Bioinformatics Server - Tcl Developer Xchange

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2 Οκτ 2013 (πριν από 3 χρόνια και 10 μήνες)

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Xerion

1



Xerion Pharmaceuticals AG


Presentation

September 2002

Xerion

2




Founded


August 1998



Business Segment

1st: Target Validation






2nd: Drug Development




Bioinformatics Tasks

1st: In Silico Analyse of Biological Data






2nd: Development of a Validated Target Database



Locations


Martinsried
-

Germany





Cambridge, MA


USA



Email:


tbusl@xerion
-
pharma.com


The Company

Tasks

Examples

Introduction

Tcl
-
Packages



Xerion

3

Tasks of a bioinformatics server

Xerion

4

Bioinformatics server


Integration of different bioinformatics applications


Web based application


Blast server


Pfam server


Designing own Hidden Markov Models


Integration of other bioinformatics tools


Setting of alerts



Automatic update mechanisms


Protein databases


Nucleotide databases


EST databases


Tasks


Tcl
-
Packages



Examples

Introduction

Xerion

5

Bioinformatics server



Developing of a propriatary target database


GUI


Client solutions for costumers embedding bioinformatics tools


Reporting mechanism (XML based)



In silico search for potential targets


Developing of dedicated filters


Automatic checking of new sequences with certain criterias



Graphical support display of scientific results



Tasks


Tcl Packages



Examples

Introduction

Xerion

6

Bioinformatics server

Tasks


Tcl Packages



Examples

Introduction

Data

flow

Xerion‘s propriatary,

validated target database

Xerion‘s LIMS

(Labor Information Management System)

Access to public available

biologic relevant data

Xerion‘s putative,

target database

Bioinformatics

filters

Xerion‘s experimental

Raw data database

Data

flow

Data

flow

Client user access

Experimental filtering of raw and in silico data stream

Xerion

7

Company

Target
Validation

Antibody
Leads

Business

Finance

Xerion extends its value chain

Tcl/Tk packages

Xerion

8

Main packages


Tclhttpd


Implementation of Web based applications



Expect


Implementing all kinds of update mechanisms



Oratcl


Implementing all kind of database access



Cgi Tcl


Cgi scripts for Web based applications



Biowish


Implementation of graphical support display




Tasks


Tcl packages



Examples

Introduction

Xerion

9

Company

Target
Validation

Antibody
Leads

Business

Finance

Xerion extends its value chain

Examples

Xerion

10

Examples Blast


Web Application: Blast


䥮灵琠浯摥


Tasks


Tcl packages



Examples

Introduction

Xerion

11

Example Applications


Web Application: Blast


剥獵汴s

Tasks


Tcl packages



Examples


Introduction

Xerion

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Example


Bioinformatics Analysis (chromosome regions)

Tasks


Tcl packages



Examples


Introduction

Xerion

13

Example Applications


Bioinformatics Analysis (single chromosome region)

Tasks


Tcl packages



Examples


Introduction