Masters of Arts in Biology - Brown University

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Masters of Arts in Biology

December 6
th
, 2011


Elizabeth O. Harrington, Ph.D.

Associate Dean, Office of Graduate & Postdoctoral
Studies

Division of Biology & Medicine


Masters of Arts in Biology


Established

in

1993

via

contractual

agreement
.



Accredited

by

Connecticut

Department

of

Education
.


Course

offering

is

a

section

of

an

existing

Brown

University

course
.

Masters of Arts in Biology


“The

quality

of

student

performance

required

is

at

least

as

rigorous

as

for

the

Master

of

Arts

degree

within

any

Graduate

Program

in

the

Division
.

The

basic

difference

is

to

make

it

easier

for

a

student

to

obtain

breadth

in

Biology

in

more

than

one

graduate

area

by

not

imposing

strict

requirements

for

specific

courses
.




http
:
//brown
.
edu/scs/adult/pfizer/


Masters of Arts in Biology

Objectives


Provide

graduate

instruction

within

the

biological

sciences

for

Pfizer

colleagues

and

contractors

who

wish

to

extend

their

knowledge

in

discrete

areas

relating

to

their

employment

and/or

interests
.


Provide

a

broad
-
based

and

rigorous

Master

of

Arts

training

in

biological

sciences
.



Masters of Arts in Biology

Experiences


“I

have

had

a

great

experience

taking

courses

through

Brown
.

I

think

the

Brown
-
Pfizer

program

is

an

excellent

one

and

I

feel

it

has

already

made

me

a

better

scientist

in

exploring

and

designing

new

experiments

for

future

treatment

of

various

diseases
.




Recent

Pfizer

applicant’s

statement

Masters of Arts in Biology

Experiences

Over 100 M.A. in Biology awarded.

Masters of Arts in Biology

Overview


Open to Pfizer contractors and colleagues.


Only one prerequisite required:


A Bachelors degree in any field.



All courses held on
-
site at Pfizer
-
Groton
campus.


Masters of Arts in Biology

Overview


Pfizer

employees

and

contractors

register

as

Special

Students

via

Office

of

Continuing

Studies
;



Standard

Brown

tuition

fees

apply
.



Students

apply

to

Graduate

School

for

the

M
.
A
.

program

after

successful

completion

of

two

courses
.


Pfizer

reimburses

colleagues

only

who

pass

with

grade

of

a

‘C’

or

better
.


Masters of Arts in Biology

Program Requirements


8

graduate

courses
:


2

of

8

courses

in

“core”

subjects



cell

biology,



biochemistry,



genetics,



pharmacology
;



6

of

8

courses

with

grade

of

‘B’

or

better
.


Passing

final

paper

or

proposal

“culminating

experience”

on

topic

approved

by

Assoc

Dean,

Graduate

&

Postdoctoral

Studies
.


Masters of Arts in Biology

Program Requirements:

Culminating Experience


As

a

culminating

experience

for

the

Master

of

Arts

in

Biology

Program,

there

are

two

options
:



an

NIH

style

research

proposal

based

on

an

original

hypothesis

or


a

final

paper

which,

based

on

the

course

work

taken

by

the

student,

represents

an

original

in
-
depth

analysis

and

literature

review

of

a

problem

in

modern

biology
.

Masters of Arts in Biology

Program Requirements:

Culminating Experience


Research

proposal

(written

as

though

you

were

preparing

a

NIH

RO
1

application)

will

include
:


project

summary/abstract,


specific

aims,



research

strategy,


literature

cited
.


Final

paper

(
10
-
15

pgs,

excluding

figures

and

references)

will

include
:



introduction,



discussion,



conclusion,



literature

cited
.

Masters of Arts in Biology

Program Requirements:

Culminating Experience


Topics

must

be

discussed

with,

and

approved

by

the

Associate

Dean

for

Graduate

and

Postdoctoral

Studies
.



The

final

project

may

be

undertaken

following

completion

of

7

courses,

but

must

be

completed

no

later

than

one

semester

following

completion

of

the

8
th

course
.


Masters of Arts in Biology


Program Requirements:

Culminating Experience


Both

projects

are

designed

to

demonstrate

the

student's

ability

to

master

and

integrate

the

knowledge

gained

in

the

prior

course

work

and

to

apply

that

knowledge

to

a

specific

problem

in

modern

biology
.



Masters of Arts in Biology

Program Requirements


No

courses

can

be

transferred

from

another

institution
.


Must

be

actively

employed

as

a

colleague

or

contractor

at

the

Groton/NL

Global

Research

Division
.


Pfizer

M
.
A
.

students

may

take

courses

toward

the

degree

on

Brown

University

campus

with

permission

of

instructor

and

Assoc
.

Dean

of

Graduate

and

Postdoctoral

Studies
.


Masters of Arts in Biology

Program Requirements


Once accepted by the Graduate School, the
students are expected to enroll in courses
continuously each semester
;


with the exception of the summer term.


If not, a request for a Leave of Absence (LOA)
must be submitted one month prior to the
start of the term via the Graduate School to
avoid billing.


Only one LOA is permissible during the
course of study.


Masters of Arts in Biology

Application Requirements


Successful completion of two Brown
University graduate courses (B or better).


Undergraduate transcript with date of
degree.


Letter of recommendation from Supervisor at
Pfizer.


1
-
2 pg. Colleague Statement


No GRE requirement or application fee!


Masters of Arts in Biology

Upcoming Courses


Spring 2011:
Molecular Genetics


Core course


Summer 2011:
The Immune System


Fall 2011:
Environmental Health &
Disease


Spring 2012:
Drug and Gene Delivery


Fall 2012:
Advance Biochemistry


Core course


Masters of Arts in Biology

Previous Courses


Advanced Biochemistry,


Advanced Microbiology,


Cancer Biology,


Cell Biology,


Developmental Biology,


Drug Delivery,


Human Physiology,


Virology

Drug & Gene Delivery

(BIOL 2110)

Beth Anne Zielinski, Ph.D.

Course Director


Novozymes

Biopharma


Course leader:

Beth
Zielinski, Ph.D
.



Contact information
:

beth_anne_zielinski@brown.edu



Course days and times:

Wednesdays
4
-
6:20PM





(
4:00
-
5:00PM,
break
, 5:00
-
5:10PM,







5:10
-
6:20PM)



Course location:


Pfizer
, Inc. (on
-
site)


20

Required
readings




Text:

Drug
Delivery: Principles and Applications,
Binghe

Wang; Gene Therapy: Treating Disease by
Repairing Genes, Joseph
Panno



Journals and lay
-
press:

Journal of Controlled
Release, Journal of Advanced Drug Delivery Reviews,
Scientific American, New York Times, Washington Post



21

Course Goals


The goals of
this course are to provide students with
a
knowledge base in the most recent advances in drug and
gene delivery.


Lectures
focusing on various therapeutic modalities to
treat specific organ
-
related and genetically
-
based
diseases will allow students to gain comprehensive views
of the disciplines of drug and gene
delivery.


Students
will be able to compare and contrast different
therapies and critically analyze the interpretations of
these developments in the lay press.

22

How Will We Approach These
Topics?


How are drug and gene delivery systems used to
treat disease?


How are drug and gene delivery systems designed
and optimized for use in these applications?


How are these systems designed and fabricated?


What are the pro’s and con’s of each system as
compared to traditional modes of therapy?


How are developments in drug and gene delivery
presented in the high
-
end lay press and how have
these presentations affected their integration into
mainstream medicine?


23

Student Assessment


Students will be required to read assigned text chapters (per
week) that pertain to the weekly topics. In addition, reading
assignments from the primary journals listed above will be
required on a weekly basis.


Number
of pages per week may vary depending upon topic
(80
-
100 pages).





Exam
1



35% (non
-
cumulative)


Final Project



30
% (student groups)


Final Exam



35
% (non
-
cumulative)

24





Reservoir System



Matrix
System

Bioerodible

System

Sigma
-
Aldrich Chemicals

Langer, R.
Science

1990
,
249
, 1527.

Kost
, J.; Langer, R.
Trends in Biotechnology

1984
,
2
, 47.

Heller, J.; Sparer, R. V.;
Zenter
, G. M.
Poly(
ortho

esters)

In Biodegradable polymers as drug delivery systems


Chasin
, M.; Langer, R., Eds.; Marcel Dekker: New York,
1990
.

University of Washington

Engineered Materials

25

The Promise of Gene Therapy and SCID
-
X1


SCID
-
X1


Mutation in gene that
encodes for the gamma
chain of an interleukin
receptor found on the
membranes of all
lymphocytes


Dr. Alain Fischer, Necker
Hospital, Paris, France


Combination of gene
therapy and stem cell
therapy

Thursday, 27 April, 2000, 18:14 GMT 19:14 UK

Gene therapy frees 'bubble babies‘

BBC News


26

Stem Cell
Therapy/Therapeutic
Cloning for
Protein Delivery and Gene Therapy

Nuclear transfer techniques

used to generate specific

cell populations for

re
-
implantation

Patient uses own healthy

cell population to generate

stem cells for his own

therapeutic use


This can also be applied to

stored cord blood

27

28

Thank You!


Questions?

Gerwald

Jogl
, PhD


BIOL 1270 S02

Advanced Biochemistry




Course Time:

Thursdays 4:00pm
-
6:
30pm


The overall goal of this course is to study how essential
concepts of biochemistry are applied in current
biomedical research.


We
will review core topics of biochemistry and read one
or two recent research articles relevant to these topics.


The
in
-
class discussion will

(
a) examine the experimental approach,

(
b) how the results of each report fit with prior knowledge,
and

(
c) how these findings moved the field forward.

30

Course Goals

Tentative Textbook

Biochemistry


The molecular basis of life.

Fifth Edition 2011

McKee & McKee, Oxford University
Press


Two recent research publications for each class.


Example: Topic RNA

Selbach
, M., et al.,

Widespread
changes in protein synthesis induced by microRNAs.


Nature
, 2008.
455
(7209): p. 58
-
63.



Topic Transcription

Cheung, A.C. and P. Cramer,

Structural
basis of RNA polymerase II backtracking, arrest and

reactivation
.


Nature
, 2011.
471
(7337): p. 249
-
53.


Reading Assignments

R
eading research papers:



1)
How did this paper advance the field?


2)
What is the key figure and why?


3)
What kinds of experimental approaches were used and why?


4)
How do the experimental approaches work?


5) What is the central conclusion of the paper?

Tentative Topics:



Proteins
(protein folding, proteomics)


Metabolism


Photosynthesis


DNA (genomics, sequencing)


Transcription
(RNA polymerases, regulation)


RNA (small RNAs, ribozymes)


Translation (antibiotics and the ribosome)


Epigenetics (histone and DNA modification and readout)


Signal Transduction (nutrients and the
mTOR

pathway)


mRNA

A
-
site tRNA

P
-
site tRNA

E
-
site tRNA

Translation: mRNA
decoding

Schmeing

… Ramakrishnan, Science 2009

Masters of Arts in Biology

How to get started????

1.
Register for course offering via the Brown
website:

http://
www.brown.edu/p
fizer

2.
Educational Assistance:


Colleagues:

Apply for via HR source. Following
the successful completion of the course (‘C’ or
better), you will be reimbursed by Pfizer to pay off
your loan.


Contractors:

None available, but Ledge Light
credit union has individual educational loan
options.


Masters of Arts in Biology

How to get started????

3.
Mail tuition check to:

Brown University Cashier's Office

164 Angell Street

Box 1911

Providence, RI 02912


Masters of Arts in Biology

Pfizer Contact


Jady

J.
Rugg


Pfizer
Global R&D
-

Groton/New London
Labs


Senior
Associate Scientist; PDM
Bioanalytical

Core
Group


B220/450F.1
MS:
8220
-
4560


Office
:
860.686.9344


Cell
:
269.317.8201


jady.j.rugg@pfizer.com


Masters of Arts in Biology


Good luck!!