Potentials in Biotechnology Sector in the Czech Republic - Norbiobase

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portunities
Potentials in Biotechnology Sector (Health care) in the Czech Republic












Potentials in Biotechnology Sector
in the Czech Republic
























February – June 2009


This document has been prepared by Daniela Vesela, Innovation Norway’s Prague office
Tel: + 420 224 810 001, GSM +420 603 820 885
Fax: + 420 224 810 002
daniela.vesela@innovationnorway.no



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1

Introduction........................................................................................................3

2

Market characteristics and potential....................................................................4

2.1

The pharmaceutical industry in the Czech Republic is one of the most developed of
the CEE countries......................................................................................................4

2.2

High standard in life-sciences related academic and institutional framework............4

2.2.1

Academy of Sciences of the Czech Republic.....................................................5

2.2.2

Largest universities (inclusive life sciences-related education and related research
activities)..............................................................................................................7

2.2.3

Biotechnology clusters..................................................................................8

2.2.4

New Centres of Excellence in the development.................................................9

2.2.5

Infrastructure and support services, technology parks, incubators......................10

2.3

Governmental policy and EU financial support....................................................12

2.4

Growing number of biotechnology companies, start-up and spin-off SMEs..............13

3

Biotech services - Contract opportunities – CROs – Clinical tests of medicals.....17

4

Sources of information, useful contacts.............................................................18

5

Lists of companies, associations and cluster´s members...................................19

5.1

ACRO, Association of Contract Research Organisations........................................19

5.2

Czech Association of Pharmaceutical companies..................................................20

5.3

Association of OTC drugs producers..................................................................20

5.4

Association of Innovative Pharmaceutical Industry..............................................21

5.5

Major Pharmaceutical producers in CR...............................................................22

5.6

Nanonomedic cluster......................................................................................22

5.7

CzechBio Association/cluster............................................................................23

5.8

CEITEC cluster – bioinformatics........................................................................24

5.9

Biotech bodies, database of Czechinvest............................................................25



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1 Introduction

The sector of life sciences as a whole is developing rapidly in the Czech Republic, mainly thanks
to a strong research base, favorable business environment, support from the government and
the EU.

Biotechnologies in general have a long tradition in the country. After a certain decline in the
1970s and 1980s caused by partial isolation from the international community, the modern
biotechnology research in the Czech Republic is again coming to the forefront. In the past ten
years, several notable teams have been established which, in cooperation with the industry
play an important role in the knowledge economy of the country and create a favorable
environment for innovations in the future.

The development of human and veterinary pharmaceuticals, diagnostics, fermentation
technologies, use of biotechnologies in waste handling, environment protection, and animal and
plant biotechnologies are currently the areas in which Czech biotechnology entities most
intensively operate.
Progress in modern biotechnologies is now primarily based on knowledge gained from
research in molecular biology and genetics, the two areas in which the country is strong.

The tradition of biotechnology expertise and life-sciences infrastructure, combined with
progressive patent protection and economic incentives have attracted investment from many
American, Asian and European countries. Some of them have launched manufacturing facilities;
others see the country as an opportunity for contract R&D and manufacturing for which the
conditions are definitely favorable.

Nearly two-thirds of enterprises in the Czech biotechnology sector are companies with up to 20
employees, which is comparable with similar firms in other developed countries.

The regulatory and patent environment has been harmonized with the EU.

The summary of the market information thereinafter provides a brief characteristics of the
sector and the market environment, as well as the conditions for further development in the
Czech Republic, outlines governmental incentives, and some of the most promising areas and
fields.
Lists of the potential partners either for research co-operations, contractual research, testing or
production are also included.




This information is mainly based on the readily available information and studies performed by
the Technology Centre of the Academy of Sciences, Czechinvest, South Moravian Innovation
centre, Technology Centre of the Academy of Sciences, and materials from the respective
associations and bodies.


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2 Market characteristics and potential
2.1 The pharmaceutical industry in the Czech Republic is one of the
most developed of the CEE countries


The Czech market for pharmaceuticals was the third largest in the region in 2009, its size is
estimated to US$4,234 million, and yearly growth is estimated to about 9.6% in the course
of next 5 years.


Long tradition in drug production, strong industrial branch, however with a high proportion
of production of generics.
The largest companies in this field comprise e.g. Zentiva (Sanofi-Aventis/Zentiva B.V.),
Farmak, Medicamenta (Glenmark Pharmaceuticals), IVAX CR (TEVA), Pliva Lachema, Spofa
ICN CR, Lonza Biotec, Tamda, Interpharma, Walmark.


There are about 45 organizations with 20 and more employees, their revenues totaled ca
EUR 1 bill last year.

Pharma industry export reached EUR 812 mill., import EUR 21,2 bill. in 2007.


There are many companies that specialize in API (Active pharmaceutical ingredient)
sourcing and contract manufacturing. There are also many companies focusing on the
manufacture of dietary supplements under contract.

2.2 High standard in life-sciences related academic and institutional
framework


Human capital - an extensive network of universities offering life sciences education
programmes, with close to 56000 students, 7400 graduates (2008/2009) in the Czech
Republic.


There are about 300 biotechnology research institutes or workplaces, in that e.g. about 90
research institutes active in the field of development of human/veterinary diagnostic,
therapeutic systems, 121 research entities in the microbial and cell biotechnology,
clearly the dominant region in all R&D activities is Prague, Brno/South Moravia, followed by
Ceske Budejovice/South Bohemia.


The important centres of biotechnology, molecular biology and pharmaceutical R&D are
located in several large cities with the Academy of Science´ institutes, universities and
other R&D entities (Prague, Brno, Olomouc, Hradec Kralove, Opava, Ceske Budejovice).



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The most important bodies include:

2.2.1 Academy of Sciences of the Czech Republic
www.cas.cz


A complete overview of the Academy of Science’s institutes
http://www.cas.cz/en/institutes.php
)


Some of the Academy facilities which achieved highly recognized results:

Institute of Biotechnology of Academy of Sciences (IBT)
Established January 1,2008 in Prague
www.ibt.cas.cz

The Institute focuses on the diagnostics for reproductive medicine, diagnostics of
autoimmune diseases, molecular therapy focusing on design and development of novel
anti-cancer agents, recombinant ligand engineering, gene expression, molecular
pathogenetics.

A particularly strong vocation of the new institute is to serve as knowledge base for the
biotech industry in the Czech Republic, where IBT has catalyzed the establishment of a
Czech Biotech Cluster centered around the biotechnology companies already having
their production sites at Vestec near Prague.

The primary ambition is to develop cutting-edge basic and oriented research on topics
opening for diagnostic and therapeutic applications in human medicine. In particular,
the institute was established to serve as a nucleation centre of BIOCEV, the planned
large Biotech&Biomed Research Centre of the Academy of Sciences and Charles
University, to be in operation by 2012 in Vestec near Prague.

Institute of Molecular Genetics
www.img.cas.cz

The Institute carries out basic research in molecular biology and genetics oriented on
microbial and mammalian genomics, oncogenes and retroviruses, mechanisms and
regulation of gene expression, structure and topology of cells, cell signaling,
mechanisms of fertilization, molecular immunology, and, most recently, molecular
developmental biology.
The Institute provides inbred and congenic mouse strains and chicken lines and also
monoclonal antibodies, prepared in its production unit.


Institute of Organic Chemistry and Biochemistry
www.uochb.cz

Medical chemistry has recently become one of the most successful scientific disciplines
in the Czech Republic. Credit for this belongs especially to Professor Antonín Holý of the
Institute of Chemistry and Biochemistry, Academy of Sciences Czech Republic.
Together with his colleagues, Professor Holý developed a range of substances that had
been developed into effective drugs for treating AIDS, hepatitis and other infectious
diseases (production by Gilead Sciences).


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Institute of Physiology
www.biomed.cas.cz

The Institute deals with scientific research of physiological and pathophysiological
processes in animals and/or humans, especially in the field of neurophysiology,
cardiovascular physiology and studies of molecular and cell mechanisms of physiological
functions.

Institute of Experimental Medicine
www.iem.cas.cz

The leading institution in the Czech Republic for biomedical research, particularly in cell
biology and pathology, neurobiology, neurophysiology, neuropathology, developmental
toxicology and teratology, molecular pharmacology, immunopharmacology, molecular
embryology, stem cells and nervous tissue regeneration. The Institute is an
internationally recognized centre in these fields, and as such it was selected as an EU
Centre of Excellence (MEDIPRA).

Institute of Experimental Botany
www.ueb.cas.cz

The Institute primarily conducts basic research in plant biology, namely in plant
genetics, physiology and biotechnology, however is also involved in applied research.
Studies of plant hormones resulted in the synthesis of compounds which delay skin
aging or show promising cytostatic effects.
Biotechnological topics include design and preparation of edible vaccines from plants
and mechanisms of phytoremediation.


A complete overview of the Academy of Science’s institutes
see http://www.cas.cz/en/institutes.php
)


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2.2.2 Largest universities (inclusive life sciences-related education and related
research activities)

Charles University in Prague www.cuni.cz

Czech University of Agriculture in Prague www.czu.cz

Institute of Chemical Technology Prague www.vscht.cz

University of South Bohemia in Ceske Budejovice www.jcu.cz

Palacky University Olomouc www.upol.cz

Masaryk university in Brno www.muni.cz

University of Veterinary and Pharmaceutical Sciences Brno www.vfu.cz

Mendel University of Agriculture and Forestry in Brno www.mendelu.cz


There is a frequent intensive cooperation between the universities and the Academy of
Sciences research institutes.
One of the most renowned ones:
Centre of Cellular Therapy and Tissue Replacements
(joint project of the Charles University, Faculty of Medicine and Academy of Sciences)
www.lf2.cuni.cz/info2lf/ustavy/cbt/eng/




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2.2.3 Biotechnology clusters
Active support of cluster initiatives has existed in the Czech Republic for several years
already.
In 2004-2006, the EU Operational Programme Industry and Enterprise Clusters
Programme was in operation with the aim to create and further strengthen the links
between the business, industry and science-and-research spheres.
In the EU Structural Fund programming period 2007-2013, the similar Cooperation
Programme further develops the Clusters Programme. This time, however, support is
expanded to more activities from the regional to the international level. Clusters, poles
of excellence and technology platforms will be supported, both in the phase of seeking
out firms for inclusion in groupings as well as in the establishment and development
phase.
This programme is open to SMEs as well as large firms, universities, science-and-
research institutes and regional administrative bodies.
The success of all supported activities is demonstrated by the fact that there is so far 25
new clusters in the Czech Republic, and a range of other projects are passing through
the mapping phase.

Clusters directly related to biotech sector:


CEITEC Cluster – Bioinformatics (Brno, South Moravia)
www.ceitec-cluster.cz

A platform fostering the development of bioinformatics and supporting cooperation
between the research and commercial spheres in this area, main activities are in the
fields of marketing, human resources, consultancy and knowledge transfer.
The cluster currently associates 15 entities.


Nanomedic, medicine-pharmaceutic cluster (Dolni Dobrouč, Eastern
Bohemia)
www.nanomedic.cz

Cluster associates ca 20 members, mainly SMEs, universities and research bodies
focusing on R&D in the area of nanomaterials and biotechnology, and production of
high-tech products for selected medical applications, e.g. microfibres, preparations
for wound-healing and tissue engineering, development of media for targeted drug
distribution, development of gene-therapy preparations.
The cluster came to the being by the initiative of the Contipro Group located in the
same area www.contipro-group.cz
(see chapter 2.4.)


Biotech Complex (Vestec near Prague)
www.exbio.cz
www.vidia.cz
www.top-bio.cz
www.proteix.cz
www.apronex.cz

Cooperation of five start-ups with the Institute of Molecular Genetics of the Academy
of Science


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CzechBio – association/cluster of biotechnological corporations of the
Czech Republic
www.czechbio.org

A rapidly growing association/cluster of companies, renowned research institutions,
and universities operating in the Czech Republic.
New cluster was established by the initiative of the Institute of Biotechnology of
Academy of Sciences in December 2008, currently has about 30 active members.
Ambitious goal is to develop the National centre for Biotechnology Production, to
perform the certification.


MedChemBio cluster (Science&Technology park in Olomouc)
www.medchembio.cz

New cluster established in May 2009
The cluster members concentrate on the research in the area of drugs for treating
cancer and infectious diseases.
The grouping, which is the only one of its kind in the Czech Republic, plans to
support the area of medical and biological chemistry and to associate all entities
with interests in these fields.
MedChemBio assists start-up firms in the successful development of active
ingredients and will enable the transfer of research findings into production. Within
the framework of the cluster, a laboratory will be established for testing the
effectiveness and safety of newly developed substances.
The MedChemBio cluster is headquartered at the Science and Technology Park of
Palacký University in Olomouc.

2.2.4 New Centres of Excellence in the development


The ongoing intensive cooperation between the Mayo Clinic USA and the
International Clinical Research Centre in Brno, Brno university of Technology
Academy of Sciences, Masaryk university, and other partners has resulted in an
ambitious project of
International Clinical Research Centre (ICRC)
www.icrcbrno.org
www.fnusa.cz/icrc.php

One of the EU most important initiatives in the area of biotechnology and
medical research.
The Centre shall focus on medical research and education, in oncology,
cardiovascular diseases, neurology, it will offer advanced clinical research facilities,
cardiovascular clinical centre, international educational centre and technology
cluster.
The ICRC shall be open in 2012.


BIOCEV Biotechnology and Biomedical Research Centre of the Academy of
Sciences (Prague) and Charles University
International centre for advanced biotechnology and medical research shall be open
in 2012 (see Academy of Sciences, Institute of biotechnology - information above)
www.ibt.cas.cz
www.lf1.cunic.z



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The Centre will concentrate top-quality infrastructure for the selected areas of
research.


CEITEC – Central European Institute of Technology
www.ceitec.eu

The CEITEC project is a unique trans-regional project being prepared at Brno area,
financed by EU funds. The project is a common idea of Brno’s universities, Academy
of Science’s Institutes and the departmental research institutes in Brno.

The project objective is to achieve the top level research and involvement primarily
in the area of biotechnologies and advanced materials and technologies in the
European Research Area and in global cooperation in research and development in a
short time. The Centre of excellence should establish conditions for effective
cooperation with business.

The centre shall be in full operation by 2015.

2.2.5 Infrastructure and support services, technology parks, incubators


Centre of Biological Technologies (Nove Hrady, South Bohemia)
www.greentech.cz/cbt

The Science and Technological Park facility includes laboratories, an incubator
(currently 6 companies) and a biotechnology hall. Services offered include
consultancy and co-financing, project management support, education focused on
development and innovative business, etc.


Initiative of university in Hradec Kralove:
Science and research potential in the fields of medicine and pharmacy
information portal
http://www.uli.lf2.cuni.cz/jitka/cd/




Innovation Biomedical Centre (IBC) of the Institute of Experimental
Medicine Academy of Sciences (in Prague)
www.bioinova.cz

- Centre of Support for Competitiveness in Biomedicine provides offices for training,
consultation and legal support in biomedicine.
- Centre of Applied Research in Biomedicine offers laboratories for applied research
and scale-up technologies, focused on regenerative medicine, cell therapy, the
development of biomaterials and pharmaceuticals as well as the design of clinical
studies.
- Business Incubator (office area, GMP-certified clean rooms) for spin-off companies.
The companies housed in the incubator benefit from shared consultation, patent, tax
and other services and take advantage of opportunities to participate in applied
research projects run in the IBC facility.
Currently there are 6 companies in the incubator (e.g. Tataa Molecular Diagnostics -
diagnostics detection and analysis of circulating tumor cells in blood of breast cancer
patients, Chondros - biomedicine healing methods)


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South Moravian Innovation Centre (JIC), Gate2Biotech portal, INBIT
biotechnology incubator
www.jic.cz

The aim of the South Moravian Innovation Centre (Jihomoravské inovační centrum,
JIC) is to create complex infrastructure for support of innovative entrepreneurship in
the South Moravian region and to become the main provider of support for
start-up innovative companies in Europe.
JIC was founded in 2003, founders are the South Moravian regional authority,
Statutory City of Brno, Masaryk university, Brno University of Technology (BUT), the
Mendel University of Agriculture and Forestry and Veterinary and Pharmaceutical
University in Brno.
JIC was a participant of the NetBioClue – Networking Activity for Biotechnology
Clusters in Europe in the frame of the 6
th
EU Framework Programme.

Incubators:
Technology incubator BUT
INBIT – see bellow
Biotechnology incubator INBIT
New incubator opened in October 2008
The building that is situated in the new campus of Masaryk University in Brno will
gradually offer services to 37 starting business firms. The area of 2957 square
meters contains labs, offices, meeting halls, kitchens and necessary technical
support and infrastructure.

Information portal www.gate2biotech.cz

The JIC operates web portal which is an important source of information concerning
biotech activities in the Czech republic

Gate2Biotech is divided into sections dedicated to:
Biotechnology companies based in the Czech Republic
Biotechnology research institutes and projects based / undertaken in the Czech
Republic
Potential founders or existing owners of biotechnology companies
Potential investors into Czech biotechnology
Education, training, development and recruitment of biotech human resources
Biotechnology current affairs (with emphasis on the Czech biotech)



Technology Centre of the Academy of Science of the Czech Republic
www.tc.cz

Information support on the EU Framework Programmes
(7FP www.fp7.cz
priority Agri, Food, Biotechnology, and priority Health),
technological support incl. technology transfer and consultancy services.
Commercialization support of publicly funded R&D and development of SMEs in the
life-science sector by providing comprehensive business services in a technology
incubator and innovation centre.


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2.3 Governmental policy and EU financial support

In 2005 the Czech Government Council for Science and Technology approved a rule which
ranks biotechnology and pharmacy among priority branches of basic research and thus
increased their funding from the state budget (through various Research and Development
Programmes/Grant Agency, Ministry of Youth and Education, Ministry of Trade and Industry)

Stabile GDP growth over the past decade (until the financial crisis outbreak in mid 2008) has
enabled increased spending on R&D, however, 0,6% of GDP/year spent on this area is lower
compared to EU15 average of 0,8%.

The Czech Republic offers financial support for life sciences sector by using an appropriate
programme based on the EU structural funds.
About EUR 5 billion is to be spent between 2007-2015 e.g. in the frame of the bellow
programmes, which are focused on the construction of an unique infrastructure and equipment
and on generating new jobs in life-science and biotechnology R&D and business in several
research centres and company clusters in the country:


Operational programme Enterprise and Innovation
Prosperity– Infrastructure for industrial research, development and innovation
Offers support for infrastructure in order to strengthen links between R&D and industry
(establishment of incubators, science and technology parks, technology-transfer centres,
etc.)
Programme of support Potential
Supports new or increased capacities of enterprises to conduct research, development and
innovation activities, aims to increase the number of enterprises carrying out their own
research, development or innovation. aims to enhance cooperation between enterprises
and R&D organizations, create high-skilled jobs, etc.

Cooperation programme
Supports the establishment and development of cooperative groupings (clusters, fields of
excellence and technology platforms) in which companies, universities and research
institutes cooperate. Support is expanded to more activities from the regional to the
international level. Clusters, poles of excellence and technology platforms will be
supported, both in the phase of seeking out firms for inclusion in groupings as well as in
the establishment and development phase.

Operational Programme Research and Development for Innovation
Among others the programme is focused on the development of technical research
capacities in regions, particularly at universities and public research institutions and the
creation of conditions and a system for the establishment of new technology firms and
utilization of protection of intellectual property at universities and public research
institutions.
Development part of the programme provides to small and medium-sized enterprises
subsidies for preparation of international research projects which seek support from the 7th
EU Framework Programme for research and technological development. The programme is
intended only for small and medium-sized enterprises.


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2.4 Growing number of biotechnology companies, start-up and spin-
off SMEs

The development of human and veterinary pharmaceuticals, diagnostics, fermentation
technologies, the use of biotechnologies in waste treatment and environment protection,
animal and plant biotechnologies are currently the most successful areas in which Czech
biotechnology entities actively operate.


There about one hundred biotechnology-oriented companies in the Czech Republic.


With few exceptions most of the local companies is rather small, nearly two-thirds of
enterprises have less then 20 employees.


Small companies often suffer from insufficient capitalization.


Majority of enterprises is concentrated in Prague and Brno (South Moravia) regions.


Several large foreign pharmaceutical and biotechnology firms have recently made their
investments and started to develop the operations in the Czech Republic (e.g. Barr
Pharmaceuticals, Lonza Biotec, Baxter International, AstraZeneca, Otsuka Pharmaceutical,
TEVA Pharmaceuticals, Beckman Coulter, etc.)


Source: Czechinvest


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About 31% of the Czech biotech companies are active in the field of microbial and cellular
biotechnology, followed by ca 19% of companies active in field of development of human
and veterinary diagnostics and pharmaceuticals




Source: PWC/Czechinvest



Czech biotech companies mostly use "DNA/RNA" as a biotechnology technique, research
bodies widely use the "DNA/RNA and Proteins and other molecules" technique.


Source: South Moravian Innovation Centre, www.gate2biotech.com




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Local biotechnology companies are mostly characterized by using biotechnology
applications "Human health" and "Environment", while the most common biotechnology
applications by research bodies are "Human health" and "Non-GM agriculture
biotechnology".


Source: South Moravian Innovation Centre, www.gate2biotech.com



Companies mostly specialize in production of the following:
Monoclonal and polyclonal antibodies
Antibody-based diagnostic kits
Immunodiagnostic reagents
Immunoanalytical tools
ELISA diagnostic kits
Recombinant proteins
Environmental-protection services



Most successful companies include:

EXBIO Praha www.exbio.cz

EXBIO entered the antibody market as a spin-off company of Czech Academy of Sciences in
1990. Nowadays EXBIO manufactures and supplies antibodies for world-wide distribution.
Strong research & development (hybridoma technology, construction of recombinant proteins
and antibodies) in co-operation with academic institutions ensures the continuous addition of
important new products.

BioVendor www.biovendor.cz

Research and Diagnostic Products Division
Production of antibodies and recombinant proteins, ELISA diagnostic kit and other research
products are used in laboratories in Northern America, Asia and the EU.
Laboratory Medicine Division


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World-class diagnostics - a complete range of products for in vitro diagnostics, from
immunochemistry through clinical biochemistry, hematology, microbiology, molecular biology
to pathology.

CPN (Contipro Group) www.contipro-group.cz

Contipro Group has a leading position in the production of hyaluronan of all levels of purity,
including the top quality designed for sterile injection preparations.
At present, the group controls 60% of the European and 30% of the world market in
hyaluronan.
The group is also involved in the rapidly developing field of nanobiopharmacy and focuses on
tissue engineering, wound healing, gene therapy and targeted drug distribution.
Contipro initiated the establishment of the NANOMEDIC medical-pharmaceutical cluster

I.Q.A. www.iqa.cz

A spin-off of the Research Institute of Biochemistry and Pharmacy, established 2000,
The main areas of expertise are development of pharmaceutical products targeted at treating
cancer and HIV, improvement of the performance and effectiveness of established drugs.
License agreement and strategic partnership with an US pharmaceutical company successfully
concluded in 2008.
Company provides also the following services
:
phase I clinical studies in oncology
bioequivalence studies
pharmaceutical developments projects, preclinical tests and development, bioanalysis,
biokinetics, pharmacokinetics
stability testing, shelf life predictions, nonstandard tests
development and validation o
f
bioanalytical and analytical methods, chiral separations


Bioveta www.bioveta.cz

The largest manufacturer of veterinary immunobiological and pharmaceutical products in the
Czech Republic. The objective is to offer a complete assortment of high-quality veterinary
products intended for diagnostics, prevention and therapeutics of animal diseases. Bioveta has
its own R&D capacity, specialized in biologic, diagnostic and hormonal products.

Vidia www.vidia.cz

The main activities of the company is the research, development and production of diagnostic
kits for human medicine, mainly immunoassays for clinical and research use:
IVD for detection of antibodies to herpetic viruses (EBV, CMV, HSV, HHV6, VZV - ELISA a
immunofluorescence kits)
Diagnostics of fecal occult blood - OKULT VIDITEST RAPID
Custom synthesis of peptides and preparation of peptide-protein conjugates

VIDIA cooperates with the Academy of Sciences and universities in research projects in the
field of virology, immunology and detection of environmental pollution and its overall impact to
human health.




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3 Biotech services - Contract opportunities – CROs – Clinical
tests of medicals

The tradition of biotechnology expertise and life-sciences infrastructure, combined with
progressive patent protection and economic incentives have attracted investment from many
American, Asian and European countries.
Some of them have launched manufacturing facilities, others see the country as an opportunity
for contract R&D and manufacturing for which the conditions are definitely favorable.

Over the last decade, the number of clinical trials in the CEE has been growing at an average
rate 30% per year and this growth is expected to continue. In particular, the Czech Republic
has shown a strong growth in clinical research over the past years due to the adoption of FDA,
US and EMEA, EU compatible regulations and a high incidence of many of the diseases most
targeted by the pharmaceutical industry.

The attractivity of the Czech Republic for CROs and pharmaceutical companies has resulted in
an increase in the number of CROs in the country, there are currently about 25 companies,
including large international ones such as Quintiles, Covance, Synteract.

However, the Czech CRO sector is facing an increasing competition from mainly from West
European companies, while competition from Asia is not that visible yet, nevertheless also
growing.
Because the biomedical companies quite often prefer full service packages, the CRO industry is
more and more focusing on a full service model, in order to be able to offer a complete range
of services.

Due to a strong growth of the number of the projects the industry has to handle the challenges
in recruiting new, well qualified employees. The companies often hire and let the best students
be involved in, thus bringing up their own qualified future employees.

Clinical trials – why Czech Republic?
- highly educated, well trained, motivated investigators
- modern technology and techniques
- reduced time and expenses
- centralized health care centres
- GCP standards, ICH-GCP (International Conference for Harmonization of Good Clinical
Practice) guidelines implemented
- no language barrier any longer

ACRO-CZ www.acro-cz.cz

is a professional association of Contract Research Organizations in the Czech Republic, which
focus on clinical research and the development of pharmaceuticals. The association was
founded in 2005 and it is a member of the European federation of CRO’s.

List of the member companies see chapter 5.



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4 Sources of information, useful contacts


Science and Technology Parks Association www.svtp.cz

Association of Research Organizations (private bodies in applied research) www.avo.cz

Association of Contract Research Organizations www.acro-cz

Association of Innovative Pharmaceutical Industries www.aifp.cz



Czechinvest www.czechinvest.com

The agency contributes to attracting foreign investment and developing domestic
companies through its services and development programmes, acts as an intermediary
between the EU and small and medium-sized enterprises in implementing structural
funds in the Czech Republic.
Mr. Martin Partl, Biotech Sector Manager, +420 296 342 526, +420 606 641 178

South Moravian Innovation Centre www.jic.z

Mr. Michal Kostka, Biotech Sector Manager, +420 541 143 017

Technology Centre of the Academy of Sciences of the Czech Republic
http://www.tc.cas.cz

Ms. Naďa Koníčková, National Contact Point for the FP7 thematic area BIO and NCP for
Joint Research Centre EC.
Ms. Judita Kinkorová, National Contact Point for the FP7 thematic area HEALTH
Mr. Jiří Vaněček, member of the group of Strategic Studies, responsible for the field of
life sciences.

Institute for Information on Education www.uiv.cz


Research and development in CR portal http://www.czechrtd.info/

R&D Council of the government of Czech Republic, information portal www.vyzkum.cz

Central register of R&D projects, intentions, tenders, results (incl.search engine)
http://www.vyzkum.cz/FrontClanek.aspx?idsekce=633


Czech Statistic Office www.czso.cz


Biotrin www.biotrin.cz

A non-profit organization formed by academic community for dissemination of information on
modern biotechnology

State Institute for Drug Control www.sukl.cz

Clinical Trials and Pharmacovigilance branch
Regulatory authority for clinical trials


Associations, clusters and individual companies listed in the chapter 5.


portunities
Potentials in Biotechnology Sector (Health care) in the Czech Republic


19

5 Lists of companies, associations and cluster´s members

5.1 ACRO, Association of Contract Research Organisations
www.acro-cz.cz

The Association’s regular members are CRO’s concerned both with the clinical evaluation of the 1 st
phase and CRO’s specialised on phases 2-4, as well as CRO’s focused on the statistic processing of
clinical evaluations.

ADDS&DSC International s.r.o. http://adds-dsc.com

A-Pharma s.r.o. www.a-pharma.cz

ARCOmed, s. r. o.
Avemedica, s.r.o. www.avemedica.cz

CEPHA s.r.o. www.cepha.cz

Chiltern International, s.r.o. http://www3.chiltern.com

Cline C Services, s.r.o. www.clinec.com

Covance Clinical and Periapproval Services LTD www.covance.com
Dux Consulting a.s. www.dux-consulting.cz

ECRON - The Czech Expert s.r.o. www.ecron.com

ICON Clinical Research, s.r.o. http://www.iconplc.com

MDS Pharma Services Czech Republic, organizační složka www.mdsinc.com

Medpace s.r.o. www.medpace.com

Omnicare Clinical Research, s.r.o. www.omnicarecr.com

PAREXEL International Czech Republic s.r.o. www.parexel.com

Pharmaceutical Research Associates CZ, s.r.o. www.pharmacon.cz

Pharmakl spol. s r.o. www.pharmakl.cz

Pharmnet s.r.o. www.pharmnet.cz

PharmTest s.r.o. pharmtest@pharmtest.cz
PPD Czech Republic s.r.o. www.ppdi.com
Prague Clinical Services, s. r. o. www.pragclin.com

Premier Research, s.r.o. www.premier-research.com

Quintiles GesmbH, organizační složka www.quintiles.com

Unimed, s. r. o. www.uni-med.cz

ZAK-Pharma Dienstleistung Ges.m.b.H.-organizační složka www.zakpharma.at



portunities
Potentials in Biotechnology Sector (Health care) in the Czech Republic


20


5.2 Czech Association of Pharmaceutical companies
http://caff.tradecentrum.cz/

Actavis CZ a.s. www.actavis.com

Apotex (ČR), s.r.o. www.apotex.cz

Ardeapharma a.s. www.ardeapharma.cz

Chauvin Ankerpharm GmbH, organizační složka www.bausch.cz

EBEWE Pharma GesmbH, Nfg KG, organizační složka www.ebewe.com

Egis Praha, spol. s r.o. www.egispraha.cz

Ewopharma, spol. s r.o. www.ewopharma.cz

IVAX Pharmaceuticals s.r.o. www.ivax-cz.com

KRKA ČR, s.r.o. www.krka.cz

Medicom International s.r.o. www.medicomint.cz

Orion Oyj, organizační složka www.orionpharma.cz

PLIVA - Lachema a.s. www.lachema.cz

PLIVA s.r.o. www.pliva.cz

PRO.MED.CS Praha a.s. www.promed.cz

ratiopharm CZ, s.r.o. www.ratiopharm.cz

Richter Gedeon www.richtergedeon.cz

Sandoz s.r.o. www.sandoz.cz

STADA PHARMA CZ s.r.o. www.stada-pharma.cz

TEVA Pharmaceuticals CR, s.r.o. www.teva.cz

Torrex Chiesi CZ, s.r.o. www.torrex-chiesi.cz

Ústav jaderného výzkumu Řež a.s. www.nri.cz/cz/; http://ujv.cz

VALEANT Czech Pharma s.r.o. www.valeant.com

VUAB Pharma a.s. www.vuab.cz

Wörwag Pharma GmbH - organizační složka www.woerwagpharma.cz

Zentiva N.V. www.zentiva.cz


5.3 Association of OTC drugs producers
www.svopl.cz

Bayer, s.r.o. Health Care www.bayer-cz.cz

Boehringer Ingelheim, spol. s r.o. boehringer-ingelheim.cz
GlaxoSmithKline, s.r.o. www.gsk.cz

IBI, spol. s.r.o. www.ibi.cz

Johnson & Johnson , s.r.o. www.jnjcz.cz

Merck spol.s.r.o. www.merck.cz

Reckitt Benckiser Healthcare www.reckittbenckiser.com

Sandoz, s.r.o. www.sandoz.cz
TEVA Pharmaceuticals, s.r.o. www.teva.cz

Urgo Medcom www.med-com.cz

Wyeth Whitehall, s.r.o. www.wyeth.com

Walmark, a.s. www.walmark.cz

Zentiva Group, a.s. www.zentiva.cz



portunities
Potentials in Biotechnology Sector (Health care) in the Czech Republic


21

5.4 Association of Innovative Pharmaceutical Industry
www.aifp.cz


ABBOTT LABORATORIES www.abbott.cz

ACTELION Pharmaceuticals www.actelion.com

AMGEN www.amgen.cz

ASTELLAS PHARMA www.yamanouchi.cz

ASTRAZENECA www.astrazeneca.cz

BAYER www.bayerscheringpharma.c

BEAUFOUR IPSEN PHARMA www.ipsen.cz/

BERLIN-CHEMIE MENARINI GROUP www.berlin-chemie.cz

BIOGEN IDEC www.biogenidec.com

BOEHRINGER-INGELHEIM www.boehringer-ingelheim.cz

BRISTOL-MYERS SQUIBB www.b-ms.cz

CELGENE www.celgene.com

ELI LILLY AND COMPANY www.lilly.cz

FERRING www.ferring.cz

GENZYME www.genzyme.cz

GLAXOSMITHKLINE www.gsk.cz

JANSSEN-CILAG /www.janssen-cilag.cz
LUNDBECK www.lundbeck.cz

MERCK SHARP & DOHME www.lundbeck.cz

MERCK-SERONO www.merckserono.cz

NOVARTIS www.novartis.com

NOVO NORDISK www.novonordisk.cz

NYCOMED www.nycomed.cz

PFIZER www.pfizer.cz

PIERRE FABRE www.pierre-fabre.cz

SANOFI-AVENTIS www.sanofi-aventis.cz

SCHERING-PLOUGH www.schering-plough.cz

SERVIER www.servier.cz

SOLVAY PHARMA www.solvay-pharma.cz

STALLERGENES www.stallergenes.com

UCB www.ucb.com

WYETH WHITEHALL www.wyeth.cz




portunities
Potentials in Biotechnology Sector (Health care) in the Czech Republic


22

5.5 Major Pharmaceutical producers in CR
Zentiva www.zentiva.cz
(Sanofi-Aventis/Zentiva B.V.)
Farmak www.farmak.cz

Medicamenta (Glenmark Pharmaceuticals) http://www.glenmarkpharma.cz/

IVAX CR www.ivax-cz.com

Pliva Lachema www.lachema.cz

Lonza Biotec www.lonza.cz

Tamda www.tamda.cz

Interpharma Praha www.interpharma-praha.com

Walmark www.walmark.eu




5.6 Nanonomedic cluster
www.nanomedic.cz

Medicine-pharmaceutic cluster (Dolni Dobrouč, Eastern Bohemia)
Ampi, spol. s r.o. www.ampi.cz

B A T I S T s.r.o. www.batist.cz

Biohem Diagnostika spol. s r.o.
BLOCK a.s. www.block.cz

CESA, a.s., Pardubice www.cesa.cz

CPN spol. s r.o. www.contipro-group.cz

Enantis s.r.o. www.enantis.com

Generi Biotech s.r.o. www.generi-biotech.com

I N O T E X spol. s r.o. www.inotex.cz

Inova Pro, s.r.o. www.inovapro.cz

Intero, Chmelan a spol., společnost s ručením omezeným www.intero.cz

MUDr. Pavel Nožička, CHS Galen
Výskumný ústav chemických vlákien, a.s. www.vuchv.sk

SAFIBRA, s.r.o. www.safibra.cz

SEDIUM s.r.o. www.sedium.cz

SEDIUM RD s.r.o. www.sedium-rd.cz

4P SYSTEM s.r.o. www.4psystem.com













portunities
Potentials in Biotechnology Sector (Health care) in the Czech Republic


23
5.7 CzechBio Association/cluster
www.czechbio.org

PRIVATE COMPANIES:
Apronex s.r.o. www.apronex.com

Ascoprot Biotech, s.r.o. www.ascoprot.com

BioInova, s.r.o. www.bioinova.cz

BIOPHARM, Výzkumný ústav biofarmacie a veterinárních léčiv a.s. www.bri.cz

BioTest s.r.o. www.biotest.cz

BioVendor - Laboratorní medicína a.s. www.biovendor.com

Bioveta, a.s. www.bioveta.cz

BVT Technologies,a.s. www.bvt.cz

CENTRAL EUROPEAN BIOSYSTEMS s.r.o. www.cebiosys.com

CS-PROJECT spol. s r.o. www.cs-project.cz

Enantis s.r.o. http://loschmidt.chemi.muni.cz/enantis

ENVISAN-GEM, a.s. www.envisan.cz

EPS, s.r.o. www.epssro.cz

GENERI BIOTECH s.r.o. www.generi-biotech.com

LABINA, spol. s.r.o. www.labina.cz

LentiKat´s a.s. www.lentikats.eu

LONZA BIOTEC s.r.o. www.lonzabiotec.cz

Protean s.r.o. http://protean.cz

Proteix s.r.o. www.proteix.cz

SEVAPHARMA a.s. www.sevapharma.cz

Top-Bio, s.r.o. www.top-bio.cz

VIDIA spol. s r.o. www.vidia.cz

KRD-obchodní společnost s.r.o. www.krd.cz

ACADEMIC INSTITUTES:
Instituteof chemical Technology Prague www.vscht.cz

Institute of biotechnology AS CR, v.v.i. www.ibt.cas.cz

Institute of Molecular Genetics AS CR, v.v.i. www.img.cas.cz




portunities
Potentials in Biotechnology Sector (Health care) in the Czech Republic


24

5.8 CEITEC cluster – bioinformatics
www.ceitec-cluster.cz


BioVendor - Laboratorní medicína a.s. www.biovendor.cz

Camea, spol. s r.o. www.camea.cz
www.unicam.cz

ECO - Management, spol. s r.o. www.ecomanag.cz

Enantis, spol. s r.o. www.enantis.com

Elisabeth Pharmacon, spol. s r.o. www.elisabeth.cz

Favea, spol.s r.o. www.favea.cz

FEI Czech republic, spol. s r.o. www.feicompany.com

Jihomoravské centrum mezinárodní mobility z.s.p.o. www.jcmm.cz

MAC, spol. s r.o. www.macsro.cz

Tescan, spol. s r.o. www.tescan.cz

Textilní zkušební ústav, s.p. www.tzu.cz

Výzkumný ústav pletařský, a.s. www.vup.cz

Masarykova Univerzita www.muni.cz

Biofyzikální ústav AV ČR www.ibp.cz

ENVISAN-GEM a.s. www.envisan.cz

GEN-TREND s.r.o. www.gentrend.cz

Jihočeská agentura pro podporu inovačního podnikání o.p.s. www.jaip.cz

STROKOM, s.r.o. www.strokom.cz

VIDIA spol. s r.o. www.vidia.cz

NETS.CZ, s.r.o. www.nets.cz

HDT s.r.o. www.hdtdental.cz

Regionální rozvojová agentura jižní Moravy www.rrajm.cz

Centrum kardiovaskulární a transplantační chirurgie www.cktch.cz

FTM Communications, s.r.o. www.ftmc.cz

Enzymo Plus s.r.o. www.enzymo-plus.eu

Protean www.protean.cz




portunities
Potentials in Biotechnology Sector (Health care) in the Czech Republic


25
5.9 Biotech bodies, database of Czechinvest
www.czechinvest.org
, http://healthcare.czechinvest.org
)

Agrobac Biotechnology,
Pharmacy
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Biotechnology of
the natural environment,
Botanical biotechnology, Microbial
and cellular biotechnology, R&D
www.agrobac.cz/index.htm

AppGenics s.r.o. Biotechnology
Animal biotechnology, R&D
www.appgenics.com/

Apronex s.r.o. Biotechnology
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Microbial and
cellular biotechnology, R&D
www.apronex.com

Ascoprot Biotech,
s.r.o.
Biotechnology
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Microbial and
cellular biotechnology, R&D
www.ascoprot.com

Avemedica s.r.o Biotechnology,
Pharmacy
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Biotechnology of
the natural environment,
Pharmacy, R&D
www.avemedica.cz

B.P.Medical s.r.o. Biotechnology
Microbial and cellular
biotechnology
www.greentech.cz/cbt/en/index.html

Biologicals s.r.o. Biotechnology
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, R&D
biologicals.cz

Biopharm,
Výzkumný ústav
biofarmacie a
veterinárních léčiv,
a.s.
Biotechnology,
Healthcare
technology and
materials,
Pharmacy
Animal biotechnology,
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Pharmacy, R&D,
Zoopharmacy
www.bri.cz

BIOPREPARÁTY,
spol. s r.o.
Biotechnology
Botanical biotechnology, Microbial
and cellular biotechnology, R&D
www.biopreparaty.cz

Bio-Skin a.s. Biotechnology,
Pharmacy
Pharmacy, R&D
www.bio-skin.eu

BioVendor –
Laboratorní
medicína a.s.
Biotechnology,
Healthcare
technology and
materials
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Implants and
instruments for traumatology and
orthopaedics, Laboratory
instruments and equipment,
biochemical diagnosis, Microbial
and cellular biotechnology, R&D,
Surgical instruments, Visualizing
diagnostic instruments
www.biovendor.cz

ELISABETH
PHARMACON, spol.
s r.o.
Biotechnology,
Healthcare
technology and
materials
Disposable and single-use
materials, Equipment of operating
rooms, Laboratory instruments
and equipment, biochemical
diagnosis, Microbial and cellular
biotechnology, Other furniture
and equipment of hospital
www.elisabeth.cz/



portunities
Potentials in Biotechnology Sector (Health care) in the Czech Republic


26
facilities, Textile and rubber
products, protective aids,
packaging, Visualizing diagnostic
instruments
Enantis, s.r.o. Biotechnology
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Biotechnology of
the natural environment, Microbial

and cellular biotechnology
www.enantis.com

ENVISAN-GEM, a.
s.
Biotechnology
Biotechnology of the natural
environment
www.envisan.cz/index.php?lang=en

EPS, s.r.o. Biotechnology
Biotechnology of the natural
environment
www.epssro.cz

EXBIO Praha, a.s. Biotechnology,
Pharmacy
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Microbial and
cellular biotechnology, Pharmacy,
R&D
www.exbio.cz

GeneAge
Technologies, a.s.
Biotechnology,
Healthcare
technology and
materials
Animal biotechnology,
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Botanical
biotechnology, Laboratory
instruments and equipment,
biochemical diagnosis, Microbial
and cellular biotechnology
www.geneagetech.com/

GENERI BIOTECH
s.r.o.
Biotechnology
Animal biotechnology,
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Botanical
biotechnology, Microbial and
cellular biotechnology
www.generi-biotech.com/

Genomac
International,
s.r.o.
Biotechnology
Animal biotechnology,
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Botanical
biotechnology, Microbial and
cellular biotechnology, R&D
www.genomac.cz/en/

GEN-TREND s.r.o. Biotechnology
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Microbial and
cellular biotechnology
www.gentrend.cz/index.php

G-servis Praha,
spol. s r.o.
Biotechnology
Biotechnology of the natural
environment
www.g-servis.cz/eng/

Immunotech a.s. Biotechnology
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Microbial and
cellular biotechnology, R&D
www.immunotech.cz

ITEST plus, s.r.o. Biotechnology,
Pharmacy
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Microbial and
cellular biotechnology, Pharmacy,
R&D
www.itest-plus.cz

LentiKat´s a.s. Biotechnology
Biotechnology of the natural
environment, Microbial and
cellular biotechnology
www.lentikats.eu/en/

Lonza Biotec, s.r.o.

Biotechnology
R&D
www.lonzabiotec.cz/



portunities
Potentials in Biotechnology Sector (Health care) in the Czech Republic


27
MEDIPHARM CZ,
s.r.o.
Biotechnology
Animal biotechnology, Microbial
and cellular biotechnology
www.medipharm.cz/uk/uvodUk.html

MEGA a.s. Biotechnology
R&D
www.mega.cz/en/

Moravian-
Biotechnology,
spol. s r.o.
Biotechnology
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals
www.moravian-biotech.com/

O.K. SERVIS
BioPro, s.r.o.
Biotechnology,
Healthcare
technology and
materials
Animal biotechnology,
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Laboratory
instruments and equipment,
biochemical diagnosis, Microbial
and cellular biotechnology, R&D
www.oks.cz

OlChemIm spol.s
r.o.
Biotechnology
Animal biotechnology,
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Botanical
biotechnology
www.olchemim.cz/INDEX_e.HTM

Pliva-Lachema
Diagnostika s.r.o.
Biotechnology
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Disposable and
single-use materials, Other
diagnostic and mesurement
devices and equipment
www.lachema.cz/en/

PROTE, spol. s r.o.

Biotechnology
Biotechnology of the natural
environment, Microbial and
cellular biotechnology
www.prote.cz

Proteix s.r.o. Biotechnology
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Microbial and
cellular biotechnology
www.proteix.cz

rEcoli spol. s r.o. Biotechnology
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Microbial and
cellular biotechnology, R&D

SITA CZ a.s. Biotechnology
Biotechnology of the natural
environment
www.sita.cz/en/page/100/

TEST-LINE, Clinical
Diagnostics, spol. s

r.o.
Biotechnology
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Biotechnology of
the natural environment
www.test-line.cz/en/

Top-Bio, s.r.o. Biotechnology
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Microbial and
cellular biotechnology
www.top-bio.cz/

TRIOS, spol. s r. o. Biotechnology
Biotechnology of the natural
environment, Microbial and
cellular biotechnology, R&D
www.trios.cz

VIDIA spol. s r.o. Biotechnology
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals
www.vidia.cz

WILDEN
ENGINEERING
spol. s r.o.
Biotechnology,
Healthcare
technology and
materials,
Biotechnology - development of
human and animal diagnostics,
pharmaceuticals, Disposable and
single-use materials, Equipment
of operating rooms, Laboratory
www.wilden.com



portunities
Potentials in Biotechnology Sector (Health care) in the Czech Republic


28
Pharmacy
instruments and equipment,
biochemical diagnosis, Microbial
and cellular biotechnology, Other
diagnostic and mesurement
devices and equipment,
Pharmacy, Plastics products,
Sterilisation, disinfection,
Therapeutic apparatus and
equipment, Visualizing diagnostic
instruments