[A.1.3.4] New biomimetics for bone tissue engineering

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14 Νοε 2013 (πριν από 3 χρόνια και 11 μήνες)

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[A.1.3.4]
New biomimetics for bone tissue engineering
T. Deyanova
1
, L. Radev
2
, M. Albu
3
, I. Titurencu
4
, P. Dineff
5
, D. Gospodinova
5
, T. Vladkova*
2
et
al
1
Sofia University, Bulgaria,
2
University of Chemical Technology and Metallurgy, Bulgaria,
3
National Research and Development Institute for Textile and Leather, Romania,
4
Romanian
Academy of Sciences, Romania,
5
Technical University, Bulgaria
Currently, about 4 million bone replacement procedures are performed annually to replace or
repair damaged bone tissue. More than half of them requir the use of bone graft materials.

The biomimetic approach, considered now as one of the most promising methods for design of
artificial bone grafts, is based on bone tissue engineering that aims at generation of clinically
applicable natural bone tissue substitutes by combining progenitor or mature cells from the body
with biocompatible porous scaffold biomaterials, with or without appropriate growth factors, to
act as templates for growth of new tissue.

Majority current bone tissue biomimetics are based on collagen containing composites since the
collagen is a main organic component of the natural extra cellular matrix (ECM). New bone
biomimetic composites are presented here based on both fibriliar or electro spun collagen and
originally synthesized bioactive glass-ceramic combined with osteoblastic cells and growth
factors.

The new biomimetic composites were characterized by FTIR, XRD, SEM-EDS, porosity,
equilibrium swelling, mechanical parameters, in vitro bioactivity in 1.5 SBF, enzymatic
biodegradation, and human osteoblasts distribution in the colonized scaffolds, RNA insulation
and PCR analyses. The most promising bone biomimetic composites were selected on the base
of their biological activity.
Keywords: bone biomimetics, collagen, bioactive glass-ceramic, hodroitin sulphate