Integrative Biophysics and Pulsed Electromagnetic Field Therapy

murmerlastΠολεοδομικά Έργα

16 Νοε 2013 (πριν από 3 χρόνια και 11 μήνες)

112 εμφανίσεις

Keith R. Holden, M.D.

Resonance Center

Jacksonville Beach, FL

www.ResonanceCenterJax.com



Integrative Biophysics.



Pulsed Electromagnetic Field (PEMF) Therapy
as an instrument of integrative biophysics.



Biomolecular effects.



Epigenetic effects.



Cellular physiologic effects.








Optimal tissue frequencies.



Proof of efficacy via peer reviewed studies,
including RDBPC clinical trials.



Ondamed® as a powerful instrument of integrative
biophysics.




Holistic integration of quantum energetic,
molecular, biochemical, and physiologic
processes.



Reflects the web
-
like interconnectedness of
all biologic systems within the body and that
of the body with its environment.




Honors energetic and biochemical
individuality.




PEMF = instrument for integrative biophysics.




Larmor Precession Model



External pulsed electromagnetic field matches the
(Larmor) spin frequency of hydrogen atom causing
energized electrons to emit a photon, which act as a
vital energy carrier for tissue repair.



Ion/ligand binding at cell membrane.


Alters cascade of biological processes for tissue growth
and repair.







Amplification of the tissue repair field (current of
injury).




Upregulation of genes involved in normal cell
growth.


(Goodwin, 2003)



Increases osteoblast intracellular calcium & alters
response to epidermal growth factor.


(Shigaku,1990)



Stimulates production of type
-
I collagen, osteocalcin,
& osteopontin.


(Cornaglia, et al., 2006)



Antiinflammatory effect via restoration of plasma
membrane calcium ATPase activity.


(Selvam, et al., 2007)




Nerve‐2 Hz


Bone‐75 Hz


Ligament‐10 Hz


Capillaries and skin‐15 Hz


(Sisken, et al., 1995)

(Shupak, 2003)



Fracture non
-
union


65
-
75Hz


Congenital pseudoarthrosis


15Hz


Osteoporosis


72Hz


Hip arthroplasty


50Hz


Arthritis


50Hz


Tinnitus


0.5
-
17Hz


Rotator Cuff Tendonitis


71
-
75Hz


Venous skin ulcers


75Hz


Multiple sclerosis


4
-
13Hz


(Shupak, 2003)




Randomized, Double Blind,

Placebo Controlled



Randomized double blind placebo controlled
(RDBPC) clinical trial.



PEMF 3X a week for 3 weeks for chronic lower
back pain.



Significant reduction in pain and disability
over placebo.


(Lee, 2006)



RDBPC clinical trial.



Chronic generalized pain from fibromyalgia or
chronic localized musculoskeletal pain.




PEMF twice daily 40 min. for 7 days.



PEMF effect over sham for fibromyalgia
approached statistical significance.


(Thomas, et al., 2007)




RDBPC clinical trial.



PEMF 30 min. 2X a day for 3 weeks.



Neck pain, PVMS, and disability scale scores
decreased, and AROM increased significantly in
the PEMF group.



No change in the sham group.


(Sutbeyaz, et al., 2006)



RDBPC clinical trial.



86 patients with OA of knee.


81 patients with OA of cervical spine.



Statistically significant improvement in treated
patients for pain and ADLs at end of treatment
and at one month follow up.


(Trock, et al.,1994)





RDBPC clinical trial.



Group I (PEMF), Group II (sham PEMF), Group III
(corticosteroid + anesthestic inj.)



Group III had lower pain than Group I and Group
II at third week.



Group I (PEMF) patients had lower pain than
Groups II and III at third month.


(Uzunca, et al., 2007)



RDBPC clinical trial.



Preclinical studies show that PEMF limits catabolic
effects of pro
-
inflammatory cytokines on
articular cartilage.



PEMF 75 Hz 4 hours per day for 60 days.



Functional recovery occurs earlier with PEMF
group.


(Benazzo, et al., 2008)






RDBPC clinical trial.



PEMF 30 min. twice a day for 3 weeks.



At 12 weeks follow up, PEMF group showed
significant improvements in pain compared to
sham PEMF.



(Sutbeyaz, et al., 2009)



RDBPC clinical trial.



PEMF for 90 days 6 hours per day.


PEMF group statistically significant improvement at
90 days.



NSAID use


PEMF (26%) & sham (75%).



3 year follow up, number of patients who completely
recovered was higher in PEMF.


(Zorzi, et al., 2007)



RDBPC clinical trial.



PEMF 4 weeks.



Assessed MSQLI
-

fatigue, bladder control,
spasticity, & QOL composite.



Statistically significant improvement in fatigue &
QOL; none bladder control; mixed spasticity.


(Lappin, et al., 2003)





RDBPC clinical trial.



PEMF 84 sessions for 30 min.



WOMAC index dec. 84.1 to 49.7 in PEMF and
73.7 to 66.9 in sham.



Secondary parameters improved over sham


gait
speed, stride length, & acceleration time.


(Nicolakis, et al., 2002)



RDBPC clinical trial.



Active group


92% success rate.



Sham group


65% success rate.




(Mooney, 1990)






RDBPC clinical trial.



Refractory rotator cuff tendinitis.



PEMF showed significant improvement over sham during
the first four weeks.



No significant difference between groups when both
received PEMF.



End of study


65% were asymptomatic.


(Binder, 1984)

CONDITION

FDA APPROVED

SUCCESS RATE

Fracture nonunion

Yes

75
-
95%

Failed joint fusions

Yes

85
-
90%

Spinal fusions

Yes

90
-
95%

Congenital
pseudoarthrosis

Yes

70
-
80%

Osteonecrosis (hip)

No

80
-
100%

Osteochondritis
dessicans

No

85
-
90%

Osteoporosis

No

85
-
90%

Chronic tendinitis


No

85
-
90%

Chronic skin ulcers

No

85
-
90%

Bassett, CA, Beneficial Effects of Electromagnetic
Fields. J of Cell Biochemistry. 1993; 51:387
-
393.




T mineralization



T angiogenesis




T collagen + GAG production



Endochondral ossification



(T osteoclasis for pseudoarthrosis)




T angiogenesis



T osteoblastic activity




T angiogenesis



T collagen + GAG production

Bassett, CA, Beneficial Effects of Electromagnetic
Fields. J of Cell Biochemistry. 1993; 51:387
-
393.



Animal data showing decrease in infarct size.



Acute affects on blood flow and
angiogenesis.



Questionable effect on superoxide dismutase
and nitrous oxide.



Animal data demonstrate decreased growth
and invasiveness of Meth A sarcoma in Balb C
mice, encapsulation and nuclear changes.



Animal data show decrease in bone
resorption in jaws.



Increased osteogenesis in tooth extraction
sockets.



Improved bacterial flora spectrum.



Clinical benefits on blood glucose reported.



? Secondary to Ca
++
effects on insulin
secretion.



Effects on axoplasmic transport.



Neuronal protein synthesis.



Ca
++
/neurotransmitter effects at synapse.



Angiogenesis.



Animal data showing improved healing.



Increased collagen and GAG synthesis.



Increased angiogenesis.



Animal data showing increased protein
synthesis.



Increased axon migration and function.



No direct evidence.



Data on neuropathy and nerve transection
may prove beneficial.



Particularly in crush injuries when sensory
and motor potential evoked potentials are
still present.



An integrative biophysics instrument that
changes the energetic terrain.



Positive affects on biologic systems with low
level specific pulsed electromagnetic
frequencies.




Specific frequencies via pulse testing provide
intelligent information.



Bassett, CA. Beneficial Effects of Electromagnetic
Fields. J of Cell Biochemistry. 1993; 51:387
-
393.



Holden, K. Pulsed Electromagnetic Field Therapy
With the Ondamed


A Tool for Integrative
Biophysics.
http://www.ondamed.net/web/publications/article
s.html. 2009.



Shupak, N. Therapeutic Uses of Pulsed Magentic
-
Field Exposure: A Review. The Radio Science
Bulletin. 2003 Dec; (307): 9
-
32.


Keith R. Holden, M.D.


Resonance Center

496 Osceola Avenue

Jacksonville Beach, FL 32250

(904) 694
-
0378

krholden@gmail.com


www.ResonanceCenterJax.com