Syed Habib Bokhari - COMSATS Institute of Information Technology

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20 Φεβ 2013 (πριν από 4 χρόνια και 6 μήνες)

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Syed Habib Bokhari


Office: 0512501223

FAX: 0514442805

Email:
habib@comsats.edu.pk


habibbokhari58@hotmail.com

DOB

: 01
-
3
-
1973


EDUCATION


Jan,
1999
-
Dec,
2
002

Univ. of Glasgow

Microbiology & Immunology Ph.D.

Jan,
1995
-
July,
1997

Q.A.U, Pakistan

Biotechnology, M.

P
hil.


RESEARCH SPECIALIZATION


Infectious Diseases, Glycoengineering, Biosensors, Bioinformatics


P
ROFESSIONAL
EXPERIENCE

2010

to date


Associate
Professor




Department of Biosciences




CIIT, Islamabad


Feb
2003
-
2010



Assistant Professor,




Department of Biosciences




CIIT, Islamabad


2008
-
2008


Head,




Department of Biosciences




CIIT, Islamabad



2007
-
present:



Affiliate faculty




Bi
oinformatics and Computational Biology




College of Science




George Mason University,
Manassas
, Virginia


2009
-
2010


Post Doc




Department of Microbial Pathogenesis





London School of Hygiene and Tropical Medicine



2005
-
2006:



Visiting Scientist





Department of Environmental Sciences and Policy




George Mason University, Fairfax, Virginia 22030


2001
-

2002:


Demonstrator (Microbiology and Molecular Biology)




Institute of Biomedical and Life Sciences




Univ. of Glasgow, Glasgow


Sep,
1996
-

Ja
n, 2003
:


Lecturer




Post Graduate Botany Department




Govt. S. E. College, Bahawalpur


Awards/Scholarships/ Memberships:


1.

Recipient of Commonwealth scholarship for Ph.D. (1999
-
2002)

2.

Short
-
listed for Fulbright scholarship (1998
-
9: Did not pursue),

3.

Fran
ce scholarship for Ph.D. (1998
-
99: Did not pursue)

4.

Selected fo
r cultural scholarship for Ph.D. (1998
-
99: Did not pursue)

5.

Awarded Roll of Honor for standing first in B.Sc. in Botany, Zoology, Chemistry group

6.

President Talent Scholarships at B.Sc. and M.Sc.
Levels


7.

Infaq Foundation Scholarship (HEC) at M.phil level


8.

Member General Council, University of Glasgow

9.

Member Zoological Society of Pakistan

10.

Member HEC curriculum committee for Bioinformatics

11.

Expert Member of HEC Project Reviewer’s committee

12.

Editor of

the journal of Integrative Computational Biosciences (JICB)

13.

Member Society for General Microbiology, UK

14.

Member

American Nanosociety

15.

Member Board of studies Department of Microbiology, QAU, Islamabad

16.

Member Board of studies Department of Biochemistry, QAU,

Islamabad














Research
Articles:







(Total Impact Factor 4
6
.
3
8
6
)


1.

H. Bokhari
,
1

F. Said
1
, M.A. Syed
1
, A. Hussain,
2

Y. F. Kazi,

2

Teemu Kallonen
c
, Qiushui He
c
,
Audrey J. King
d

K. Heuvelman
3

and F. R. Mooi
3
.
2011
.
Molecular typing of
Bordetella

parapertussis

isolates circulating in Pakistan

(
Accepted
:

FEMS Immunology & Medical
Microbiology
) (IF=
2
.
35
)

2.

Bokhari Habib
1*
,
Zafar Sadia
1

and Bilal Iram
1
.
2011
.
BORDETELLA AUTOTRANSPORTER
PROTEIN C IS AN ADHESION FACTOR FOR BORDETELLA PERTUSSIS.
(
Accept
ed
:

Jo
urnal
of
basic
Micro
biology

( IF= 1.
3
9
)

3.

H. Bokhari
,F. Said, M.A. Syed, A. Hussain, Y. F. Kazi,

K. Heuvelman A. king, He Q and F. R.
Mooi
.
2011
.
Whooping cough in Pakistan: Bordetella pertussis vs Bordetella

parapertussis in
2005


2009

(
Available onl
ine
:

Scandinavian journal of infectious diseases
( IF= 1.
72
)

4.

M. A. Syed
1*
, A. S. Bhatti
2
, R. Guduru
3
, C. Z. Li
3

and
S. H. A. Bokhari

.
2011
.
Use of SPR
biosensor for the study of proteolytic action of a serine protease enzyme

(
Accepted
: American
Journal of

Biomedical Sciences)

5.

H. Bokhari
, H. Bilal, M. Anwer & Patrick Gillevet.
2011
.
Evidences of lateral gene transfer
between Archaea and pathogenic bacterial genomes
(Bioinformation
,
6(8): 293
-
296
); ( IF= 1.43)

6.

Asif Raza, Hira Shareef, Hira Salim, Rashid Khus
hal,
Habib Bokhari
&

2011
.
Selection of
predicted siRNA as potential antiviral therapeutic agent against influenza virus
(
Bioinformation
, 6(9): 340
-
343
; ( IF= 1.43)

7.

Sadia Zafar, Arshan Nasir,
Habib Bokhari
.
2011
.
Computational analysis reveals abundance of

potential glycoproteins in Archaea, Bacteria and Eukarya
.

Bioinformation
,
6(9): 352
-
355
; ( IF=
1.43)


INDIA

8.

Mojtaba Noofeli,
Habib Bokhari
, Paul Blackburn, Mark Roberts, John Coote & Roger Parton.
2011
.
BapC autotransporter protein is a virulence deter
minant of Bordetella pertussis
.

M
icrobial Pathogenesis:
51(3):169
-
77.

(
IF= 2.34)

9.

Syed Tabish, Abbas Raza, Arshan Nasir
,
Sadia Zafar

and
Habib Bokhari
.
2011
.
Analysis of
glycosylation patterns and glycosyltransferases in Bacteria and Archaea (
Bioinformati
on,
6(5):
191
-
195
; (
IF= 1.43)

10.

Idrees, M., Mussarat, U., Badshah, Y.,

Qadir, M

and
Bokhari, H
*
.

2011
. Prevalence of
antimicrobial resistance and integrons in uropathogenic Escherichia coli, from Punjab,
Pakistan : Brazilian Journal of Microbiology
42: 462
-
466

( IF= 0.62)

11.

Maleeha Azam
,

Rob W.J.Collin,Ayesha Malik
,

Muhammad I. Khan, Syed Tahir A. Shah
1

Aftab A.
Shah,

Alamdar Hussain, Ahmed Sadeque,

Kentar Arimadyo Muhammad Ajmal
,

Ayesha Azam
Nadeem Qureshi
,

Habib Bokhari
, Tim M. Strom, Frans P. M. Cremers
,

Ra
heel Qamar
,

Anneke I.
den Hollander.

2011.
Identification of novel mutations in Pakistani families with autosomal
recessive retinitis pigmentosa (
In Press
/
Accepted
.
Archives of Ophthalmology (IF= 3.86)

12.

Syed M. A and
Bukhari S. H. A
*
. 2011
. Gold nanoparticl
e based microbial detection and
identification. J. Biomed. Nanotechnol.
Vol. 7, 1

9, 2011

(IF=
2
.6
26
)

13.

Muhammad Idrees
1
, Muhammad Ali Shah
1

Raheel Qamar
1

and
Habib Bokhari
1
*
.
2011
.
Antimicrobial Resistant Escherichia coli Strains Isolated from Food Animals i
n Pakistan.

Pakistan Journal of Zoology.
43(2), 303
-
310, (IF= 0.15)

14.

H. Bokhari
*
,

C. Smith, K. Veerendra, J. Sivaraman, M. Sikaroodi, P. Gillevet
.
2010
.

Novel
Fluorescent Proteins From Hydnophora Rigida Possess Cyano emission. Biochemical and
Biophysical R
esearch Communications 396(3):631
-
636.

(IF= 2.
59
)

15.

Amna Salman, Atefeh Taherian Fard Arshan Nasir &
Habib Bokhari. 2010.

Comparative
analysis of organophosphate degrading enzymes from diverse species.

Bioinformation 5(2): 67
-
72 ( IF= 1.43)

16.

Muhammad Ali Syed
, Umair Manzoor, Ismat Shah and
Habib Ali Bukhari
*
. 2010.
.
Antibacterial
effects of Tungsten nanoparticles on the Escherichia coli strains isolated from catheterized
urinary tract infection (UTI) cases and Staphylococcus aureus. New Microbiologica.,
33(4):
329
-
35.

( IF= 0.96)

17.

Idrees, M., Mussarat, U., M., Badshah, Y.,

Qamar, R.

and
Bokhari, H
*
.

2010
. Virulence factors
profile of drug resistant Escherichia coli isolated from urinary tract infections, in Punjab,
Pakistan (European Journal of Clinical Microbi
ology & Infectious Diseases,
29(12):1533
-
7.

IF=
2.65)

18.

Muhammad Ali Syed,
Syed Habib Ali Bukhari
*
.
2010
. Adult and adolescent pertussis should not
be underestimated!. Pak J Med Sci. Vol. 26 No. 1, 44
-
45. ( IF= 0.2)

19.

Taimoor Hashmi
1
, Shakil Khan
1
, Valeed
1
,
H
abib Bokhari
*1
2010
. In silico identification of
vaccine candidates against enteric pathogens by comparative genome sequence. (Asian Pacific
Journal of Molecular Biology and Biotechnology, 18(3): 327
-
331

20.

Hasan Bilal Mirza, Maryam Anwar &
Habib Bokhari
.
201
0
.
In silico
identification of potential horizontal gene transfer events between Archaea and
pathogenic Bacteria.

Journal of Bioinformatics and Sequence Analysis (JBSA
).
2(3), 36
-
41,
2010

21.

Muhammad

Ajmal, Waqas

Ahmed, Ahmed

Sadeque, Syeda

Hafiza

Benish

Ali,

Syed

Habib

Bokhari
, Nuzhat

Ahmed and Raheel

Qamar.
2010
.

Identification of
a recurrent
insertion mutation in the LDLR gene in a Pakistani family with autosomal dominant
hypercholesterolemia
.

Molecular
Biology Report
s
. 37(8); 3869
-
3875
.
(
IF= 2.038)

22.

Muhamma
d Ali Syed
1
, Shaista Babar
2
, A. S. Bhatti
2
, &
Habib A. Bokhari
*
.

2009
. Antibacterial
effects of silver nanoparticles on the bacterial strains isolated from catheterized urinary tract
infection cases. Journal of Biomedical Nanotechnology., 5: 209
-
214 ( IF=
2
.6
26
).

23.

Muhammad Ali Syed, Fahad Said,
S. Habib Ali Bukhari
*
.
2009
.
Seroepidemiology of Bordetella
pertussis infections in the twin cities of Pakistan
.

North Am J Med Sci. 1: 353
-
355.

24.

Atefeh Taherian Fard
&

1
, Amna Salman
1
, Bahram Kazemi
2

and
Habib Bokhar
*
.

2009
. In silico
comparative genome analysis of malaria parasite Plasmodium falciparum and Plasmodium vivax
chromosome 4. Parasitology Research., 104 (6): 1361 (IF= 1.
81
)

25.

Maleeha Azam1,2, Muhammad Imran Khan1, Alamdar Hussain1, Syed Tahir Abbas Shah1,
M
uhammad Shakil Khan1,3, Ahmed Sadeque1,
Habib Bokhari1
, Rob W.J. Collin2,4, Maria M.
van Genderen5, A.I. den Hollander2,4, Frans P. M. Cremers2,4, Raheel Qamar1, 3.
2009
.

A
homozygous p.Glu150Lys mutation in the opsin gene of two

Pakistani families with
au
tosomal recessive retinitis pigmentosa
: Molecular Vision,

3;15:2526
-
34
.
( IF= 2.33).

26.

Siddiqa, A., Niazi, M., Mustafa, F.,
Bokhari, H
., Hussain, A., Akram, N., Shaheen, S., Ahmed, F.
and Iqbal, S.
2009
.


A new hybrid agent
-
based modeling & simulation decis
ion support system
for breast cancer data analysis. In: Proc Information and Communication Technologies, pp. 134
-
139.


ICICT '09 International Conference on Aug. 15
-
16.
(ISI
-
Indexed, Non
-
IF).

27.

S. HABIB BOKHARI
*

& P. BLACKBURN.
2008
. Purification and prote
ctive efficacy of re
-
natured C
-
terminal domain (P.30) of pertactin autotransporter protein of B. pertussis. Pak. J.
Bot., 40(2):825
-
832 ( IF= 0.
947
)

28.

S. HABIB BOKHARI
*

& P. BLACKBURN.
2008
. Pertactin processing and secretion in
protease(s) deficient strains

of Escherichia coli suggestive of the possible role of proteases in
folding of autotransporter proteins. Pak. J. Bot., 40(2):815
-
824( IF= 0.
947
)

29.

Shahid Mahmood Baig, Ayesha Azhar, Hammad Hassan, Jamshaid Mahmood Baig, Ayesha
Kiyani, Uzma Hameed, Fazli Ra
bbi,
Habib Bokhari
, Muhammad Aslam, Mohammad Amin Ud
Din, Shehla Anjum Baig, Khalid Hassan, Javed Anwar Qureshi and Tariq Zaman.
2006
.
Spectrum of beta
-
thalassemia mutations in various regions of Punjab and Islamabad, Pakistan:
establishment of prenatal di
agnosis. Haematologica/The hematology journal. 91(1), 3
-
5.
(IF=6.
532
)

30.

S. M. Baig, F. Rabbi, U. Hameed, J. A. Qureshi, Z. Mahmood,
S.H. Bokhari
, A. Kiani, H,
Hassan, J.M. Baig, A. Azhar, T. Zaman.
2005
.
Molecular characterization of mutations causing
β
-
thal
assemia in Faisalabad Pakistan using the amplification refractory mutation system (ARMS
-
PCR). Ind. J. Hum. Gen.11(2), 80
-
83
(Pubmed Indexed).



Manuscripts Submitted & in Preparation:


1

Syed M. A
.

and
Bukhari S. H. A.

2011
.
Serosurveillance of Pertussis to
xin IgG in infants and
children of the twin cities of Pakistan (Islamabad and Rawalpindi). (
Minor Revision
: J. col. Phy.
Surg). ( IF= 0.55)

2


3

Ashfaq Mahmood
1,
Muhammad Ismail, Muhammad Athar, Rashid Khushal,

Mehmood Qadir
2
,
Riaz Ahmed, Muhammad Idrees
1
, Muh
ammad Rauf,
Habib Bokhari
1
*

.Antimicrobial efficacy of
metal
-
barbiturate conjugates against pathogenic strains of Escherichia coli and Staphylococcus
aureus.
(
Revision

Submitted
:
Letters in Drug Design & Discovery
); (IF=0.805).

4

Bokhari H
, Shah MA, Asad S,
Fariha S and Wren BW. Analysis of Diarrheagenic Escherichia
coli and V. cholerae subsequent to the 2010 Floods in Pakistan.
(
Submitted

FEMS Microbiology
Ecology

(
IF=
3
.
9
)

5

Sadaf Afzal, Shams ul Islam, Bilal Ghori, M. Saleet Jafri,
Habib Bokhari
*. Mathematic
al model
for disinfection of drinking water from Local pathotypes of Escherichia coli (
Submitted

International journal of Biomathematics
(IF= 1.61)

6

Mughal. A. A, Kazi Y., Bokhari S. H. and Syed M. A. Pertussis resurgence in Khairpur Pakistan
among vaccinat
ed children. (
Submitted
: J. Public Health). (IF= 1.23)

7

Muhammad Ali Syed
1
, Fahad Said
1
, Amjad Mughal
2
, Yasmeen Kazi
2

and Habib Bokhari
1
*
.
Analysis of Quinolone and Sulfonamide resistance in Bordetella parapertussis isolates in
Pakistan

(
Submitted
: J. Medi
cal Microbiology.) (IF= 2.65)

8

Pervez S., Syed M. A
,

Azam A., Nawaz E., Akhter S.,
Bukhari S. H. A

and Ali Q. Isolation and
characterization of Mycobacterium tuberculosis and Mycobacterium bovis in clinical isolates
from patients of pulmonary tuberculosis i
n Rawalpindi and Islamabad. (
Submitted
: Pakistan
Journal of Zoology);
(IF= 0.15)

9

A. Rauf
1*

H. McNab
2
H. Bokahari

& A. M. Qureshi
3
. SYNTHESIS AND UREASE INHIBITION
OF N
-
ARYL SUBSTITUTED 3
-
AMINOMETHYLENECHROMAN
-
2,4
-
DIONES AND THIER
ANTI
-
INFLAMMATORY BURST AC
TIVITY STUDIES ON HUMAN RESPIRATORY
NEUTROPHILS

(
Submitted:

Journal of Medicinal Chemistry)
;
(

IF=
1
.
03
)

10

Sadia Zafar, Syed Tarique Moin, Zaheer Ul
-
Haq &
Habib Bok
h
a
ri.

In silico template
-
based
structural modeling and molecular dynamics simulation of two bact
erial Oligosaccharyl
Transferases (
Submitted:

Molecular graphics and
M
odeling);
(IF=2.033)

11

Fariha S,.
Saba A,
Akram

M
, Naila Batool, Mehwish I
, Shah MA, Wren BW
&
Bokhari H
.

Analysis of Diarrhea associated
Escherichia coli

pathotypes following the 2010 Flood
s in
Pakistan

(
Submitted
:
European Journal of Clinical Microbiology & Infectious Diseases, (
IF=
2.65)

12

Habib Bokhari
, Rebecca Langdon, Dennis Linton and Brendan Wren. Oligosaccharyly
transferase PglB of Campylobacter jejuni is a glycoprotein. (In preparatio
n)

13

Ahmed F, Iqbal S, Shaheen S, Siddiqa A, Akram N, Shan M.K.N, Niazi M, Mustafa F and
Bokhari H.

Epidemiological Study of Breast Cancer in Pakistan (In preparation)

14

Bokhari H*, Akram M, Ehsan S, Ali S

Detection of non
-
tuberculous mycobacteria and members
of mycobacterium tuberculosis complex by culture and molecular methods (In preparation).

15

Bibi.Z ,Hayat.R and
Bokhari. H
. EpiCIIT’
-

a customized tool for visualization and analysis of
Epidemio
l
ogical data.
methods (In preparation).

16

Saba A, Shah MA, Wren BW
&
Bokhari H.

Antibiotic resistance profile and detection of
qnr
genes among Diarrheogenic Bacterial Pathogens in Pakistan
.
(In preparation)


17

Habib Bo
kh
a
r
i

,
Mojtaba Noofeli

,
Blac
k
bu
r
n

P
.
Cloning, expression and purification of
Bap
-
C antigen of Bordetella
pertussis in E. coli and its characterization
(In preparation)

18

Muhammad Idrees and

Habib Bokhari.
Methyl parathion degrading bacteria isolated from
agricultural areas of Pakistan
(In preparation)

19

Saba Asad

1
,
Madeeha Hussain
1
,
Ayesha Siddequa
1
,
Habib Bokha
ri
1
§.
In silico approaches for the
identification & differentiation of Mycobacterium
s
pecies
(In preparation)

20

Muhammad Idrees, Muhammad Akram, Muhammad Ajmal, Raheel Qamar and
Habib
Bokhari
. Paraoxonase
-
1 contribution to familial hypercholesterolemia in Pa
kistani
families

(In preparation)
.







Papers & Posters Presented and Published at Refereed International Conferences:


Bokhari, S
.
H.
, Blackburn, P., Coote, J., Roberts, M. and Parton, R.
2006
.

BapC, a newly
identified member of the Bordetella Pertussis

autotransporter family & its pathogenic
potential.

Proceedings of Fifth International Biennial Conference of Pakistan Society for
Microbiology, “Molecular Mechanism of Host
-
Pathogen Interactions”. Karachi, Pakistan


Bokhari, S
.
H.
, Blackburn, P., Coote,
J., Roberts, M. and Parton, R.
2003.

The role of
Bordetella pertussis
Bap
-
5 protein in serum resistance and colonization in vitro and in vivo.

First international and national symposium on Biotechnology. Jamshoro, Pakistan.


Bokhari, S
.
H
., Blackburn, P.
, Coote, J., Roberts, M. and Parton, R.
2002
. Bap
-
5, a newly
identified member of the Bordetella Pertussis autotransporter family. Poster 11.

American
Society for Microbiology, Seventh International Symposium on Pertussis.

Hinxton, United
Kingdom.


Baig,

S. M., Zaman, T., Hameed, A., Rabbi, F.,

Bukhari, S.H.
et al.
2004
.

Molecular
characterization of mutations causing β
-
thalassemia i
n Pakistan using amplification
refractory mutation system (ARMS) and allele specific oligon
ucleotide (ASO) hybridization.
HG
VS Scientific and Annual General Meeting.

Toronto, Canada.


Habib & Bokhari
; Raheel Qamar, Muhammad

Idrees, Yasmin Badshah & Uzma
Mussarat
.

2007
.

The prevalence of integrons among Escherichia coli isolated from different sources in
Pakistan and associated

drug resistance patterns.
II International
onference on
Environmental, Industrial and Applied Microbiology
;

November

1 December
, Seville, Spain


Habib & Bokhari
; Umair Manzoor, Muhammad Ali, Asad Razzaq & Ismat Shah
.

2007
.

Antibacterial effect of Tungsten

nanoparticles on the

E. coli strains isolated from
catheterized
urinary tract infection (UTI) cases and Staphylococcus aureus
.
II International
Conference
on Environmental, Industrial and Applied Microbiology
.
November

1
December, Seville,
Spain




Press,

Papers & Posters Presented and Published at National Conferences:



Bioinformatics: Science of Future. In Press (NEWS,
2003
).
S. Habib Bokhari
, CIIT,

Islamabad



Baig, S.M.,
Bukhari, S.H.,

Shah, W.A., Arshad, M., Shamsi, T.S. and Qureshi, J.A.
1997
.

-

Thalassemia mutations in Pakistan: A strategy for prenatal diagnosis. First

National

Symposium on Biotechnology for Sustainable

Development. 24
-
27, November, Lahore,

Pakistan.



Baig, S.M.,
Bukhari, S.H.,

Shah, W.A., Arshad, M., Shamsi, T.S. and Quresh
i, J.A.
1997
.

Characterization of mutations causing

-
Thalassemia in Pakistan. 21
st


National conference of

Pakistan Association of Pathologists, 14
-
16, November,

Faisalabad, Pakistan.



Baig, S. M.,
Bukhari, S.H
., Shah, W. A., Khattak, K.F., Ahmad, M.,

Asghar, M.S. and Qureshi,

J.A. Detection of HCV by RT
-
PCR and genotyping by dot
-
blot

hybridization in Pakistani

patients with chronic hepatitis C and hepatocellular

carcinoma. Third Shaukat Khanum

Memorial Cancer Symposium, 22
-
24,

February, Lahore,
Pakistan.



Baig, S.M.,

Bukhari, S.H.,

Shah, W.A., Khattak, K.F. and Qureshi, J.A.
1996
. Determination of

the spectrum of

-
Thalassemia genes in Pakistan by use of amplification refractory mutation

system (ARMS) and radiolabelled allele specific oligonuc
leotide (ASO) hybridization. Inaugural

International Conference on

Genetics, 26
-
28, November, Islamabad, Pakistan.



Baig, S.M.,
Bukhari, S.H.,

Shah, W.A. and Qureshi, J.A.
1996
. Spectrum of

-
Thalassemia

mutations in Pakistan. Third National Symposium
on Basic Health Care

and

Social

Development, 21
-
22, September, Karachi, Pakistan.



Muhammad Idrees, Raheel Qamar and
Habib Bokhar
.
2007
. Molecular

characterization and

comparison of drug resistance patterns among E. coli isolates

from

human subjects

with

UTI and food animals. Ist Symposium of Microbiology and

Molecular

Genetics on

Genomics, Proteomics, Metabolomcs: Recent trends in Biotechnology,

University of Punjab,

Lahore



Yasmin Badshah, Safia Khatoon, Raheel Qamar and
Habib Bokhari
.

2007
.

Prevalence of

virulence factors among extraintestinal clinical isolates of Escherichia coli obtained from

clinically diagnosed urinary tract infection patients. Ist Symposium of Microbiology and

Molecular Genetics on Genomics, Proteomics, Metabolomics:

Recent trends in Biotechnology,

University of Punjab, Lahore



Muhammad Ali Syed, Arshad Bhatti and
Habib Ali Bokhari.

2007
. Effects of silver

nanoparticles on the E. coli isolates from urinary tract infection cases. Ist Symposium of

Microbiology and M
olecular Genetics on Genomics, Proteomics, Metabolomics: Recent

trends

in Biotechnology, University of Punjab, Lahore



Hasan Bilal Mirza, Maryam Anwar and
S. Habib Bokhari
.
2007
. In silico identification

of

potential horizontal gene transfer events fr
om archaea to pathogenic bacteria. Ist


Symposium

of

Microbiology and Molecular Genetics on Genomics, Proteomics, Metabolomics:

Recent trends in

Biotechnology, University of Punjab, Lahore



Asif raza, Hira shareef, Hira salim and
Habib Bokhari
.

2007
. B
ioinformatics Approaches for

Devising Antiviral/Therapeutic Agent against Influenza. Ist Symposium of Microbiology and

Molecular Genetics on Genomics, Proteomics, Metabolomics: Recent trends in Biotechnology,

University of Punjab, Lahore



Muhammad Ali
Syed,
Umair Manzoor, Ismat Shah
a
nd
Habib Ali Bokhari
.

2008
.
Effect of Silver

and Tungston Nanoparticles on bacterial isilates from urinary tract infections and, International

thematic workshop on Nanomedicine: The use of nanoparticles in medical diagnos
tic
s’

Comstech
-
Islamabad.


Muhammad Ali Syed,
Umair Manzoor, Ismat Shah
a
nd
Habib Ali Bokhari
.

200
9.
Development of

SPR

based immunosensor for the detection of Staphylococcus aureus’ First

Conference

of

Microbiology at Shah Abdul Latif University Kha
irpur, Sindh
..


Antibacterial effects of silver nanoparticles on the bacterial strains isolated from

catheterized

urinary tract infection cases

200
9.

A
t First National Conference of Microbiology organized by

Shah Abdul Latif University,Khairpur.


(21/2
2.11.09:.
First prize for the poster
)







Book in preparation:


Huma Naveed, Sadia Zafar Habib Bokhari.
Protein Modeling & Docking of Oligosaccharyl
transferases

of
Campylobacteraceae
.




Additional Information:


Designed curriculum for Bioinformatics und
ergraduate degree program (CIIT) and started this

program at COMSATS in
2003


Included in Approved supervisors list of HEC


Included in the panel of Examiners & Paper setter at Punjab University Lahore


Associated with Intel and Ministry of Education as a
n assessor of student’s innovative


projects in the field of Biosciences


Contributed in preparing the PC
-
1 for Infrastructure development for teaching and

research in Bioinformatics at CIIT, Islamabad


Contributed in formulating the National Bioinform
atics Policy document


Resource Person at Workshop on “Bioinformatics for computer scientists” at COMSTECH

21
st
-
26
th

May,
2007


Resource Person at Workshop on “National Workshop on Techniques in Molecular

Biology, Bio
-
informatics & Vaccine Production” a
t CASVAB at University of Baluchistan,

Quetta
-
28
th
-
30
th

May,
2007


Resource Person at Workshop on “Use of Therapeutic agents and Diagnostic Kits” held at

Arid Agriculture University in
2005


Resource Person at
2
nd

International Symposium on “
Biomedical M
aterials:

Current Research and Future Signposting
2010


held at COMSATS, Lahore
.


Workshops & Meetings:


Attended SGM, UK meeting on “Glycoengineering” at H
e
rriot Watt University, Edinburgh,

September
200
9
.


Attended Qiagen’s Workshop on Molecular Biolo
gy Research, Edinburgh,
2001.


Attended International Workshop on Bioinformatics, Islamabad,
2003.


Attended International Workshop on Bioethics, Islamabad,
2004
.


Attended Workshop on Identification Maintenance & Preservation of Microorganism, Q.A.U,

Isl
amabad,
2004.




Ongoing Research Projects


Development of an integrated whole
-
cell based biosensors to detect bioavailable organophosphates from
environment: HEC: As PI, In collaboration with Dr. Patrick Gillevet,
GMU, USA
; Dr. Jayaraman
Sivaraman,
NUS, S
ingapore
. (HEC funded 3.9 Pak M. Rs.)


Epidemiological investigation of Pertussis infection in Pakistan by studying the distribution of

ptx, prn &
fim alleles (Pakistan Science Foundation): As PI, In collaboration with Prof. Dr. Frits. R. Mooi, Lab for
Vac
cine Preventable Diseases (LTR) RIVM, Bilthoven, Netherlands. (PSF funded
-

1.0 M. Rs.)


Development of an integrated system comprising of engineered bacteria based Biosensors for the
detection of bioavailble toxic metals from environment: HEC: As PI, In co
llaboration with Dr. Patrick
Gillevet, GMU, USA (HEC Funded: 1.6 M. Rs.)

Source Tracking and Surveillance System Of Bacterial Pathogens In Pakistan As PI, In collaboration
with Prof. Brendan Wren,
London School of Hygiene & Tropical Medicine
, Keppel Street
, London,
WCIE 7HT
(
British Council:

Pak
-
UK

linkage
:
Award

70,000
Pounds
),
Prof. Gadi Frankel,
Imperial
college London
, Prof. Gordon Dougan,
Sanger Centre


Projects Completed

Joint COMSATS Institute of Information Technology
-
George Mason University

Initia
tive in
Bioinformatics” (Completed: POCR, HEC).


Cloning of Fluorescent protein from Coral, initial spectroscopic Analysis/ characterization and
development of whole cell Biosensors (CIIT Project: Completed)


Distribution pattern of antimicrobial resistan
ce genes and virulence factors among isolates of E. coli
from clinically diagnosed urinary tract infection patients and molecular pathogenesis (CIIT Project:
Completed)

Other Research Interests

1.

Epidemiological investigation and molecular pathogenesis of co
mmonly occurring pathogens
such as Helicobacter pylori, Mycobacterium tuberculosis.

2.

Study of the molecular mechanisms of drug resistance in community and hospital acquired
infections

3.

Studying Host
-
Pathogen Interaction

4.

Vaccine development

5.

Microbial dive
rsity & metagenomic

6.

Detection and classification of pathogens using Microfluidics, waveguide and

SPR approaches

7.

The structural studies of fluorescent molecules HriGFP, HriCFP & PglB (Using SPR & AFM)

8.

Glycoengineering & Glycoproteins


Thesis Supervisions


B
S (Bioinformatics):



17

completed


BS (Bioinformatics):



0
2

under supervision


MS (Bioinformatics):



02 Submitted


MS (Microbiology/Immunology):

01 under supervision


MS (Microbiology/Immunology):

0
7

completed


MS (Microbiology/Immunology):

0
2

(Co
-
supe
rvisor: completed)


MS: (Mol.Gen.):



02(Co
-
supervisor: completed)


PhD: (Microbiology/Immunology):

01 (Submitted)


PhD: (Microbiology/Immunology):

04 (under supervision)


P
hD: (Microbiology/Immunology):

0
2

(Co
-
supervisor
:
under supervision)

BS Bioinformat
ics Projects Supervised


S. #

Student’s Name

Thesis title

Year

1

Hasan Bilal &
Maryam Anwer

IN SILICO IDENTIFICATION OF POTENTIAL HORIZONTAL GENE
TRANSFER EVENTS FROM ARCHAEA TO PATHOGENIC
BACTERIA

Fall
2007

2

Asif Raza, Hira
Shareef & Hira
Saleem

Bioinf
ormatics Approaches for Devising Antiviral/Therapeutic Agent
Against Influenza

Fall
2007

3

Hina Sajid Ali
Bangash & Sadia
Zafar

In silico Identification Of New Autotransporter Potential Vaccine
Candidates & Development Of Software Program For Their Predi
ction

Fall
2008

4

Hassan Khalid

Bacterial Surface Layer Homology Domain Analysis and Structure
Fall
Prediction of Bacillus sphaericus JG
-
A12 S
-
layer Protein

2008

5

Bibi Shazia Sabir


Structural Modeling of HriCFP and HriGFP from Coral reef and
developm
ent of tool for determining Fluorophore in protein sequence

Fall
2008

6

Rabia
Ali &
Sara
Mahmood


In silico
analysis of Autotransporter Proteins and Structure Prediction of
BapC


Fall
2008

7

Saba Asad,
Madiha and
Ayesha Saddiqua

Linking Mycobacterial Spe
cies with Functionality

Sp
2008

8

Taimoor
A.Hashmi,
Muhammad
Shakil Khan &
Waleed

In silico Identification of Vaccine Candidates Against Enteric Pathogens by
Comparative Genome Sequence Approach

Sp
2009

9

Syed Muhammad
Tabish

Analysis of Glycosyltransfe
rases and Patterns of Glycosylation in
Prokaryotic and Eukaryotic Models

Sp
2009

10

Fauzia Ahmed &
Sarah Iqbal

Epidemiological Study of Breast Cancer in Pakistan

Sp
2009

11

Sadia
Muazzam
,
Saniya Hafeez &
Faheema
Kalsoom

Epidemiological and Statistical A
nalysis of Colorectal Cancer in Pakistan

Fall
2009

12

Mehrosh
P
ervaiz
& Zainab

Asrar

Investigating Glycosylation and Phosphorylation Trends in Prokaryotic and
Eukaryotic Proteins

Fall
2009

13

Sadaf & Eesha
Najee
b

STATISTICAL AND MACHINE LEARNING TECHNIQ
UES FOR
ANALYSIS OF CLIMATIC FACTORS ON DIARRHEAL OUTBREAKS

Sp
2011

14

Huma Naveed &
Zumra Malik

Promoter Prediction, Protein Modeling & Docking of Oligosaccharyl
transferases in species of Campylobacteraceae

Sp
2011

15

Atif Noor & Syed
Aleem Haider

Data
base Development Of Human Oligosaccharyltransferase Variants &
Comparative SNP
Analysis

Fall
2011

16

Rizwan Hayat &
Zohra Bibi

EpiCIIT’
-

a customized tool for visualization and analysis of
Epidemiological data

Fall
2011

17

Anum Zeb
Abbasi &
Wajeeha Salee
m


Vibrio Cholera

Dynamics In Drinking Water: Mathematical & Statistical
Analysis

Fall
2011

M. Phil/MS Thesis Supervised
/Co
-
supervised (Microbiology/Immunology/Genetics)


S. #


Student’s Name

Thesis title


Year

1


Muhammad Idrees

Distribution of antimic
robial resistance patterns among
E.
coli

isolates from human subjects with UTI and food
animals


2007

2


Uzma Mussarat

Molecular Epidemiological Studies Of
E. coli

In Urinary Tract
Infections & Antimicrobial Resistance Among Isolates In
Pakistan


2007

3


Yasmeen Badshah

Prevalence of Virulence Factors Among Extraintestinal Clinical
Isolates of Escherichia coli Obtained From Clinically Diagnosed
Urinary Tract Infection Patients & Molecular Pathogenesis


2007

4


Fahad Said

Differences of circulating
Bordet
ella pertussis

population

2009



in Pakistan

5


Syed Mehmood Qadir

Development of an integrated Green Fluorescent Protein
Based Assay for Diverse High Throughput Screening
(HTS) Applications


2009

6


Saba Asad

Surveillance Of Diarrheogenic Bacterial Patho
gens in
Pakistan by PCR/restriction fragment length
polymorphism (RFLP) and amplified fragment length
polymorphism



2010

7


Abrar Wali

Molecular Characterization of
Campylobacter jejuni

Strains Isolated from Patients with Gastroenteritis and
Guillain Bar
re Syndrome



2010

8


Muhammad Imran (Co
-
Supervised)


Candidate Gene Analysis of Retinitis Pigmentosa


2007

9


Ayesha Malik (Co
-
Supervised)


“Exclusion Analysis of Retinitis Pigmentosa Gene”


2007

10


Sara Riaz

(Co
-
Supervised)


“Synthesis of Novel Photo
chemical Precursors and Biological
Studies of Metal Barbiturates”


2009







11


Muhammad Javed (Co
-
Supervised)

Studies of Antibiotic Resistance Patterns & Genetic Diversity in
Campylobacter population isolated from broiler chicken


2010

12


Sania Akht
ar
(Co
-
Supervised)


Molecular Analysis of Bacterial Pathogens Associated with
Diarrhea Outbreaks in Pakistan



2010



M. Phil/MS Thesis Supervised

(Bioinformatics)



S. #


Student’s Name

Thesis title


Year

1


Sadia Zafar (MS
Bioinformatics)

Modeling and
Simulation of
Wolinella succinogenes’s
Oligosaccharyl Transferase
and Development of
Computational Program for Statistical Analysis of Proteomes
at ExPASy’s Databases



2011

2


Sadaf Afzal (MS
Bioinformatics)

Mathematical Model for sterilization of drinki
ng water from
Diarrheaogenic Bacteria


2011


PhD
Thesis Supervised
/Under Supervision


S. #


Student’s Name

Thesis title


Year

1


Muhammad Ali Syed

“Efficacy of DTP vaccine in Local Population and Development of
Rapid Diagnostic Techniques for Microbes”



(Submitted in
March 2011)

2


Muhammad Idrees (4
th

Year)

Development of a Biosensor for Methyl parathion Detection And
Genetic Risk Assessment of Exposed Population



Under
Supervision

3


Muhammad Ali Shah

(4
th

Year)

Molecular epidemiological study

of

the
E. coli

and
Vibrio cholerae
strains isolated from different hospitals of Pakistan.



Under
Supervision

4


Fariha Siddique (2
nd

year)

Characterization of
Campylobacter jejuni
strains isolated from
diarrheal patients and environmental sources.



Under

Supervision

5


Naila Batool (2
nd

year)

Characterization of
Enteropathogenic, Enterotoxigenic &
Enter
o
aggregative
Escherichia coli

from
diarrheal patients and
environmental sources.



Under
Supervision



M. Phil/MS Thesis
Under Supervision


S. #


Stu
dent’s Name

Thesis title


Year

1


Ayesha Khan

Phylotypin
g and Clonal group gA screening of
Escherichia coli

isolates
from Pakistan


Under
Supervision



Editor

Journal of Integrative Computational Biosciences

Advances in Infectious Diseases


Internationa
l collaboration
s


1.

Prof. Dr. Frits. R. Mooi, Lab for Vaccine Preventable Diseases (LTR) RIVM, Bilthoven,
Netherlands

2.

Prof. Qiushui He, Pertussis Reference Laboratory, Department of Infectious Disease
Surveillance & Control, National Institute for Health and

Welfare, Turku, Finland

3.

Prof. Brendan Wren, London School of Hygiene & Tropical Medicine, Keppel Street,
London, WCIE 7HT

Prof. Gadi Frankel, Imperial college London

4.

Prof. Gordon Dougan, Sanger Centre

5.

Prof. Lee Department of Biomedical Engineering Florid
a International University

6.

Prof. Saleet Jafri, Head Computational biology, GMU, USA.

7.

Dr. Patrick Gillevet, Environmental Biocomplexities, GMU, USA.

8.

Dr. Jayaraman Sivaraman, Biochemistry, NUS, Singapore.


References:



Dr. Shazad A. Mufti


Advisor,


Biosci
ences, CIIT.

E. mail:
mufti@comsats.edu.pk









Dr. Roger Parton

Senior Lecturer, Division of Infection and
Immunity, Institute of Biomedical and Life
Sciences, Joseph Black Building, G12 8QQ,
University of Glasgow, Glasgow, U.K.

E. mail: r.parton @bio.gla.ac.uk


Dr. Patrick Martin Gillevet

Associate Professor,

Environ
mental Biocomplexity & Policy,

Manassas, George Mason University,

Virginia, U.S.A.

E. mail: gillevet@ib3.gmu.edu