Nano-biomimetics: Materials for the future From Biomass to Bioproducts

prunemareΤεχνίτη Νοημοσύνη και Ρομποτική

14 Νοε 2013 (πριν από 4 χρόνια και 1 μήνα)

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3
©Copyright 2011
CollPlant
5
May 2012
C
a-
P
500
￿m
Bone void filler
6
SEM
imaging
Bi
nd
er
Col
lag
en
heart valve leaflets
7
Cornea
8
Vergenix™Wound Dressing Clinical Study
with Maccabi Healthcare
9

Study objective is to evaluate the
Safety of Vergenix™Wound
Dressing

16 Patients with Diabetic Foot Ulcer

Study endpoints: wound
assessment, wound dressing
acceptability and adverse events

Study duration: 2 weeks treatment
and 1 week follow up

To-date nine patients were treated
with excellent healing response. No
adverse events were reported

Study completion: 6/2012
10
Patient Day 0Day 7Day 14Day 21
TM
AI
AH
01001
01002
01003
Nano Crystalline Cellulose
Composite Foams
from Renewable Resources
11
•A Cleantech & nanotechnology spinoff of HUJI and
the European FP7 program “WOODY Project”
•Founded by Mr. Tord Gustafsson (Sweden), Dr.
Shaul Lapidot (Israel) and Prof. Oded Shoseyov in
2010
•CEO, Mr. Yoram Shkedi
•Melodea combines expertise in biomaterials and
nanotechnology with industrial expertise in the field
of composite materials
•The company had recently signed an investment
agreement with HOLMEN AB, Sweden
Melodea in Brief
Melodea in Brief
Melodea Ltd.-Proprietary Information
12
Melodea
Melodea


s Technologies
s Technologies
•Production of Nano Crystalline Cellulose (NCC)
from the waste of the pulp and paper industry
•Nano structured foams made from NCC for
sandwich composites applications
Supporting Academic Research
(HUJI)
•Development of NCC based applications
for the construction sector
Melodea Ltd.-Proprietary Inforamtion
13
NCC Production Scheme
NCC Production Scheme
14
Production of NCC from cellulose fibers
Cellulose fibers contain amorphous and crystalline
areas
NCC is
recovered
Nano Crystalline Cellulose (NCC) Production
Nano Crystalline Cellulose (NCC) Production
15
Production of NCC from Pulp & Paper Waste
Production of NCC from Pulp & Paper Waste
11 Million tons of waste is
produced in Europe annually (Monte et al, Waste Management, 2009) Main advantages as raw
material:•Most of the required energy
and chemicals were already
invested •High availability
•Paper mill sludge is converted
into a valuable product •Reduced carbon footprint of the
industry
Melodea Ltd.-Proprietary Information
16
NCC Produced from Paper Mill Waste
NCC Produced from Paper Mill Waste
NCC was produced from
different wastes:

Hygienic tissue paper production

Deinked recycled paper

Paper board production
TEM of NCC
samples
Melodea Ltd.-Proprietary Information
17
NCC Self
NCC Self
-
-
Assembly to Films with Highly
Assembly to Films with Highly
Ordered Architeceture
Ordered Architeceture
Transparent films
18
NCC
layers
High Resolution SEM (Magellan™) scan
Melodea Ltd.-Proprietary information
Magellan
Magellan


XHR Scanning of NCC films
XHR Scanning of NCC films
shows highly ordered structures
shows highly ordered structures
Cross section zoom
Top view
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12 nm
Compact ordered arrangement with nano scale pores
Melodea Ltd.-Proprietary Information
Pilot Production of NCC from Paper Mill Waste;
Pilot Production of NCC from Paper Mill Waste;
From Lab Towards Industrial Production
From Lab Towards Industrial Production
NCC
product
20

Process optimization

Acid and water recycling
Melodea Ltd.-Proprietary Information
Main Application; Production of Nano Structured
Main Application; Production of Nano Structured
Foams
Foams
SEM analysis of NCC foam
Anisotropic Structural Sandwich Core
Anisotropic Structural Sandwich Core
Material Principles
Material Principles
•Strength in through-thickness compression and through-
thickness shear.
•Plane properties are less important as these forces are
predominantly carried by the facings.
Figure from Hexcel (www.hexcel.com)
Melodea Ltd.-Proprietary Information
23
SEM of the Foams Shows High Level of
SEM of the Foams Shows High Level of
Ordered Architecture
Ordered Architecture
Top view shows pillars
structure
Side view
Melodea Ltd.-Proprietary Information
25
•Wind energy
•Transportation
•Building &
construction
•Rigid foamed
boards
•Additives for
construction
Extraction of
natural nano
fibers
Paper industry sludge
NCC foam
Markets
Product
Technology
NCC Film Forms Well-ordered Structure
Magellan™XHR Scanning micrographs display
cross section overview of the film
Enables homogenous dispersion of NP –no agglomeration
Protects NPs from oxidation
NCC -Excellent Carrier & Binder for Nano-Particles
Nano Particle QDs Have Tunable Spectral Properties
Band gap can be tuned by size,
composition & shape
Controlling the optical properties
using NCC with different NP
Bulk
band
gap
Increased strength at lower thickness
Gas barrier but transparent to Foreign Object
Detectors
Tunable spectrum –e.g. transparent with UV/IR
control
Excellent Printing platform
Other….
NCC-NPs coating applications
D1
Dia 30
D1
to spek about the other features we can get from other NP
Dov; 20-2-2013
Resilin-chitin Composites Enable Cat
Fleas Jumping Skills Equivalent to
Human Jumping 400 m High

The ultimate rubber

High resilience

Found in all arthropods

Found in specialized regions of the
cuticle –joints

Naturally binds the chitin via chitin
binding domain
(Biomacromolecules 2009)
Highly Elastic and Shape Memory Foams
Produced from NCC and Resilin-CBD