M Pharm Syllabus 2010-11 - Modified ver 1

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Syllabus


Master of Pharmacy (M. Pharm.)


Session: 2010
-
2011













Pharmacy Discipline

Life Science School

Khulna University, Khulna
-
9208




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14


Pharmacy Discipline

Life Science School

Khulna University, Khulna
-
9208


M. Pharm. Syllabus

Session: 2010
-
11


First Year Term
-
I

Course
Code

Course Title

Credit

Core



Pharm
-

5101

Natural Products Chemistry and Drug Discovery

03

Pharm
-

5103

Advanced Pharmaceutical Technology

03

Pharm
-

5105

Pharmaceutical Biotechnology, Molecular Biology and Immunology

03

P
harm
-

5150

Thesis

06

Core Total


15

Optional



Pharm
-

5113

Advanced Pharmacology and Toxicology

03

Pharm
-

5115

Pharmaceutical Management and Marketing

03

Pharm
-

5117

Research Methodology and Project Management

03

Optional Total


03


Total: Theory
: 3 Core + 1 Optional (any of the optional courses)

18




First Year Term
-
II



Course
Code

Course Title

Credit

Core



Pharm
-

5207

Advanced Pharmaceutical Analysis

03

Pharm
-

5209

Advanced Biopharmaceutics and Pharmacokinetics

03

Pharm
-

5211

Pharma
ceutical Industrial Management

03

Pharm
-

5250

Thesis

06

Core Total


15

Optional



Pharm
-

5219

Advanced Medicinal Chemistry

03

Pharm
-

5221

Food Technology and Cosmetology

03

Pharm
-

5223

Hospital Pharmacy and Drug Regulatory Affairs

03

Optional Tot
al


03


Total: Theory: 3 Core + 1 Optional (any of the optional courses)

18






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First Year Term
-
I

Title of the Course
:
Natural Product Chemistry and Drug Discovery

Course No.
PHARM 5101

03 Credit Hour; 03 Contact Hour/Week

Section A


1.

Sources of drugs: (e
.g., plant, marine, fungi, bacteria, synthetic), g
enesis of new drugs:
Serendipity, random screening, extraction of active principles from natural sources,

2.

Therapeutic potential of plant
-
derived compounds: realizing the potential.

3.

Recent trends in the use

of Natural products and their derivatives i.e.
terpenes, flavonoids,
coumarins, alkaloids, polyketides and macrolides, etc

as potential Pharmaceutical and biologically
active agents.
Bioengineering in production of novel natural products. Total synthesis
of natural
products and retro
-
synthetic analysis.

4.

Highlights of research on Plant
-
derived Natural Products and their analogs with
reference to
antiviral, antibacterial and antiparasitic, anticancer,

Anti
-
tumor, Anti
-
HIV and anti
-
fungal
activity.
Chemical a
nd Biological assays. Robotics in pharmaceutical analysis and drug discovery.
High Throughput Screening (HTS).

Section
-

B


5.

Naturally occurring Anti
-
mutagenic and Cytoprotective agents. Fractionation of plants to discover
substances to combat cancer.

6.

A st
rategy for rapid identification of Novel Therapeutic leads from Natural Products.

7.

Marine Natural Products as leads to develop new drugs and insecticides. Commercialization of
Plant
-
derived Natural Products as pharmaceuticals.

8.

Naturally Occurring Free Radic
als and Anti
-
oxidants: Hydrogen peroxide in biological system,
protection against oxidants in biological systems, superoxide theory and oxygen toxicity, Lipid
peroxidation
-

a free radical chain reaction, Free radical and toxicology, free radical as useful
species, Free radical in ageing and diseases like artereosclerosis, ischemic heart diseases, ageing
process and neurodegradative conditions.


Recommended Books:

1.

Heinrich
, M.;
Barnes
, J.;
Gibbons
, S.;
Williamson
, E.
Fundamentals of
Pharmacognosy and
Phytot
herapy
, churchill
Livingstone
,
Taylor & Francis Publishers,
London

and New York,
2002.

2.

Evans, W.C. 1989. Trease & Evans' Textbook of Pharmacognosy. 13th edition. University
Press, Cambridge.

3.

Jean Brunton, “
Text Book of Pharmacognosy, Photochemistry and Me
dicinal Plants”,

Intercept
Limited, Andover, England, U.K.

4.


W.H.O. Monographs on herbal drugs

5.

Herbal Medical Products, Dr. Fruke Gaedeke and Dr. Barbare Steinholf

6.

Ali, M. 1994. Textbook of Pharmacognosy. Satish Kumar Jain for CBS.

7.

Tyler, V.E. and Brady,
L.R. 1988. Pharmacognosy. 9th edition. Philadelphia.

8.

Ghani, A. 1998. Medicinal Plants of Bangladesh: Chemical Constituents & Uses. 1
st

Edition.
Asiatic Society of Bangladesh.








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Title of the Course
:
Advanced Pharmaceutical Technology

Course No.
PHARM 51
03

03 Credit Hour; 03 Contact Hour/Week

Section
-

A

1.

Tabletting technology:

Granulation, Tablet Compression, Tablet Press, Tablet Toolling,
Troubleshooting, Tablet Coating technology and troubleshooting during coating, Tablet
packaging technology and trouble

shooting, Various IPC of tablet manufacturing, Environmental
control during tabletting of some special drugs, compaction of powders, Dry suspension,
capsulation.

2.

Modified Release Dosage Form (MRDF)

such as sustained release, target release, transdermal
pa
tch, liposomes, novel drug delivery system, microencapsulation, pellet technology, Vaginal
drug delivery system, Intrauterine drug delivery system, hydrogel based drug delivery system,
Iontophoresis, Sonophoresis.

3.

Sterile (Large and Small volume) products
,

MDI products, Ophthalmic and nasal preparation,
their production technique and quality control.

4.

General management

procedure of a pharmaceutical industry, TQM, productivity, inventory
management technique for pharmaceutical industries.


Section
-

B


5.

Clean
room for aseptic pharmaceutical manufacturing, HVAC and Sandwich panel for clean
room, Validation of clean rooms, Container and closure cleaning and sterilization, Aseptic filling
of sterile powders, Blow
-
Fill
-
Seal aseptic packaging technology, Clean in pl
ace (CIP), and Sterile
in place(SIP) systems.

6.

Validation techniques for pharmaceutical industries
: Definition and scope of validation,
Hierarchy of validation, Validation protocol, Prospective, retrospective and concurrent validation,
Benefits of validatio
n, Process validation: Validation of solid, liquid , sterile products, facilities,
equipments and service validation, Raw material validation, sampling validation, cleaning
validation, Analytical method validation, Computer system validation

7.

Product develo
pment
, cGMP, ISO, TGA, MHRA and other regulatory body’s audit in the
pharmaceutical industries. Product development and pilot batch scale up.

8.

Materials of construction for pharmaceutical manufacturing:

General considerations
affecting choice of materials,
chemical and physical factor considerations, metal and nonmetals
used in pharmaceutical plants; Mechanism, type and adverse effects of metal corrosion in
pharmaceutical industry.

Recommended books:

1.

Remington’s Pharmaceutical Sciences

2.

Dispensing of Pharmace
utical Students


Cooper and Gunn

3.

Dispensing of Medication

4.

Bentley’s Textbook of Pharmaceutics

5.

An Introduction to Pharmaceutical Formulations


Fishburn

6.

Pharmaceutical Dosage Forms


Ansel

7.

Pharmaceutics and Pharmacy Practice


Banker and Chalmers

8.

The Art,

Science and Technology of Pharmaceutical Compounding


Loyd V. Allen Jr.

9.

Theory and practice of Industrial Pharmacy


Lachmann

10.

American Pharmacy
-

Sprowl

11.

Pharmaceutics


Aulton

12.

Trgeted and controlled Drug Delivery, Novel.







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Title of the Course
:
Pharmace
utical Biotechnology, Molecular Biology and Immunology

Course No.
PHARM 5105

03 Credit Hour; 03 Contact Hour/Week

Section
-

A

1.

Gene Therapy:

Central concept of gene therapy, basic molecular mechanism of gene transfer,
prerequisite of human gene therapy, bio
logical basis of gene therapy strategies, vehicles for gene
transfer, clinical gene therapy studies, gene therapy for hereditary disease, gene therapy for
cancer, gene therapy for HIV

2.

Principles of genetic Engineering (genetic recombination):

a)

Introduction
of recombinant DNA technology.

b)

Gene cloning, Enzymes used in gene cloning.

c)

Construction of gene libraries.

d)

Techniques of genetic recombination i) Cloning vectors. ii) Plasmids ii) Bacteriophages, iv)
Cosmids v) Cloning strategies vi) Isolation of clone
of interest, vii) Characterization of gene
clones viii) Genomic analysis ix) Sub
-
probe analysis

e)

Polymerase chain reaction (PCR) in gene amplification

f)

Application in pharmaceutical Science

1.

Bioinformatics:

Definition and concepts, importance of bioinformat
ics, biological database,
primary sequence database, protein sequence database, DNA sequence database. Multiple
sequence alignment and importance of multiple sequence alignment for drug design.

2.

Genome
-
Based Medicine:


i.

An overview of the Human Genome Initia
tive.

ii.

Positional Cloning

A method of Identifying Disease Genes.

iii.

Inheritance and the Genome

iv.

Cloning Disease Genes

v.

Internet Access to Human Genetic Maps

vi.

Strategies for mapping the Human Genome

vii.

Methods for Tracking Disease Genes

viii.

Role of Bio
-
informatics in Ge
nome
-
based Therapy

ix.

Analysis of Human Disease Genes


Section
-

B

5.

General features of major histocompatibility complex (MHC) and their roles in antigen
presentation; Recognition of antigens by lymphocytes; Activation of T & B lymphocytes.

6.

Effector mechanisms
of immune responses:

Effector mechanisms of phagocytes, natural killer
(NK) cells, T lymphocytes and B lymphocytes in immune responses; Cytokines and their roles in
immune responses.

7.

Immunological techniques:

precipitation; agglutination, co
-
agglutination
& haemagglutination;
complement fixation; immunodiffusion; immunoelectrophoresis; immunoassays; immunoblotting;
immunofluorescences, and fluorescence activated cell sorter (FACS).

Recommend Books:

1. Cellular and Molecular Immunology by Abul K Abbas, Andre
w H Lichtman, Jordan S Pober, 4th
ed.

2. Immunology by Ivan Roitt, Jonathan Brostoff , David Male,7th Edition.

3. Molecular Biology by PC Turner, AG Mclennam, AD Bates,30 Jun 2010.

4. The Cell: A molecular Approach by Alberts B et al 3ª Ed, Sinauer, 2004

5
. Molecular Cell Biology by Lodish et al, 5th ed.

6. Molecular Biology of Cells by Alberst et al Fifth Edition,December 2007
...

7. Applied therapeutics by young kode kihble et.al 15 Feb 2004.

8. Hand book of Drug Interaction by karalliedde & Hanry



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Title
of the Course
:
Thesis


Course No.
PHARM 5150

06 Credit Hour; 06 Contact Hour/Week

Each candidate should consult with corresponding supervisor and should submit dissertation for
the completion of their degree.


Optional Courses

Title of the Course
:
Advanced

Pharmacology and Toxicology

Course No.
PHARM 5113

03 Credit Hour; 03 Contact Hour/Week

Section
-
A

1.

Receptor

Pharmacology:


a)

5
-
Hydroxytryptamine: Introduction, Chemistry, Biosynthesis and metabolism, 5
-
HT receptor
subtypes, Site of 5
-
HT action, 5
-
HT agonists

and antagonists, Serotonergic receptors in the
cardiovascular system, Signaling pathway, Biochemical and molecular aspects, Clinical
implications.

b)

Molecular and cellular mechanisms of 1) Glutamate receptors, 2) GABA and its receptors, 3)
Catecholamine rec
eptors (

-

and

-
adrenoceptors, dopamine receptors), 4) Acetylcholine
receptors (nicotinic and muscarinic receptors), 5) Opioid receptors.

2.

Cardiovascular

pharmacology
:

a)

Vasodilators: Nitric oxide
-

Biosynthesis of nitric oxide and its control, Degradation a
nd
carriage of nitric oxide, Effects of nitric oxide, Therapeutic use of nitric oxide and nitric oxide
donors, Inhibition of nitric oxide, Clinical conditions in which nitric oxide may play a part.

b)

Pathophysiology of Heart

c)

Drug of Heart disease

d)

Ion channel
s, exchangra and pumps: Transduction mechanisms as targets of drug action,
voltage sensitive ion channels

structure and function, K
+

channels. Voltage sensitive Ca
+2

channels and the pharmacology of their inhibitors. Agonists at

-
adrenoceptors.
Pharmacolo
gy of Na
+
/K
+

ATPase and gap junctions.

3.

Neuropharmacology
:

a)

Pathophysiology of CNS

b)

Diseases and treatment of

Neurogenerative disorders
-

Neurodegenerative disorders:
Introduction, Mechanisms of neuronal death, Ischemic brain damage (Strokes), Alzheimer’s
di
sease, Parkinson’s disease, Huntington’s disease, Neurodegenerative prion disease

4.

Cancer biology and therapy:

Introduction to biology of cancer, modes of treatment: radiotherapy,
chemotherapy, surgery, biological therapy including immunology and gene thera
py.





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Section
-

B

5.

Basic concept in toxicology
: Introduction to toxicology and its subdivisions, Types of adverse
drug reaction, Risk assessment and toxicity testing, Nonmetalic environmental toxicants,
Chelators and heavy metal intoxication.

6.

The mechanism

of toxin action
: General mechanisms of toxin
-
induced cell damage and death


hepatotoxicity and nephrotoxicity, Mutagenesis and carcinogenecity


Biochemical mechanisms
of mutagenesis, Carcinogenesis


genotoxic and epigenetic carcinogens, Teratogenesis a
nd drug
-
induced foetal damage, Allergic reactions to drugs.

7.

The biotransformation of toxins, their inactivation and removal from the body
: An introduction to
biotransformation. The cytrochrome P
-
450 system


its function, mechanism of action and
regulation
. Glutathione and glutathione
-
S
-
transferase

its function, mechanism of action and
regulation.

8.

Reactive intermediates:
Types of metabolically generated reactive intermediates and their role in
drug toxicity. Epoxidation and drug toxicity, N
-
oxidation and dr
ug toxicity, toxicity and sulphur
xenobiotics.

9.

Environment and health
: Heavy metal poisoning. Arsenicosis in Bangladesh. Cadmium dilemma.

10.

Toxicity Tests: Principles, factors (translocation, concentration, structure relationship), categories
of toxicity tes
ts (acute, prolonged, chronic, potentiation, teratogenic, reproduction, mutagenesis,
carcinogenesis, skin and eye tests)


Recommended Books:

1.

The Pharmacological Basis of Therapeutics


by Goodman and Gilman.

2.

Pharmacology


by H.P. Rang et al.

3.

Pharmacology


by Lippincott et al.

4.

Pharmacology


by Kalant et al.

5.

Basic and Clinical Pharmacology


by Bertram G. Katzung.

6.

Pharmacology and Therapeutics


by R.S. Satoskar et al.

7.

Medical Pharmacology


by Goth.

8.

Essentials of Medical Pharmacology


by K.D. Tripatti.

9.

F
undamentals of Toxicology


by Pandey, Shukla & Trivedi

10.

Essentials of Toxicology


by Ted. A. Loomis




Title of the Course
:
Pharmaceutical Management and Marketing

Course No.
PHARM 5115

03Credit Hour; 03 Contact Hour/Week

Section
-
A

1.

Pharmaceutical managem
ent:
i) Definition, objective, nature & principle and steps of
pharmaceutical management; ii) objective, types & steps of pharmaceutical planning, issues and
problems related to planning.

2.

Organization structure:
Types
-

social & legal, sole proprietorship,

partnership, private & public
limited company, their comparative advantages & drawbacks.

3.

Personnel management:

Principles, methods, motivation, staff recruitment & selection steps,
socialization.

4.

Pharmaceutical market analysis process:

Market oriented st
rategic planning and
pharmaceutical market analysis (‘SWOT’ analysis); Methods of market segmentation, problems
associated with market segmentation, identifying market segments; Target market selection.

Section
-

B

5.

Market development strategies:

Differen
tiating and positioning product in a particular market,
Types of positioning & positioning strategies; Product life cycle (PLC); New product
development; Designing value networks and marketing channels; Managing integrated marketing
communications & managi
ng sales force.


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6.

Post
-
marketing activities of pharmaceutical companies:

Pharmacovigilence [Study on
methods to detect possible adverse drug reactions (ADRs)], intensive surveillance and
spontaneous reporting through medical information service (MIS), study

on methods to determine
risk & casualty of market, estimation of cost benefit as well as legal considerations.

7.

Pharmacoeconomics:

Environment of local & global pharmaceutical industry; Demand, and
supply of pharmaceutical products; Global market impac
t on WTO
-
TRIPS; New drug
development related issues: measurement of cost & outcomes; Health policy versus industrial
policy in pharmaceutical sector, how to compromise, drug policies in different countries; Pricing
of pharmaceutical products: how to fix pr
icing, factors affecting cross national price differences.

Recommended Books:

1.

Principles of Marketing


by Philip Kotler

2.

Books related to Management and Marketing




Title of the Course
: Research Methodology and Project Management

Course No.
PHARM 5117

03C
redit Hour; 03 Contact Hour/Week

Section
-
A

1.

Introduction:
i) Definition and importance of research; process of research; characteristics of a
good research project; defining and selecting a researchable problem; components of research
protocol; steps involv
e in a research process.

2.

Methods of research:
Definition, classification, and explanation of different methods of
research
-

Data Collection, organizing, analyzing and presentation methods, Design a
questionnaire, ethics in research.

3.

Techniques of sampling:

Population, sample, Sampling techniques, sample size and its
determination, sampling error and non sampling error


Section
-
B


4.

Research Hypothesis:

Definition, attributes, advantages and types of hypothesis; test of
hypothesis, p value, type 1 and type 2
errors, two tailed and one tailed test, Power of hypothesis
test, test of significance.

5.

Design of experiments in Pharmaceuticals:

Discussion of different types of experiments used in
pharmaceutical research.

6.

Preparing a research proposal and writing a thes
is/report:

Discussion on different sections of
research proposal and thesis/reports, their construction. Manuscript submission requirements /
guidelines for publications in any journal, style of referencing.



Recommended References:

1.

Abedin, M.Z. 1996. A h
andbook of research for the fellows of M. Phil and Ph.D.
Programmes. Book Syndicate, Dhaka

2.

Ahmed, A.R., M.A.A. Bhuiya and M.Z. Hossain.2003. Experimental Designs: theory and
application. Rokeya Sultana Mili. Dhaka

3.

Ahuja, R.2001. Research Methods, Rawat Pub
lications, New Delhi.

4.

Ahmed, A.R., M.A.A. Bhuiy, Z.A Reza and M.Z. Hossain.2004. Methods of statistics. S.
Ahmed and Associates, Manikgnaj.

5.

Kothari, C.R. 2001. Research Methodology: Methods and Techniques (2
nd

ed.). Wishwa
Prakashani, New Delhi.





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First Y
ear Term
-
II


Title of the Course
:
Advanced Pharmaceutical Analysis


Course No.
PHARM 5207

03 Credit Hour; 03 Contact Hour/Week

Section
-

A


1.

Nuclear Magnetic Resonance: Principles,
1
H and
13
C NMR, instrumentation including cryogenic
probe, solid state NMR an
d FT
-
NMR. 1D and 2D NMR, principle of decoupling, gated
decoupling, DEPT, APT, 1D NOE. Use of 2D NMR spectroscopy in structure elucidation.
1
H
-
1
H
COSY, HMBC, HMQC, HSQC, TOCSY, NOESY, ROESY, INADEQUATE. NMR in drug
screening, reaction monitoring and study
of drug receptor interactions. Application of magnetic
resonance in medical sciences.

2.

Mass Spectrometry: Theory, instrumentation and ionization techniques (FAB, ESI, MALDI, FD
etc). Applications of MS
-
MS, GC
-
MS, LC
-
MS. Application of mass spectrometry in d
rug
discovery and omic analysis, structure elucidation of small molecules, secondary metabolites,
peptides and macromolecules.

3.

ESR: Principles, application in detection of free radical reactions in chemical and biological
systems.

Section B

4.

Electrophoresis
: Agarose gel electrophoresis,, pulse field gel electrophoresis, polyacrylamide gel
electrophoresis (PAGE), SDS
-
PAGE, 2D gel electrophoresis, isoelectric focusing,
isotachophoresis, capillary electrophoresis.

5.

Polymerase chain reaction (PCR), reverse transc
ription polymerase chain reaction (RT
-
PCR),
asymmetric PCR, nested PCR.

6.

ELISA (Enzyme Linked ImmunoSorbent Assay)

7.

Blotting techniques: Western, Northern and Southern blotting techniques.

8.

DNA microarray technique

Recommended Books:

1.

One and two Dimensional N
MR spectroscopy. By Atta
-
ur
-
Rahman, Elsevier, 1989.

2.

Organic Spectroscopy. By D.W. Brown, A.J. Floyd, and M. Sainsbury, John Wiley and Sons,
1988.

3.

J. K. M. Sanders and B. K. Hunter
, “
Modern NMR Spectroscopy
” Oxford.
University Press,
1993.

4.

Modern NMR Techn
iques for Chemistry Research
, J. K. M. Sanders and B. K.
Hunter
, 2nd
Ed. Oxford 1993.

5.

R. J. Abraham and P
.
Loftus
, "
Proton and Carbon
-
13 NMR Spectroscopy
, An
Integrated
Approach," Heydon, London, 1978

6.

Principles of Instrumental Analysis, by D.A. Skoog
, F
.J. Holler, and S.R. Crouch
., 6th Ed.,
Brooks Cole 2007.

7.

Sharma, 1995, Spectroscopy.

8.

Introduction to Organic Laboratory Techniques. By D.L. Pavia, G.M. Lampman and G. S.
Criz. W.B. Saunders Company, 1976.

9.

Natural Products
-

A Laboratory Guide. By Raphel
Lkan, Academic Press Inc, 1991.

10.

Practical Pharmaceutical Chemistry. 4
th

Edition, Part
-
1. By A.H. Beckett and J.B. Stenlake.
The Athlane press, 1989.





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Title of the Course
:
Advanced Biopharmaceutics and Pharmacokinetics


Course No.
PHARM 5209

03 Credit Hou
r; 03 Contact Hour/Week

Section


A


1.

Biopharmaceutical Considerations in Drug Product Designs
: Pharmaceutical factors affecting
drug bioavailability, various methods of dissolution testing,
in

vitro
and
in
-
vivo
correlation of
dissolution, various consider
ations in drug product designing.

2.

Modified
-
released Drug Products and Targeted Drug Delivery Systems:
Introduction,
Advantages and Disadvantages of modified release drug products, Considerations in the
evaluation of modified release products, Targeting dru
g delivery.

3.

Application of Pharmacokinetics in Clinical Situations:
Introduction, Therapeutic drug
monitoring, Design of dosage regimens, Conversion from IV infusion to oral dosing.
Determination of dose, Effect of changing dose and dosing interval on C
max
, C
min
and C
nv
,


Determination of frequency of drug administration, Determination of both dose and dosage
interval, Dosing of drugs in infants, elderly and obese patients.


Section


B


4.

Nonlinear Pharmacokinetics:
Introduction, Equations for drug distribut
ed as one compartment
model and eliminated by nonlinear pharmacokinetics, Bioavailability of drugs that follow
nonlinear pharmacokinetics. Nonlinear pharmacokinetics due to drug
-
protein binding.

5.

Physiologic, Pharmacokinetic Models, Statistic moment and Mea
n Residence Time:
Introduction to physiologic pharmacologic model, Physiologic pharmacologic model with
binding, Application and limitations of physiologic pharmacokinetic models, Statistic movement
theory. Introduction to mean residence time. Mean residen
ce time for multi
-
compartment model
with elimination from the central compartment, Mean absorption time and mean dissolution time,
Selection of pharmacokinetic models.

6.

Relationship between Pharmacokinetics and Pharmacological Response:

Introduction,
Rela
tion of dose to pharmacologic response, Pharmacodynamic models relating to drug response.

7.

Biopharmaceutical Calculations:
Intravenous admixture and rate of flow calculation, drug
availability and pharmaceutical calculations.


Recommended Books:


1.

Applied Bi
opharmaceutics and Pharmacokinetics by Leon Shargel 4th Revised edition edition
(
1

Jan 1999).

2.

Biopharmaceutics and Clinical Pharmacokinetics by Milo Gibaldi 1977.

3.

Biopharmaceutics and Clinical Pharmacokinetics by R.E. Notari 1987.

4.

Biopharmaceutics and drug

interactions by D.E.Cadwallader 3rd ed..




Title of the Course
:
Pharmaceutical Industrial Management


Course No.
PHARM 5211

04 Credit Hour; 04 Contact Hour/Week

Section
-
A

1.

Basic Management Principle:
Modern management Principles, decision making, functio
ns of a
manager, recruitment process, personnel evaluation system, Job responsibilities, Job evaluation
systems.

2.

Production Management & Total Quality Management:
Application of GMP, General
facilities for pharmaceutical plant, environmental factors, dust
collection and cross contamination,

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chemical weighing area, tablet granulation area, tablet compression area, tablet coating area,
liquid manufacturing area , packaging area, water housing, shipping, and receiving materials.

3.

Productivity:
Importance of pro
ductivity in pharmaceutical industry, productivity enhancement,
productivity analysis.

4.

Techniques of inventory Management for Pharmaceutical Industries:

Inventories, Inventory
management, The ABC concept, Inventory reporting and analysis, conversion of in
ventory value
of months of supply, sales, forecasting, economic order quantity, statistical inventory control vs.
material requirements planning, concepts of the order point system, cost controls.

Section
-

B

5.

Pharmaceutical Facility, Design and Requirement
s:
WHO guideline for setup of Medium
Scale Plant construction.

6.

Water Treatment Facility for Pharmaceutical Industry:
Water sources, potable water, water
softening, water deionization, water distillation, reverse osmosis, water storage and distribution.

7.

Ind
ustrial Hazards and Safety:
Environmental Requirement and Pollution control for
pharmaceutical industry, fire management for pharmaceutical industry, waste water other material
management.



Title of the Course
:
Thesis

Course No.
PHARM 5250

03Credit Hou
r; 02 Contact Hour/Week


Each candidate should consult with corresponding supervisor and should submit dissertation for the
completion of their degree.


Optional Courses


Title of the Course
:
Advanced Medicinal Chemistry


Course No.
PHARM 5219

02 Credit Ho
ur; 02 Contact Hour/Week

Section A

1.

Drug discovery and development:

Present, past and future. Lead finding, sources of drug (e.g.,
plant, marine, fungi, bacteria, synthetic),
Genesis of new drugs:
Serendipity, random screening,
extraction of active principl
es from natural sources, molecular modification of known drugs,
selection or synthesis of soft and hard drugs, and rational drug design. high throughput screening.

2.

Molecular Modeling:

Introduction to Molecular Mechanics, Quantum Mechanics, Molecular
Dynami
cs, Molecular Graphics and Molecular Docking.

3.

Computer aided drug design
:

a)

An overview of the role of computational chemistry in therapeutic drug design.

b)

Computational chemistry in small
-
molecule drug design:

i.

Designing drugs without a target 3D structure

ii.

Computational aspects of small molecule design

iii.

Application of pharmacophore based drug design


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11

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14


iv.

Receptor based drug design
-

use of X
-
ray crystallographic and NMR structure

v.

Structure based drug design

4.

QSAR:

Introduction, tools and techniques, physicochemical
parameters, quantitative models,
introduction to 2D and 3D QSAR.

Section B

5.

Organic drug and analogue synthesis

a)

General considerations.

b)

Assymetry in synthesis.

c)

Designing organic synthesis.

d)

Partial organic synthesis of xenobiotics.

6.

Combinatorial Chemistry:
I
ntroduction, solid phase synthesis, liquid phase synthesis, methods
of parallel and mixed combinatorial synthesis.

7.

Classification, mechanism of action, synthetic approach & recent advances of
-

a)

Anti
-

HIV agents.

b)

ACE inhibitors and statins.

8.

Classification, m
echanism of action,SAR, synthetic approach and recent advances of fourth
generation cephalosporins and fluoroquinolone antibacterials.

9.

Classification, mechanism of action and recent advances of
-

a.

COX
-
2 inhibitors.

b.

Macrolides and anti
-
cancer antibiotics.

Rec
ommended Books:


1.

An Introduction to Medicinal chemistry, 2
nd
.ed. 2001, G.L.Patrick, Oxford University press.

2.

Wilson and Gisvolt’s Text Book of Organic, Medicinal and Pharmaceutical Chemistry, 10
th

ed. Lippincott
-
Raven, 1998

3.

Advanced Practical Organic Chemi
stry, 2
nd
. ed., by J. Leonard
et al
.Academic press.

4.

Advanced Organic Chemistry, Bernard Miller, Prentice Hall. 1995

5.

Advanced Organic Chemistry,7
th

ed. Jerry march, Wiley Interscience. 31 May 2007

6.

Mechanism and theory of Organic Chemistry, Lowry and Richard
son, Harper 3rd ed 1987..

7.

Physicochemical Principles of Pharmacy, 3
rd

ed. 1998, A.T. Florence and A.D. Palgrave.


Title of the Course
:
Food Technology and Cosmetology

Course No.
PHARM 5221

03 Credit Hour; 03 Contact Hour/Week

Section A


1.

Introduction to Foo
d Sciences:
Importance of hygienic food uptake, Role of Pharmacist in food
sector, Milk and Milk Products, Meat and poultry, Sea foods, Fats and oil products, Cereals and
legumes, Vegetables and fruits, Juices and beverages, confectionary and chocolate pro
ducts.

2.

Food Spoilage and Preservation:
Deterioration and spoilage of food products, Factors affecting
food spoilages


microbial and non
-
microbial factors, Measures of preventing food spoilage, Food
preservation and storage, Heat and cold preservation, Dehy
dration.

3.

Food Additives:
Food additives and their roles in food processing, Types of food additives,
Rationale use of food additives, Illegal use of banned food additives.

4.

Food Packaging and Storage:
Packaging materials for food and food products, Proper p
acking
and conditions for food storage.

5.

Food Security:
Concepts of food security, Injudicious and unsafe use of various substances in
food production


antibiotics, hormones, growth promoters, pesticides, insecticides.


Page
12

of
14


6.

Quality of Food Products:
Importance
of maintaining food quality, Adulteration of food
products, Quality control and specification of food products.

7.

Food Irradiation:
Irradiation and microwave heating of food products
-

effects of radiation on
foods, safety aspects and application.

8.

Food ferm
entation
:

Principles, Importance, Microbial aspects and applications of fermentation
technology in food processing.


Section


B


9.

Sensitization of the Skin by Cosmetic Ingredients:
Introduction, irritation, inflammation,
hypersensitivity and allergy, Tests

for predicting irritation and sensitization.

10.

Skin Products for Babies and Young People:
Skin problems in babies, Functional requirements
of baby products, safety of baby products, Formulations of baby products, Adolescent skin
problems, Products for oily
skin, Treatments of acne.

11.

Perfumes:
Perception of perfume and fragrance, Perfumery raw materials, Formulation of
perfumes, Perfume blending, Stability of perfumes products, Perfuming of other cosmetic
products.

12.

Herbal Cosmetic Products:
Herbs and herbal in
gredients in cosmetics, traditional and modern
uses, Efficacy, safety and stability of herbal cosmetic products, Representative examples.


Recommended Books:


1.

Poucher’s Perfumes, Cosmetics and Soaps, Hilda Butler, Kluver Academic Press 1
st

edition,
1992.

2.

C
osmetics
,
Science

and Technology by M. S.
Balsam

(1992, Hardcover)
...

Author:
M. S.
Balsam
. Publisher: Krieger Pub Co.

3.

Harris Cosmetology. The Willow Tree Salon. 140 South State Street,
London

4.

WHO Journals.

5.

Eskin
, M. 1990.
Biochemistry of foods
.
Second
edition
. Academic Press, Inc. San
Diego.

6.

Andrews, S. 1994, Food and Beverage Service Manual


18
th

Edition

7.

Food Technology


Srilaxmi

8.

R. Dking


1996, Food Biotechnology


John Wily and Sons, USA

9.

Robert K, Murray Daryl K. Gronner, Harper


Illustrated Bio
chemistry




Title of the Course
:
Hospital Pharmacy and Drug Regulatory Affairs


Course No.
PHARM 5223

02 Credit Hour; 02 Contact Hour/Week

Section A


1.

Introduction:
goals, minimum standards, abilities required for a hospital pharmacists,
organisational pat
tern, management and administration, different departments and services, role of
a pharmacist in hospital.

2.

Safe use of Medications in the Hospital
: Medication error, Factors contributing to medication
error, Corrective measures, ASHP guidelines relative to

safe use of medication in Hospital, Drug
interaction surveillance, Joint commission on prescription drug use.

3.

Nuclear Pharmacy:
Introduction, Licensure information, Types of application forms,
Radioisotope committee, Responsibility of permit holders, Resp
onsibility of individual user,
NABP model regulations for nuclear pharmacy, Role of Pharmacist in the Hospital with an
isotope pharmacy, Role of Pharmacist in the Hospital without an isotope pharmacy, Training
students in nuclear pharmacy, Sources of infor
mation.

4.

Computers in the Hospital Pharmacy:

Terminology, Program criteria, Managing computer
system development, ASHP technical assistant bulletin on Hospital drug distribution and control,
Impact of the computer on dispensing time, Model computer regulati
ons.


Page
13

of
14


5.

Professional practice and relations:

Opportunities for a public relation program, Participation in
administrative committee work, Role of Pharmacist in infection control, Membership in
professional association, Cooperation with medical research staff,

local pharmacists and nursing
staff, Maintain an efficient professional pharmacy, Participation in comprehensive health care
programs, Health maintenance organisation, Home care service, Drug rehabilitation programs,
Drug consultation programs.


Section B


6.

Current Good Manufacturing Practice (cGMP) :
General concept, cGMP regulations to assure
quality of marketed drug products; Applications to manufacturer’s organization, personnel,
facilities & equipment control system; Production and process control; La
boratory procedures
and record control; FDA methods of enforcement to by inspecting manufacturing premises.

7.

FDA review requirement:

Examining informational content for: investigational new drug
applications (IND), investigational device exemptions (IDE)
, new drug applications (NDA),
product license applications (PLA) and biologics license applications (BLA) for FDA review.

8.

Governmental regulatory bodies, Pharmacy law & acts:

Drug administration, Pharmacy
Council of Bangladesh, their scopes and functions;

Pharmacy Act & Ordinance 1976 and Drug
Acts in Bangladesh (Drug Act 1940, Poison Act 1952 & Drug Control Ordinance 1982),
Essential drug policies in other developing countries; Drug ethics to regulate medicines &
professionals: Pharmacists code of ethic
s; Parts of registration dossiers; Rules & regulations to
govern advertising, promotion, and labeling for prescription drugs, biologics, medical devices,
OTC drugs & alternative medicines; Forensic Pharmacy: epidemiology of poisoning, influencing
factor
s for poisoning, locally & systemically used antidotes for poison control & treatment.

9.

Rational Drug Usage:
WHO’s guideline and actions to regulate supply & usage of drugs
rationally, Essential Drug Policy (EDP) for rational use, its implementation in deve
loping
countries; Rational approach for health planning process and role of pharmacists in rational health
policy making.


Recommended Books

1.

Hospital Pharmacy
-

William Hassan