Molecular Biomimetics - NSF Nanoscale Science and Engineering ...

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15 Νοε 2013 (πριν από 3 χρόνια και 9 μήνες)

88 εμφανίσεις

Molecular
Biomimetics
:

Genetically
-
Engineered Molecular Materials for Technology & Medicine

Mehmet Sarikaya
,
1,2


Beth Traxler,
3

R. Samudrala,
3
A. Jen,
1,4

B. Parviz,
5

Fran
ç
ois Baneyx,
2,6

Daniel T. Schwartz,
2

& Candan Tamerler
1

GEMSEC: Genetically Engineered Materials Science and Engineering (an NSF
-
MRSEC at the UW)

Participating Departments:
1
Materials Sci. & Eng.,
3
Chemical Eng.
2
Microbiology,
4
Chemistry, Electrical Eng., and
6
Bioengineering, University of Washington, Seattle, WA 98195, USA,

sarikaya@u.washington.edu; http://www.GEMSEC.washington.edu & http://depts.washington.edu/nanobio

Summary: Utilizing recent advances in biology and physical sciences, we unite molecular genetic tools with synthetic nanoscal
e c
onstructs to create a hybrid field,
molecular biomimetics
. Here, we adapt bio
-
schemes including combinatorial mutagenesis,
bioinformatics, and computational biology to design novel peptides with specific binding to and assembly on functional nanosc
ale

solids. Based on genome
-
based design, molecular recognition, and self
-
assembly principles, we engineer peptides as synthesizers
,
molecular erectors and assemblers in diverse areas from quantum electronic devices to molecular imaging and cell
-
free tissue eng
ineering. Research supported by GEMSEC, an NSF
-
MRSEC & NIH.

New Materials Revolution!

Bioinformatics


In silico

Designed Peptides

Nanofabrication

Tissue Engineering

Potential Implementations

Molecular Characterization

Material Recognition and Selectivity by Peptides

Lessons from Mother Nature

Interdisciplinary Collaboration

Fundamentals

&

Implementations

Dissemination

Projects Supported by NSF
-
MRSEC, NSF
-
BioMat, NSF
-
IRES, ARO, NIH

Principles of materials formation in Biology

Combinatorial Mutagenesis

Peptides are workhorses in biology via ligand/receptor interactions


If we design a ligand peptide recognizing a nanoinorganic,

then we can genetically engineer materials systems for technology & medicine!!

Neurodegenerative Diseases

Towards Quantum Electronic Devices

Cell Adhesion

Polydisciplinary Research & Implementation

Human revolutions proceeded materials revolutions

Summary