Academic - University of Ontario Institute of Technology

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University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization




1


1.

Organization and Program Information



1.1

Submission Title Page


Full Legal Name of Organization:


University of Ontario Institute of Technology


Operating Name of Organization:

University of Ontario Institute of Technology


Common acronym of Organiza
tion:

UOIT


URL for Organization Homepage:

www.uoit.ca


Degree Level and Type to be awarded for program or part of program:

Bachelor of Science (Honours) in Chemistry


Proposed Degree Titles:

Bachelor of Science (Honours) in Chemistry
-

specialization i
n Pharmaceutical Chemistry


Proposed Degree Nomenclature:


B.Sc. (Hons.) in Chemistry
-

Specialization

in Pharmaceutical Chemistry


Date of Submission:



Location where program to be delivered:


University of Ontario Institute of Technology

2000 Simcoe
St. N

Oshawa, ON

L1H 7K4


Contact Information
:



Persons responsible for this submission:



Dr. William Smith

Dean, School of Science

University of Ontario Institute of Technology



2000 Simcoe Street North

Oshawa, Ontario, L1H 7K4

Tel:

905
-
721
-

3235

Fax
:

905
-
721
-

3304

Email:

william.smith@uoit.ca








University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization




2


EXECUTIVE SUMMARY


Proposed Program Title:

Bachelor of Science (Honours) in Chemistry
-

specialization in Pharmaceutical Chemistry


Proposed Credential Nomenclature:

B.Sc. (Honours) in Chemistry

Discip
lines/Fields of Study:


Pharmaceutical Chemistry


Is a work experience/work placement term required for degree completion?


Work experience is not required for degree completion, but work placements

will be facilitated for interested students through the

University's Career and Employment
Services Office.


Anticipated Program Start Date:

First
-
year entry in September 2006. Given sufficient
demand and background preparation, students may enter the second year of the
program in September 2006.



Descripti
on of the Proposed Program and Program Strengths

The Faculty of Science proposes the addition of a Pharmaceutical Chemistry
specialization within the Chemistry
(
Honours
)

B
.
Sc
. p
rogram. The program map for the
proposed specialization is provided. The prog
ram is based on courses in the existing
Chemistry
(
Honours
)

program, and consists of an integrated and focused combination of
existing Chemistry and Biology

(Pharmaceutical Biotechnology specialization)

courses
,
with the addition of 3 new courses in the or
ganic/medicinal chemistry area (Structure
Determination of Organic Molecules: CHEM3220U;
Pharmaceutical Discovery
: CHEM
4510U; and
Advanced
Topic
s in Pharmaceutical Chemistry
: CHEM4520U), and the
courses Introductory Physiology: BIOL2010U; Principles of Ph
amacology and
Toxicology: BIOL3020U; and Advanced Topics in Pharmaceutical Biotechnology:
BIOL4050U.


The proposed specialization in the B
.
Sc
. (H
onours) Chemistry program provides an
integrated basic grounding in science fundamenta
l to the pharmaceutical r
esearch and
industry
, providing an attractive program for students wishi
ng to proceed into industry, or

into post
-
degree studies in chemistry, biology, pharmacy, dentistry, or medicine. Like all
the existing specializations in Science (B
iology, Chemistry,

Physics
), it has a common
fi
rst year core

of courses in calculus, biology, chemistry, and physics, providing
a sound
and broad foundati
on in basic areas of science.
The specified second
-
year courses are
the same as the
core courses in the Chemistry (H
ono
urs) program, with the addition of a
specified physiology course in the proposed specialization. The specified third
-
year
courses are the same as the
core courses in the Chemistry (H
onours) program, with the
addition of a specified pharmacology course.
This common core provides flexibility for
students in deciding upon their ultimate specialization.

University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization




3



Admission, promotion and graduation requirements are exactly the same as tho
se in
place for the Chemistry (H
onours) program.


Rationale for int
roduction of
new specialization

The pharm
aceutical industry plays a key role in the economy of the Greater Toronto
Area
, and
its success
requires heavily on access to
local,
highly
qualified personnel.

UOIT is a market
-
orientated university, and a
s t
he pharmaceutical
industry is rooted in
chemistry,

it is a natural focus for specialization
.

The study of the

basic and applied

aspects of

chemistry
,
under the umbrella of
the
science of the
pharmaceutical in
dustry,
will provide students with the training

necessary to supp
ort this

important
industry
, or

with
the skills necessary for
further
success in the chemical and medical sciences.



Program Learning Outcomes and Curriculum Design

All the attributes of the original Chemistry (Honours) program are retained, includin
g
program learning outcomes, course content
, sequencing

and the maintenance of
appropriate degree level standards.
In order to cover the breadth of
biology/pharmacology courses required for a specialization in Pharmaceutical Chemistry,
the following 4000
-
level Chemistry (Honours) courses were replaced by biological and
specialist chemistry courses: CHEM 40
1
0U
Industrial

Chemistry, CHEM 4060U
Molecular Spectroscopy, and CHEM 4050U Environmental Chemistry, but remain
available as science electives.
Addition
al program learning

outcome specific to this
specialization

include:




Understanding the major physiological process involved in animal growth;



Understanding the action and toxicity of drugs;



Understanding
the
research and application of pharmaceutical biot
echnology

in
selected areas including psychopharmacology, cardiovascular pharmacology,
neuropharmacology, endocrine pharmacology, quantitative pharmaceutical
analysis, drug discovery and design, safety and quality assurance, and protein
engineering
;



Unders
tand the chemical
techniques

used by the pharmaceutical industry to

the
development of
novel
therapeutics
.


Only
three

of the courses in the proposed program are new (
Structure Determination of
Organic Molecules

(shared with the proposed Biological Chemist
ry specialization)

and
Pharmaceutical Discovery and Advanced
Topics in P
harmaceutical Chemistry
); draft
outlines for these new courses are
provided in this submission.


Capacity to Deliver
-

Resource Requirements

(Human and Physical)


None of the new cours
es required for the specialization involve laboratory components
.

In view of its modest resource requirements, t
he
proposed
specialization is expected to
be a very cost
-
effective addition to the UOIT
Science

program
.




University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization




4


Projected Enrolment and Faculty Gro
wth

Projected steady
-
state enrolment is
2
0 students per year

entering the program
. Since
there are only
3

new courses required for the program, the faculty resource requirements
are minimal
.
These new courses entail the addition of the equivalent of
appr
oximately

0.
7
5

faculty

member, beginning in July, 2007
.


Employment Opportunities

There are many opportunities for graduates holding an undergraduate degree in
Pharmaceutical Chemistry
, whether the student wants to continue on to higher
education, especial
ly Medical School, or go directly

into the workplace
. Some of the
options available to UOIT
Pharmaceutical Chemistry

graduates include:


-

Pharmaceutical industry

-

Research laboratories

-

Professional school (Medicine, Dentistry, Pharmacy, Business
, Law
)

-

Grad
uate School (Chemistry or related fields)



Program Support/Recognition from Profession

The Faculty of Science is seeking letters of support
on the quality of the proposed
specialization
from Provincial, Canadian, and International Pharmace
ut
ical Companies
.
















University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization




5


Program Map
-

BSc in
Chemistry
-

Specialization in
Pharmaceutical Chemistry

Shading

indicates a new course. All other courses have been previously
approved by PEQAB in conjunction with the Chemistry, Biological Science or
other UOIT pro
grams.


Year
-
Sem.

Subject

Subject

Subject

Subject

Subject

1
-
1

Chemistry I

CHEM1010U

Biology I

BIOL1010U

Physics I

PHY1010U

Calculus I

MATH 1010U

Scientific
Computing Tools

CSCI1000U

1
-
2

Chemistry II

CHEM1020U

Biology II

BIOL1020U

Physics II

PHY1020U

Calc
ulus II

MATH1020U


Elective*


2
-
1

Structure and
Bonding

CHEM2010U

Introduction to
Organic Chemistry

CHEM2020U

Analytical
Chemistry

CHEM 2030U

Introductory
Physiology

BIOL2010U

Statistics and
Probability for
Physical Science

STAT201
0U

2
-
2

Thermodynamics
a
nd kinetics

CHEM2040U

Organic Chemistry

CHEM2120U

Biochemistry

BIOL2040U

Elective*

Elective*

3
-
1

Advanced Organic
Chemistry

CHEM3120U


Instrumental
Analysis I

CHEM3530U


Inorganic
Chemistry I

CHEM3510U

Principles of
Pharmacology and
Toxicology

BIOL3020U

E
lective*

3
-
2

Structure
Determination of
Organic Molecules

CHEM3220U

Instrumental
Analysis II

CHEM3540U


Inorganic
Chemistry II

CHEM3520U

Fundamentals of
Physical
Chemistry

CHEM3040U

Elective*

4
-
1

Physical
Chemistry

CHEM4040U

Pharmaceutical
Discovery

CHEM
4510U

Thesis

CHEM4400U

Elective*


Elective*

4
-
2

BIOL 4050U
-

Advanced Topics
in Pharmaceutical
Biotechnology

Advanced
Topic
s
in Pharmaceutical
Chemistry

CHEM4520U


Elective*


Elective*


Elective*



*Students are required to take 4 science electives and
6

liberal studies electives

(which
must include BUSI 1600U: Management of the Enterprise, and BUSI 2000U:
Collaborative Leadership.

*Recommended science electives:


CSCI 1020
U



Fundamentals of Programming


BIOL 2030U


Cell Biology



CHEM 4010U


Industrial

Chemistry


CHEM 4110U


Bio
-
Organic Chemistry

University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization




6



PROGRAM ADMISSIONS REQUIREMENTS




Program Admission Requirements

Academic








Grade 12U English

Grade 12U Advanced Functions and Introductory Calculus
2 Grade 12U credits from: Biology, Chemistry, Phys
ics, or
Geometry & Discrete Mathematics

2 additional 12U or 12U/C credits

Applicants will be required to have a minimum 70% overall
average. A combined minimum average of 70% is also
required in the mathematics and science courses.

Language Proficiency
Te
st

All applicants are required to give evidence of their oral and
written proficiency in English. This requirement can be
satisfied with one of the following criteria:

-

Their mother tongue or first language is English. OR

-

They have studied full time

for at least three years (or
equivalent in part
-
time studies) in an educational institution
where the language of instruction and examination was
English. OR

-

They have achieved the required proficiency on one of the
tests in English language acceptab
le to UOIT.


English Second Language Test Requirements


Recommended UOIT Scores

TOEFL Paper


㔶〠 呏䕆䰠䍂T


㈲〠 fbiTp



Mb䱁B






PROMOTION AND GRADUATION REQUIREMENTS



COURSE TYPE

PROMOTION

GRADUATION

Courses in Disciplines
Outside
the Main Field(s) of
Study


GPA of
2.0 (60
-
66%)



GPA of 2.0 (6
0
-
66%)


Courses in Disciplines
Within the Main Field(s) of
Study


GPA of
2.0 (6
0
-
66%)



GPA of 2.0 (6
0
-
66%)


Overall




GPA of
2.0 (6
0
-
66%)



GPA of 2.0 (6
0
-
66%)







University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization




7


Program Comparison Sta
tement


The applicant has on file and available upon request the research undertaken to
complete Appendix 6.3. The applicant found that there
are not
more than
4

similar or
related existing programs offered at Ontario universities and that there
are

no

sim
ilar or
related existing programs offered at universities in other
Canadian
jurisdictions that could
have been included in appendix 6.3.


Institution:
York University

Program Name and Credential:

B
.
Sc
.

in Chemistry with
Pharmaceutical and Biological Chemi
stry (Honours) stream

Program Description:

This is a program of study designed for students interested in Biochemistry, Bio
-
organic
and/or Bio
-
Inorganic Chemistry (enzyme mechanisms, biomimetics) and/or Bioanalytical
Chemistry, Pharmaceutical Chemistry or

other aspects of biologically related chemistry.
The program provides a solid grounding in Chemistry plus a specialized exploration of
the chemistry of biologically and pharmaceutically relevant substances and processes.
Thus, it provides a broader, more
chemical focus than is available in other degree
programs dealing with these subjects (Spec. Hon. BSc in Biochemistry, Hon. Double
Major in CHEM and BIOL, or Hon. Major/Minor in CHEM and BIOL).


http://www.chem.yorku.ca/ugrad/P&BC.html

Similarities and D
ifferences:

UOIT's proposed curriculum is similar to York's four
-
year specialized program, in that it
emphasizes core chemistry subjects.

How
ever, t he pr oposed UOI T pr ogr am
i s mor e
i ndust r y f ocused

and cont ai ns

and

the designated UOIT breadth courses Coll
aborative
Leadership, and Management of the Enterprise, which are particularly relevant in the
pharmaceutical industry. As well, the UOIT program
specializes on the chemical,
physiological, pharmacological and toxicological aspects of drugs
, and
not
on th
e

biological

sciences
, as does York’s program
K


Institution:
University of Guelp
h

Program Name and Credential:

B.Sc (Tech) in Applied Pharmaceutical Chemistry

Program Description:

The B.Sc. (Tech) program was designed for students who do not intend to

pursue post
-
graduate studies and are strongly focused on securing industrial employment that makes
use of the knowledge acquired in their bachelors degree. This program provides
students with the knowledge and skills deemed to be essential by employers a
nd
exemplifies the positive benefits of cooperation between colleges and universities. The
program combines rigorous theory with practical applications.

http://www.uoguelph.ca/undergrad_calendar/c10/c10bsc_tech
-
appc
-
c.shtml

Similarities and Differences:

The proposed UOIT
specialization
focuses on the practical aspects of chemistry, and the
theoretical aspects of chemistry, physiology, pharmacology, and toxicology in drug
design, at a level required for students to continue on with post
-
graduate studies.
Importantly, by maintaining a clear emphasis on the core aspects of chemistry, the UOIT
program gives students more versatility to adapt to market demands outside of the
pharmaceutical industry.

Whi l e t he Guel ph pr ogr am cont ai ns a col l ege management
University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization




8


cours
e, it lacks a course equivalent to the UOIT breadth course Collaborative
Leadership which is particularly relevant for future research group leaders of the
pharmaceutical industry, which the UOIT program aims to produce.


Institution:
Laurentian Universit
y

Program Name and Credential:

Certificate in Medicinal Chemistry

Program Description:

Graduates of the 4
-
year B.Sc. in Chem
istry or those students enrolled in a

4
-
year B.Sc.
in Chemistry
program are eligible for admission to the certificate programs, a
value
-
added feature of the 4
-
year specialized program in Chemistry. The program (30 credits)
provides the student with a solid background in chemistry and a unique insight into the
important issues and concepts used in the development of drugs in the phar
maceutical
industry.

http://laurentian.ca/chem/index.html

Similarities and Differences:

The Laurentian Certificate adds a significant amount (30 credits) of chemistry courses to
an existing B.Sc. degree and thus offers a broader range of chemistry courses

than the
UOIT specialization. However, the Certificate is focused primarily on the chemical
aspects of the pharmaceutical industry and does not address the interaction of chemistry
with physiological and pharmacological processes. Nor does it offer the
designated
UOIT breadth courses Collaborative Leadership, and Management of the Enterprise,
which are particularly relevant to the pharmaceutical industry.




Institution:
University of Toronto

Program Name and Credential:

B
.
S
c.

in
Pharmaceutical Chemist
ry

Program Description:

Collaborative Program of the Faculty of Arts & Science and the Leslie Dan Faculty of
Pharmacy. Pharmaceutical Chemistry combines knowledge of the biological, medical,
and physical sciences in the study of the scientific aspect of

drug therapy. The emphasis
is on the chemical nature of the reactions and interactions involved in drug therapy. The
students will receive a solid background in the aspects of chemistry the most relevant to
drugs: physical, organic, and analytical chemist
ry. They will also learn the fundamental
aspects of the synthesis, manufacture, use, and mode of action of drugs.


http://www.artsandscience.utoronto.ca/ofr/calendar/prg_phc.htm

Similarities and Differences:

The University of Toronto offers a Pharmaceuti
cal Chemistry program
with very similar
course content to the proposed UOIT Pharmaceutical Chemistry specialization. U of T’s
灲pgram offer猠a 扲潡摥r 捨ci捥f 敬散瑩e攠捯ers敳Ⱐrefl散ti湧 its 扡獥⁩s 愠a敤i捡c
獣桯潬I 扵t t桥 獥t of 捯c攠捯畲獥猠i渠扯th

programs is very similar. U of T’s program
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University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization




9


PROGRAM LEVEL LEARNING OUTCOMES


The sh
ading indicates new UOIT
courses associated with the proposed
specialization.
The remaining courses have all been previously approved by PEQAB as part of the
Chemistry, Biological Science or other UOIT programs.


Program Level Learning Outcomes

Program re
quirement(s), or
segments of requirements, that
contribute to this outcome

Apply knowledge and understanding of the

basic concepts, theories, and principles of
chemistry and the related physical and
biological sciences to theoretical and
practical proble
ms in these areas

Chemistry I and II, Physics I and II,
Calculus I and II, Biology I and II,
Structure and Bonding,
Thermodynamics and Kinetics,
Introduction to Organic Chemistry,

Organic Chemistry,

Biochemistry,
Analytical Chemistry,

Introductory
Physiol
ogy, Principles of Pharmacology
and Toxicology

explore the current state of knowledge in
chemistry and investigate innovative
solutions to significant related scientific
problems


Advanced
Organic Chemistry,
Structure
Elucidation of Organic Molecules,
Fun
damentals of Physical Chemistry,
Inorganic Chemistry
I and
II,
Instrumental Analytical Chemistry
I and

II,

Pharmaceutical Discovery, Advanced

Topic
s in P
harmaceutical Chemistry
,

Thesis Project
, Advanced Topics in
Pharmaceutical Biotechnology.

utilize know
ledge to analyze, evaluate, and
apply the scientific concepts, techniques or
processes needed in the
study and
application of chemistry


Any course with laboratory exercises
and reports meets these requirements.
Chemistry I, Chemistry II, Introduction
to
Organic Chemistry, Analytical
Chemistry, Instrumental Analytical
Chemistry I, Instrumental Analytical
Chemistry II, Organic Chemistry,
Fundamentals of Physical Chemistry,
Inorganic Chemistry I, Inorganic
Chemistry II,
Advanced Organic
Chemistry,
Structure
Elucidation of
Organic Molecules
,

Physical Chemistry
,
Pharmaceutical Discovery, Advanced

Topics in Pharmaceuti
cal Chemistry
,

Thesis Project

communicate effectively in written, spoken
and visual format with both technical
experts and members of the general

public
on science issues


Collaborative Leadership.

All courses with lab reports, discussion
components, cooperative learning
activities, and oral presentations will
contribute to this learning outcome.

Written analyses, essays, lab reports,
University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







and tests wi
ll require students to use
written communication skills regularly.
This is applicable to all required science
and non
-
science electives.

understand and utilize contemporary
laboratory and measurement techniques,
procedures, safety protocols and
equipment
necessary for conduct of work in
chemistry

and related sciences

Physics I and II, Chemistry I and II,
Biology I and II
, Analytical Chemistry,
Introduction to Organic Chemistry,
Thermodynamics and Kinetics,
Advanced Organic Chemistry,
Instrumental Analysis
II and II,
Inorganic Chemistry I and II,
Fundamentals of Physical Chemistry,
Thesis Project, Introductory Physiology.


Program Level Learning Outcomes

Program requirement(s), or
segments of requirements, that
contribute to this outcome

plan and implemen
t experiments and
investigations, critically examine the results
and draw valid conclusions


Advanced Organic Chemistry,

Structure
Elucidation of Organic Molecules
,
Instrumental Analysis II and II,
Inorganic Chemistry I and II, Physical
Chemistry, Thesis P
roject
,

apply to scientific study, an appreciation for
the level of uncertainty in experimental
results and theoretical predictions;


Most laboratory experiments will give
students experience with variability in
data and present an opportunity to
evaluate

and explain the variation.
Statistics and Probability for Physical
Science

apply relevant numerical skills including
statistical an
alysis as necessary for
chemical

sciences


Statistics and Probability for Physical
Science

use current Information Tec
hnology to
access, store and retrieve information, to
acquire and process data, and to analyze
and solve problems


All students in UOIT will be supplied
with a laptop computer and will access,
store and retrieve information on a daily
basis in every cours
e. Scientific
Computing Tools

contribute as effective participant in
multidisciplinary and multi
-
cultural teams, in
both membership and leadership roles


Collaborative Learning.

The population of the geographic region
from which the students of UOIT wil
l
come is very culturally diverse. Thus
the student population of UOIT will be
diverse. Daily experience in labs,
tutorials, group work and student life
activities will prepare students for
participation in varied roles.

University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







This is applicable to all require
d and
science electives, as well as non
-
science electives.

recognize and value the alternative
outlooks that people from various social,
ethnic and religious backgrounds may bring
to scientific endeavours


Collaborative Learning.

Due to the diverse stude
nt population
and exposure to representatives from
business and industry through field
visits and guest presentations, this is
also applicable to all required and
science electives, as well as non
-
science electives.


Program Level Learning Outcomes

Progra
m requirement(s), or
segments of requirements, that
contribute to this outcome

understand management and/or business
practices relevant to employment
situations, including the importance of
quality management and quality
performance.


Management of the E
nterprise

have well developed strategies to update
knowledge, maintain and enhance learning


Collaborative Leadership.

Learning enhancement with a laptop
computer will continually update
students relative to a vast array of
knowledge.



This is also ap
plicable to all courses in
which students are required to utilize
various resources and conduct
research to prepare for discussions,
reports, assignments or presentations.

understand management and/or business
practices relevant to employment
situations,
including the importance of
quality management and quality
performance

Collaborative Leadership, Management
of the Enterprise

appreciate and evaluate the importance of
new and emerging chemical technologies
in biological sciences


Pharmacology and Toxicol
ogy,
Advanced Topics in Pharmaceutical
Biotechnology,
Pharmaceutical
Discovery
,
Advanced
Topics
in
Pharmaceutical Chemistry

appreciate and evaluate the central role of
chemistry in the pharmaceutical industry

Pharmacology and Toxicology,
Advanced Topics i
n Pharmac
eutical
Biotechnology, Pharmaceutical
Discovery
,
Advanced
Topics in
Pharmaceutica
l Chemistry


University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







COURSE OUTLINES AND OTHER GRADUATION REQUIREMENTS

Mode of Delivery

UOIT has a ubiquitous computing environment. We have a comprehensive laptop
program t
hat includes all students and faculty and our physical plant infrastructure has
been built to enhance the use of computing. The computer network has been installed
throughout all classrooms and public spaces and most areas also are accessible to the
networ
k through wireless connections. In addition to the hardware aspects of our
technological infrastructure, we have a mandate to implement the use of computer and
information technologies into our pedagogy. This is written into our policies and all
faculty ar
e aware of this as part of their work setting. We have also dedicated technical
and pedagogical support personnel. This level of focus on the pedagogical development
of the use of technology in teaching is reflected in the UOIT academic administration
thro
ugh the office of Associate Provost, Learning Technologies.


Our commitment to pedagogical development with the use of learning technologies has
implications for the mode of delivery of our programs.


Enhancing Tradit
ional Education in a Technology
-
Rich
Hybrid Environment


We are engaged in the enhancement of traditional educational delivery. In doing this, we
are shifting the way that traditional education will be done.


Traditional education occurs within the context of a physical campus with frequent

face
-
to
-
face interaction among students and faculty. There are many aspects of traditional
education that are malleable and open to change. Traditional university education has
varied greatly in terms of the weight given to lectures, seminars, independent

study,
group work, library research, labs, apprenticeship and individual consultation. Our
technology rich environment provides the possibility for a hybrid of traditional face
-
to
-
face elements along with online components.


Over the last generation in m
any universities there has been a drift toward a greater
reliance on the lecture and lecture contact hours, partly because the lecture delivery
mode accommodates great numbers with efficiency. We intend to reverse this trend.


In the Faculty of Science at

UOIT, we intend to continue using the lecture as one of the
tools available to us. Indeed our technology infrastructure is being used to enhance the
delivery of lectures with presentation packages and online resources. However, over
time we intend to decr
ease our use of face
-
to
-
face lecture contact time. This will be done
in a number of ways. Using our online infrastructure and the standardization of the
laptop environment, we will shift some class time to online seminars and consultations.
We will use onl
ine interaction tools to displace low interaction lecture time with high
interaction online time. Of course, in our traditional education context the use of online
communication tools is an elaboration of face
-
to
-
face interaction and is supplemented by
inf
ormal and formal opportunities for face
-
to
-
face interaction among students and faculty.
Another way that we will move away from lectures is in developing some of our
pedagogy in the direction of problem and inquiry based learning. This can be done
without
the use of computers, however, in our standardized computer
-
mediated,
communication rich environment we are better able to coordinate student work,
individually and in groups, and support their explorations when they are outside of the
University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







classroom. A third w
ay that we will move away from lectures is through the use of the
laptop as a movable lab. In some courses we will be increasing our lab work using
analytical programs since we will not have to ration student access to these programs.
Of course, another wa
y that we will move away from face
-
to
-
face lectures is with the
recording of some lectures. Some of this is being done now at UOIT on an experimental
basis with the use of Silicon Chalk, a computer package that records computer screen
and audio portions of

lectures. This is being piloted as a way for students to be able to
review lecture material. It is not difficult to imagine a situation where some lecture
material that is relatively static may be recorded in this or another way for review by
students. In

this way some face
-
to
-
face lecture material may become computer
delivered. This does not move away from lectures but rather moves away from some
face
-
to
-
face lectures.
Laboratory experiences will continue to be delivered in face
-
to
-
face sessions.


No matt
er how some traditional face
-
to
-
face contact time is displaced or supplemented
with other activity or contact time, all of our courses will maintain a core component of
face
-
to
-
face contact. All of our courses take advantage of the hybrid of a face
-
to
-
face

and a computer mediated online environment. This type of environment is developing to
various extents at other Canadian universities. UOIT, with its comprehensive ubiquitous
computing environment, will be at the forefront in developing this face
-
to
-
face a
nd online
hybrid evolution of traditional physical campus based education.


It will take time for us to develop our pedagogy to take advantage of our hybrid computer
mediated and face
-
to
-
face environment. Our typical faculty member will have been
educated

in a traditional lecture mode. Traditional lectures will be the easiest way for us
to teach in the short term. The structure of our contact hours will shift over time as we
are able to develop our pedagogy to fully take advantage of our hybrid environment
.
Perhaps the easiest way to express this is through the number of traditional face
-
to
-
face
lecture hours in a course. In 2005, many courses will still be delivered with a 3 face
-
to
-
face lecture hours per week format. By this time, some courses will have a
lready moved
to 2 hours of traditional lecture with some other mode of delivery for the third hour. This 2
and 1 model for the standard lecture based course is one that we would like to achieve
in the fairly short term. Some innovative faculty may be able
to shift their pedagogy
sooner than others. We suspect that the 2 and 1 model will remain dominant for the
foreseeable future. We expect that within a few years some instructors may go further
and adopt the format of one traditional face
-
to
-
face lecture ho
ur per week with the other
two structured contact hours being replaced with a combination of face
-
to
-
face and
online assisted interaction and activities. Beyond lectures altogether it remains to be
seen to what extent we will find it useful and possible to

develop some courses in an
inquiry or problem based mode where all or most lectures become irrelevant. Although
this pedagogy does not require a computer mediated environment, we believe that it
would be greatly enhanced with this technology. We anticipat
e that our courses will end
up with a range of delivery modes that take advantage of our technology rich hybrid
environment. In all cases, our courses will have some traditional face
-
to
-
face lecture or
personal contact component. We believe that this hybri
d is the future of education in a
technology rich computer enhanced environment. We will be at the forefront in this
evolution of traditional campus based education.



University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







Course Descriptions


New courses
for the
area

of specialization
are indicated by shadin
g
.

The other courses
described below were reviewed and approved in the original assessment
s

of UOIT's BSc
in Biological Science
and

the

BSc in Chemistry program
s
.


YEAR 1, SEMESTER 1



PHY 1010U Physics I.

Introduction to basic mechanics. Newton’s laws of

motion;
kinematics and dynamics in one and two dimensions; work and energy; friction;
momentum and collisions; angular momentum, torque and rotation of rigid bodies;
planetary motion; simple harmonic motion; static equilibrium; fluid mechanics. 3 cr, 3
l
ec, 3 lab (biweekly), 2 oth (biweekly). Prerequisites: Advanced Functions and
Introductory Calculus 4U or OAC Calculus (required); Physics 4U or OAC Physics
(recommended). Notes: Students without the Physics prerequisite require the
permission of the in
structor in charge of the course, and will be responsible for making
up background material.

Credit restrictions: PHY 1030U, PHY 1810U.


MATH 1010U Calculus I.
Study of limits and continuity, the derivative, Rolle's theorem,
the Mean
-
Value Theorem for De
rivatives, Fermat’s Theorem, the differential and anti
-
differentiation, the definite integral, area, the Mean
-
Value Theorem for Integrals, the
Fundamental Theorem of Calculus, and other topics as time permits. Applications to
science and engineering will

be incorporated. Lect: 3hrs, Other: 2hrs. Prerequisites:
OAC Calculus or 12U Advanced Functions and Introductory Calculus.


CHEM 1010U Chemistry I.
The concepts of chemistry including simple reactions and
stoichiometry; atomic and molecular structur
e and chemical bonding; chemical equilibria
involving gases; acids, bases, salts, buffers and ionic equilibria; titration; introduction to
organic chemistry and the reactions of organic compounds; polymer chemistry. Lect:
3hrs, Lab: 3hrs Bi
-
Weekly, Othe
r: 2hrs Bi
-
Weekly. Prerequisites: OAC or 12U
Chemistry (recommended). Note:
Students without the Chemistry prerequisite require
the permission of the instructor in charge of the course, and will be responsible for
making up background material. Credi
t may be obtained for only one of CHEM 1010U
and CHEM 1800U.


BIOL 1010U Biology I.
This course examines the evolutionary basis of life and the
structure and function of living organisms. The major tissues, organs, and organ systems
and their development f
rom simple structures to more complicated systems will be
examined. Lect: 3hrs, Lab: 3hrs Bi
-
Weekly, Other: 2hrs Bi
-
Weekly. Prerequisites:
OAC or 12U Biology (recommended). Credit Restrictions: BIOL 1840U. Note:
Students without the Biology pre
-
r
equisite may be admitted by permission of the course
instructor, and will be responsible for making up background material.


CSCI 1000U Scientific Computing Tools.
A course covering the use of various
software tools for use in the UOIT web
-
centric and lap
top environment in Science.
Modules will be included on: web tools, spreadsheets, file management, meta
-
computing
tools (Maple, Matlab), basic graphics tools, scientific text processing, presentation tools
(Powerpoint, Visio). Lect: 3hrs, Other: 2hrs.



YEAR 1, SEMESTER 2

University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization








PHY 1020U Physics II.

Introduction to electromagnetism and optics. Electric charge
and Coulomb’s law; electric field, electric flux, Gauss' law; electrostatic potential,
capacitance; Kirchoff’s laws in DC circuits. Magnetic forces
and magnetic field; Biot
-
Savart law; Ampere’s law; magnetic flux, Faraday's law, inductance; AC circuits.
Electromagnetic waves; wave propagation; waves in matter. Geometrical and wave
optics. 3 cr, 3 lec, 3 lab (biweekly), 2 oth (biweekly). Prerequisite
: PHY 1010U. Credit
restrictions: PHY 1040U, PHY 1810U.


MATH 1020U Calculus II.
A continuation of Calculus I that addresses techniques of
integration, applications of integration to volumes, arc length and surface area,
parametric equations, polar coord
inates, functions of two or more variables, partial
derivatives, differentials, Taylor and MacLauren series, double and triple integrals, and
other topics as time permits. Applications to science and engineering will be
incorporated. Lect: 3hrs, Other:
2hrs. Prerequisites: MATH 1010U


CHEM 1020U Chemistry II.

Introduction to the fundamental principles governing
chemical transformations. Thermochemistry and thermodynamics (energy, heat,
enthalpy, entropy and free energy); the rates of reaction, the la
w of radioactive decay
and reaction mechanisms; redox reactions and electrochemistry. Lect: 3hrs, Lab: 3hrs
Bi
-
Weekly, Other: 2hrs Bi
-
Weekly. Prerequisites: CHEM 1010U.
Credit may be
obtained for only one of CHEM 1020U and CHEM 1800U.


BIOL 1020U Bio
logy II.
Biology explores some of the basic challenges that organisms
face in order to develop, survive and reproduce. The second half of the course will
address the fundamental principles of ecology and give a basic understanding of
individual populati
ons and communities. Lect: 3hrs, Lab: 3hrs Bi
-
Weekly, Other: 2hrs
Bi
-
Weekly. Prerequisites: BIOL 1010U.


Elective


Students may select science or liberal studies electives from a variety of courses offered
by other schools in UOIT or through Trent Un
iversity at Durham. Pre
-
requisite(s): As
required for selected subject.



YEAR 2, SEMESTER 1



CHEM 2010U Structure and Bonding.

An introduction to modern inorganic chemistry
which provides a systematic overview of bonding theories designed to explain mole
cular
arrangements, with emphasis on structure and reactivity. An introduction to transition
group elements, as well as the use of modern structural methods to determine
composition, structure and bonding. 3 cr, 3 lec, 1 oth. Prerequisite: CHEM 1020U.


CHEM 2020U Introduction to Organic Chemistry.

An introduction to the principles
and techniques of organic chemistry, including a study of the correlation of reactions and
physical properties of organic compounds with structure and energetic concepts;
st
ructure, bonding, properties, reactions and synthesis of mono
-
functional aliphatic and
aromatic compounds; stereochemistry and reaction mechanism theory; study of infrared,
nuclear magnetic resonance and mass spectroscopy. Lect: 3hrs, Lab: 3hrs Bi
-
Weekl
y,
Other: 2hrs, Bi
-
Weekly. Prerequisites: CHEM 1020U.


University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







CHEM 2030U Analytical Chemistry.

A study of the principles of analytical chemistry
through demonstrations of applications in chemistry, biology, medicine and the study of
the environment. Includes
: standard analytical chemistry techniques based on chemical
equilibrium, volumetric analysis, analytical electrochemistry; use of buffers for pH
-
control; statistical treatment of analytical data. 3 cr, 3 lec, 3 lab (biweekly), 2 oth
(biweekly). Prerequi
site: CHEM 1020U.


STAT 2010U Statistics and Probability for Physical Science.
This course introduces
the concepts and techniques of statistics and probability to collect, present, analyze and
interpret data, and make decisions in the presence of variabi
lity. Students study a
selection of topics relevant to biological science, selected from: basic concepts of
probability theory: events, sample spaces, probability; basic concepts of discrete
mathematics: set theory, propositional logic, combinatorics; prob
ability: marginal
probability, conditional probability, independence, discrete and continuous random
variables; probability distributions: binomial, Poisson, uniform, normal, etc.; mean and
variance; the central limit theorem; statistical inference: estima
tion, significance tests,
confidence intervals; introduction to experimental design; applications to quality control.
Lect: 3hrs, Other: 1hr. Prerequisites: MATH 1020U. Credit may be obtained for only
one of the following: STAT 2010U, STAT 2020U, STA
T 2800U, STAT 3800U, BUSI
1450U, JSTS 2810U.


BIOL 2010U Introductory Physiology.
Overview of the

major physiological processes
involved in plant and animal growth and development including the mechanism of action
of growth regulators and hormones. Emphas
is is placed on the use of genetic,
biochemical, and physiological approaches to understand the regulation of different
systems in plants and animals. Lect: 3hrs, Lab: 3hrs Bi
-
Weekly, Other: 2hrs Bi
-
Weekly. Prerequisites: BIOL 1020U.



YEAR 2, SEMES
TER 2



BIOL 2040U Biochemistry.
Focuses on enzyme mechanisms and stereochemistry,
carbohydrate metabolism, glycolysis, glycogen breakdown and synthesis, transport
across membranes, the citric acid cycle, electron transport and oxidative
phosphorylation,
the pentose phosphate pathway and the glycoxylate pathway, lipid
metabolism, synthesis and role of ketone bodies, amino acid metabolism, and an
overview of the urea cycle. Lect: 3hrs, Other: 2hrs Bi
-
Weekly. Prerequisites: BIOL
1020U, CHEM 2020U. Cred
it Restrictions: BIOL1810U.


CHEM
21
20U Organic Chemistry.
Mechanistic analysis of chemical reactivity of
common functional groups with a focus on nucleophilic substitutions at carbonyl centers,
functional group transformations in organic synthesis; arom
atic chemistry, alkanes, alkyl
halides, alkynes, alkenes, and alcohols; carbohydrates, amino acids, proteins,
heterocycles; applications of spectroscopic techniques.
Lect: 3 hrs, Lab: 3hrs
. Pre
-
requisites: CHEM 2020U.


CHEM 2040U Thermodynamics and Kinet
ics.

Classical thermodynamics: first and
second laws, Gibbs and Helmholtz functions, chemical potential; phase diagrams,
applications to phase equilibrium in one, two, and many component systems, Gibbs
phase rule; phase diagrams for steels and other alloy
s; behaviour of real gases; steam
tables. Chemical kinetics: gas phase kinetics; Arrhenius rates; enzyme kinetics. 3 cr, 3
University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







lec, 3 lab (biweekly). Prerequisites: CHEM 1020U, MATH 1020U. Credit restriction:
PHY 2050U.


2
Elective
s


Students may select
science or liberal studies electives from a variety of courses offered
by other schools in UOIT or through Trent University at Durham. Pre
-
requisite(s): As
required for selected subject.



YEAR 3, SEMESTER 1



CHEM 3120U Advanced Organic Chemistry
.
Applica
tion of advanced synthetic
methodologies used in modern organic synthesis. Emphasis will be placed on the use of
retrosynthetic analysis, stereochemical control, and protection/ deprotection schemes.

3
cr 3 lec 3 lab. Prerequisite: CHEM 2120U
.


CHEM 3530U

Instrumental Analytical Chemistry I.
Instrumental methods of trace
chemical analysis. This course deals with the scope and use of instruments in chemical
analysis, and the theory and applications of ultraviolet/visible, infrared and atomic
absorption sp
ectroscopy. A range of other analytical techniques is examined. 3 cr, 3 lec,
1 oth. Prerequisite: CHEM 2030U. Credit restriction: CHEM 3830U. Note: Students are
expected to take CHEM 3540U in the following semester.


CHEM 3510U Inorganic Chemistry I.
D
etailed treatments of inorganic and
organometallic coordination chemistry of the transition and main group elements; the
emphasis is on structure, bonding, and reactivity; solid state chemistry; acid
-
base
chemistry; inorganic chemistry in non
-
aqueous media
. The lab portion of this course will
emphasize the use of modern structural methods to determine composition, structure
and bondin
g. 3 cr, 3 lec, 3 lab
. Pre
-
requisite: CHEM 2010U. Note: Students are
expected to take CHEM 3520U in the following semester.


BIOL 3020U Principles of Pharmacology and Toxicology.
An overview of the action
and toxicity of drugs that affect the autonomic nervous system, the central nervous
system, and cardiovascular function in both normal and pathological conditions.
Toxicolo
gical effects of food, food additives, household and industrial products and
wastes will also be examined. 3 cr, 3 lec, 1 oth. Prerequisites: BIOL 2010U, BIOL
2040U. Credit restriction: BIOL 2810U.



Elective


Students may select science or liberal st
udies electives from a variety of courses offered
by other schools in UOIT or through Trent University at Durham. Pre
-
requisite(s): As
required for selected subject.



YEAR 3, SEMESTER 2



CHEM

3220U Structure Determination of Organic Molecules

This course

explores the theory and the application of mass spectrometry, and NMR,
ultraviolet/visible, and IR spectroscopy to the structure determination of organic
molecules. 3 cr. 3 lec. Prerequisites: CHEM 2120U.


University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







CHEM 3540U Instrumental Analy
sis
II.
A continua
tion of the topics of Instrumental
Analytical Chemistry I. Arc, spark and inductively
-
coupled plasma, emission
spectroscopy and ICP mass spectroscopy; X
-
ray fluorescence; gas chromatography;
surface characterization, vacuum ultraviolet and X
-
ray photoelec
tron spectroscopy;
auger and SIMS; neutron activation analysis; electrochemical techniques; HPLC. 3 cr, 3
lec, 1 oth. Prerequisite: CHEM 3530U. Credit restriction: CHEM 3830U. Note: Students
are expected to take this course immediately after CHEM 3530U.


CHEM 3520U Inorganic Chemistry II.
A continuation of the lecture and laboratory
topics of Inorganic Chemistry I. Spectroscopy of metal complexes, reaction mechanisms
of d
-
block complexes, d
-
block organometallic complexes, catalysis; introduction to
bio
inorganic chemistry
. 3 cr, 3 lec, 3 lab
. Prerequisite: CHEM 3510U. Note: Students
are expected to take this course immediately after CHEM 3510U.


CHEM 3040U Fundamentals of Physical Chemistry.
Thermodynamics concepts
including solution thermodynamics,
phase equilibria, and electrochemistry; transport
phenomena, the random walk problem and diffusion; introduction to statistical mechanics
including probability distributions and entropy, fluctuations, the Boltzmann distribution,
and partition functions and

their relation to thermodynamic function
s. 3 cr, 3 lec, 3 lab
.
Prerequisite: CHEM 2040U.



Elective


Students may select science or liberal studies electives from a variety of courses offered
by other schools in UOIT or through Trent University at Durham.

Pre
-
requisite(s): As
required for selected subject.



YEAR 4, SEMESTER 1



CHEM4400U Thesis
.
The thesis project provides students with the opportunity to
integrate and synthesize knowledge gained throughout their program of study, to satisfy
specific obj
ectives and requirements. The project may comprise an individual or group
project, or an individual research project. Each student must write an individual thesis
independently. 3 cr. Prerequisite: Completion of three years of chemistry specialization.
Not
e: Students will carry out independent or group work under the guidance of individual
Chemistry professors


CHEM 4040U Physical Chemistry.
An introduction to phenomena at surfaces and
interfaces: colloids, adsorption, thermodynamic treatments and examples

of
technological applications. The course describes modern methods to characterize
surfaces in materials science and chemical dynamics at electrode interface
s. 3 cr, 3 lec,
3 lab
. Prerequisite: CHEM 3040U.



CHEM
451
0U Pharmaceutical Discovery
.
This cours
e explores topics in the drug
discovery process from the discovery of lead molecular candidate
s to their optimization
as drug candidates
. Topics include natural products drug discovery; combinatorial
chemistry; medicinal synthetic organic chemistry. 3 cr.

3 lec. Prerequisites: CHEM
3120U.


University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







Ele
ctive
s


Students may select science or liberal studies electives from a variety of courses offered
by other schools in UOIT or through Trent University at Durham. Pre
-
requisite(s): As
required for selected subject



YEAR 4, SEMESTER 2


Electives


Students may select science or liberal studies electives from a variety of courses offered
by other schools in UOIT or through Trent University at Durham. Pre
-
requisite(s): As
required for selected subject


BIOL 4050U Advance
d Topics in Pharmaceutical Biotechnology.
Highlights the
fundamental research and industrial applications of pharmaceutical biotechnology in
selected areas including psychopharmacology, cardiovascular pharmacology,
neuropharmacology, endocrine pharmacolog
y, quantitative pharmaceutical analysis,
drug discovery and design, safety and quality assurance, and protein engineering. 3 cr,
3 lec. Prerequisite: BIOL 3020U. Note: An independent term project will be part of this
course.


CHEM4520U
Advanced
Topic
s in Pharmaceutical Chemist
ry
.
This course covers
current research topics in pharmaceutical chemistry with a focus on techniques that
facilitate a drug candidate’s entry into the marketplace.
Topics in
clude
molecular
modeling, pharmacokinetics, and pharma
ceutics
. 3 cr. 3 lec.
Prerequisites: CHEM
4510U.



Recommended Science Electives


CSCI 1020U Fundamentals of Programming
(Formerly CSCI 1600U)
.
This course
provides a basic introduction to computer programming using the C programming
language. Topics inc
lude basic computer hardware and software concepts, problem
analysis, design of algorithms and programs, the basic principles of object
-
oriented
languages. 3 cr, 3 lec, 2 oth. Prerequisite: CSCI 1000U. Credit Restrictions: BUSI
1830U
, ENGR 1200U
, CSCI 1600
U.



BIOL 2030U Cell Biology.
Provides a basic knowledge of the structural and functional
properties of cells. Emphasizes the mechanisms by which signalling molecules and the
process of signal transduction integrate and coordinate the functions of many i
ndividual
cells in a multi
-
cellular organism. Explores factors regulating the cell cycle and growth. 3
cr, 3 lec, 3 lab (biweekly), 2 oth (biweekly). Prerequisite: BIOL 1020U. Credit
restriction: BIOL 2840U.


CHEM 4010U Industrial Chemistry

This cour
se introduces the principles and practice
of industrial chemistry with a survey of the chemical industry, pollution control, plant
design, corrosion and similar topics. Selected industrial processes will be discussed in
detail, such as production of primar
y petrochemicals; plastics and synthetic fibres;
pharmaceutical agents; insecticides, herbicides and insect pheromones, dyes,
detergents, perfumes and flavours. Tours of chemical plants and industrial laboratories
University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







are included to show the student the prac
tical side of production
.

3 cr. 3 lec.
Prerequisite: CHEM 3520U.


CHEM 4110
U

Bio
-
Organic Chemistry.
This course will explore the structure and
function of biological molecules including proteins, nucleic acids, carbohydrates, lipids,
and alkaloids. Pharm
aceutical implications will also be discussed. Prerequisites: CHEM
2120U.

(course from the proposed
Biological Chemistry specialization)


9.1

Program Design and Credential Recognition


Research was conducted to compare the breadth and rigour of the elements of

th
e
Pharmaceutical Chemistry

program to similar programs in Canada and elsewhere.


Upon graduation,
students in the proposed program

will have achieved the Degree Level
Standard for a

B.Sc. degree in
Chemistry

(Honours)
.



9.2

Consultation

The
Chemistry (Ho
nours) degree with a specialization in
Pharmaceutical Chemistry

has
been carefully designed to provide a pathway to graduate study for students who wish to
pursue advanced academic study in their science discipline

or

industry employment
.
It is
understood

that other institutions will review the academic credentials and related
experiences of UOIT graduates on a case
-
by
-
case basis.








University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







COURSE OUTLINES


Provided on the pages that follow are the three courses specific to the Pharmaceutical
Chemistry spec
ialization and new to the B
.
Sc
.

in Chemistry

(Honours) p
rogram.


Course Title:
Spectroscopy in Organic Chemistry CHEM 322
0U


Pre
-
Requisites: Organic

Chemistry CHEM 212
0U



Year and Semester:


Year 3
, Semester 2




Course Description and Content Outline
(by t
opic)
:


This course explores the theory and the application of mass spectrometry, and NMR, IR
,
Ultraviolet/Visible and chiroptical

spectroscopy to the
structure determination of organic
molecule
s.



The course covers the following topics:

Mass spectromet
ry
: This s
ection describes ionization techniques, mass analyzers,
high resolution MS, and the analysis of mass spectral fragmentation patterns.

Nuclear magnetic resonance spectroscopy
: This section deals with the
theory of
NMR and spin ½ nuclei, chemical s
hifts, and scalar coupling; as well as, the
analysis of 1D NMR spectra, the nuclear Overhauser effect, and an introduction
to 2D NMR spectra
.

Infrared spectroscopy
: This section explains the
theory of infrared spectroscopy and
the analysis of IR spectra.


Ultraviolet/Visible spectroscopy
: This section reviews the
theory of UV/Visible
spectroscopy and the analysis of UV/Visible spectra
.


Chiroptical spectroscopy
: This section describes plane
-

and circularly polarized light
and

explains the background and ap
plication of optical rotary dispersion and
circular dichroism spectroscopies


Applications of techniques to chemical and biochemical problems:
This section

provide
s
examples for
the
use of spectroscopic techniques in investigating
biosynthesis and enzyme m
echanisms, reaction mechanisms, and protein
structure characterization.




Methods of Delivery:

3 hours of lecture per week
.

University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







Spectroscopy in Organic Chemistry CHEM 322
0U

continued…




Student Evaluation
:
This course will involve extensive problem solving usin
g complex
spectra; therefore, students will be evaluated with multiple problem sets, two midterms

and a
comprehensive final exam.




Resources to be purchased/provided by students:

Textbook, reference sources
and internet access (see Textbook requirements b
elow).




Textbook requirements:
representative texts are:

Lambert, J.B.; Shruvell, H.F.;
Lightner, D.A.; Cooks, R.G. 1998.
Organic Structural Spectroscopy,
Prentice
-
Hall, Inc.

Pavia, D.L.; Lampman, G.M.; Kriz, G.S. 2000.
Introduction to Spectroscopy
, 3
rd

E
dition,
Brooks
-
Cole, Inc. Crews, P.; Jaspars, M.; Rodriguez, J.; Rodriguez, J. 1998.
Organic
Structure Analysis
. Oxford University Press. Field, L.D.; Sternhell, S.; Kalman, J.R.
2002.
Organic Structures from Spectra
. 3
rd

Edition. John Wiley & Sons.




Lea
rning Outcomes.
Students who successfully complete the course have reliably
demonstrated the ability to:


Outcome 1:
Describe currently available types of mass spectral analyses with regards

to ionization source and mass analyzers, and select the app
ropriate method of analysis
for a specific organic analyte
.

Outcome 2:

Interpret the mass spectra of organic molecules
.

Outcome 3: Describe the theory of 1D NMR spectroscopy
.

Outcome 4: Interpret 1D NMR spectra of organic molecules
.

Outcome 5:

Desc
ribe the theory of IR spectroscopy
.

Outcome 6:

Interpret IR spectra of organic molecules
.

Outcome 7:


D
escribe
the theory of UV/Visible spectroscopy
.

Outcome 8:

Interpret UV//Visible spectra of organic molecules
.

Outcome 9:

Describe the theory and a
pplication of chiroptical spectroscopic methods

Outcome 10: Describe the use of spectroscopic techniques in chemistry and
biochemistry.


Information about Course Designer/ Developer:

Course designed by T. Barsby, Ph.D; K. Paal, Ph.D; W. Smith, Ph.D.


List
faculty eligible to teach the course
T. Barsby, Ph.D; K. Paal, Ph.D.


Are there any plans to teach all or portions of this course on
-
line?

A course website will play an integral role in the delivery of resources for this course:
syllabus, schedule, assign
ments, solutions to assignments, handouts, supplementary
notes, etc.


This course may take advantage of the UOIT laptop hybrid environment by using a
combination of face
-
to
-
face lecture hours and online course activities. Over time, there
may be an evoluti
on of the course's mode of delivery to increase the amount of online
structured contact time and decrease the amount of conventional face
-
to
-
face lecture
time. As a hybrid course, a core component of face
-
to
-
face contact will always be
preserved. Laborator
y experiences will continue to be delivered in face
-
to
-
face sessions.

University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







Spectroscopy in Organic Chemistry CHEM 322
0U

continued…


Please see the general statement on mode of delivery in the preface to the course
outlines for a discussion of these possibilit
ies.


Faculty Qualifications to teach/supervise the course:

Postgraduate degree with
expertise in
organic chemistry
.


Classroom requirements:

technology
-
enhanced classroom with laptop connections,
data projector, internet access


Equipment requirements:
No
ne



University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







Course Title:
Pharmaceutical Discovery

CHEM 4510
U


Pre
-
Requisites: Advanced Organic

Chemistry
CHEM 3120U



Year and Semester:


Year 4
, Semester
1




Course Description and Content Outline
(by topic)
:


This course explores topics involved in the drug d
iscovery process from the discovery of
lead molecular candidates to their optimization as drugs. Topics include

high
-
throughput
screening,

natural products drug discovery; combinatorial chemistry/diversity
-
orientated
synthesis;
and
medicinal synthetic org
anic chemistr
y.



The course covers the following topics:

Natural products drug discovery
: This s
ection describes the history of the use of
drugs from nature, the main classes of secondary metabolites, the process of
discovery (bioassay
-
guided fractionatio
n and structure elucidation), and new
approaches to natural products drug discovery (biosynthetic engineering).

High
-
throughput screening
: This section reviews the

processes of robotics, assay
development, assay optimization, and experimental design, and t
heir effect of the
drug discovery paradigm and its shift from natural products to synthetics.

Diversity
-
orientated synthesis
: This section deals with the
theory and practice of
combinatorial chemistry, and diversity
-
orientated synthesis, in the production
of
libraries of drug candidates. Specific chemical reactions will be profiled.


Medicinal synthetic organic chemistry
: This section explains the

process of the
bioassay
-
guided optimization of an identified drug candidate to a lead compound
using syntheti
c organic chemistry.
Specific chemical reactions will be profiled and
the difference between medicinal and process chemistry will be highlighted. The
role of metabolic studies will be introduced.





Methods of Delivery:

3 hours of lecture per week
.




Studen
t Evaluation
:
Multiple assignments will cover each of the four unit
s, a term
oral
presentation is required alongside a comprehensive final exam.




Resources to be purchased/provided by students:

Textbook, reference sources
and internet access (see Textbook

requirements below).


Textbook requirements:
No specific textbook for the course is required. Weekly
readings will be selected from articles of peer
-
reviewed electronic journals (Science,
Nature, Proceedings of the National Academy of Science, USA, Journa
l of the American
Chemical Society, Angewandte Chemie International Edition, Journal of Medicinal
Chemistry, Journal of Natural Products, Bioorganic & Medicinal Chemistry, etc.). Some
r
epresentative texts

that

will be made available
are:

Thomas, G. 2000.
M
edicinal
Chemistry, An Introduction
, John Wiley and Sons Ltd. Dewick, P.M. 1997

University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







Pharmaceutical Discovery CHEM 4510
U

continued…




Medicinal Natural Products, A Biosynthetic Approach
. John Wiley and Sons Ltd.
Delgado, J.N.; Gisvold, O.; Remers, W.A. 1998
Wi
lson and Gisvold’s Textbook of


Organic Medicinal and Pharmaceutical Chemistry
. 10
th

edition. Lippincott Williams, &
Wilkins. Silverman, R.B. 2004.
The Organic Chemistry of Drug Design and Drug Action
.
2
nd

Edition. Academic Press.




Learning Outcomes.
S
tudents who successfully complete the course have reliably
demonstrated the ability to:


Outcome 1:
Discuss the drug discovery process from the use of natural products to



synthetic
chemical libraries.

Outcome 2: Identify the chemical features
of families of secondary metabolites, and




their roles in current therapies.

Outcome 3: Identify the impact of high
-
throughput screening on the discovery process,




and the principles that govern the successful implementation of a
high
-




throughput protocol.

Outcome 4: Discuss the theory of combinatorial/diversity
-
orientated synthesis and the


features of adaptable synthetic methodology.

Outcome 5: Apply knowledge of appropriate synthetic transformations

to the design of a


combinatorial/diversity
-
orientated strategy.

Outcome 6: Discuss the protocols of medicinal chemistry, and how they differ from



process chemistry.

Outcome 7: Apply knowledge of synthetic organic chemistry to the s
ynthesis of a target




molecule.


Information about Course Designer/ Developer:

Course designed by T. Barsby, Ph.D; K. Paal, Ph.D; F. Naumkin, Ph.D; W. Smith, Ph.D.


List faculty eligible to teach the course
T. Barsby, Ph.D; K. Paal, Ph.D.


Are t
here any plans to teach all or portions of this course on
-
line?

A course website will play an integral role in the delivery of resources for this course:
syllabus, schedule, assignments, solutions to assignments, handouts, supplementary
notes, etc.


This
course may take advantage of the UOIT laptop hybrid environment by using a
combination of face
-
to
-
face lecture hours and online course activities. Over time, there
may be an evolution of the course's mode of delivery to increase the amount of online
struct
ured contact time and decrease the amount of conventional face
-
to
-
face lecture
time. As a hybrid course, a core component of face
-
to
-
face contact will always be
preserved. Laboratory experiences will continue to be delivered in face
-
to
-
face sessions.
Pleas
e see the general statement on mode of delivery in the preface to the course
outlines for a discussion of these possibilities.


Faculty Qualifications to teach/supervise the course:

Postgraduate degree with
expertise in
organic chemistry, or industrial exp
erience
.


University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







Pharmaceutical Discovery CHEM 4510
U

continued…


Classroom requirements:

technology
-
enhanced classroom with laptop connections,
data projector, internet access


Equipment requirements:
None













University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







Course Title:
Advance
d

Topics in
Pharmaceuti
cal Chemis
try
CHEM 4520
U


Pre
-
Requisi
tes: Pharmaceutical Discovery

CHEM 4510
U



Year and Semester:


Year 4
, Semester
2




Course Description and Content Outline
(by topic)
:


This course cover
s current research topics in

pharmaceutical chemistry
with a focus

on
techniques
that facilitate a drug candidate’s

entry
in
to the marketplace
.


The course covers the following topics:

Molecular Modeling
: This section deals with the computational chemistry, computer
-
aided drug design, virtual screening, virtual combina
torial libraries, protein
structure predictions, and pharmacophore development

Pharmacokinetic
s
: This s
ection describes the pharmacological response to drugs, the
concept of bioavailability, kinetics, metabolism, clearance, and dosing. The role
of synthet
ic functional groups at improving bioavailability will also be discussed.

Pharmaceutics
: This section explains the

physicochemical features of dosage forms,
the design of dosage regimes, and advanced formulations.




Methods of Delivery:

3 hours of lecture p
er week
.




Student Evaluation
:
Multiple assignments will be used for each section, a term oral
presentation, and a comprehensive final exam.




Resources to be purchased/provided by students:

Textbook, reference sources
and internet access (see Textbook req
uirements below).


Textbook requirements:
No specific textbook for the course is required. Weekly
readings will be selected from articles of peer
-
reviewed electronic journals (Science,
Nature, Proceedings of the National Academy of Science, USA, Journal of

the American
Chemical Society, Angewandte Chemie International Edition, Journal of Medicinal
Chemistry, Journal of Natural Products, Bioorganic & Medicinal Chemistry, etc.). Some
r
epresentative texts

that

will be made available
are:

Delgado, J.N.; Gisvold
, O.; Remers,
W.A. 1998
Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical
Chemistry
. 10
th

edition. Lippincott Williams, & Wilkins. Silverman, R.B. 2004.
The
Organic Chemistry of Drug Design and Drug Action
. 2
nd

Edition. Academic Press.

Kwon,
Y. 2001.
Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug
Metabolism for Industrial Scientists.

1rst Edition. Kluwer Academic Press. Aulton, M.E.
2001.
Pharmaceutics: The Science of Dosage Form Design.

2
nd

Edition. Churchill
Livings
ton. Cohen, N.C. 1996.
Guidebook on Molecular Modeling in Drug Design
.
Academic Press. Ahuja, S. and Scypinski, S. 2001.
Handbook of Modern
Pharmaceutical Analysis
. Academic Press.
Leach,

A. 2001.

Molecular Modelling:
Principles and Applications
.
2
n
d

Edit
ion
.

Prentice Hall
.
Schlick,

T.

Molecular Modeling
and Simulation
,

2002. Springer
-
Verlag,



University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







Advanced Topics in Pharmaceutical Chemistry CHEM 4520
U

continued…




Learning Outcomes.
Students who successfully complete the course have reliably
demonstrated the
ability to:


Outcome 1:
Discuss the impact of computer simulations on the design of drugs.

Outcome 2:
Use computer software to model
pharmacophores

and protein
-
ligand
interactions.


Outcome 3: Identify
sites of metabolism of lead compounds.


Outcome 4
: Discuss techniques used to identify metabolic compounds, and the role of




metabolism studies in the design of drug candidates.


Outcome 5: Discuss the chemical principles involved in drug formulation.


Outcome 6: Discuss the impact of c
hemistry on novel research in drug formulation.


Information about Course Designer/ Developer:

Course designed by T. Barsby, Ph.D;
K. Paal, Ph.D; F. Naumkin, Ph.D
; W. Smith, Ph.D.


List faculty eligible to teach the course
T. Barsby, Ph.D; K. Paal, Ph.D.


Are there any plans to teach all or portions of this course on
-
line?

A course website will play an integral role in the delivery of resources for this course:
syllabus, schedule, assignments, solutions to assignments, handouts, supplementary
notes, etc.


This course may take advantage of the UOIT laptop hybrid environment by using a
combination of face
-
to
-
face lecture hours and online course activities. Over time, there
may be an evolution of the course's mode of delivery to increase the amount of online
s
tructured contact time and decrease the amount of conventional face
-
to
-
face lecture
time. As a hybrid course, a core component of face
-
to
-
face contact will always be
preserved. Laboratory experiences will continue to be delivered in face
-
to
-
face sessions.
Please see the general statement on mode of delivery in the preface to the course
outlines for a discussion of these possibilities.


Faculty Qualifications to teach/supervise the course:

Postgraduate degree with
expertise in
organic chemistry, or industria
l experience
.


Classroom requirements:

technology
-
enhanced classroom with laptop connections,
data projector, internet access


Equipment requirements:
None







University of Ontario Institute of Technology


Bachelor

of Science in Chemistry


Pharmaceutical Chemistry Specialization







Pharmaceutical Chemistry Business Plan


The Business Plan is based on the following assumptio
ns:


-

Annual intake of 20 students

-

Attrition factors of 0.8, 0.7, and 0.65 in years 2, 3, and 4, relative to first year

-

Operating Grant per FFTE = $2736 per first year student, and $7,858 for subsequent years
(government instructions)

-

One student =
1 FFTE

-

Tuition for Forensic Science = $4184

-

No inflation factor is used.

-

Average salary for FT faculty member is $90,000 plus 18.5% benefits.

-

TA cost per hour = $35

-

New lecture sections are required only for the new courses in this program.

-

Exi
sting Science courses are taken in existing sections; faculty costs are shared according to
enrolment (e.g. if 25 students in a program are part of a lecture section of 150, then 25/150 of the
cost of the faculty member is attributed to the program

-

All m
arginal lab and tutorial costs are calculated on the same basis as for other Science
programs.
The hours for existing courses are specified in the Calendar, while hours for new
courses are specified in the course descriptions.

-

Electives and required cou
rses from other Faculties are estimated at $11,000 per section of
maximum 50 students; costs include faculty and TA’s.


Using the above assumptions, the following revenues and expenses are estimated as the
program rolls out (intake of 20 students each year
):




2006/07

2007/08

2008/09

2009/10


Revenue:


$138,400

$331,072

$499,660

$656,206




Expenditures:


$38,130

$93,365

$183,923

$322,648



Expenditures/Revenue:


27.6%

28.2%

36.8%

49.2%