BM1304 Bioinformatics - Dsgroups.org

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BM1304
-
BIOINFORMATICS

SEMESTER
-
V


III YEAR

UNIT

I

PART
-
A

(2 MARKS)

1.

Define WWW

?

2.

Explain few a
pplication

of DNA sequencing in biological classification?

3.

Define protein structure?

4.

Write short notes on DNA micro arrays
?

5.

Explain few

implications in
bioinformatics
?

6.

Explain Linnaeus method of nomenclature of a species
?

7.

Explain information flow in bioinformatics?

8.

Write short notes about biological classification?



PART
-
B (16 MARKS)


1.

Explain the advantages of using computers in the field of biology?

2.

Define WWW and explain its relevance with bioinformatics

3.

Explain about biological classification & its need in detail. Also mention the Linnaeus
method of nomenclature of a species

4.

What is the application of DNA sequencing in biological classification? Ex
plain?

5.

Explain about protein structure prediction & engineering

6.

Explain in detail about
DNA micro arrays
?

7.

Explain the hierarchy of protein architecture with neat sketches

8.

Explain
in detail
about clinical implications in bioinformatics


UNIT

I
I

PART
-
A (2 M
ARKS)

1.


Write short notes on SINES & LINES
?

2.

Define genome?

3.

Define PDB?

4.

Define homo sapiens?

5.

Write a short notes on the genome of prokaryotes?

6.

Write a short notes on the genome of eukaryotes?

7.

Write a short notes on the human genome ?

8.

Define proteomics?




PART
-
B (16 MARKS)

1.

Give a brief description on the genome of prokaryotes

2.

Define genome and explain its constituents

3.

Explain in detail about
SINES & LINES
?

4.

Explain about the methods of eavesdropping on genetic information
?

5.

Write about identification of drug
targets & gene therapy
?

6.

Explain about PDB
?

7.

Explain about the genome of prokaryotes with two examples
?

8.

Explain genome of homo sapiens?

9.

Explain genome of eukaryotes?

10.


Explain in detail about evolution of genome?



UNIT

II
I

PART
-
A (2 MARKS)

1.

Define archives?

2.

Define database?

3.

Write short notes on expression & proteomics databases

4.

Write short notes on metabolic pathway data bases

5.

Define genome database?

6.

Define PIR?

7.

Define SRS?

8.

Define EXPASY?

PART
-
B (16 MARKS)

1.

Explain about gate ways to archives
?

2.

What is mapping
between mappings? Explain about it
?

3.

Explain briefly about the concepts data bases and their management and also define data
archiving
?

4.

Explain briefly about the concepts data bases and their management and also define data
archiving
?

5.

Explain about high res
olution maps.
?

6.

What is Homo Sapien? To which category does it bel
ong? Explain about its genome?

7.

Give a brief description on boutique data bases
?

8.

Explain about nucleic acid sequence data bases
?

9.

Explain about protein sequence data bases
?

10.

Explain in detail a
bout

expression & proteomics databases

11.

Explain in detail about

metabolic pathway data bases

12.

Explain about SRS
?

13.

Explain about database indexing and specification?

14.

Write about PIR
?

15.

Explain about bibliographic databases
?




UNIT

I
V

PART
-
A (2 MARKS)

1.

Define
dotplot?

2.

What is phylogeny
?

3.

Write a short note about multiple sequence alignment?

4.

Define PSI
-
BLAST?

5.

Explain in short about hidden markov model?

6.

Explain the clustering method used in phylogenetic tree?

7.

Explain the cladistic method used in phylogenetic tree?

PART
-
B (16 MARKS)

1.

E
xplain about conformational energy calculations and molecular dynamics

2.

How can you recognize protein folds?

3.

Write about ROSETTA and LINUS

4.

What is phylogeny? Explain the various aspects of phylogenetic trees

5.

Write about hidden Markov mod
el

6.

Define multiple sequence alignment and explain its application to database searching

7.

How is optimal pair wise sequence alignment done?

8.

Explain about the measures of similarity

9.

What is dotplot? What is its relation with sequence alignment? Explain with a

suitable
example

10.

Write about ExPASY

11.

W
rite a perl program to describe the translation of DNA from any six amino acids using
their standard genetic code

12.

Assume you already have the standard genetic function in an associated array
%standardgeneticcode
, write a simple perl program to obtain an amino acid sequence
where the input DNA sequence is stored in a simple array called $DNAinfo. Also
mention comments at the end of each code line

13.

Explain about FASTA and PSI
-
BLAST


UNIT

V

PART
-
A (2 MARKS)

1.

Define
DALI?

2.

Define protein stability?

3.

Define sidechain ?

4.

Explain protein folding?

5.

Write any two application of hydrophobicity?

6.

Write a short note about

protein stability and folding

PART
-
B (16 MARKS)

1.

Explain about distance matrix alignment

(DALI)
?

2.

Explain about
critical assessment structure prediction
?

3.

Explain about secondary structure prediction
?

4.

Write about assignment of protein structures to genomes
?

5.

Explain about protein function prediction
?

6.

W
rite about the lead compound of drug discovery
?

7.

W
hat is the role bi
oinformatics in drug discovery
?

8.

Explain about quantitative structure activity relationships
?

9.

Explain in detail about protein stability and folding?

10.

Explain the classification of protein structure in detail?

11.

Explain in detail about protein structure
prediction and modeling?