Northeastern Illinois Regional Crime Laboratory

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15 Νοε 2013 (πριν από 3 χρόνια και 8 μήνες)

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Northeastern Illinois Regional Crime Laboratory

Request
for

Proposal

Drug Chemistry and Toxicology

Please Contact Garth Glassburg with the Request for Proposal by August 28, 2013.
The units
shall be invoiced and delivered by September 30, 2013.
The Proposal can be emailed to
Gglassburg@nircl.org
. All proposals shall be confidential.



One GCMS system wi l l be for the toxi col ogy secti on and two wi l l be used i n Drug Chemi stry. The Toxi col ogy
secti on wi
l l requi re a turbo
-
pump, whi l e the Drug Chemi stry Secti on wi l l requi re a di ffusi on pump. The wi nni ng
contract wi l l be for the enti re package and wi l l not be broken i nto di fferent vendors.

The Gas Chromatograph (GC)
and the auto
-
sampl er shal l be used for

both the turbo
-
pump uni t and the

two

di ffusi on uni t
s
.

Please Note: Attach a list of forensic labs that are using your system for both Toxicology and Drug Testing
applications
.

Trai ni ng wi l l be avai lable after the i nstal lati on of the three i nstruments.

Au
to
-
sampl er

Speci fi cati ons:

A: The auto
-
sampl er shal l have a sampl e capacity of 16 sampl es wi th the standard turret

B: The i njector shal l have a varyi ng depth of
-
2 to + 30mm above defaul t

C: The auto
-
i njector has the capabi l ity to ri nse the syri nge both pr
e and post i njecti on wi th two separate sol vents
(A and B) of 0
-
15 ti mes for each sol vent

D: The auto
-
i njector shal l al low for 0
-
15 pre
-
washes of sampl e and 0
-
15 pre
-
washes of pre


sampl e pumps

E: The auto
-
i njector

shal l have a del ay of 0
-
7 seconds

F: The
auto
-
sampl er al l ows 1
-
99 i njecti ons of speci fied syri nge vol umes

G: The auto
-
i njector shal l have a range of i njecti on vol umes from 10 nanol i ters to 250 mi crol i ters dependi ng on
syri nge si ze

H: Syri nges used shal l be

1,2,5,10, and 100ul maxi mum vol ume wi th
standard syri nge carriage of 250 uL and 500 ul
maxi mum vol ume

I: The auto
-
sampl er shal l al low i njecti on vol ume setti ngs of 1% to 50% of syri nge vol ume i n i ncrements of 1%

J: The auto
-
sampl er shal l be control l ed through the GC keyboard or the
Chromatographi c Data System

K: The i njector shal l hol d up to 2 vi al s of sol vent. Each vi al i s 4 ml wi th 2 ml of sol vent usabl e sol vent. The system
hol ds 10 4 ml vi al s wi th sol vent capaci ty of 20 ml s

L: The auto
-
sampl er shal l be auto
-
al i gning and i s i nst
all ed or removed wi th or wi thout tool s

M: The sampl e tray shal l hol d at l east 150 vi al s

N: The system shal l al low access, randoml y, to al l vi al posi tions on the tray

O: There must be removabl e trays

P: The vi al must be gri pped so that the vi al i s grabbed b
y the si des, not under the cap

Q: There must be a sensor so that the sampl er veri fi es the vi al i s hel d

R: An opti onal chi ller modul e wi th a sensor to moni tor average cool ant temperature i n pl ate of 5
-
60 degrees C.



GC Speci fi cati ons:

A: Retenti on ti me
repeatabi l i ty: <0.008% or <0.0008 mi n

B:
S
i x EPC modul es can be i nstal led, provi di ng control of up to 16 channel s of EPC

C: Wi th capi l lary col umns, four modes are avai l able, constant pressure, ramped pressure (3 ramps), constant fl ow
or ramped fl ow (3 ramp
s). Col umn average vel oci ty i s cal culated.

D: The GC

soft
-
ware
shal l be abl e to have counters, chromatographi c attri butes, i nstrument di agnosti cs,
mai ntenance run and l ogs, access to manual s and vi deos

E: The LAN i nterface must al l ow real
-
ti me moni tori ng
of the GC when connected wi th moni tori ng software when
connected to the data system

F: Have preprogrammed l eak tests

G: Oven must accommodate up to two capi l lary col umns

H: Oven operati ng range shal l be +4 C to 450 C over ambi ent temperature

I: Oven tempe
rature set poi nt shal l be 0.1 C

J: Oven supports up to 20 ramps wi th 21 pl ateaus
. Negati ve ramps al l owed.

K: Ramp rates

a
re up to 120 C/mi nute

L: Maxi mum run ti me shal l be veri fi ed

M: Ramp rates for temperatures of
175 to 300 C shal l be 80 degrees per mi n
ute and at l east 50 degrees per mi nute
at 300
-
450 C.

N: Cool down (22 C ambi ent) 450 to 50 C i n 4 mi nutes

O: Oven rejecti on of <0.01 C/mi n

P: Oven turns off when door opened

Q: Gas turns off i f i nl et pressure drops si gni ficantl y

R: Pneumati cs are

el ectroni c and programmabl e

S: Inl et must have el ectroni c pneumati c control of carri er, spl i t and septum purge gases i ncl udi ng ON/OFF

T: Avai l abl e pressure uni ts are psi, kPa or bar

U:
Carri er g
as types supported are He, hydrogen,
and ni trogen

V: In
l
et mo
dul es have accuracy of , <
+

2% ful l scale, fl ow sensors of <
+
5% (repeatabi l i ty of <
+
0.35% and detector
modul es of <
+
3ml/mi n

W: Have two i nl ets

from the fol l owi ng:

spl i t/split
-
l ess, purged packed i njecti on port, temperature programmed
cool on
-
col umn, progr
ammabl e temperature vapori zer and vol ati l es i nl et

X: Spl i t/spl it
-
less i
nl et
s

must have el ectroni c control of carri er, spl i t and septum purge gases and el ectroni c
ON/OFF: modes of spl i t, spl it
-
l ess and pressure pul sed spl it
-
l ess

Y: Gas saver mode bui l t i n t
he uni t

Z: The spl i t and septum purge changed wi thout al teri ng the col umn fl ow

AA:

The system shal l met ISO
9001
gui del i nes

Gas Chromatograph Safety Features

a. Auto reboot after power fai l ure to restore heated zones

b. Hydrogen carri er gas safety
features. Vendor must be abl e to demonstrate the safeguards. (e.g. connecti ons to
vent exhausted gas, bui l t
-
i n l eak detecti on/automated shutdown features)

Two GC/MS with a Diffusion Pump for Drug Chemistry

Mass Spectrometer

must i ncl ude the fol l owi ng featu
res:

a. The
Q
uadrupol e m
a
ss fi l ter shal l consist of a monol i thi c quartz structure wi th a true hyperbol i c shape
.

b. The Quadrupol e i s i ndependentl y heated to be user sel ectabl e from 100
-
200 degrees centi grade
;

c. Ion source can be temperature control l ed fr
om 100
-
350 degrees
centi grade;

thi s source i s constructed from a
sol i d i nert source whi ch i s not stai nl ess steel

d
. Qu
a
drupol e

el ectrode surfaces covered by ti tani um composi te and gol d thi n and thi ck fi l ms to prevent oxi dati on

e
. Mass fi l ter and Detector
on the same pl ate as Ion Source for accessi bility

f
.
El ectroni c scan rate of 20,000 u/sec


g
. Mass range scan from 1.6 to 1050 u.

h
. SIM capaci ty 100 groups wi th capaci ty of a mi ni mum of 60 i ons per group

i
. SIM dwel l ti me set i n 1 msec i nterval, to as l ow

as 1 msec dwel l

j
. El ectroni cs shall have the capaci ty to col l ect SCAN and SIM data wi th the same acqui sition cycl e; SIM setup shal l
have the abi l i ty to convert to a ful l Scan
method to a

SIM method
or a SIM/SCAN method
and confi gure the
number of SIM gro
ups, SIM cycl es across a peak wi th the i ons added to each group.


k. Maxi mum col umn fl ow to MS i s 3 mL/mi n


Sensitivity

a. Capable of yielding at least
300
:1 S/N from a 1
-
u
l injection of 1pg/
u
l of octafloronapthalene (OFN)

scanning from 50
-
300 u at nominal m/z 272 ion at install
.

Tune Parameters

a. Tunes usi ng a cal i brati on gas of perfl uorotri butyl ami ne (PFTBA)

b. Tune opti ons to i ncl ude a customi zabl e tune and a standard tune wi th an “
automated “fi el d”

to set and store
rel
ati ve abundance target val ues for vari ous i ons.

c. Cal i bration val ve must automati cal ly open when the tune i s started and must automati cal ly cl ose when tune i s
compl eted.

d. Easy access to refi l l reference standard i n cal ibrati on val ve.

Filament

a. Gi ves
an error message that fi l ament i s bl own (i.e. no emi ssi on current) and stops the GC/MS run.

b. Easy access to source and fi l ament(s) for cl eani ng and repl acement.

c. Abi l i ty to change fi l aments wi thout cool i ng and venti ng the system such as dual fi l aments
wi th a fi l ament
sel ecti on and status i ndi cator control led by the system software

Mass Spectrometer Safety Features

a. Safety system protecti on for vacuum l oss, excess si gnal and excess temperature

b. The system has a vacuum moni tori ng wi th readout, such as

i on gauge control l er.

c. Auto reboot after power fai l ure to restore heated zones and vacuum systems or appropri ate safeguards


Gas Chromatograph Injection Port

a. Injector port to i ncl ude fl i p
-
top or turn top i nl et system. Injector port must handl e the me
chani cal septa. (e.g.
Jade Val ve, Merl i n Mi croseal )


Data System Report Capabilities

a. The data system must have the abi l i ty to save i nstrument parameters wi th each data fi l e. Data fi l es can be
automati cal l y assigned or manual l y entered i n the batch or se
quence tabl e. Data fi l es must be retri evabl e for
reprocessi ng purposes and not be overri dden wi thout a message prompt.

b. The data system must have the capabi lity of al l owi ng the user to add, del ete or reuse posi ti ons, i n non
-
sequenti al order, duri ng a bat
ch or sequence run wi thout stoppi ng or requi ri ng a restart, and be capabl e of
anal yzi ng at l east several di fferent methods and mul ti pl e i njecti on vol umes.

c. The data system has the capabi l ity of retri eval of i nformati on that tracks i nstrument operati on.

d
. The data system must al l ow the user to sel ect run parameters wi th a si ngl e method choi ce. Thi s method woul d
set parameters for the i njecti on, GC, MS and post
-
acqui siti on macros.

e. The data system must al l ow sequences to contai n mul ti pl e methods usi ng di
fferent i nstrument tunes.

f. The data system must have the abi l ity to tune speci fi c i ons.

g. The computer workstati ons must be capabl e of bei ng connected to the l aboratory’s i ntranet.

h. The data system must al l ow for the addi ti on of user l i braries wi th al
l of the same search capabi lities as
commerci al l y marketed l i braries.

i. Data system must do i on searches and subtracti ons.

Data System Macro Capabilities

a. The data system must be capabl e of at l east one or both of the fol l owi ng:

1. Al l ows the user to wri te macro programs for data processi ng and report generati on. The system must process
exi sti ng
NIRCL

macros

2. A reporti ng program i ntegrated wi th the software whi ch al l ows for customi zed report templ ates, to i ncl ude
headers and foo
ters on every page, and the capabi l ity to pri nt mul ti pl e Total Ion Chromatograms (TIC) and spectra
on a page.


Reporting

a. Header i nformati on refl ects sampl e i nformati on pul l ed di rectl y from a data fi l e. Reprocessed data must refl ect
the ori gi nal i nstrum
ent parameters, i ncl udi ng the ori gi nal run date and ti me.

b. Have an absol ute footer abl e to refl ect i nstrument condi ti ons at ti me of run.

c. Pri nt mul ti pl e spectra for one sampl e per page.

d. Pri nt mul ti pl e sampl es per page. Must have i nset chromatogram,
pre
-
purge and post
-
purge of the spool er.

e. Abi l i ty to pri nt a TIC and spectrum on one page wi th the header and footer, exactl y as they appear on the screen
and the abi l ity to onl y pri nt the TIC on a si ngl e page wi thout a spectrum.

f. Abi l i ty to have mul ti
pl e i ntegrati on target areas, but onl y pri nt a TIC and spectrum when a peak i s found i n the
target area.

Commodities to be quoted with each system:

a. Wi l ey Regi stry 10th Edi ti on / NIST 2012 Mass Spectral Li brary or most current edi ti on (di gi tal copy)

b.
Mass Spectral and GC Data of Drugs, Poisons, Pesticides, Pollutants and Their Metabolites,
by Hans H. Maurer, Karl
Pfl eger, Armi n A. Weber , most current edi ti on
(di gi tal copy and vol ume set)

c. Mass Spectra of Desi gner Drugs 2012 by
Peter Rösner

most current edi ti on (di gi tal copy)


d. Other l i braries ava
ilable on your system, ei ther for purchase or access.

e. Ion Gauge Detector that measures Torr i n the Mass Spectrometer

Electrical

Instrumentati on uti l i zes 120 VAC or 208 VAC, unl ess otherwi se approved by
NIRCL

and the VAC requi rement i s
cl earl y stated.


O
ne GC/MS with a Turbo Pump for Toxicology

Mass Spectrometer

must i ncl ude the fol l owi ng features:

a. The Quadrupol e mass fi l ter shal l consist of a monol i thi c quartz structure wi th a true hyperbol i c shape.

b. The Quadrupol e

i s i ndependentl y heated to be user sel ectabl e from 100
-
200 degrees centi grade;

c. Ion source can be temperature control l ed from 100
-
350 degrees centi grade; thi s source i s constructed from a
sol i d i nert source whi ch i s not stai nl ess steel

d. Quadrupol e el
ectrode surfaces covered by ti tani um composi te and gol d thi n and thi ck fi l ms to prevent oxi dati on

e. Mass fi l ter and Detector on the same pl ate as Ion Source for accessi bility

f. El ectroni c scan rate of 20,000 u/sec

g. Mass range scan from 1.6 to 1050 u.

h. SIM capaci ty 100 groups wi th capaci ty of a mi ni mum of 60 i ons per group

i. SIM dwel l ti me set i n 1 msec i nterval, to as l ow as 1 msec dwel l

j. El ectroni cs shall have the capaci ty to col l ect SCAN and SIM data wi th the same acqui sition cycl e; SIM setup sh
al l
have the abi l i ty to convert to a ful l Scan or SIM method and confi gure the number of SIM groups, SIM cycl es across
a peak wi th the i ons added to each group.


k. Maxi mum col umn fl ow to MS i s
4

mL/mi n

l
. Abi l i ty to back
-
fl ush at end of run to keep source

cl eaner

m
. Abi l i ty to change GC col umn wi thout venti ng MS

n
. Shal l have a “2
-
way spl i tter” to merge two col umns i n one Mass Detector j. . Ion source can be temperature
control l ed from 100
-
350 degrees centi grade; thi s source i s constructed from a sol i d i ne
rt source whi ch i s not
stai nl ess steel

o
. SIM capaci ty 100 groups wi th capaci ty of a mi ni mum of 60 i ons per group

p. El ectroni cs

shal l have the capaci ty to col l ect SCAN and SIM data wi th the same acqui si tion cycl e; SIM setup shal l
have the abi l i ty to conve
rt to a ful l Scan or SIM method and confi gure the number of SIM groups, SIM cycl es across
a peak wi th the i ons added to each group

q
. SIM speed down to 0.1 msec

r
. Software automati cal l y can confi gure the number of SIM groups, wi th SIM cycl es across the pe
ak and i ons added
to each group

s
. Maxi mum col umn fl ow shal l be between 1 and 2 ml/mi n i n EI wi th the maxi mum sustai ned fl ow of 50 mL/mi n
for back
-
fl ushing

t
. At l east a 10 year avai lability for parts and servi ce or gi ve a resi dual value credi t for repl ace
ment

Sensitivity

a. Capable of yielding at least 1500:1 S/N from a 1
-
ul injection of 1pg/ul of octafloronapthalene (OFN)
scanning from 50
-
300 u at nominal m/z 272 ion at install.

Tune Parameters

a. Tunes usi ng a cal i brati on gas of perfl uorotri butyl ami ne (P
FTBA)

b. Tune opti ons to i ncl ude a customi zabl e tune and a standard tune wi th an “automated “fi el d” to set and store
rel ati ve abundance target val ues for vari ous i ons.

c. Cal i bration val ve must automati cal ly open when the tune i s started and must automati c
al ly cl ose when tune i s
compl eted.

d. Easy access to refi l l reference standard i n cal ibrati on val ve.

Filament

a. Gi ves an error message that fi l ament i s bl own (i.e. no emi ssi on current) and stops the GC/MS run.

b. Easy access to source and fi l ament(s) for

cl eani ng and repl acement.

c. Abi l i ty to change fi l aments wi thout cool i ng and venti ng the system such as dual fi l aments wi th a fi l ament
sel ecti on and status i ndi cator control led by the system software

Mass Spectrometer Safety Features

a. Safety system prot
ecti on for vacuum l oss, excess si gnal and excess temperature

b. The system has a vacuum moni tori ng wi th readout, such as i on gauge control l er.

c. Auto reboot after power fai l ure to restore heated zones and vacuum systems or appropri ate safeguards


Data
System Report Capabilities

a. The data system must have the abi l i ty to save i nstrument parameters wi th each data fi l e. Data fi l es can be
automati cal l y assigned or manual l y entered i n the batch or sequence tabl e. Data fi l es must be retri evabl e for
reprocess
i ng purposes and not be overri dden wi thout a message prompt.

b. The data system must have the capabi lity of al l owi ng the user to add, del ete or reuse posi ti ons, i n non
-
sequenti al order, duri ng a batch or sequence run wi thout stoppi ng or requi ri ng a restart
, and be capabl e of
anal yzi ng at l east several di fferent methods and mul ti pl e i njecti on vol umes.

c. The data system has the capabi l ity of retri eval of i nformati on that tracks i nstrument operati on.

d. The data system must al l ow the user to sel ect run parame
ters wi th a si ngl e method choi ce. Thi s method woul d
set parameters for the i njecti on, GC, MS and post
-
acqui siti on macros.

e. The data system must al l ow sequences to contai n mul ti pl e methods usi ng di fferent i nstrument tunes.

f. The data system must have the

abi l ity to tune speci fi c i ons.

g. The computer workstati ons must be capabl e of bei ng connected to the l aboratory’s i ntranet.

h. The data system must al l ow for the addi ti on of user l i braries wi th al l of the same search capabi lities as
commerci al l y marketed

l i braries.

i. Data system must do i on searches and subtracti ons.

Data System Macro Capabilities

a. The data system must be capabl e of at l east one or both of the fol l owi ng:

1. Al l ows the user to wri te macro programs for data processi ng and report generati
on. The system must process
exi sti ng NIRCL macros

2. A reporti ng program i ntegrated wi th the software whi ch al l ows for customi zed report templ ates, to i ncl ude
headers and footers on every page, and the capabi l ity to pri nt mul ti pl e Total Ion Chromatograms (
TIC) and spectra
on a page.

Reporting

a. Header i nformati on refl ects sampl e i nformati on pul l ed di rectl y from a data fi l e. Reprocessed data must refl ect
the ori gi nal i nstrument parameters, i ncl udi ng the ori gi nal run date and ti me.

b. Have an absol ute foot
er abl e to refl ect i nstrument condi ti ons at ti me of run.

c. Pri nt mul ti pl e spectra for one sampl e per page.

d. Pri nt mul ti pl e sampl es per page. Must have i nset chromatogram, pre
-
purge and post
-
purge of the spool er.

e. Abi l i ty to pri nt a TIC and spectrum on

one page wi th the header and footer, exactl y as they appear on the screen
and the abi l ity to onl y pri nt the TIC on a si ngl e page wi thout a spectrum.

f. Abi l i ty to have mul ti pl e i ntegrati on target areas, but onl y pri nt a TIC and spectrum when a peak i s fou
nd i n the
target area.

Commodities to be quoted with each system:

a. Wi l ey Regi stry 10th Edi ti on / NIST 2012 Mass Spectral Li brary or most current edi ti on (di gi tal copy)

b.
Mass Spectral and GC Data of Drugs, Poisons, Pesticides, Pollutants and Their Metabolites,
by Hans H. Maurer, Karl
Pfl eger, Armi n A. Weber , most current edi ti on (di gi tal copy and vol ume set)

c. Mass Spectra of Desi gner Drugs 2012 by
Peter Rösner

most current edi ti on (di gi tal copy)

d. Other l i braries available on your system, ei ther for purchase or access.

e. Ion Gauge Detector that me
asures Torr i n the Mass Spectrometer

Electrical

Instrumentati on uti l i zes 120 VAC or 208 VAC, unl ess otherwi se approved by NIRCL and the VAC requi rement i s
cl earl y stated.