic disorders. He has been on faculty at
Harvard Medical School and Beth Israel Deaconess Medical Center since 1982 and is currently
Prof
essor of Medicine at Harvard Medical School. He also serves as the Chief of the
Hematology Section and Co
-
chair of the Research Institutional Review Board at VA Boston
Healthcare System. His research interests have included the development and clinical
ev
aluation of sensitive activation markers) for the detection of hypercoagulable states, the
definition and elucidation of the mechanisms leading to the development of
the
prethrombotic
state, and the clinical evaluation of new antithrombotic drugs.


Associ
ate Director:

Dr. Furie

is co
-
chief of the Division of Hemostasis and Thrombosis at Beth
Israel Deaconess Medical Center and Professor of Medicine at Harvard Medical School. He has
been internationally recognized for his research in the field of hemostasis

and thrombosis
including the identification of structure
-
function relationship of blood coagulation proteins,
discovery of P
-
selectin, and development of novel instrumentation for real time in vivo confocal
and widefield imaging of thrombus formation in t
he microcirculation of a living mouse. He has
demonstrated a long commitment to training physician
-
scientists, and, as a physician
-
scientist
himself, recognizes the special need and support that this group requires to ensure their
success.

Associate Dire
ctor:
Dr Zwicker

is an Assistant Professor of Medicine
at Harvard Medical
School based
at Beth Israel Deaconess Medical Center. He completed a Masters Degree in
Medical Sciences at Harvard Medical School and his research interests include translational
stu
dies in thrombotic disorders including the investigation of risk factors underlying
hypercoagulable states and developing novel treatment strategies. He is currently the overall
lead investigator of translational, multi
-
center, investigator
-
initiated rando
mized controlled
studies and is the Director of Benign Hematology Research
Group
at Beth Israel Deaconess
Medical Center. He is internationally recognized for his work on tissue factor bearing
microparticles and cancer thrombosis.



Curricula

The design o
f the didactic component of the curricula is geared towards facilitating the ability of
the clinician to pursue translational research by expanding their understanding of biostatistics,
biomedical ethics, clinical trial design, and grantsmanship.
The curri
cula will be adapted
specifically based on the interests of the investigator.

The program will interface with, and
take full advantage of existing resources including courses offered by the Harvard Catalyst
Program, Harvard Medical School, and Harvard Scho
ol of Public Health.




Most participants will also apply to the
Clinical Investigator Training Program

at Beth
Israel Deaconess Medical Center
. This
is a master’s degree program through Harvard
Medical School that provides formal training in translational investigation. Additional
information is available at:
http://www.bidmc.org/CITP
.




Introduction to Clinical

Investigation.

Participants complete a 1
-
week instructional
course through the Harvard Catalyst Postgraduate Education Program. This introductory
course is designed for clinicians interested in a career in clinical investigation. Formal
instruction is pro
vided on the design of phase I (first
-
in
-
human research), phase II, and
phase III clinical trials as well as population
-
based research.




Intensive Training in Translational Medicine.
In the second year, participants
complete a 2
-
week advanced topics cours
e offered through the Harvard Catalyst
Postgraduate Education Program that is specifically designed for clinical investigators
interested in translational research. The goal of the course is to provide formal training in
drug development and the incorporat
ion of novel biomarkers into human studies.
Approximately 50 faculty from Harvard teaching hospitals teach this course including
many internationally recognized leaders.

Specific themes include:




Principles of Study Design



Clinical and Experimental
Pharmacology



Modern Biomarker Technologies (including genomics, proteomics, and imaging)



Academic/Industrial Relationships in Drug Development (including technology
transfer)



The Regulatory Process and Environment in Drug, Device, and Biomarker
Development



Leadership and Team Dynamics in Research



Ethics in Human Research



Statistics.
Three statistical courses will be taken at the Harvard School of Public
Health which offer rigorous three week courses specifically designed for clinician
researchers. The cours
es are taught by Harvard faculty and are the same as those
offered during the academic year but in a condensed format including several hours
of lecture, lab, and home study on a daily basis.

o

Principles of Biostatistics

(BIO 202 and BIO 203, 5.0 credits/60

hours).
These introductory statistical courses will enable the clinician to understand
basic biostatistics relevant to translational research including applications and
interpretation of numerical summary measures, rates and standardization and
life table
s. The clinician will gain familiarity with the software package STATA.
These classes are offered in an intensive 3
-
week format over the summer
and are specifically designed for clinicians.

o

Principles of Clinical Trials

(BIO 214, 2.5 Credits/30 hours).

Thi
s course
covers a variety of statistical topics relevant to design and conduct of clinical
trials including t
reatment allocation, randomization and stratification, quality
control, sample size requirements, and interpretation of results. Students
develop t
heir own protocol as a component of the course.



Didactics in Hemostasis and Basic Science

o

In
-
progress research seminars:

The trainee is expected to participate in the
weekly work
-
in
-
progress meeting for the Division of Hemostasis and
Thrombosis. Dr. Barbar
a Furie is the faculty organizer and moderator for this
seminar. These sessions provide an opportunity for oral presentation of
research results early in the training program and constructive criticism in a
non
-
threatening setting, thereby building up conf
idence of trainees in their
presentation skills.

o

Seminar Series.
The Center for Hemostasis and Thrombosis Research has
an active research seminar series.

o

V
ascular Seminar Series
.
A Harvard
-
wide vascular biology seminar series is
held on Thursday
afternoons under the support of the medical School and
adjacent teaching hospitals including Beth Israel Deaconess Medical Center.
Speakers for this series are from both inside and outside the Harvard
community.



Ethics

o

Harvard Clinical Bioethics Course.
This course is sponsored by the Harvard
Medical School Division of Medical Ethics. This three day course explores
topics in politics, laws, ethics in medical care and research including research
ethics, medical errors, and financial conflicts of interest.




Advanced Topics Elective Course

Depending on the research focus or their individual interests, each trainee will be
encouraged to attend a 1
-
week advanced training course in a field of interest during the
second year of the program.
Possible courses inclu
de:
Advanced Flow Cytometry
Cou
rse at Bowdoin College in Maine;
“Optical Microscopy & Imaging in the Biomedical
Sciences” at the Marine Biology Laboratory in Woods Hole
, MA;
participation in the
Clinical Research Training Institute offered by the

American
Society of Hematology;

“Biomedical Informatics” at Marine Biology Laboratory, and additional seminar series
through the Harvard Catalyst including “High
-
throughput Microarray Analysis”, “Applied
Longitudinal Analysis” (60 hours), “Introductory Genomics & B
ioinformatics for Health
Research” (28 hours), or “Analysis of Case
-
control and Cohort Studies” (28 hours).



Sample

Curricula

















YEAR 2

Summer

Fall

Winter

Spring

Statistics

Advanced courses at
(HSPH)




Translational
Research
Training

Intensive
Training in
Translational
Medicine
(CTSC)

Advanced
Topics
Course

Advanced
Curriculum
Compendium
(CTSC)

Advanced
Curriculum
Compendium
(CTSC)

Advanced
Curriculum
Compendium
(CTSC)

Ethics

Harvard Clinical Bioethics
Course

(HMS)




Hemostasis
Topics/
Weekly
seminars

Division of Hemostasis
-
Thrombosis (BIDMC)

Research
Project








YEAR 1

Summer

Fall

Winter

Spring

Statistics

BIO202

(HSPH)

BIO 203

(HSPH)




Translational
Research
Training


BIO214
Principles of
Clinical Trials
(HSPH)

Advanced
topics course


Introduction
to Clinical
Research
(CTSC
)

Hemostasis
Topics/ Weekly
seminars

Division of Thrombosis
-
Hemostasis (BIDMC)

Research Project




Research


Clinician scientists will be expected to dedic
ate 75% time to the program to participate in a
mentored research project. Dr. Bauer and Dr. Zwicker will work closely with the trainee and
other senior investigators to identify research projects to undertake within the Division of
Hemostasis and Thrombos
is. In keeping with the translational goal of the curriculum, at least
one element of the research project will include a laboratory component within the Center for
Thrombosis and Hemostasis.


The clinician
-
scientist

will be expected present their work at

national meetings and publish in
peer reviewed journals. The goal is not only to achieve a broader understanding of clinical
research techniques, but ultimately demonstrate a level of accomplishment that will facilitate
their ability to obtain independent

funding and academic promotion.


Mentoring

The proper mentoring of trainees or young faculty is a critically important determinant of
successful career development and is central to this curriculum. Dr. Kenneth Bauer, the leader
of the Tr
anslational
Research Skills Program
, will provide significant time and effort in fostering
the training and career development of the clinicians in the program through
frequent

one
-
on
-
one meetings with the trainee. Dr. Zwicker will work closely with the fellows especially in areas
of clinical trial design, protocol development, statistical analysis, adverse event reporting, and
regulatory compliance. Dr Furie will provide close
mentoring for each trainee in laboratory based
component of the research project. Scheduled meetings with Dr. Bauer, Dr. Zwicker, and Dr.
Furi
e .
The initial focus will be in helping to identify a well
-
defined clinical res
earch project for the
clinician. Th
e
meetings will serve as a forum for discussing initial research findings and future
research directions, either in the laboratory or the clinic. The formal didactic curriculum has
been designed to advance the knowledge base of the clinician scientist. Dr.

Bauer will review
with the trainee the value of the various classes and assess whether curriculum modifications
are necessary for future trainees. Also, this will provide an opportunity for the clinician to discuss
what additional coursework or seminars w
ould be beneficial to their training. Arrangements will
be made to try to remedy any perceived deficiencies in the curriculum. Assistance will be
provided with respect to timing of submissions of research grants along with grant and
manuscript writing.


Tr
avel

Travel to one medical conference per year will be provided with the expectation that the trainee
will present their research when appropriate.


Salary

Annual salary is $75,000 with typical fringe package. Appointment to
a
full time faculty position
wi
ll be considered fo
r outstanding participants.


Important
Dates
:

Application deadline: January 15, 2013

Decisions will be made by March 1
st
, 2013.

Start date of the program is July 1, 2013.





Translational Investigator Training Program

Hemostasis and
Thrombosis at Beth Israel Deaconess Medical Center


Application due date
: January 15, 2013

Name
:

Degree:

US Citizen?



If no, permanent resident? Visa?

Home Address:

Home Phone:




email

address:

Current Institution:


Current position :


Division Chief or Program Director who will provide letter of support:


Name:


Title:


Institution:


Address:


Phone


Email:






Letters of reference

Please provide two to three letters of reference. The
se letters should be confidential and sent
directly to the program office and should arrive by the due date.

Referee #1:

Phone:

Email:


Referee #2:

Phone:

Email:


Referee #3 (optional)

Phone:

Email:


Applicants are requested to have their referees send letters of support. Notification will be
sent when the application is complete.


Candidates Personal Statement on Career Goals

Please provide a personal statement detailing your career goals and how yo
u envision this
program would assist you in achieving these goals.


Please send all materials and CV to:

Ms. Juanita Caine

Division of Thrombosis and Hemostasis

Beth Israel Deaconess Medical Center

330 Brookline Avenue, CLS 905

Boston, MA 02215



Ms. Cain
e can be reached at 617 735
-
4002.