The Powell Lab

porcupineideaΒιοτεχνολογία

16 Δεκ 2012 (πριν από 4 χρόνια και 10 μήνες)

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The Powell Lab
is actively investigating the application of immune
-
based therapy for
cancer. Building on interrogations in basic T cell biology in the lab, bench
-
to
-
bedside
translational immunology is being developed, with a strong focus on T cell
-
based
therapy for cancer.


Major areas of focus:
Human Cancer Immunotherapy



Natural tumor
-
reactive T cells



Genetically modified lymphocytes (TCR/CAR)



Cancer vaccination & immunomodulation



Impact of
costimulation

on T cell function and memory formation



Innovative approaches to genetic engineering of T cells (Universal receptors and approaches)



Novel T cell isolation & expansion methods



Th9 cells in cancer

Unique resources:



Viable Primary Human Tumor Cell Bank



Human ovarian cancer cell lines, models



Unique
lentiviral
/retroviral constructs



Xenograft

mouse studies

Collaborations:



Protein chemistry (looking for unique protein binding partners with high affinity)



Bispecific

antibody production



Sensitive in vivo imaging

for antibodies and cells



Costimulatory

signal transduction cascades


Rotations:
available in Spring 2013.



TCR gene cloning



Mouse models of macrophage
-
involved Inflammatory Disease / Autoimmunity