Mark Borodovsky, Director, Center for Bioinformatics and ...

educationafflictedΒιοτεχνολογία

4 Οκτ 2013 (πριν από 3 χρόνια και 8 μήνες)

80 εμφανίσεις


----

Mark
Borodovsky

a short intro


Position open:

Scientist
-

Pathway Informatics (June 2009)


THE POSITION

The successful candidate will join the Computational Science & Bioinformatics team


and will play a major role in the processing and
analysis of large scale data sets

from
various post genomic technologies
and their applications in biomarker discovery.

He/she will also have responsibility for
establishing and maintaining analysis

pipelines geared toward the identification of disease signature genes and pathways


from experimental system response profiles.

He/she will have the opportunity to apply and when necessary
develop methods

for systems wide analysis of gene expression patterns, their transcription factor


and epigenetic control, and the role of small RNAs in regulating gene/protein products
.


Specifically,
you will:


Establish innovative computational analysis for identification of deregulated pathways


in various disease states


Provide analysis of large scale array based data (genomics,
transcriptomics
,

proteomics) to support the Computational Disease Biology team


THE PERSON


You have
PhD in bioinformatics
or related field


You have academic or industrial experience in bioinformatics with focus on


integrated analysis of biological systems
(gene/protein expression data,

array CGH,
ChiP
-
chip)


Good programming skills in Perl, C/C++,or Java
,


you have also solid expertise in R/
Bioconductor
, or
Matlab



You have previous
experience in Gene Regulatory Network reconstruction

and pathway analysis

This

International

Research

Training

Group

(IRTG)

is

formed

by

groups

from


Humboldt

University

Berlin,

Free

University

Berlin,

Boston

University,


Kyoto

University

and

the

University

of

Tokyo
.


It

focuses

on

the

education

of

doctoral

students


in

the

emerging

field

of

genomics

and

systems

biology

of

biomolecular

networks
.


The

processes

to

be

studied

carry

out

fundamental

processes

within

living

cells,


such

as

metabolic

interconversions
,

cell

division,

cell

differentiation

and

apoptosis
.


The

basic

research

performed

in

this

program

is

highly

relevant

for

future


medical

applications,

in

particular

with

respect

to

cancer

and

other

diseases


resulting

from

a

dysfunction

of

signaling

pathways

and

gene
-
regulatory

networks
.


The

IRTG

provides

the

doctoral

students

with

a

wide

range

of

interdisciplinary


and

topical

research

projects

in

four

areas
:


(A)

Dynamics

and

topology

of

metabolic

networks,


(B)

Regulation

of

gene

expression,


(C)

Intra
-

and

intercellular

signal

transduction,

and


(D)

Structure

and

function

of

protein

families
.

Candidates/jobs ratio


May & June 2009,

source: naturejobs.org


BINF



252
jobs



SystemsBio


21 jobs


Question #
1

Bioinformatics community has grown up earlier than the Systems Biology one;

PhD
in Bioinformatics programs has already been in place at many universities.


Now
Systems Biology may become a
new name
for a PhD major.


Should a System Biology PhD program be separate from a Bioinformatics PhD
program
?


or

Should
a PhD in Bioinformatics extend its name to PhD in Bioinformatics and
Systems
Biology (Comp Bio)?


Question #2

Will addition of
wet lab
courses to Computational Biology graduate training

lead
to loosing the Comp Bio identity?