Indiana CTSI HUB Update

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Indiana
CTSI

ACCELERATING CLINICAL AND

TRANSLATIONAL RESEARCH

Indiana CTSI
HUB Update



Bill Barnett

Director,

Information Infrastructures,

Indiana CTSI


iCTSI Program Directors Meeting

February 23, 2010

www.indianactsi.org


Indiana
CTSI

ACCELERATING CLINICAL AND

TRANSLATIONAL RESEARCH

Summary


Goals of this Presentation


What is the Indiana CTSI HUB?


HUB Accomplishments


Current HUB
-
based Initiatives


How Can the HUB Help Your Program?






www.indianactsi.org

Indiana
CTSI

ACCELERATING CLINICAL AND

TRANSLATIONAL RESEARCH

Goals


You understand what the HUB is, its role in the Indiana
CTSI, and its capabilities


You know what services are available through the HUB,
and what is in the works


You provide ideas that use the HUB to make your
program more successful



www.indianactsi.org

Indiana
CTSI

ACCELERATING CLINICAL AND

TRANSLATIONAL RESEARCH

What is the Indiana CTSI HUB?


The central web portal for Indiana CTSI translational activities.


The Indiana CTSI HUB is based on the Joomla! Web 2.0 software
framework (
www.joomla.org
), which supports modular, integrated web
components or standalone applications in a model
-
view
-
controller
architecture, with a MySQL backend.


A HUB is a virtual organization portal designed to support researchers
pioneered by Purdue, funded by NSF, refined over the past 10 years.


HUB software is based on community source development, the
HUBzero Consortium, sponsored by Purdue, IU, Wisconsin, and
Clemson. It will be released as open source in April, 2010.
(
www.hubzero.org
)



www.indianactsi.org

Indiana
CTSI

ACCELERATING CLINICAL AND

TRANSLATIONAL RESEARCH

How do we develop HUB services?

We determine needs, then take a least cost, rapid development approach
to developing HUB tools and services to meet those needs:

1.
We prefer to use existing HUB components or Joomla! software
Extensions (4281 as of 2/22/2010).

2.
We then look for existing open source Web 2.0 applications we can
easily plug into the Joomla! (eg., HUB) framework.

3.
We then adapt existing non Web 2.0 applications into the HUB

4.
If all else fails, we develop our own Joomla! Extensions or applications.



www.indianactsi.org

Indiana
CTSI

ACCELERATING CLINICAL AND

TRANSLATIONAL RESEARCH

The HUB Comes With


Integrated Search (plus we added Google Search)


Calendars, events, announcements, news and other communications


Tools to submit content for citation, peer review, tagging


Personalized HUB Pages


User Group support


Wikis and Blogs


Usage Metrics


Feedback, knowledge base, and online user support


www.indianactsi.org

Indiana
CTSI

ACCELERATING CLINICAL AND

TRANSLATIONAL RESEARCH

HUB Accomplishments for Years 1 and 2


Put Clinical Trials Listings on the HUB


Added PubMed and IUSM faculty publications into integrated search (IU grants
coming next)


Developed a Grants Management Tool for internal grant programs


Put the Project Development Teams (PDTs) Online


Developed a web presence for CHEP


Put the Indiana CTSI Cores online (the TTR Service Cores)


Provided Discussion Forum, Form, and Survey Tools


Authentication through Federated Identity with 6 other institutions (including NIH)


Redesigned the home page to improve usability (more coming)


www.indianactsi.org

Indiana
CTSI

ACCELERATING CLINICAL AND

TRANSLATIONAL RESEARCH

Current HUB Projects

(partially funded by a CTSI ARRA Supplement)


Federated Identity support for all applications


Ontology tagging for all content



Alfresco Share Private Group Collaboration


i2iconnect.org Industry Partner Discovery Tool


REDCap (Research Electronic Data Capture) from Vanderbilt


OpenMRS Patient Recruitment


Online submission of next year’s annual report via forms



Next phase of usability improvements


Hosting to be moved to IU cyberinfrastructure

www.indianactsi.org

Indiana
CTSI

ACCELERATING CLINICAL AND

TRANSLATIONAL RESEARCH

Current HUB Projects: Cyberinfrastructure


Federated Identity support for all applications







Ontology tagging for all content

www.indianactsi.org

Indiana
CTSI

ACCELERATING CLINICAL AND

TRANSLATIONAL RESEARCH

Current HUB Projects:
Alfresco Share


www.indianactsi.org

Private Group Collaboration



Based on expressed need
of researchers at different
institutions to privately
share documents for grant
proposals and projects


Will support ePHI data sets


An open source product
used by over 50
organizations internationally


Indiana
CTSI

ACCELERATING CLINICAL AND

TRANSLATIONAL RESEARCH

HUB Prototype:
i2iconnect.org


Discover Industry Licensors



Database of Industry
licensing reps by
specialization and
disease


Partnership with Cook
Medical, IURTC, IHIN,
and Biocrossroads


Currently over 1,000
names in the database


Business model in
development.

Indiana
CTSI

ACCELERATING CLINICAL AND

TRANSLATIONAL RESEARCH

Current HUB Projects: REDCap


Research Electronic Data Capture tool from Vanderbilt (pioneered by
Biostatistics)


“REDCap is a secure, web
-
based application for building and
managing online databases. Using REDCap's stream
-
lined process
for rapidly developing databases, you may create and design
databases using 1) the online method from your web browser using
the Online Form Editor; and/or 2) the offline method by constructing a
"data dictionary" template file in Microsoft Excel, which can be later
uploaded into REDCap. REDCap provides automated export
procedures for seamless data downloads to Excel and common
statistical packages (SPSS, SAS, Stata, R), as well as a built
-
in
project calendar, a scheduling module, ad hoc reporting tools, and
advanced features, such as branching logic, file uploading, and
calculated fields” (https://www.mc.vanderbilt.edu/victr/dcc/redcap/)


www.indianactsi.org

Indiana
CTSI

ACCELERATING CLINICAL AND

TRANSLATIONAL RESEARCH

Current HUB Projects: OpenMRS Patient Recruitment



Review of Open Source and Commercial Patient Recruitment
systems found them to not have sufficient features or sustainability
(open source) or too expensive and inflexible (commercial)


Review of Research Match national patient recruitment found it not to
provide sufficient researcher access plus it did not take advantage of
Indiana’s great wealth of health records data in the INPC to prequalify
patients.


OpenMRS is a sustainable, flexible medical records software
framework that uses HL
-
7 standards and already integrates well with
INPC. OpenMRS development is being lead out of Regenstrief.


Scope of Work and workflows are currently being finalized



www.indianactsi.org

Indiana
CTSI

ACCELERATING CLINICAL AND

TRANSLATIONAL RESEARCH

The Indiana CTSI HUB Team

www.indianactsi.org


Bill Barnett (Lead):
barnettw@iu.edu


Anurag

Shankar (Technical Lead):
ashankar@indiana.edu



Mike McLennan (HUB Architect):
mmclenna@purdue.edu



Lilith Reeves (Chief Scientist):
lreeves@iupui.edu



Bob Davis (Usability):
davisrol@iupui.edu


Joe Hunt (Evaluation):
johunt@iupui.edu



Samantha
Scahill

(Content Management):
sscahill@iupui.edu



Jere

Odell (Education and Bioethics):
jdodell@iupui.edu



Elaine
Skopelja

(Library Informatics):
eskopelj@iupui.edu



Beth Whipple (Library Informatics):
ewhipple@iupui.edu


Indiana
CTSI

ACCELERATING CLINICAL AND

TRANSLATIONAL RESEARCH

How Can the Indiana CTSI HUB
help you accomplish your
program goals?

Bill Barnett (
barnettw@iu.edu
)

Anurag Shankar (
ashankar@iu.edu
)