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OGM
Recherche bibliographique
Réalisée par
VACHEZ Dominique
CNRS-INIST
Avril 2008
OGM
Définition
.............................................................................................................................................
3
Mises au point scientifiques et technologiques (articles de synthèse)
...............................................
4
Français
.................................................................................................................................................................
4
ORIGINAL TITLE: Impact environnemental des cultures transgéniques : I. La migration des transgènes
....
4
ORIGINAL TITLE: Impact environnemental des cultures transgéniques : II. L'impact des caractères

recombinants
.....................................................................................................................................................
5
ORIGINAL TITLE: Modification génétique des oléagineux pour de nouvelles matières grasses et

perspectives nutritionnelles
...............................................................................................................................
6
ORIGINAL TITLE: Plantes génétiquement modifiées (PGM) et pays en développement
..............................
7
ORIGINAL TITLE: Les applications de la transgenèse animale
.....................................................................
9
Anglais
.................................................................................................................................................................
10
ORIGINAL TITLE: Implementing isolation perimeters around genetically modified maize fields
..............
10
TITLE: Pharming and transgenic plants.
.........................................................................................................
11
ORIGINAL TITLE: Agricultural applications for transgenic livestock
.........................................................
12
ORIGINAL TITLE: Studies on feeds from genetically modified plants (GMP) : Contributions to nutritional

and safety assessment. Advances in feed safety
..............................................................................................
13
ORIGINAL TITLE: A review of the detection and fate of novel plant molecules derived from

biotechnology in livestock production. Advances in feed safety
....................................................................
14
ORIGINAL TITLE: Advances in transgenic rice biotechnology
...................................................................
16
ORIGINAL TITLE: Use of genetically engineered microorganisms (GEMs) for the bioremediation of

contaminants
....................................................................................................................................................
17
ORIGINAL TITLE: Transgenic plants with improved dehydration-stress tolerance : progress and future

prospects
..........................................................................................................................................................
18
ORIGINAL TITLE: Review : genetically modified plants for the promotion of human health
....................
19
ORIGINAL TITLE: Genetic modification of plant metabolism for human health benefits
...........................
20
ORIGINAL TITLE: Landscape gene flow, coexistence and threshold effect : The case of genetically

modified herbicide tolerant oilseed rape (Brassica napus)
..............................................................................
21
ARTICLE TITLE: Transgenic approaches for abiotic stress tolerance in plants: retrospect and prospects
...
22
ARTICLE TITLE: Feedstock crop genetic engineering for alcohol fuels
......................................................
23
TITLE: Transgenic farm animals: an update.
..................................................................................................
24
TITLE: Animal transgenesis: state of the art and applications.
......................................................................
25
TITLE: The production of unusual fatty acids in transgenic plants.
...............................................................
26
Etudes sur les problématiques d’ordre sanitaire, environnemental ou économique (analysant les

avantages et les risques)
....................................................................................................................
28
Français
...............................................................................................................................................................
28
ORIGINAL TITLE: Les plantes transgéniques (OGM végétaux) : connaissances et inconnues sur les

risques d'allergénicité
......................................................................................................................................
28
ORIGINAL TITLE: Le principe de précaution demande-t-il d'interdire les OGM?
......................................
29
ORIGINAL TITLE: OGM et santé : mythes et réalités
..................................................................................
30
ORIGINAL TITLE: La construction incomplète du marché européen des OGM : Une comparaison des

cadres institutionnels européen et américain à partir de la théorie des droits de propriété
.............................
31
TITLE: Les zones sans plantes genetiquement modifiees en droit Europeen. L'illegalite comme strategie

juridique.
..........................................................................................................................................................
32
ORIGINAL TITLE: Les plantes génétiquement modifiées dans les PVD : Entre discours et réalité
............
33
ORIGINAL TITLE: Les plantes génétiquement modifiées peuvent-elles nourrir le tiers monde ?
...............
34
ORIGINAL TITLE: Conditions, résultats et perspectives d'utilisation du coton génétiquement modifié

(coton bt) dans les pays en développement
.....................................................................................................
35
ORIGINAL TITLE: La biosécurité dans les pays en développement : Du protocole de carthagène aux

réglementations nationales
..............................................................................................................................
36
ORIGINAL TITLE: Cultures épistémiques et engagement public des chercheurs dans la controverse OGM
.........................................................................................................................................................................
37
Anglais
.................................................................................................................................................................
38
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1
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OGM
ORIGINAL TITLE: New analysis of a rat feeding study with a genetically modified maize reveals signs of

hepatorenal toxicity (Séralini et al. (2007))
.....................................................................................................
38
ORIGINAL TITLE: Report of an Expert Panel on the reanalysis by Séralini et al. (2007) of a 90-day study

conducted by Monsanto in support of the safety of a genetically modified corn variety (MON 863)
...........
40
ORIGINAL TITLE: Characterization of genetically modified maize in weakly contaminated seed batches

and identification of the origin of the adventitious contamination
..................................................................
41
TITLE: Fate of transgenic plant DNA in the environment.
............................................................................
42
ORIGINAL TITLE: Assessing Genetically Modified Crops to Minimize the Risk of Increased Food

Allergy: A Review
...........................................................................................................................................
43
ORIGINAL TITLE: Fate and effects of insect-resistant Bt crops in soil ecosystems
....................................
44
ORIGINAL TITLE: HERBICIDE TOLERANT CROPS : 10 YEARS LATER
...........................................
45
ORIGINAL TITLE: Strategies to evaluate the safety of bioengineered foods
...............................................
46
ORIGINAL TITLE: Hybridisation within Brassica and allied genera : evaluation of potential for transgene

escape
..............................................................................................................................................................
47
ORIGINAL TITLE: Toxicity Studies of Genetically Modified Plants : A Review of the Published Literature
.........................................................................................................................................................................
49
ORIGINAL TITLE: Review of potential environmental impacts of transgenic glyphosate-resistant soybean

in Brazil
...........................................................................................................................................................
49
ORIGINAL TITLE: Molecular farming on the rise -GMO regulators still walking a tightrope
....................
51
ORIGINAL TITLE: The politics and science behind GMO acceptance
........................................................
52
ORIGINAL TITLE: Biotechnology in agriculture
..........................................................................................
53
ORIGINAL TITLE: Patents and transgenic plants. Proceedings of the Vth International Symposium on In

Vitro Culture and Horticultural Breeding. Debrecen, Hungary, September 12-17, 2004
...............................
54
ORIGINAL TITLE: Patents and transgenic plants. Proceedings of the Vth International Symposium on In

Vitro Culture and Horticultural Breeding. Debrecen, Hungary, September 12-17, 2004
...............................
55
ORIGINAL TITLE: Letting the gene out of the bottle : the population genetics of genetically modified

crops
................................................................................................................................................................
57
ORIGINAL TITLE: Molecular plant breeding : achievements in green biotechnology and future

perspectives
.....................................................................................................................................................
58
ORIGINAL TITLE: Environmental risks of genetic engineering. Plant breeding and crop domestication as

sources of new invasive species
......................................................................................................................
59
ORIGINAL TITLE: Genetically modified plants and food hypersensitivity diseases : Usage and

implications of experimental models for risk assessment
...............................................................................
60
ORIGINAL TITLE: Gene Flow and Multiple Herbicide Resistance in Escaped Canola Populations
...........
61
ORIGINAL TITLE: Ecological versus ecotoxicological methods for assessing the environmental risks of

transgenic crops
...............................................................................................................................................
62
ORIGINAL TITLE: Recasting "substantial equivalence" : Transatlantic governance of GM food
...............
63
TITLE: Genetically modified organisms: do the benefits outweigh the risks?
...............................................
64
TITLE: Allergenicity assessment of genetically modified crops--what makes sense?
...................................
65
TITLE: Genetic and ecological consequences of transgene flow to the wild flora.
........................................
66
TITLE: Assessing effects of transgenic crops on soil microbial communities.
..............................................
67
TITLE: Assessing environmental risks of transgenic plants.
..........................................................................
68
TITLE: Ecological impacts of genetically modified crops: ten years of field research and commercial

cultivation.
.......................................................................................................................................................
69
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2
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OGM
Définition
On considérera préférentiellement les Organismes génétiquement modifiés (OGM) qui font

actuellement l’objet de débats

: OGM d’intérêt agricole, végétaux cultivés ou animaux d’élevage (à

l’exclusion des animaux de laboratoire) à finalité alimentaire, énergétique ou pharmaceutique et

susceptibles d’être disséminés à grande échelle dans l’environnement.
-
3
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OGM
Mises au point scientifiques et technologiques (articles de

synthèse)
Français
Notice ISD (International Science Database)
ORIGINAL TITLE: Impact environnemental des cultures transgéniques : I. La migration des

transgènes
TRANSLATED TITLE:
Environmental impact of transgenic crops : I. Transgene migration
PERSONAL AUTHOR:
Michaud-Dominique
AFFILIATION OF AUTHOR:
Centre de recherche en horticulture : Université Laval, Québec

(Québec) : Canada G1K 7P4
SOURCE:
Phytoprotection. 2005; 86 (2): 93-105,
http://id.erudit.org/iderudit/012510ar
NOTES: 160
PUBLISHER:
Société de protection des plantes du Québec , Saint-Faustin-Lac carré, CANADA
PUBLICATION YEAR: 2005
COUNTRY OF PUBLICATION:
CANADA
LANGUAGE: French
LITERATURE TYPE:
Serial
ABSTRACT:
L'adoption à grande échelle des cultures
transgéniques
depuis dix ans a soulevé de

nombreuses questions quant aux impacts possibles de ces nouvelles lignées végétales sur les

écosystèmes agricoles et naturels. Des questions ont été soulevées, en particulier, sur le devenir des

transgènes
dans le milieu et sur une possible " pollution " du patrimoine génétique des organismes

vivants à l'échelle des écosystèmes. Après une énumération des impacts environnementaux associés

aux végétaux
transgéniques
, cet article de
synthèse
dresse un aperçu des connaissances actuelles

sur le devenir - ou la migration - des
transgènes
dans le milieu. Les phénomènes d'hybridation et

d'introgression génique en direction d'espèces ou de lignées apparentées sont d'abord abordés, après

quoi sont considérés les phénomènes de transfert horizontal des
transgènes
en direction

d'organismes non apparentés. Un article complémentaire publié dans ce même numéro traite de

l'impact environnemental des protéines recombinantes encodées par les
transgènes
(Michaud

2005).
The large-scale adoption of
transgenic
crops over the last ten years has led several groups to

question the possible impacts of these new plant lines on agricultural and natural ecosystems. In

particular, questions have been raised about the impact of the
transgenes
on the environment, and

about an eventual "pollution" of the overall genetic pool of living organisms at the ecosystem level.

After an introduction on the possible environmental impacts of
transgenic
plants, this
review

summarizes the current knowledge on the fate - or migration - of
transgenes
in the environment.

Hybridization and introgression processes involving
transgenic
crops and their close relatives are

first considered.
Transgene
integration in non-related organisms by horizontal gene transfer is then

considered. A companion
review
in this same issue addresses the environmental impacts of

recombinant proteins encoded by the
transgenes
(Michaud 2005).
ABSTRACT INDICATOR:
AB
-
4
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OGM
AUTHORS DESCRIPTORS:
Environmental-impact;
transgene-introgression
; horizontal-gene-
transfer; interspecific-hybridization; intraspecific-hybridization;
transgenic-crops
;
Cultures-
transgéniques
; hybridation-interspécifique; hybridation-intraspécifique; impact-environnemental;

introgression-génique; transfert-génique-horizontal
JOURNAL NAME:
Phytoprotection
LOCATION OF PRIMARY DOCUMENT:
INIST No. 354000600020200005
ACCESSION NUMBER:
19232805
SOURCE OF INDEXING:
ERUDIT
COPYRIGHT:
Tous droits réservés (c) Société de protection des plantes du Québec (SPPQ), 2005
UPDATE:
20080107
VOLUME:
86
NUMERO:
2
FIRST PAGE:
93
LAST PAGE:
105
Notice ISD (International Science Database)
ORIGINAL TITLE: Impact environnemental des cultures transgéniques : II. L'impact des

caractères recombinants
TRANSLATED TITLE:
Environmental impact of transgenic crops : II. Impact of recombinant

traits
PERSONAL AUTHOR:
Michaud-Dominique
AFFILIATION OF AUTHOR:
Centre de recherche en horticulture : Université Laval, Québec

(Québec) : Canada G1K 7P4
SOURCE:
Phytoprotection. 2005; 86 (2): 107-124,
http://id.erudit.org/iderudit/012511ar
NOTES: 188
PUBLISHER:
Société de protection des plantes du Québec , Saint-Faustin-Lac carré, CANADA
PUBLICATION YEAR: 2005
COUNTRY OF PUBLICATION:
CANADA
LANGUAGE: French
LITERATURE TYPE:
Serial
ABSTRACT:
La publication d'un article scientifique sur les effets néfastes d'un hybride de maïs

transgénique
exprimant une delta-endotoxine du Bacillus thuringiensis contre des larves du

papillon monarque causait, il y a quelques années, une controverse sans précédent sur l'impact

environnemental des caractères recombinants introduits au bagage génétique des cultures agricoles.

Le présent article de
synthèse
, complémentaire à un article de ce même numéro abordant la

migration des
transgènes
dans l'environnement (Michaud 2005), discute de l'impact des caractères

recombinants encodés par les
transgènes
sur l'incidence et le développement des différents

organismes vivants du milieu. L'impact des nouveaux caractères est d'abord considéré à l'échelle

des écosystèmes, à la lumière des effets exercés par les pratiques agricoles courantes sur la diversité

biologique au champ. L'impact de ces caractères est ensuite considéré en fonction des interactions

spécifiques établies au champ ou en conditions de laboratoire entre la plante modifiée et une gamme

d'espèces modèles incluant des ravageurs herbivores secondaires, des arthropodes prédateurs et

différents organismes du sol.
A scientific communication reporting the deleterious effects on monarch butterfly larvae of a

transgenic
corn hybrid expressing a Bacillus thuringiensis delta-endotoxin has caused, a few years

ago, an unprecedented controversy on the environmental impact of recombinant traits introduced

-
5
-
OGM
into the genome of agricultural crops. This
review
, complementing a
review
in this same issue on

transgene
migration in the environment (Michaud 2005), addresses the impact of these new traits

on the development and survival of different non-target living organisms present in the

environment. The impact of these new traits is first considered at the ecosystem level, in relation

with the effects of current agricultural practices on field biodiversity. The impact of these traits is

then considered in relation with the specific interactions established in the field or under laboratory

conditions between the modified plant and a collection of model organisms including secondary

herbivorous pests, predatory arthropods and different species of the soil community.
ABSTRACT INDICATOR:
AB
AUTHORS DESCRIPTORS:
Biodiversity-; environmental-impact; multitrophic-interactions;

recombinant-proteins;
transgenic-crops
; Biodiversité-;
cultures-transgéniques
; impact-
environnemental; interactions-multitrophiques; protéines-recombinantes
JOURNAL NAME:
Phytoprotection
LOCATION OF PRIMARY DOCUMENT:
INIST No. 354000600020200006
ACCESSION NUMBER:
19232806
SOURCE OF INDEXING:
ERUDIT
COPYRIGHT:
Tous droits réservés (c) Société de protection des plantes du Québec (SPPQ), 2005
UPDATE:
20080107
VOLUME:
86
NUMERO:
2
FIRST PAGE:
107
LAST PAGE:
124
Notice ISD (International Science Database)
ORIGINAL TITLE: Modification génétique des oléagineux pour de nouvelles matières grasses et

perspectives nutritionnelles
PERSONAL AUTHOR:
PASCAL-Gérard
AFFILIATION OF AUTHOR:
Inra, Paris, FRANCE
CONFERENCE OR MEETING INFORMATION:
Journées Chevreul de l'Association française

pour l'étude des corps gras (AFECG), 20050405, Paris, FRANCE
SOURCE:
OCL.-Oléagineux,-corps-gras,-lipides.
2005; 12 (5-6): 366-369
NOTES: 5 ref.
PUBLISHER:
Libbey-Eurotext, Montrouge, FRANCE
ISSN:
1258-8210
PUBLICATION YEAR: 2005
COUNTRY OF PUBLICATION:
FRANCE
LANGUAGE: French
LITERATURE TYPE:
Serial; Conference-Meeting
ABSTRACT:
The difference between the potential applications of
genetically

modified
plants

(GMP) and the reality of agriculture is very big; it is enough to compare the laboratory applications

published in scientific
reviews
or the patents, with what is effectively cultivated today. The real

applications concern almost exclusively four botanical species, soya, corn, cotton and canola and

two types of modifications, herbicide tolerance and insects resistance. An attempt of prospective is

presented here. It is based on the strategies of development of two of the biggest firms of vegetable

biotechnologies, Monsanto and DuPont. The recent or future applications in human food or animal

feed of GMP which concern fats are rare; they concerned modifications of content in lipids and

-
6
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OGM
especially composition in fatty acids essentially in soya, even corn. The current applications

concern soya oils with lowered content in a linolenic acid which have hardly just been launched on

the market. In longer term, soya oils containing n-3 long chain fatty acids should make their

appearance on the market. But the major developments will always concern the agronomic

characters of plants of large cultures, within the framework of an extensive agriculture in the big

agricultural countries or in country in emergence as well as uses of PGM for energy production

purposes.
ABSTRACT INDICATOR:
AB
CLASSIFICATION CODE:
002A31C02A5B; 002A32D02B; 002A35B08; 215
DESCRIPTORS ENGLISH:
Unsaturated-fatty-acid; Polyunsaturated-fatty-acid; Biochemical-
compound; Lipids-; Cereal-crop; Oils-and-fats-industry; Vegetable-oil; Genetic-engineering;

Biotechnology-; Fiber-crop;
Genetically-modified-organism
; Malvaceae-; Cruciferae-;

Monocotyledones-; Gramineae-; Spermatophyta-; Angiospermae-; Dicotyledones-; Leguminosae-;

Energy-plantation; Animal-feeding; Oilseed-; n-3-fatty-acid; Fatty-acids; Gossypium-; Brassica-
napus-var.-oleifera; Zea-mays; Glycine-max; Soybean-oil;
Genetically-modified-food
; Nutritive-
value; New-product; Fat-; Vegetable-fat;
Transgenic-plant
;
Genetic-transformation
; Oil-plant-
(vegetal)
DESCRIPTORS FRENCH:
Acide-gras-insaturé; Acide-gras-polyinsaturé; Composé-
biochimique; Lipide-; Plante-céréalière; Industrie-corps-gras; Huile-végétale; Génie-génétique;

Biotechnologie-; Plante-à-fibres;
Organisme-génétiquement-modifié
; Malvaceae-; Cruciferae-;

Monocotyledones-; Gramineae-; Spermatophyta-; Angiospermae-; Dicotyledones-; Leguminosae-;

Plantation-énergétique; Alimentation-animale; Graine-oléagineuse; Acide-gras-n-3; Acide-gras;

Gossypium-; Brassica-napus-var.-oleifera; Zea-mays; Glycine-max; Huile-soja;
Aliment-
transgénique
; Valeur-nutritive; Produit-nouveau; Matière-grasse; Corps-gras-végétal;
Plante-
transgénique
;
Transformation-génétique
; Plante-oléagineuse
AUTHORS DESCRIPTORS:
PGM-; fatty-acids; soya-; corn-; n-3-
JOURNAL NAME:
OCL.-Oléagineux,-corps-gras,-lipides
LOCATION OF PRIMARY DOCUMENT:
INIST-CNRS, Shelf Number 22926, INIST No.

354000142771320040
ACCESSION NUMBER:
17652021; 060232568
SOURCE OF INDEXING:
INIST
COPYRIGHT:
Copyright 2006 INIST-CNRS. All rights reserved.
UPDATE:
20080107
VOLUME:
12
NUMERO:
5-6
FIRST PAGE:
366
LAST PAGE:
369
SHELF NUMBER:
22926
Notice ISD (International Science Database)
ORIGINAL TITLE: Plantes génétiquement modifiées (PGM) et pays en développement
TRANSLATED TITLE: Genetically

modified
plants (GMPs) and developing countries
PERSONAL AUTHOR:
HOUDEBINE-Louis-Marie
AFFILIATION OF AUTHOR:
Institut national de la recherche agronomique (Inra), Unité mixte

de recherche (UMR) Biologie du développement et reproduction, 78352 Jouy-en-Josas, FRANCE
SOURCE:
Agricultures. 2006; 15 (2): 227-231
-
7
-
OGM
NOTES: 55 ref.
PUBLISHER:
Libbey Eurotext, Montrouge, FRANCE
ISSN:
1166-7699
PUBLICATION YEAR: 2006
COUNTRY OF PUBLICATION:
FRANCE
LANGUAGE: French
LITERATURE TYPE:
Serial
ABSTRACT:
Une partie significative des produits agroalimentaires provient désormais de plantes

génétiquement

modifiées
(PGM). Quatre plantes de grande culture - le maïs, le coton, le soja et le

colza - se partagent actuellement le marché des PGM. Le niveau de ces cultures tend vers un plateau

dans les pays ou elles se sont implantées en premier, les États-Unis et le Canada. Ces nouvelles

variétés apportent, selon les cas, des avantages limités mais significatifs aux agriculteurs:

simplification des cultures, augmentation des revenus, diminution de la pollution de

l'environnement. Ce sont essentiellement des PGM résistantes à des maladies ou à des herbicides

qui sont actuellement exploitées. Ces PGM sont par ailleurs en très grande majorité utilisées pour

l'alimentation animale. La papaye résistante à un virus est une des rares PGM destinée aux

consommateurs humains et effectivement exploitée. En toute logique, l'obtention de nouvelles

variétés via la
transgenèse
doit pouvoir apporter dans certains cas des avantages beaucoup plus

substantiels et surtout rapides aux communautés humaines qui souffrent de pénuries alimentaires.

Des PGM en cours d'études visent à améliorer la qualité des aliments, en particulier, en augmentant

leur teneur en vitamines, en antioxydants, en acides gras polyinsaturés, etc. Certains projets en

cours indiquent que l'approche PGM commence à répondre aux espoirs qu'on avait placés en elle.

L'utilisation des PGM dans certains pays en développement reste limitée par une diffusion encore

restreinte des techniques, par des problèmes de
propriété

industrielle
mais plus directement par

une insuffisance des instances réglementaires locales chargées de définir comment les PGM

peuvent être utilisées sans
risque
particulier. Cet article se propose de faire le point sur les

conditions dans lesquelles les pays en développement peuvent tirer avantage des PGM.
ABSTRACT INDICATOR:
AB
CLASSIFICATION CODE:
002A32D02B
DESCRIPTORS ENGLISH:
Genetic-engineering;
Transgenic-plant
; Cultivated-plant;

Developing-countries
DESCRIPTORS FRENCH:
Génie-génétique;
Plante-transgénique
; Plante-cultivée; Pays-en-
développement
JOURNAL NAME:
Agricultures
LOCATION OF PRIMARY DOCUMENT:
INIST-CNRS, Shelf Number 27105, INIST No.

354000153325060070
ACCESSION NUMBER:
17603435; 060390226
SOURCE OF INDEXING:
INIST
COPYRIGHT:
Copyright 2006 INIST-CNRS. All rights reserved.
UPDATE:
20080107
VOLUME:
15
NUMERO:
2
FIRST PAGE:
227
LAST PAGE:
231
SHELF NUMBER:
27105
Notice ISD (International Science Database)
-
8
-
OGM
ORIGINAL TITLE: Les applications de la transgenèse animale
TRANSLATED TITLE:
Applications of animal
transgenesis
PERSONAL AUTHOR:
HOUDEBINE-Louis-Marie
AFFILIATION OF AUTHOR:
Unité de Biologie du Développement et Reproduction, Institut

National de la Recherche Agronomique, 78352 Jouy-en-Josas, FRANCE
SOURCE:
Bulletin-de-l-Académie-vétérinaire-de-France. 2005; 158: 487-498
NOTES:
31 ref.
PUBLISHER:
Académie vétérinaire de France, Paris, FRANCE
ISSN:
0001-4192
CODEN:
BAVFAV
PUBLICATION YEAR: 2005
COUNTRY OF PUBLICATION:
FRANCE
LANGUAGE: French
LITERATURE TYPE:
Serial
ABSTRACT:
La
transgenèse
offre la possibilité de replacer un gène dans son environnement

complexe qu'est un organisme entier et de créer des lignées d'animaux portant des caractères

génétiques nouveaux ou ayant perdu un gène. Ceci permet de mieux comprendre les mécanismes de

la régulation de l'expression des gènes mais aussi leur fonction dans l'organisme. La
transgenèse

permet de créer des modèles pour l'étude de maladies humaines et de préparer des animaux qui sont

potentiellement des sources d'organes et de cellules pour l'homme mais aussi de protéines

thérapeutiques. Les animaux d'élevage peuvent être
génétiquement

modifiés
et
bénéficier
ainsi

d'un accroissement accéléré et ciblé de la diversité génétique. Les succès de la
transgenèse
animale

se heurtent encore à divers problèmes notamment techniques et financiers. Le transfert de gène reste

difficile chez les gros animaux même si de nouvelles techniques ont apporté des progrès décisifs.

Un autre problème est celui de l'expression des
transgènes
qui est souvent mal contrôlée. Ceci

oblige à multiplier le nombre des animaux fondateurs de lignées pour ne garder que les meilleurs et

pour limiter les effets secondaires imprévisibles de la
transgenèse
. Les applications de la

transgenèse
aux animaux d'élevages sont également limitées par la disponibilité de gènes

susceptibles d'apporter une amélioration significative des lignées préexistantes. Les applications de

la
transgenèse
animale doivent également faire face à des problèmes de
biosécurité
et

d'acceptabilité par les consommateurs. Cette revue se propose de faire le point sur les avancées de la

transgenèse
animale.
ABSTRACT INDICATOR:
AB
CLASSIFICATION CODE:
002A05
DESCRIPTORS ENGLISH:
Veterinary-; Microbiology-
DESCRIPTORS FRENCH:
Vétérinaire-; Microbiologie-
AUTHORS DESCRIPTORS: transgenèse-
; animaux-d'élevage;
biosécurité-
; acceptabilité-
JOURNAL NAME:
Bulletin-de-l-Académie-vétérinaire-de-France
LOCATION OF PRIMARY DOCUMENT:
INIST-CNRS, Shelf Number 815, INIST No.

354000115137110040
ACCESSION NUMBER:
17485011; 060128969
SOURCE OF INDEXING:
INIST
COPYRIGHT:
Copyright 2006 INIST-CNRS. All rights reserved.
UPDATE:
20080107
VOLUME:
158
FIRST PAGE:
487
LAST PAGE:
498
SHELF NUMBER:
815
-
9
-
OGM
Anglais
Notice ISD (International Science Database)
ORIGINAL TITLE: Implementing isolation perimeters around genetically modified maize fields
PERSONAL AUTHOR:
DEVOS-Yann
;
REHEUL-Dirk
;
THAS-Olivier
;
DE-CLERCQ-Eva-M
;

COUGNON-Mathias
;
CORDEMANS-Karl
AFFILIATION OF AUTHOR:
Department of Plant Production, Faculty of Bioscience

Engineering, Ghent University, Coupure Links 653, 9000 Ghent, BELGIUM; Department of

Applied Mathematics, Biometrics and Process Control, Faculty of Bioscience Engineering, Ghent

University, Coupure Links 653, 9000 Ghent, BELGIUM; Department of Forest and Water

Management, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000

Ghent, BELGIUM; Department of Rural Development, Flemish Land Agency, Gulden Vlieslaan

72, 1060 Brussels, BELGIUM
SOURCE:
Agronomy-for-sustainable-development.
2007; 27 (3): 155-165
NOTES:
3/4 p.
PUBLISHER:
EDP Sciences, Les Ulis, FRANCE
ISSN:
1774-0746
PUBLICATION YEAR: 2007
COUNTRY OF PUBLICATION:
FRANCE
LANGUAGE: English
LITERATURE TYPE:
Serial
ABSTRACT:
Due to the growing cultivation area of genetically modified (GM) maize and the

rising number of GM maize varieties commercially available to European farmers, the co-existence

between GM and non-GM maize is becoming a burning issue in some European regions. Hence,

Member States are imposing or discussing specific co-existence measures to keep the adventitious

presence of GM material in non-GM produces below the established labelling threshold. As maize

is a cross-pollinated crop that uses wind for the dispersal of its pollen, on-farm co-existence

measures may rely on the spatial isolation of GM and non-GM maize fields. In this study, we

developed an approach that combines geographic information system (GIS) datasets with Monte

Carlo simulations to assess the feasibility of implementing isolation perimeters around GM maize

fields, since its practical implementation is rarely addressed in the co-existence debate. More

specifically, five scenarios differing in shares and spatial distributions of GM maize were tested for

various isolation perimeters in two agricultural areas in Flanders (Belgium). The GIS analyses

emphasised the small size of maize fields and their scattered distribution throughout the cropped

area. The feasibility of implementing isolation perimeters was largely affected by the (GM) maize

share, the spatial distribution of GM maize, and the width of isolation perimeters. The higher the

(GM) maize share and the wider the isolation perimeter, the higher the proportions of farmers with

non-GM maize fields occurring within the implemented isolation perimeter. Compared with

randomly distributed GM maize fields, the clustering of GM maize fields on a larger scale and at

the farm level increased the feasibility of implementing isolation perimeters. The approach

developed proved to be a valuable tool to quantify the feasibility of implementing isolation

perimeters under real agricultural conditions.
ABSTRACT INDICATOR:
AB
-
10
-
OGM
CLASSIFICATION CODE:
002A31D07E; 002A32D02B; 215
DESCRIPTORS ENGLISH:
Agroecosystem-; Reproductive-pattern; Sexual-reproduction; Floral-
biology; Genetic-engineering; Biotechnology-; Cereal-crop;
Genetically-modified-organism
;

Europe-; Spermatophyta-; Angiospermae-; Monocotyledones-; Gramineae-; Scenario-(modeling);

Cross-pollination; Conventional-cultivar; Belgium-; Zea-mays; Implementation-; Perimeter-;

Isolation-;
Transgenic-plant
; Cultivated-field
DESCRIPTORS FRENCH:
Zone-tempérée; Europe-Ouest; Agroécosystème-; Régime-
reproduction; Reproduction-sexuée; Biologie-florale; Génie-génétique; Biotechnologie-; Type-C4;

Plante-céréalière;
Organisme-génétiquement-modifié
; Europe-; Spermatophyta-; Angiospermae-;

Monocotyledones-; Gramineae-; Scénario-(modélisation); Pollinisation-croisée; Cultivar-
conventionnel; Belgique-; Echelon-régional; Variation-géographique; Répartition-spatiale;

Pollinisation-; Mélangeage-; Flux-matière; Coexistence-; Allogamie-; Système-information-
géographique; Simulation-statistique; Mauvaise-herbe; Flore-associée; Cultivar-; Pollen-;

Isolement-géographique;
Biosécurité-
; Zea-mays; Implémentation-; Périmètre-; Isolement-;
Plante-
transgénique
; Champ-cultivé
AUTHORS DESCRIPTORS:
adventitious-mixing; co-existence-; cross-fertilisation-;
genetically-
modified-crops
; geographic-information-system; isolation-perimeters; pollen-flow; regional-
variation; simulations-
JOURNAL NAME:
Agronomy-for-sustainable-development
LOCATION OF PRIMARY DOCUMENT:
INIST-CNRS, Shelf Number 18476, INIST No.

354000162371260010
ACCESSION NUMBER:
18908573; 070364780
SOURCE OF INDEXING:
INIST
COPYRIGHT:
Copyright 2007 INIST-CNRS. All rights reserved.
UPDATE:
20080107
VOLUME:
27
NUMERO:
3
FIRST PAGE:
155
LAST PAGE:
165
SHELF NUMBER:
18476
Notice MEDLINE
TITLE: Pharming and transgenic plants.
AUTHOR:
Lienard,-D
;
Sourrouille,-C
;
Gomord,-V
;
Faye,-L
ADDRESS OF AUTHOR:
Universite de Rouen, CNRS UMR 6037, IFRMP 23, GDR 2590,

Faculte des Sciences, Bat. Ext.
Biologie, 76821 Mont-Saint-Aignan cedex, France.
SOURCE:
Biotechnol-Annu-Rev.

2007; 13:
115-47
JOURNAL NAME:
Biotechnology-annual-review
ISSN (PRINT VERSION):
1387-2656
PUBLICATION YEAR:
2007
LANGUAGE: English
COUNTRY OF PUBLICATION:
Netherlands
MAIN ABSTRACT:
Plant represented the essence of pharmacopoeia until the beginning of the

19th century when plant-derived pharmaceuticals were partly supplanted by drugs produced by the

industrial methods of chemical synthesis. In the last decades, genetic engineering has offered an

alternative to chemical synthesis, using bacteria, yeasts and animal cells as factories for the

-
11
-
OGM
production of therapeutic proteins. More recently, molecular farming has rapidly pushed towards

plants among the major players in recombinant protein production systems. Indeed, therapeutic

protein production is safe and extremely cost-effective in plants. Unlike microbial fermentation,

plants are capable of carrying out post-translational modifications and, unlike production systems

based on mammalian cell cultures, plants are devoid of human infective viruses and prions.

Furthermore, a large panel of strategies and new plant expression systems are currently developed

to improve the plant-made pharmaceutical's yields and quality. Recent advances in the control of

post-translational maturations in transgenic plants will allow them, in the near future, to perform

human-like maturations on recombinant proteins and, hence, make plant expression systems

suitable alternatives to animal cell factories.
PUBLICATION TYPE:
Journal-Article
JOURNAL CATEGORY:
Biotechnology
SUBSET:
Index-Medicus
UPDATE CODE:
20070918
ENTRY DATE:
20070918
RECORD OWNER:
National-Library-of-Medicine
ACCESSION NUMBER:
17875476
PUBLISHING MODEL:
Citation processed from: Print
Journal available in: Print
RECORD FEATURES:
IN-DATA-REVIEW (IR); ABSTRACT (AB)
Notice ISD (International Science Database)
ORIGINAL TITLE: Agricultural applications for transgenic livestock
PERSONAL AUTHOR:
WHEELER-Matthew-B
AFFILIATION OF AUTHOR:
Institute for Genomic Biology, Beckman Institute for Advanced

Science and Technology, Laboratory of Molecular Embryology, Department of Animal Sciences,

University of Illinois, Urbana, IL 61801, UNITED-STATES
SOURCE:
Trends-in-biotechnology. 2007; 25 (5): 204-210
NOTES: 51 ref.
PUBLISHER:
Elsevier Science, Oxford, UNITED-KINGDOM
ISSN:
0167-7799
CODEN:
TRBIDM
PUBLICATION YEAR: 2007
COUNTRY OF PUBLICATION:
UNITED-KINGDOM
LANGUAGE: English
LITERATURE TYPE:
Serial
ABSTRACT: Transgenic
animals are produced by introducing 'foreign' DNA into the genetic

material of pre-implantation embryos. This DNA is present in all tissues of the resulting individual.

This technique is of great importance to many aspects of biomedical science, including gene

regulation, the immune system, cancer research, developmental biology, biomedicine,

manufacturing and agriculture. The production of
transgenic
animals is one of several new and

developing technologies that will have a profound impact on the genetic improvement of livestock.

The rate at which these technologies are incorporated into production schemes will determine the

speed at which we will be able to achieve our goal of more efficiently producing livestock that

meets consumer and market demand.
ABSTRACT INDICATOR:
AB
-
12
-
OGM
CLASSIFICATION CODE:
002A31; 215
DESCRIPTORS ENGLISH: Review-
;
Transgenic-animal
; Livestock-; Application-;

Agriculture-
DESCRIPTORS FRENCH:
Article-synthèse;
Animal-transgénique
; Bétail-; Application-;

Agriculture-
JOURNAL NAME:
Trends-in-biotechnology
LOCATION OF PRIMARY DOCUMENT:
INIST-CNRS, Shelf Number 20229, INIST No.

354000149518760050
ACCESSION NUMBER:
18699972; 070412792
SOURCE OF INDEXING:
INIST
COPYRIGHT:
Copyright 2007 INIST-CNRS. All rights reserved.
UPDATE:
20080107
VOLUME:
25
NUMERO:
5
FIRST PAGE:
204
LAST PAGE:
210
SHELF NUMBER:
20229
Notice ISD (International Science Database)
ORIGINAL TITLE: Studies on feeds from genetically modified plants (GMP) : Contributions to

nutritional and safety assessment. Advances in feed safety
PERSONAL AUTHOR:
BLAIR-Robert,

Editor
;
WISEMAN-Julian,

Editor
;
FLACHOWSKY-G
;

AULRICH-K
;
BÖHME-H
;
HALLE-I
AFFILIATION OF AUTHOR:
Faculty of Land and Food systems, University of British

Columbia, Vancouver, BC, CANADA; Division of Agricultural and Environmental Sciences,

Sutton Bonnington Campus, University of Nottingham, UNITED-KINGDOM; Institute of Animal

Nutrition, Federal Agricultural Research Centre (FAL), Bundesallee 50, 38116 Braunschweig,

GERMANY; Institute of Organic Farming, Federal Agricultural Research Centre (FAL), Trenthorst

32, 23847 Westerau, GERMANY
SOURCE:
Animal-feed-science-and-technology. 2007; 133 (1-2): 2-30
NOTES:
2 p.1/4
PUBLISHER:
Elsevier, Amsterdam, NETHERLANDS
ISSN:
0377-8401
CODEN:
AFSTDH
PUBLICATION YEAR: 2007
COUNTRY OF PUBLICATION:
NETHERLANDS
LANGUAGE: English
LITERATURE TYPE:
Serial
ABSTRACT:
Since 1997, 18 studies with feeds from genetically modified plants (GMP) in the

nutrition of dairy cows, growing bulls, growing and finishing pigs, laying hens, chicken for

finishing as well as growing and laying quails were conducted at the Federal Agricultural Research

Centre (FAL) in Braunschweig (Germany). The majority of the experiments (16) were undertaken

with GMP of the so-called first generation (plants with input traits and without substantial changes

in composition) such as Bt-maize, Pat-maize, Pat-sugar beet, Gt-soybean, Gt-potatoes and Bt-
potatoes. Two studies were carried out with GMP of the second generation (plants with output traits

or with substantial changes in their chemical composition) such as an altered fatty acids profile in

-
13
-
OGM
rapeseed or inulin potatoes. In all experiments, feeds from GMP were compared with their isogenic

counterparts. The iso- and transgenic feeds were analysed for their composition (proximates, fibre

fraction, amino acids, fatty acid pattern, minerals) and undesirable substances (e.g., mycotoxins).

Animal studies were carried out for nutritional and safety assessment such as digestibility, feed

intake, health and performance of target animal species and quality of food of animal origin.

Reproduction was studied in a 10-generation experiment with quails and a 4-generation experiment

with laying hens. Duration of experiments and number of animals were limited in some cases due to

small amounts of GM-feed available for experimentation. Attention was drawn to the fate of DNA

during feed processing (silage making, oil extraction), in the digestive tract of animals (slaughtering

of animals 0, 4, 8, 12 and 24 h after feeding) and in the animal body (samples from several organs

and tissues). In agreement with more than 100 animal studies available to date, results show no

significant differences in the nutritional value of feeds from GMP of the first generation in

comparison with non-GMP varieties. To date, no fragments of recombinant DNA have been found

in any organ or tissue sample from animals fed GMP. The lower content of mycotoxins in Bt-maize

and side effects in GMP of the second generation are of safety concern. The results indicate that

routine feeding studies with target animal species add little to nutritional assessment of feed from

GMP of the first generation, but they are of public interest and important for safety assessment.

These studies will play a more important role in nutritional and safety assessment of feeds from

GMP with output traits. Proposals for such studies were made on the basis of previous experiments.
ABSTRACT INDICATOR:
AB
CLASSIFICATION CODE:
002A35B15
DESCRIPTORS ENGLISH:
DNA-; Chemical-composition; Nutrition-; Animal-; GMP-;

Transgenic-plant
; Feed-
DESCRIPTORS FRENCH:
DNA-; Composition-chimique; Nutrition-; Animal-; GMP-;
Plante-
transgénique
; Aliment-pour-animal
AUTHORS DESCRIPTORS:
Genetical-modified-plants; Animal-nutrition; Composition-;

Nutritional-assessment; Fate-of-DNA
JOURNAL NAME:
Animal-feed-science-and-technology
LOCATION OF PRIMARY DOCUMENT:
INIST-CNRS, Shelf Number 17215, INIST No.

354000159608010010
ACCESSION NUMBER:
18455119; 070097912
SOURCE OF INDEXING:
INIST
COPYRIGHT:
Copyright 2007 INIST-CNRS. All rights reserved.
UPDATE:
20080107
VOLUME:
133
NUMERO:
1-2
FIRST PAGE:
2
LAST PAGE:
30
SHELF NUMBER:
17215
Notice ISD (International Science Database)
ORIGINAL TITLE: A review of the detection and fate of novel plant molecules derived from

biotechnology in livestock production. Advances in feed safety
PERSONAL AUTHOR:
BLAIR-Robert,

Editor
;
WISEMAN-Julian,

Editor
;
ALEXANDER-
Trevor-W
;
REUTER-Tim
;
AULRICH-Karen
;
SHARMA-Ranjana
;
OKINE-Erasmus-K
;
DIXON-
Walter-T
;
MCALLISTER-Tim-A
-
14
-
OGM
AFFILIATION OF AUTHOR:
Faculty of Land and Food systems, University of British

Columbia, Vancouver, BC, CANADA; Division of Agricultural and Environmental Sciences,

Sutton Bonnington Campus, University of Nottingham, UNITED-KINGDOM; Agriculture and

Agri-Food Canada Research Centre, P.O. Box 3000, Lethbridge, Alberta, T1J 4B1, CANADA;

Department of Agricultural, Food and Nutritional science, University of Alberta, Edmonton.

Alberta, T6G 2P5, CANADA; Federal Agricultural Research Centre, Institute of Organic Farming,

23847 Westerau, GERMANY
SOURCE:
Animal-feed-science-and-technology. 2007; 133 (1-2):
31-62
NOTES: 5 p.1/4
PUBLISHER:
Elsevier, Amsterdam, NETHERLANDS
ISSN:
0377-8401
CODEN:
AFSTDH
PUBLICATION YEAR: 2007
COUNTRY OF PUBLICATION:
NETHERLANDS
LANGUAGE: English
LITERATURE TYPE:
Serial
ABSTRACT:
Since the commercialization of the first
genetically

modified
(
GM
)
crop
in 1996,

the amount of arable land dedicated to the production of GM feed has increased significantly.

Despite widespread adoption of GM foods and feeds, public perception of their safety remains

mixed. To provide consumers the opportunity for choice, some countries have adopted mandatory

labeling of GM foods and feeds when their adventitious presence exceeds a defined threshold

percentage. Methods for detecting and quantifying
GM

plants
in feeds include protein- and DNA-
based assays, but their sensitivity may be influenced by the techniques used in feed processing.

Interest in the consumption of
transgenic
protein and DNA has prompted investigations of their

fate within the gastrointestinal tract of livestock and the potential to which
transgenes
or their

products may be incorporated into tissues.
Transgenic
protein has not been detected in any animal

tissues or products. Fragments of DNA from endogenous, high-copy number chloroplast genes

from plants have been detected in poultry, pig and ruminant tissues. Low-copy endogenous and

transgenic
DNA in animal tissues have been detected but to a lesser extent than high-copy genes.

Current research suggests that the passage of dietary DNA fragments across the intestinal wall is a

natural physiological event, the likelihood of which is dependent on their concentration in the feed.

To date, the
transgenic
traits approved for expression in crops used as feeds have not posed a

safety concern for livestock.
ABSTRACT INDICATOR:
AB
CLASSIFICATION CODE:
002A35B15; 002A36C03
DESCRIPTORS ENGLISH:
Farming-animal; Digestion-; Recombinant-protein; Gene-; Feed-;

Genetically-modified-organism
;
Transgenic-plant
; Production-; Livestock-; Biotechnology-;

Control-method; Analysis-method; Detection-;
Review-
DESCRIPTORS FRENCH:
Animal-élevage; Digestion-; Protéine-recombinante; Gène-; Aliment-
pour-animal;
Organisme-génétiquement-modifié
;
Plante-transgénique
; Production-; Bétail-;

Biotechnologie-; Méthode-contrôle; Méthode-analyse; Détection-; Article-synthèse
AUTHORS DESCRIPTORS: Genetically-modified-plant
;
Genetically-modified-feed
;

Transgene-dejection
; Gene-transfer; Recombinant-protein-detection; Digestion-
JOURNAL NAME:
Animal-feed-science-and-technology
LOCATION OF PRIMARY DOCUMENT:
INIST-CNRS, Shelf Number 17215, INIST No.

354000159608010020
ACCESSION NUMBER:
18455120; 070097913
SOURCE OF INDEXING:
INIST
-
15
-
OGM
COPYRIGHT:
Copyright 2007 INIST-CNRS. All rights reserved.
UPDATE:
20080107
VOLUME:
133
NUMERO:
1-2
FIRST PAGE:
31
LAST PAGE:
62
SHELF NUMBER:
17215
Notice ISD (International Science Database)
ORIGINAL TITLE: Advances in transgenic rice biotechnology
PERSONAL AUTHOR:
KATHURIA-Hitesh
;
GIRI-Jitender
;
TVAGI-Himani
;
TYAGI-Akhilesh-
K
AFFILIATION OF AUTHOR:
Interdisciplinary Center for Plant Genomics and Department of

Plant Molecular Biology, University of Delhi South Campus, New Delhi-110021, INDIA
SOURCE: Critical-reviews-in-plant-sciences
. 2007; 26 (2):
65-103
NOTES: 11 p.3/4
PUBLISHER:
Taylor & Francis, Colchester, UNITED-KINGDOM
ISSN:
0735-2689
CODEN:
CRPSD3
PUBLICATION YEAR: 2007
COUNTRY OF PUBLICATION:
UNITED-KINGDOM
LANGUAGE: English
LITERATURE TYPE:
Serial
ABSTRACT:
Rice is the most amenable crop plant for
genetic

manipulation
amongst monocots

due to its small genome size, enriched genetic map, availability of entire genome sequence, and

relative ease of transformation. Improvement in agronomic traits of rice is bound to affect a sizeable

population since it is a primary source of sustenance. Recent advances like use of 'clean gene'

technology or matrix attachment regions would help improve rice transformation. Function of

several novel genes and their promoters has been analyzed in
transgenic
rice. Significant progress

has been made in introducing traits like herbicide, biotic stress and abiotic stress tolerance.

Attempts also have been made to enhance nutritional characteristics of the grain and yield.

Identification of genes controlling growth and development can be used to modify plant architecture

and heading period.
Transgenic
rice can serve as a biofactory for the production of molecules of

pharmaceutical and industrial utility. The drive to apply
transgenic
rice for public good as well as

commercial gains has fueled research to an all time high. Successful field trials and biosafety of

transgenic
rice have been reported. This would act as a catalyst for greater acceptance of

genetically

modified
food crops. The lessons learnt from rice can be extended to other cereals

thereby opening new opportunities and possibilities.
ABSTRACT INDICATOR:
AB
CLASSIFICATION CODE:
002A31C02A5B; 002A32D02B; 215
DESCRIPTORS ENGLISH:
Cereal-crop; Spermatophyta-; Angiospermae-; Monocotyledones-;

Gramineae-; Oryza-sativa;
Review-
; Genetic-improvement; Seed-yield;
Transgenic-plant
;

Tolerance-; Stress-; Genomics-;
Genetic-transformation
; Biosafety-
DESCRIPTORS FRENCH:
Plante-céréalière; Spermatophyta-; Angiospermae-;

Monocotyledones-; Gramineae-; Oryza-sativa; Article-synthèse; Amélioration-génétique;

-
16
-
OGM
Rendement-semence;
Plante-transgénique
; Tolérance-; Stress-; Génomique-;
Transformation-
génétique
; Biosécurité-
AUTHORS DESCRIPTORS:
biosafety-; biotechnology-; genetic-enhancement;
genetic-
transformation
; genomics-; regulatory-elements; stress-tolerance;
transgenic-plants
; yield-
JOURNAL NAME:
Critical-reviews-in-plant-sciences
LOCATION OF PRIMARY DOCUMENT:
INIST-CNRS, Shelf Number 20941, INIST No.

354000149443350010
ACCESSION NUMBER:
18727786; 070268783
SOURCE OF INDEXING:
INIST
COPYRIGHT:
Copyright 2007 INIST-CNRS. All rights reserved.
UPDATE:
20080107
VOLUME:
26
NUMERO:
2
FIRST PAGE:
65
LAST PAGE:
103
SHELF NUMBER:
20941
Notice ISD (International Science Database)
ORIGINAL TITLE: Use of genetically engineered microorganisms (GEMs) for the bioremediation

of contaminants
PERSONAL AUTHOR:
URGUN-DEMIRTAS-Meltem
;
STARK-Benjamin
;
PAGILLA-Krishna
AFFILIATION OF AUTHOR:
Department of Chemical and Environmental Engineering, Illinois

Institute of Technology, Chicago, IL, UNITED-STATES; Department of Biological, Chemical and

Physical Sciences, Illinois Institute of Technology, Chicago, IL, UNITED-STATES
SOURCE: Critical-reviews-in-biotechnology
. 2006; 26 (3):
145-164
NOTES: 4 p.1/4
PUBLISHER:
CRC Press, Boca Raton, FL, UNITED-STATES
ISSN:
0738-8551
CODEN:
CRBTE5
PUBLICATION YEAR: 2006
COUNTRY OF PUBLICATION:
UNITED-STATES
LANGUAGE: English
LITERATURE TYPE:
Serial
ABSTRACT:
This paper presents a critical
review
of the literature on the application of

genetically engineered microorganisms (GEMs) in bioremediation. The important aspects of using

GEMs in bioremediation, such as development of novel strains with desirable properties through

pathway construction and the modification of enzyme specificity and affinity, are discussed in

detail. Particular attention is given to the genetic engineering of bacteria using bacterial hemoglobin

(VHb) for the treatment of aromatic organic compounds under hypoxic conditions. The application

of VHb technology may advance treatment of contaminated sites, where oxygen availability limits

the growth of aerobic bioremediating bacteria, as well as the functioning of oxygenases required for

mineralization of many organic pollutants. Despite the many advantages of GEMs, there are still

concerns that their introduction into polluted sites to enhance bioremediation may have adverse

environmental effects, such as gene transfer. The extent of horizontal gene transfer from GEMs in

the environment, compared to that of native organisms including benefits regarding bacterial

bioremediation that may occur as a result of such transfer, is discussed. Recent advances in tracking

-
17
-
OGM
methods and containment strategies for GEMs, including several biological systems that have been

developed to detect the fate of GEMs in the environment, are also summarized in this
review
.

Critical research questions pertaining to the development and implementation of GEMs for

enhanced bioremediation have been identified and posed for possible future research.
ABSTRACT INDICATOR:
AB
CLASSIFICATION CODE:
002A31; 215
DESCRIPTORS ENGLISH:
Contaminant-; Bioremediation-;
Genetically-modified-
microorganism
DESCRIPTORS FRENCH:
Contaminant-; Bioremédiation-;
Microorganisme-génétiquement-
modifié
AUTHORS DESCRIPTORS: genetically-engineered-microorganisms
; bioremediation-;

contaminants-
JOURNAL NAME:
Critical-reviews-in-biotechnology
LOCATION OF PRIMARY DOCUMENT:
INIST-CNRS, Shelf Number 21234, INIST No.

354000157126160020
ACCESSION NUMBER:
18103769; 060429851
SOURCE OF INDEXING:
INIST
COPYRIGHT:
Copyright 2006 INIST-CNRS. All rights reserved.
UPDATE:
20080107
VOLUME:
26
NUMERO:
3
FIRST PAGE:
145
LAST PAGE:
164
SHELF NUMBER:
21234
Notice ISD (International Science Database)
ORIGINAL TITLE: Transgenic plants with improved dehydration-stress tolerance : progress and

future prospects
PERSONAL AUTHOR:
CHERIAN-S
;
REDDY-M-P
;
FERREIRA-R-B
SOURCE:
Biologia-plantarum. 2006; 50 (4):
481-495
PUBLISHER:
Academia, Praha, CZECH-REPUBLIC
ISSN:
0006-3134
CODEN:
BPABAJ
PUBLICATION YEAR: 2006
COUNTRY OF PUBLICATION:
CZECH-REPUBLIC
LANGUAGE: English
LITERATURE TYPE:
Serial
ABSTRACT:
This
review
summarizes the recent progress made towards the development of

transgenic plants with improved tolerance to water stress and salinity. Of the various strategies

employed, emphasis has been given to the genes engineered for the biosynthesis of osmoprotectants

and osmolytes. This
review
also briefly discusses the importance of the use of specific stress

inducible promoters and the future prospects of transgenic plants with improved agronomic traits.
ABSTRACT INDICATOR:
AB
AUTHORS DESCRIPTORS:
compatible-solutes; environmental-stress; overexpression-; rd29A-
promoter; regulatory-proteins-
-
18
-
OGM
JOURNAL NAME:
Biologia-plantarum
LOCATION OF PRIMARY DOCUMENT:
INIST-CNRS, Shelf Number 9182, INIST No.

354000159780350010
ACCESSION NUMBER:
18486439
SOURCE OF INDEXING:
INIST
COPYRIGHT:
Copyright 2008 INIST-CNRS. All rights reserved.
UPDATE:
20080107
VOLUME:
50
NUMERO:
4
FIRST PAGE:
481
LAST PAGE:
495
SHELF NUMBER:
9182
Notice ISD (International Science Database)
ORIGINAL TITLE: Review : genetically modified plants for the promotion of human health
PERSONAL AUTHOR:
YONEKURA-SAKAKIBARA-Keiko
;
SAITO-Kazuki
AFFILIATION OF AUTHOR:
RIKEN Plant Science Center, 1-7-22, Suehiro, Tsurumi-ku,

Yokohama 230-0045, JAPAN
SOURCE:
Biotechnology-letters. 2006; 28 (24):
1983-1991
NOTES: 1 p.1/4
PUBLISHER:
Springer, Dordrecht, NETHERLANDS
ISSN:
0141-5492
CODEN:
BILED3
PUBLICATION YEAR: 2006
COUNTRY OF PUBLICATION:
NETHERLANDS
LANGUAGE: English
LITERATURE TYPE:
Serial
ABSTRACT:
Plants are attractive biological resources because of their ability to produce a huge

variety of chemical compounds, and the familiarity of production in even the most rural settings.

Genetic engineering gives plants additional characteristics and value for cultivation and post-
harvest. Genetically modified (GM) plants of the "first generation" were conferred with traits

beneficial to producers, whereas GM plants in subsequent "generations" are intended to provide

beneficial traits for consumers. Golden Rice is a promising example of a GM plant in the second

generation, and has overcome a number of obstacles for practical use. Furthermore, consumer-
acceptable plants with health-promoting properties that are genetically modified using native genes

are being developed. The emerging technology of metabolomics will also support the commercial

realization of GM plants by providing comprehensive analyzes of plant biochemical components.
ABSTRACT INDICATOR:
AB
CLASSIFICATION CODE:
002A31; 215
DESCRIPTORS ENGLISH:
Spermatophyta-; Angiospermae-; Monocotyledones-; Gramineae-;

Vitamin-; Rice-; Flavonoid-; Oryza-sativa; Carotenoid-; Health-; Human-;
Transgenic-plant
;

Review-
DESCRIPTORS FRENCH:
Spermatophyta-; Angiospermae-; Monocotyledones-; Gramineae-;

Vitamine-; Riz-; Flavonoïde-; Oryza-sativa; Caroténoïde-; Santé-; Homme-;
Plante-transgénique
;

Article-synthèse
-
19
-
OGM
AUTHORS DESCRIPTORS:
Carotenoids-; Flavonoids-;
Genetically-modified-plants
; Golden-
Rice; Vitamin-A
JOURNAL NAME:
Biotechnology-letters
LOCATION OF PRIMARY DOCUMENT:
INIST-CNRS, Shelf Number 18225, INIST No.

354000145190790020
ACCESSION NUMBER:
18373811; 070041264
SOURCE OF INDEXING:
INIST
COPYRIGHT:
Copyright 2007 INIST-CNRS. All rights reserved.
UPDATE:
20080107
VOLUME:
28
NUMERO:
24
FIRST PAGE:
1983
LAST PAGE:
1991
SHELF NUMBER:
18225
Notice ISD (International Science Database)
ORIGINAL TITLE: Genetic modification of plant metabolism for human health benefits
PERSONAL AUTHOR:
DAVIES-Kevin-M
SOURCE:
Mutation-research.-Fundamental-and-molecular-mechanisms-of-mutagenesis. 2007;

622 (1-2): 122-137
PUBLISHER:
Elsevier, Amsterdam, NETHERLANDS
ISSN:
1386-1964
PUBLICATION YEAR: 2007
COUNTRY OF PUBLICATION:
NETHERLANDS
LANGUAGE: English
LITERATURE TYPE:
Serial
ABSTRACT:
There has been considerable research progress over the past decade on elucidating

biosynthetic pathways for important human health components of crops. This has enabled the use of

genetic modification (GM) techniques to develop crop varieties with increased amounts of essential

vitamins and minerals, and improved profiles of 'nutraceutical' compounds. Much of the research

into vitamins and minerals has focused on generating new varieties of staple crops to improve the

diet of populations in developing nations. Of particular note is the development of new rice lines

with increased amounts of provitamin A and iron. Research on modifying production of

nutraceuticals has generally been aimed at generating new crops for markets in the developed

nations, commonly to deliver distinctive cultivars with high consumer appeal. Most progress on

nutraceuticals has been made with just a few types of metabolites to date, in particular in the

production of novel long-chain polyunsaturated fatty acids in oil-seed crops and to increase

amounts of flavonoids and carotenoids in tomato and potato. However, given the rapid progress on

elucidating plant metabolite biosynthetic pathways, wide-ranging success with metabolic

engineering for levels of human health-related compounds in plants would be expected in the near

future. A key aspect for future success will be better medical information to guide metabolic

engineering endeavors. Although the desired levels of many vitamins are known, detailed

information is lacking for most of the nutraceuticals that have attracted much interest over the past

few years.
ABSTRACT INDICATOR:
AB
-
20
-
OGM
AUTHORS DESCRIPTORS:
Biofortification-;
Genetic-modification
; Human-health; Plant-
breeding
JOURNAL NAME:
Mutation-research.-Fundamental-and-molecular-mechanisms-of-mutagenesis
LOCATION OF PRIMARY DOCUMENT:
INIST-CNRS, Shelf Number 12206 A, INIST No.

354000150060010120
ACCESSION NUMBER:
19001039
SOURCE OF INDEXING:
INIST
COPYRIGHT:
Copyright 2008 INIST-CNRS. All rights reserved.
UPDATE:
20080107
VOLUME:
622
NUMERO:
1-2
FIRST PAGE:
122
LAST PAGE:
137
SHELF NUMBER:
12206 A
Notice ISD (International Science Database)
ORIGINAL TITLE: Landscape gene flow, coexistence and threshold effect : The case of

genetically modified herbicide tolerant oilseed rape (Brassica napus)
PERSONAL AUTHOR:
GRAZIANO-CEDDIA-M
;
BARTLETT-Mark
;
PERRINGS-Charles
AFFILIATION OF AUTHOR:
Environment Department, University of York, Heslington, YO10

5DD York, UNITED-KINGDOM; Department of Computer Science, University of York,

Heslington, YO10 5DD York, UNITED-KINGDOM; Global Institute of Sustainability, Arizona

State University, 85287-2402 AZ, UNITED-STATES
SOURCE:
Ecological-modelling. 2007; 205 (1-2): 169-180
NOTES: 1 p.1/4
PUBLISHER:
Elsevier, Amsterdam, NETHERLANDS
ISSN:
0304-3800
CODEN:
ECMODT
PUBLICATION YEAR: 2007
COUNTRY OF PUBLICATION:
NETHERLANDS
LANGUAGE: English
LITERATURE TYPE:
Serial
ABSTRACT:
Globally there have been a number of concerns about the development of genetically

modified crops many of which relate to the implications of gene flow at various levels. In Europe

these concerns have led the European Union (EU) to promote the concept of 'coexistence'to allow

the freedom to plant conventional and genetically modified (GM) varieties but to minimise the

presence of transgenic material within conventional crops. Should a premium for non-GM varieties

emerge on the market, the presence of transgenes would generate a 'negative externality' to

conventional growers. The establishment of maximum tolerance level for the adventitious presence

of GM material in conventional crops produces a threshold effect in the external costs. The existing

literature suggests that apart from the biological characteristics of the plant under consideration (e.g.

self-pollination rates, entomophilous species, anemophilous species, etc.), gene flow at the

landscape level is affected by the relative size of the source and sink populations and the spatial

arrangement of the fields in the landscape. In this paper, we take genetically modified herbicide

tolerant oilseed rape (GM HT OSR) as a model crop. Starting from an individual pollen dispersal

function, we develop a spatially explicit numerical model in order to assess the effect of the size of

-
21
-
OGM
the source/sink populations and the degree of spatial aggregation on the extent of gene flow into

conventional OSR varieties under two alternative settings. We find that when the transgene

presence in conventional produce is detected at the field level, the external cost will increase with

the size of the source area and with the level of spatial disaggregation. On the other hand when the

transgene presence is averaged among all conventional fields in the landscape (e.g. because of grain

mixing before detection), the external cost will only depend on the relative size of the source area.

The model could readily be incorporated into an economic evaluation of policies to regulate

adoption of GM HT OSR.
ABSTRACT INDICATOR:
AB
CLASSIFICATION CODE:
002A14A02
DESCRIPTORS ENGLISH:
Spermatophyta-; Angiospermae-; Dicotyledones-; Cruciferae-;

Pesticides-; Brassica-napus; Brassica-napus-var.-oleifera; Herbicide-; Models-; Aggregation-;

Coexistence-;
Gene-flow
; Landscape-
DESCRIPTORS FRENCH:
Spermatophyta-; Angiospermae-; Dicotyledones-; Cruciferae-;

Pesticide-; Brassica-napus; Brassica-napus-var.-oleifera; Herbicide-; Modèle-; Agrégation-;

Coexistence-; Flux-génique; Paysage-
AUTHORS DESCRIPTORS: Gene-flow
; Coexistence-; Threshold-effect; Spatial-aggregation;

Oilseed-rape-(B.-napus)
JOURNAL NAME:
Ecological-modelling
LOCATION OF PRIMARY DOCUMENT:
INIST-CNRS, Shelf Number 15732, INIST No.

354000149627580140
ACCESSION NUMBER:
18777310; 070264466
SOURCE OF INDEXING:
INIST
COPYRIGHT:
Copyright 2007 INIST-CNRS. All rights reserved.
UPDATE:
20080107
VOLUME:
205
NUMERO:
1-2
FIRST PAGE:
169
LAST PAGE:
180
SHELF NUMBER:
15732
Notice CC Search(R)
ACCESSION NUMBER: 0002532021-0001
See Contents-Page

RECORD TYPE:
Bibliographic-Record
PUBLICATION TYPE:
Journal
ARTICLE TITLE: Transgenic approaches for abiotic stress tolerance in plants: retrospect and

prospects
ARTICLE AUTHOR:
Bhatnagar-Mathur-P
;
Vadez-V
;
Sharma-KK
REPRINT AUTHOR:
Sharma, KK; Int Crops Res Inst Semi Arid Trop; Patancheru 502324;

Andhra Pradesh; India
RESEARCH INSTITUTION:
Int Crops Res Inst Semi Arid Trop, Patancheru 502324, Andhra

Pradesh, India
EMAIL ADDRESS:
Sharma, KK: k.sharma@cgiar.org
SOURCE:
PLANT-CELL-REPORTS
. MAR 2008; 27 (3) :
411-424
DOCUMENT TYPE: Review
PUBLICATION YEAR: 2008
-
22
-
OGM
ISSN:
0721-7714
LANGUAGE: English
ABSTRACT:
Abiotic stresses including drought are serious threats to the sustainability of crop

yields accounting for more crop productivity losses than any other factor in rainfed agriculture.

Success in breeding for better adapted varieties to abiotic stresses depend upon the concerted efforts

by various research domains including plant and cell physiology, molecular biology, genetics, and

breeding. Use of modern molecular biology tools for elucidating the control mechanisms of abiotic

stress tolerance, and for engineering stress tolerant crops is based on the expression of specific

stress-related genes. Hence, genetic engineering for developing stress tolerant plants, based on the

introgression of genes that are known to be involved in stress response and putative tolerance,

might prove to be a faster track towards improving crop varieties. Far beyond the initial attempts to

insert "single-action" genes, engineering of the regulatory machinery involving transcription factors

has emerged as a new tool now for controlling the expression of many stress-responsive genes.

Nevertheless, the task of generating
transgenic
cultivars is not only limited to the success in the

transformation process, but also proper incorporation of the stress tolerance. Evaluation of the

transgenic
plants under stress conditions, and understanding the physiological effect of the inserted

genes at the whole plant level remain as major challenges to overcome. This
review
focuses on the

recent progress in using
transgenic
technology for the improvement of abiotic stress tolerance in

plants. This includes discussion on the evaluation of abiotic stress response and the protocols for

testing the
transgenic
plants for their tolerance under close-to-field conditions.
ABSTRACT INDICATOR:
Yes
JOURNAL SUBJECT CATEGORIES:
PLANT-SCIENCES; ANIMAL-AND-PLANT-
SCIENCE
AUTHOR KEYWORDS:
abiotic-stress; drought-tolerance; genetic-engineering; transcription-
factors; transpiration-efficiency
KEYWORDS PLUS:
RESPONSIVE-GENE-EXPRESSION; HEAT-SHOCK-PROTEINS;

TREHALOSE-6-PHOSPHATE-SYNTHASE-GENE; MANGANESE-SUPEROXIDE-
DISMUTASE; ENHANCES-FREEZING-TOLERANCE; ELEMENT-BINDING-FACTOR;

DROUGHT-TOLERANCE; ABSCISIC-ACID; SIGNAL-TRANSDUCTION; ARABIDOPSIS-
THALIANA
CC EDITION:
Agriculture-Biology-and-Environmental-Sciences; Life-Sciences
NUMBER OF REFERENCES: 152
ISI DOCUMENT SOLUTION NUMBER:
263FD
Notice CC Search(R)
ACCESSION NUMBER: 0002514090-0004
See Contents-Page

RECORD TYPE:
Bibliographic-Record
PUBLICATION TYPE:
Journal
ARTICLE TITLE: Feedstock crop genetic engineering for alcohol fuels
ARTICLE AUTHOR:
Sticklen-MB
REPRINT AUTHOR:
Sticklen, MB; Michigan State Univ; Dept Crop & Soil Sci; Plant & Soil Sci

Bldg; E Lansing; MI 48824; USA
RESEARCH INSTITUTION:
Michigan State Univ, Dept Crop & Soil Sci, E Lansing, MI 48824

USA
EMAIL ADDRESS:
Sticklen, MB: stickle1@msu.edu
SOURCE:
CROP-SCIENCE
. NOV-DEC 2007; 47 (6) :
2238-2248
-
23
-
OGM
DOCUMENT TYPE:
Review
PUBLICATION YEAR: 2007
ISSN:
0011-183X
LANGUAGE: English
ABSTRACT:
One of the goals of the U.S. government is to have "cellulosic ethanol" produced

from a variety of sources, including feedstock crop biomass (a mass of raw material used in alcohol

fuels processing), because these biomass sources contain polysaccharides that can be converted into

fermentable sugars. Furthermore, the feedstock biomass sources are renewable and could become

available at a billion tonnes per year in the United States. There are three major steps associated

with the conversion of feedstock biomass into cellulosic ethanol. The first is the production of

hydrolysis enzymes such as microbial cellulases, which convert the cellulose of feedstock biomass

into fermentable sugars. The second step is the pretreatment processes used to break down the

recalcitrant lignocellulose complex of feedstock into more reactive intermediates and to remove the

lignin residues so the cellulase enzymes can have access to cellulose. The third step is fermentation

of sugars into ethanol. The first two steps are the subject of this
review
.
Plant

genetic

engineering

has been used to directly express heterologous versions of cellulase and hemicellulase enzymes in

situ. Plants have also been
genetically

modified
for less lignin content or for more digestible lignin.

An increase in feedstock polysaccharides and an increase in overall crop biomass via
crop

genetic

engineering
have also been reported. This article
reviews
the advancements made in feedstock

crop

genetic

engineering
in the above areas and discusses possible near-future perspectives.
ABSTRACT INDICATOR:
Yes
JOURNAL SUBJECT CATEGORIES:
AGRICULTURE/AGRONOMY-
KEYWORDS PLUS:
PLANT-CELL-WALLS; MADS-BOX-GENE; CELLULOSE-
BIOSYNTHESIS; TRANSGENIC-TOBACCO; BETA-GLUCOSIDASE; ACIDOTHERMUS-
CELLULOLYTICUS; PRETREATMENT-TECHNOLOGIES; LIGNOCELLULOSIC-BIOMASS;

CLOSTRIDIUM-THERMOCELLUM; LIGNIN-BIOSYNTHESIS
CC EDITION:
Agriculture-Biology-and-Environmental-Sciences
NUMBER OF REFERENCES: 126
ISI DOCUMENT SOLUTION NUMBER:
237XF
UPDATE CODE:
200802
Notice MEDLINE
TITLE: Transgenic farm animals: an update.
AUTHOR:
Niemann,-H
;
Kues,-W-A
ADDRESS OF AUTHOR:
Department of Biotechnology, Institute for Animal Breeding,

Mariensee, 31535 Neustadt, Germany. niemann@tzv.fal.de
SOURCE:
Reprod-Fertil-Dev.
2007; 19(6): 762-70
JOURNAL NAME:
Reproduction,-fertility,-and-development
ISSN (PRINT VERSION):
1031-3613
PUBLICATION YEAR:
2007
LANGUAGE: English
COUNTRY OF PUBLICATION:
Australia
MAIN ABSTRACT:
The first transgenic livestock species were reported in 1985. Since then

microinjection of foreign DNA into pronuclei of zygotes has been the method of choice. It is now

being replaced by more efficient protocols based on somatic nuclear transfer that also permit

targeted genetic modifications. Lentiviral vectors and small interfering ribonucleic acid (siRNA)

-
24
-
OGM
technology are also becoming important tools for transgenesis. In 2006 the European Medicines

Agency (EMEA) gave green light for the commercialistion of the first recombinant protein

produced in the milk of transgenic animals. Recombinant antithrombin III will be launched as

ATryn for prophylactic treatment of patients with congenital antithrombin deficiency. This

important milestone will boost the research activities in farm animal transgenesis. Recent

developments in transgenic techniques of farm animals are discussed in this
review
.
MAJOR MESH DESCRIPTORS:
*
Animals,-Domestic-genetics
; *
Animals,-Domestic-
metabolism
; *
Animals,-Genetically-Modified-genetics
; *
Animals,-Genetically-Modified-
metabolism
; *
Gene-Transfer-Techniques
; *
Pharmaceutical-Preparations-metabolism
;

*
Recombinant-Proteins-biosynthesis
MINOR MESH DESCRIPTORS:
Agriculture-
;
Cloning,-Molecular
;
Swine-genetics
CHECK TAGS AND RESEARCH SUPPORT:
Animals
;
Humans
PUBLICATION TYPE:
Journal-Article; Research-Support,-Non-U.S.-Gov't; Review-
SUBHEADINGS:
genetics
;
metabolism
;
biosynthesis
CAS REGISTRY NUMBER:
0; 0
PRIME NAME OF SUBSTANCE:
Pharmaceutical-Preparations
;
Recombinant-Proteins
JOURNAL CATEGORY:
Reproductive-Medicine
REVIEW REFERENCES: 89 refs
.
SUBSET:
Index-Medicus
UPDATE CODE:
20071011
ENTRY DATE:
20070823
COMPLETION DATE:
20071011
RECORD OWNER:
National-Library-of-Medicine
ACCESSION NUMBER:
17714630
PUBLISHING MODEL:
Citation processed from: Print
Journal available in: Print
RECORD FEATURES:
ABSTRACT (AB)
Notice MEDLINE
TITLE: Animal transgenesis: state of the art and applications.
AUTHOR:
Melo,-E-O
;
Canavessi,-A-M
;
Franco,-M-M
;
Rumpf,-R
ADDRESS OF AUTHOR:
EMBRAPA Genetic Resources and Biotechnology, Av. W/5, Norte

Final, PBI, Sala 7B, Brasilia, DF, Brazil, CEP 70770-900. eom@cenargen.embrapa.br
SOURCE:
J-Appl-Genet.
2007; 48(1):
47-61
JOURNAL NAME:
Journal-of-applied-genetics
ISSN (PRINT VERSION):
1234-1983
PUBLICATION YEAR:
2007
LANGUAGE: English
COUNTRY OF PUBLICATION:
Poland
MAIN ABSTRACT:
There is a constant expectation for fast improvement of livestock production

and human health care products. The advent of DNA recombinant technology and the possibility of

gene transfer between organisms of distinct species, or even distinct phylogenic kingdoms, has

opened a wide range of possibilities. Nowadays we can produce human insulin in bacteria or human

coagulation factors in cattle milk. The recent advances in gene transfer, animal cloning, and assisted

reproductive techniques have partly fulfilled the expectation in the field of livestock transgenesis.

This paper
reviews
the recent advances and applications of transgenesis in livestock and their

-
25
-
OGM
derivative products. At first, the state of art and the techniques that enhance the efficiency of

livestock transgenesis are presented. The consequent reduction in the cost and time necessary to

reach a final product has enabled the multiplication of transgenic prototypes around the world. We

also analyze here some emerging applications of livestock transgenesis in the field of

pharmacology, meat and dairy industry, xenotransplantation, and human disease modeling. Finally,

some bioethical and commercial concerns raised by the transgenesis applications are discussed.
MAJOR MESH DESCRIPTORS:
*
Animals,-Domestic-genetics
; *
Animals,-Genetically-
Modified-genetics
MINOR MESH DESCRIPTORS:
Cloning,-Organism-history
;
Cloning,-Organism-trends
;

Cloning,-Organism-veterinary
;
Disease-Models,-Animal
;
Genetic-Engineering-history
;
Genetic-
Engineering-trends
;
Genetic-Engineering-veterinary
;
History,-20th-Century
;
History,-21st-Century
;

Milk-metabolism
;
Recombinant-Proteins-biosynthesis
;
Recombinant-Proteins-genetics
;

Transplantation,-Heterologous
CHECK TAGS AND RESEARCH SUPPORT:
Animals
;
Female
;
Humans
PUBLICATION TYPE:
Historical-Article; Journal-Article; Review-
SUBHEADINGS:
genetics
;
history
;
trends
;
veterinary
;
metabolism
;
biosynthesis
CAS REGISTRY NUMBER:
0
PRIME NAME OF SUBSTANCE:
Recombinant-Proteins
JOURNAL CATEGORY:
Genetics
REVIEW REFERENCES: 129 refs.
SUBSET:
Index-Medicus
UPDATE CODE:
20070328
ENTRY DATE:
20070202
RECORD OWNER:
National-Library-of-Medicine
ACCESSION NUMBER:
17272861
PUBLISHING MODEL:
Citation processed from: Print
Journal available in: Print
RECORD FEATURES:
ABSTRACT (AB)
Notice MEDLINE
TITLE: The production of unusual fatty acids in transgenic plants.
AUTHOR:
Napier,-J-A
ADDRESS OF AUTHOR:
Rothamsted Research, Harpenden, Hertfordshire, United Kingdom.

johnathan.napier@bbsrc.ac.uk
SOURCE:
Annu-Rev-Plant-Biol.
2007; 58:
295-319
JOURNAL NAME:
Annual-review-of-plant-biology
ISSN (PRINT VERSION):
1543-5008
PUBLICATION YEAR: 2007
LANGUAGE: English
COUNTRY OF PUBLICATION:
United-States
MAIN ABSTRACT:
The ability to genetically engineer plants has facilitated the generation of

oilseeds synthesizing non-native fatty acids. Two particular classes of fatty acids are considered in

this
review
. First, so-called industrial fatty acids, which usually contain functional groups such as

hydroxyl, epoxy, or acetylenic bonds, and second, very long chain polyunsaturated fatty acids

normally found in fish oils and marine microorganisms. For industrial fatty acids, there has been

limited progress toward obtaining high-level accumulation of these products in transgenic plants.

-
26
-
OGM
For very long chain polyunsaturated fatty acids, although they have a much more complex

biosynthesis, accumulation of some target fatty acids has been remarkably successful. In this

review
, we consider the probable factors responsible for these different outcomes, as well as the

potential for further optimization of the transgenic production of unusual fatty acids in transgenic

plants.
MAJOR MESH DESCRIPTORS:
*
Fatty-Acids-biosynthesis
; *
Plants,-Genetically-Modified-
metabolism
MINOR MESH DESCRIPTORS:
Fatty-Acid-Desaturases-genetics
;
Fatty-Acid-Desaturases-
metabolism
;
Fatty-Acids-chemistry
;
Fatty-Acids,-Unsaturated-biosynthesis
;
Fatty-Acids,-
Unsaturated-chemistry
;
Fish-Oils-biosynthesis
;
Genetic-Engineering
;
Lipid-Metabolism
;

Transgenes-
PUBLICATION TYPE:
Journal-Article; Research-Support,-Non-U.S.-Gov't; Review-
SUBHEADINGS:
genetics
;
metabolism
;
biosynthesis
;
chemistry
CAS REGISTRY NUMBER:
0; 0; 0
EC NUMBER:
EC 1.14.99.-; EC 1.14.99.-
PRIME NAME OF SUBSTANCE:
Fatty-Acids
;
Fatty-Acids,-Unsaturated
;
Fish-Oils
ENZYME NAMES:
Fatty-Acid-Desaturases
;
delta-12-fatty-acid-desaturase
JOURNAL CATEGORY:
Botany
REVIEW REFERENCES: 156 refs.
SUBSET:
Index-Medicus
UPDATE CODE:
20070731
ENTRY DATE:
20070502
COMPLETION DATE:
20070731
RECORD OWNER:
National-Library-of-Medicine
ACCESSION NUMBER:
17472567
PUBLISHING MODEL:
Citation processed from: Print
Journal available in: Print
RECORD FEATURES:
ABSTRACT (AB)
-
27
-
OGM
Etudes sur les problématiques d’ordre sanitaire,

environnemental ou économique (analysant les avantages et

les risques)
Français
Notice ISD (International Science Database)
ORIGINAL TITLE: Les plantes transgéniques (OGM végétaux) : connaissances et inconnues sur

les risques d'allergénicité
TRANSLATED TITLE: Transgenic
plants (GM plants) : What we do and don't know about the

risks of
allergenicity
PERSONAL AUTHOR:
MONERET-VAUTRIN-Anne-D
AFFILIATION OF AUTHOR:
Service de médecine interne, immunologie clinique et

allergologie
, hôpital universitaire, 29, avenue du Maréchal-de-Lattre-de-Tassigny, 54035 Nancy,

FRANCE
SOURCE: Revue-française-d-allergologie-et-d-immunologie-clinique
.
2006; 46 (2): 85-91
NOTES: 32 ref.
PUBLISHER:
Elsevier, Paris, FRANCE
ISSN:
0335-7457
CODEN:
RFAIBB
PUBLICATION YEAR: 2006
COUNTRY OF PUBLICATION:
FRANCE
LANGUAGE: French
LITERATURE TYPE:
Serial
ABSTRACT:
Les
OGM
alimentaires d'origine végétale suscitent beaucoup d'attention en raison du

postulat d'un risque
allergénique
. Aucun risque
allergique
n'a été documenté pour les
OGM
de

première génération conférant aux variétés végétales une résistance aux herbicides et aux larves

d'insecte. Les expérimentations actuelles sur des
OGM
hypoallergéniques sont rapportées et

discutées. La seconde génération d'OGM portant sur des améliorations nutritionnelles correspondra

à des protéines d'intérêt d'origine végétale, présentes dans une fourchette prévisible de 4 à 8 % du

contenu protéique total. L'évaluation d'une potentialité
allergénique
différente de celle des variétés

naturelles devra être examinée au niveau des produits alimentaires - risque d'allergie alimentaire - et

au niveau des pollens - risque d'allergie respiratoire pour les populations vivant en régions de

culture. Les directives de l'OMS-FAO du Codex Alimentarius et de l'EFSA prévoient, pour les

protéines
transgéniques
, la recherche d'homologie in silico puis une recherche de réactivité croisée

avec les
allergènes
actuellement identifiés, ainsi qu'une étude précise d'éventuelles modifications

du protéome de la plante hôte. Une immunogénicité potentielle devra faire l'objet d'études animales

in vivo. Aucune étape ne permet de statuer formellement sur une absence de potentialité

allergénique
, C'est pourquoi l'ensemble de ces données orientera plus vers une absence de

commercialisation de plantes
transgéniques
ne répondant pas à des critères de sécurité

correspondant au poids de l'évidence, qu'elle ne permettra d'affirmer l'absence certaine de risque de

-
28
-
OGM
produits qui seront commercialisés. La surveillance des
OGM
végétaux commercialisés sera donc

indispensable. Cette revue précise les nécessités de sérothèques publiques de référence, et complète

les propositions de sélection des sérums issus de l'OMS-FAO par des critères précis. Elle propose la

mise en place de systèmes d'allergovigilance alliant les agences nationales et européennes de

sécurité sanitaire alimentaires et des centres de référence hospitalo-universitaires cliniques et