07_21

kissimmeemisologistΒιοτεχνολογία

14 Δεκ 2012 (πριν από 4 χρόνια και 10 μήνες)

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Agenda 07/21/2010


Enzyme Speech


Mutations


Genetic
Engineering


Type 2 Diabetes


Body Systems

Playdoh

speech


Work with partner



Explain Replication and
Enzyme Synthesis by using
playdoh
!



Look at your sketches,
notes, and book for
assistance.

Really Understand Enzyme Synthesis?

½ sheet paper


Front: Explain Transcription


Back: Explain Translation

Practice 3


DNA sequence:


GACAAGTCCACAATC



Please give the following:


M
-
RNA sequence:


T
-
RNA
anticodons


Amino Acids (p.203)


Protein Chain


M
-
RNA sequence:


CUGUUCAGGUGUUAG



T
-
RNA
anticodons
/Amino Acids


GAC = Aspartic acid


AAG = Lysine


UCC = Serine


ACA =
Threonine


AUC =
Isoleucine



Aspartic acid


Lysine


Serine


Threonine

-

Isoelucine

Protein Synthesis practice 4


M
-
RNA sequence:


CCAUCUAGUUUUACU



Please give the following


T
-
RNA
anticodons
:


Protein Chain:


DNA sequence:



Lets say during transcription
there was a deletion of the
2
nd

A within the M
-
RNA, how
would this effect the protein
chain?


T
-
RNA: GGU AGA UCA AAA
UGA



Protein Chain:
Glycine
-
Arginine
-
Serine
-
Lysine
-
Stop



DNA: GGTAGATCAAAATGA



Mutated

Protein:


T
-
RNA: GGU AGA CAA
AAU GA_


Glycine
-
Arginine
-
Glutamine
-
Asparagine
-


MUTATIONS


Mendelian


Sex
-
linked


Meiosis


Replication


Transcription


Translation





Chromosomal:
partial or whole


Nondisjunction


(Polyploidy)





Gene:


Point


Frame shift



Deleted


Duplicated


Translocated
/inserted




Meiosis
-

chromosomal


Down syndrome


Full
nondisjunction

c21



Cri
-
du
-
Chat



partial
nondisjunction

c5



Turner Syndrome


Full
nondisjuction



X



Klinefelter

Syndrome


Full
nondisjunction

-

X



Mendelian Mutations


Mendelian


Recessive:


Albinism

-

frameshift


Cystic fibrosis

-

point


Tay
-
Sachs

-

point


Dominant:


Huntington disease



frameshift
c4


Codominant:


sickle
-
cell anemia

-

point

Genetic Engineering


Uses:


Agriculture/Livestock (genetic modified
food)


Beetles/Corn


Giant Strawberries


Engineered animals


lab mice


Textiles


Wool better waterproof


Genetic Disorders


Cure or Symptoms


Diseases


䑩D扥t敳


Diabetes


楮獵汩渠wa猠s桥h晩fs琠
man
-
made hormone/protein


Use to use insulin from pigs


EXPENSIVE!!!


桡搠t漠r慩獥s瑨攠
灩杳


Now make human insulin in lab!


Types:


Cloning


Stem Cells


Gene Therapy (Gene
Pharming
)

Genetic
engineering (GE)
is the
manipulation of
genetic material
in a cell or an
organism in order
to make desired
traits and/or to
eliminate
unwanted ones

Type II Diabetes


Most common form



Body does not make enough Insulin or Ignores it



Why is insulin important?


Necessary for body to use glucose


睨礠業灯牴慮琿


OUR ENERGY!!!! Broken down in Respiration to useable energy


Insulin “transports” glucose from blood into cells


Like a bus


w攠ee琠楮i慮搠w攠ge琠t潶敤e獯浥睨敲e


Think: “lock
-
key”


insulin enzyme that “fits” into glucose



Watch Video

Sources


http://www.mayoclinic.com/health/type
-
2
-
diabetes
-
in
-
children/DS00946/DSECTION=symptoms



http://www.diabetes.org/diabetes
-
basics/type
-
2/


http://diabetes.webmd.com/tc/type
-
2
-
diabetes
-
prevention