Peilin Jia

skirlorangeΒιοτεχνολογία

1 Οκτ 2013 (πριν από 3 χρόνια και 11 μήνες)

85 εμφανίσεις

Presentation


Session
:



Convergent Evidence for Wnt Signaling Pathway in Psychotic
Disorders




Peilin Jia
, PhD

Departments of Biomedical Informatics and Psychiatry

Vanderbilt University

School of Medicine




Time/Date

Session






Abstract
:

Wnt

signaling pathway is involved in multiple cell processes including cell differentiation, cell
development, and cell fate. Mutations in the Wnt pathway genes have been frequently found
to cause cancer. Recently, there has been emerging evidence showing tha
t abnormality of
the Wnt pathway may also be involved in neurogenesis and synaptic plasticity; thus, it may
play important roles in psychotic disorders. Here we performed a systematic collection and
analysis of data from multiple sources linking Wnt pathwa
y genes to indicate convergent
evidence for this pathway in psychosis, especially in schizophrenia and bipolar disorder.
Specifically, we explored KEGG pathways, protein
-
protein interactions (PPIs), association
studies, genome
-
wide association (GWA) studie
s, and our recently developed schizophrenia
gene resource (SZGR) database. Our analysis suggested some potential genes, including
PPARD
,
FZD3
,
GRIN1
, and
AXIN1
, warrant future genetic and functional validation of their
roles in schizophrenia. In summary, w
e provided a unique integrative analysis of Wnt
pathway genes in psychotic disorders.




Biographical Sketch:



Peilin Jia graduated from Dalian University of Technology, China
,

in 2003
.

She
studied in
Shanghai Institutes for Biological Sciences (SIBS) of
Chinese Academy of
Sciences

(CAS)
during

2003
-
2008 and
received
her
PhD degree
in bioinformatics
in 2008.

She joined Dr. Zhongming Zhao's group as a postdoctoral researcher in
Virginia Institute for
Psy
chiatric and Behavioral Genetics, Vi
rginia Commonwealth University
,
in

September

2008
.
She moved to Vanderbilt University as a post
-
doctoral researcher in

July 2009.


The research interest of Peilin Jia is

to
appl
y
bioinformatics and systems biology
approaches to studying complex diseases, especially neurop
sychiatric d
isorders such as
s
chizophrenia, epilepsy and bipolar

disorder
.
Some of her recent work includes the
development of b
ioinformatics methods
for

integrative
analysis
of genetic data from mu
ltiple
lines of evidence

such as
from
genome
-
wide association studies, linkage studies,
and
copy
number variation studies.
She also performed

biological pathway and network analysis of
high throughput gen
omic data for complex diseases,
aiming to understand

the
pathogenesis
of these diseases
at the systems level
.