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McGill University

Department of Chemical Engineering


CHEE 370

Elements of Biotechnology

Fall 2009


Tuesdays and Thursday
s 13:05
-
14:25, Rm
McConnell 11


Instructors:


Professor Elizabeth Jones


Office: M.H.Wong, Rm 4230

E
-
mail:
liz.jones@mcgill.ca












Phone: 514
-
398
-
4275


Office hours: Wednesday 15:00
-
17:00 or by appointment



Professor Nathalie Tufenkji


Office: M.H.Wong, Rm 4300


Phone: 514
-
398
-
2999


E
-
mai
l:
nathalie.tufenkji@mcgill.ca






Office hours:
Thursdays 15:00
-
16:3
0 or by appointment


Teaching Assistants:

Ms. Bahareh Asadishad (
bahar
eh.asadishad@mail.mcgill.ca
) Office: Wong, Rm 6220
Office Hrs:
TUES: 10:00
-
12:0
0;
THURS: 10:00
-
12
:00


Ms. Azadeh Kermanshahi pour (
azadeh.kermanshahipour@mcgill.ca
) Wong, Rm 7090



Office Hrs:
MON: 10:00
-
12:00; WED
: 10:00
-
12:00





Course Credit:
3


General Course Description:
In this course, students are introduced to the basic principles of
microbiology relevant to biotechnology and biochemical engineering. This course i
s the first of a
series of two courses in the undergraduate core curriculum dealing with Biochemical Engineering.
The second course will focus on the engineering principles involved in the design of bioprocessing
equipment. The course provides an overview

of cell structure and metabolism, enzyme kinetics,
proteins, carbohydrates and other biomolecules, and industrially significant microbes. An introduction
to genetic engineering and modern molecular techniques will also be included.


Prerequisites:
CHE
M 234


Learning Objectives:


(1)

To become familiar with the structure, intracellular characteristics, and metabolism of
industrially
-
relevant microorganisms

(2)

To recognize the importance of shape and structure in protein function

(3)

To be able to describe the ro
le of enzymes in cell metabolism and industrial processes, and to
identify the factors that influence the rate of enzyme
-
catalyzed reactions

(4)

To understand the fundamentals of microbial growth and metabolic activity

(5)

To become familiar with the process of ge
ne expression and genetic manipulation



Instructional Methods:


The primary means of instruction will be in
-
class lectures, supplemented with reading assignments
from the course textbook.



Reading Materials:


There is a required textbook which is ava
ilable at the McGill Bookstore. Reading assignments are
listed in the course outline below.


Madigan, M. T. and Martinko, J.M.
Brock Biology of Microorganisms
, 12
th

edition, Prentice Hall,
2007.


Suggested Reading/References:


Students will find the fo
llowing resources which have been placed on reserve at the Schulich Library
helpful:

Bailey and Ollis, “Biochemical Engineering Fundamentals” McGraw
-
Hill.

Shuler and Kargi, “Bioprocess Engineering: Basic Concepts” Prentice Hall.


There is also a complete s
et of online course materials that accompany the textbook. These include
tutorials, online quizzes, links to other websites and animations. Students are encouraged to make use
of these resources.


Student Evaluation:


Homework Assignments (4): 6%

(due a
t the beginning of class on the due date)

Laboratory Exercise (1): 4%

Midterm Exam I: 20%

Midterm Exam II: 20%

Final Exam (comprehensive): 50%


Exams are closed
-
book, closed
-
notes.


Assignment Submission Policy:
Assignments should be completed individua
lly and submitted in
class (not by email).

Assignments submitted one day late: lose 50% of the marks; if more than one day
late: receive a zero (unless you have a valid reason; e.g., medical note).

The TA will post your
assignment grade on WebCT one week
after it has been submitted
--

if you are missing a grade and
have submitted your assignment, you must see me within 1 week of the grades being posted for the
assignment in question.


McGill University values academic integrity. Therefore, all students mus
t understand the meaning
and consequences of cheating, plagiarism and other academic offences under the Code of Student
Conduct and Disciplinary Procedures (see
www.mcgill.ca/integrity/

for more information).


“In the event of extraordinary circumstances beyond the University’s control, the content and/or
evaluation scheme in this course is subject to change.”



Tentative

Outline of Lecture Topics

Week

Date

Topic

Notes

1

Sept 1

Course Introduction

NT

Unit 1. Introduction to Microbiology

Unit 2. Macromolecules and Cell Structure

RA
: Brock
Chapters 3 (51
-
64)
and 4 (68
-
84;96
-
105)

Sept 3

Unit 2. Macromolecules and Cell Structure

NT

2

Sept 8

Unit 3. Cell Nutrition and Metabolism EJ

RA
: Brock Chapter
5 (108
-
133).

Sept 10

Unit 3. Cell Nutrition and Metabolism EJ



RA
: Brock Chapter
6 (142
-
157)

3

Sept 15

Unit 4. Microbial Growth and Culture NT



Sept 17

Unit 4. Microbial Growth and Culture NT


HW #1 due

4

Sept 22

Unit 5.
Microbial Growth Control NT


Sept 24

Unit 6. Enzyme Kinetics NT


RA
: Brock
Chapters 27 (780
-
794) and 4 (94
-
95)

5

Sept 29

Unit 6. Enzyme Kinetic
s NT


Oct 1


Tutorial Session for Midterm

I NT


HW #2 due

6

Oct 6


MIDTERM EXAM 1


NT



Oct 8

Unit 7. Principles of Microbial Molecular Biology NT

RA
: Brock Chapter
7 (175
-
201).

7

Oct 13

Unit 7. Principles of Microbial Molecular Biology N
T


Oct 15

Unit 7. Principles of Microbial Molecular Biology NT


8

Oct 20

Unit 7. Principles of Microbial Molecular Biology NT

RA
: Brock Chapter
9 (225
-
231).

Oct 22

Laboratory Exercise

EJ

9

Oct 27

Laboratory Exercise
EJ


Oct 29

Unit 8. Regulation of Gene Expression EJ

RA
: Brock Chapt
er
11 (285
-
301) and
sections 12.3, 12.4,
12.9 and p.334.

10

Nov 3

Unit 9. Bacterial Genetics EJ

HW #3 due

Nov 5

Unit 9. Bacterial Genetics

EJ

RA
: Brock Chapter
25 (734
-
759).

11

Nov 10

Unit 10A. Industrial Microbiology/Biocatalysis EJ

Nov 12

Unit 10A. Industrial Microbiology/Biocatalysis EJ


12

Nov 17


MIDTERM EXAM 2

EJ


Nov 19

Unit 11. Genetic Engineering and Biotechnology EJ

RA
: Brock
Sections 12.9,
12.10, 12.11,12.13,
Chapter 26 (762
-
765).

13

Nov 24

Unit 11. Genetic Engineering and Biotechnology

EJ

Nov 26

Unit 12. Recent Developments Emerging from Biotechnology EJ

HW #4 due


NOTE:
RA

= Reading Assignment



The Department of Chemical Engineering is committed to providing a safe laboratory environment for
its faculty,

staff, students and visitors. All students must wear appropriate attire and personal
protective equipment when present in the lab. Students must also report all accidents, dangerous
incidents or suspected occupational illnesses to their immediate superv
isor without delay. You must
also refrain from manipulating any potentially hazardous materials prior to undergoing appropriate
safety training and receiving safety instructions. Failure to abide by any of these rules will result in
your dismissal from t
he lab and return only after appropriate safety measures are approved by the
supervisor. All students should understand their rights and responsibilities in the laboratory as outlined
in the McGill Laboratory Safety Manual.

(https://home.mcgill.ca/ehs/la
boratory/labsafety/).