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Michael F. Summers

December 14, 2013


Page
1


PUBLICATIONS

1.

Summers, M.F., Toscano, P.J., Bresciani
-
Pahor, N., Nardin, G., Randaccio, L., Marzilli,
L.G. "A Very Long Cobalt to Nitrogen Bond in a Coenzyme B
12

Model. Relevance to the
Role of the 5,6
-
Dimethylbenzimidazole in Co
-
C Bond Cleavage in Coen
zyme B
12,
"
J. Am.
Chem. Soc
.
105
, 6259 (1983).

2.

Bresciani
-
Pahor, N., Randaccio, L., Summers, M.F., Toscano, P.J. "Structural Distortions
in Alkylcobaloximes Containing Triphenylphosphine as Axial Ligand. The X
-
Ray
Structures of trans
-
Bis(dimethylglyoxim
ato)(bromo
-
methyl)(triphenylphosphine)cobalt(III) and trans
-
Bis(dimethyl
-
glyoximato)
-
(cyanomethyl)(triphenylphosphine)cobalt(III),"
Inorg. Chim. Acta
,
68
, 69 (1983).

3.

Marzilli, L.G., Summers, M.F., Ramsden, J.H., Bresciani
-
Pahor, N., Randaccio, L.
"Synth
esis, Structure and Solution Behavior of trans
-
Bis
-

(dimethylglyoximato)(ethyl)(4
-
methylpyridylimidate)cobalt(III),"
J. Chem. Soc. Dalton Trans
.,
511

(1984).

4.

Summers, M.F., Marzilli, L.G. "Observation of Distinct Cadmium
-
113 NMR Signals for
Complexes
of N
-
Donor Ligands in Solution at Ambient Temperature,"
Inorg. Chem
.,
23
,
512 (1984).

5.

Summers, M.F., Marzilli, L.G., Bresciani
-
Pahor, N., Randaccio, L. "Unusual Bond
Lengths, Conformations, and Ligand Exchange Rates in B
12

Models with the
Bis(salicylidi
ne)
-
o
-
phenylenediamine Equatorial Ligand,"
J. Am. Chem. Soc.
,
106
, 4478
(1984).

6.

Bauman, G.C., Summers, M.F., Hutchinson, J.P. Zubietta, J., Marzilli, J.G. "Preparation of
a New Ligand Containing Disulfide and Imidazole Donor Groups. Structure of
Dibrom
o[5
-
(1,2,5
-
dithiazepan
-
5
-
ylmethylene)
-
4
-
methyl
-
2
-
ethylimidazole]cadmium(II).
113
Cd and
13
C NMR Studies of Complex Formation,"
Inorg. Chem
.,
23
, 3104 (1984).

7.

Randaccio, L., Bresciani
-
Pahor, N., Orbell, J.D., Calligaris, M., Summers, M.F., Snyder,
B., T
oscano, P.J., Marzilli, J.G. "Correlation of Rate, Spectroscopic and Structural Data
for (L)bis(dimethylglyoximato)
-
organocobalt complexes, where L = Pyridine or
Triphenylphosphine,"
Organometallics
,
4
, 469 (1985).

8.

Rossi, M., Glusker, J.P., Randaccio, L
., Summers, M.J., Toscano, P.J., Marzilli, L.G. "The
Structure of a B
12

Coenzyme: Methylcobalamin Studies by X
-
ray and NMR Methods,"
J.
Am. Chem. Soc
.,
107
, 1729 (1985).

9.

Bresciani
-
Pahor, N., Forcolin, M., Marzilli, L.G., Randaccio, L., Summers, M.F., T
oscano,
P.J. "Organocobalt B
12

Models: Axial Ligand Effects of the Structural and Coordination
Chemistry of Cobaloximes,"
Coord. Chem. Revs
.,
63
, 1 (1985).

10.

Marzilli, L.G., Summers, M.F., Bresciani
-
Pahor, N., Zangrando, E., Charland, J.P.,
Randaccio, L.

"Rare Examples of Structurally Characterized Five
-
Coordinate

Michael F. Summers

December 14, 2013


Page
2


Organocobalt Complexes. Novel Dynamic NMR Evidence For Synergistic Enhancement
of Cis and Trans Effects in B12 Models,"
J. Am. Chem. Soc
.,
107
, 6880 (1985).

11.

Bresciani
-
Pahor, N., Calligaris,
M., Randaccio, L., Marzilli, L.G., Summers, M.F.,
Toscano, P.J., Grossman, J., Liotta, D. “The 2,2,2
-
Trifluoreothyl Ligand: A Structural
“Reporter” Group for Its Carbanion Character in Organometallic Compounds,”
Organometallics
,
4
, 630 (1985).

12.

Brescia
ni
-
Pahor, N., Randaccio, L., Zangrando, E., Summers, M.F., Ramsden, J., Marzilli,
P., Marzilli, L.G. "Organocobalt B
12

Models with Very Long Co
-
C (tertiary) Bonds.
Synthesis, Spectroscopic, Kinetic, and Structural Properties of trans
-
Bis(dimethylglyoximat
o)
-
(adamantyl)(L)Co(III) with L = Trimethylphosphite and
Triisopropylphosphite,"
Organometallics
,
4
, 2086 (1985).

13.

Summers, M.F., Andrew Byrd, R., Gallo, K.A., Samson, C.J., Zon, G., Egan, W. "Nuclear
Magnetic Resonance Studies of the Duplex
-
Single Stra
nded Hairpin Loop Equilibrium for
the Oligodeoxyribonucleotide Sequence d(CGCGATTCGCG),"
Nucl. Acids Res
.,
13
, 6375
(1985).

14.

Zon, G., Gallo, K.A., Samson, C.J., Shao, K., Summers, M.F., Byrd, R.A. "Analytical
Studies of Mixed Sequence Oligodeoxyribonucl
eotides Synthesized by Competitive
Coupling of either Methyl
-

or

-
Cyanoethyl
-
N,N
-
diisopropylamino Phosphoramidite
Reagents,"
Nucl. Acids. Res
.,
13
, 8181 (1985).

15.

Marzilli, L.G., Parker, Jr., W.O., Charland, J.P., Summers, M.F. "Relevance of
Organocobalt B
12

Models to B
12

Biochemistry", in
"Frontiers in Bioinorganic
Chemistry,"

A. V. Xavier, Ed., VCH: Fed. Republic of Germany, p. 647 (1986).

16.

Byrd, R.A., Summers, M.F., Fouts, C.S., Marzilli, L.G. "A New Approach for Assigning
31
P Signals and Correlating Adjacent Nucleotide Moieties via
1
H Detected Multiple
Quantum
NMR. Application to the Adduct of d(TGGT) with the Anti
-
Cancer Agent,
Pt(ethylenediamine)Cl
2
,”
J. Am. Chem. Soc
.,
108
, 504 (1986).

17.


Bax, A., Summers, M.F. "
1
H and
13
C Assignments from Sensitivity Enhanced Detection
of Heteronuclear Multiple Bond Connec
tivity by 2D Multiple Quantum NMR,"
J. Am.
Chem. Soc
.,
108
, 2093 (1986).

18.

Marzilli, L.G., Summers, M.F., Zangrando, E., Bresciani
-
Pahor, N., Randaccio, L.
"Unusually Detailed Insight into the Dynamic Behavior of Coordinated Ambidentate
Ligands. Factors
Influencing the Binding Mode of 2
-
Aminopyridines in B
12

Models,"
J.
Am. Chem. Soc
.,
108
, 4830 (1986).

19.

Summers, M.F., van Rijn, J., Reedijk, J., Marzilli, L.G. "Unusual Slow
-
Exchange
113
Cd
NMR Spectra Observed at Ambient Temperature for Halide, Cyanide,

and Mercaptide
Cadmium Coordination Compounds with Benzimidazole Ligands. Applications to Cd
-
Substituted Metalloproteins,"
J. Am. Chem. Soc
.,
108
, 4285 (1986).


Michael F. Summers

December 14, 2013


Page
3


20.

Summers, M.F., Bax, A., Marzilli, L.G. "Complete
1
H and
13
C Assignment of Coenzyme
B
12
Thro
ugh the Use of New Two
-
Dimensional NMR Experiments,"
J. Am. Chem. Soc
.,
108
, 4285 (1986).

21.

Summers, M.F., Powell, C., Egan, W., Byrd, R.A., Wilson, W.D., Zon, G. "Alkyl
Phosphotriester Modified Oligodeoxyribonucleotides. VI. NMR and UV Spectroscopic
Stu
dies of Ethyl Phosphotriester (Et) Modified Rp
-
Rp and Sp
-
Sp Duplexes,
[d(GGAA(Et)TTCC)]
2,
"
Nucl. Acids Res
.,
14
, 7421 (1986).

22.


LaPlanche, L., James, T.L., Powell, C., Wilson, W.D., Summers, M.F., Zon, G.
"Phosphorothioate
-
Modified Oligodeoxyribonucleo
tides. III. NMR and UV Spectroscopic
Studies of the Rp
-
Rp, Sp
-
Sp and Rp
-
Sp Duplexes, [d(GGsAATTCC)]2, Derived from
Diastereomeric O
-
Ethyl Phosphorothioates,"
Nucl. Acids Res
.,
14
, 9081 (1986).


23.

Zon, G., Summers, M.F., Gallo, K.A., Shao, K.L., Koziolkie
wicz, M., Uzanski, G., Stec,
W.J. in
"Phosphorous Chemistry Directed Towards Biology,"

W. J. Stec, Ed., Elsevier,
Amsterdam, p.1 (1986).

24.

Bax, A., Sklenar, V., Summers, M.F. "Direct Identification of Relayed Nuclear Overhauser
Effects,"
J. Magn. Reson
.
,
70
, 327 (1986).

25.


Boyd, V.L., Summers, M.F., Ludeman, S.M., Egan, W., Zon, G., Regan, J.B. "NMR
Spectroscopic Studies of Intermediary Metabolites of Cyclophosphamide. 2. Direct
Observation, Characterization, and Reactivity Studies of Imino
-

cyclophosp
hamide and
Related Species,"
J. Med. Chem
.,
30
, 366 (1987).

26.

Bax, A., Marzilli, L.G., Summers, M.F. "New Insights Into the Solution Behavior of
Cobalamins. Studies of the Base
-
Off Form of Coenzyme B12 Using Modern Two
-
Dimensional NMR Methods,"
J. Am. Ch
em. Soc
.,
109
, 566 (1987).

27.

Bower, M., Summers, M.F., Powell, C., Shinozuka, K., Regan, J.B., Zon, G., Wilson,
W.D. “Oligoneoxyribonucleotide Methylphosphonates. NMR and UV Spectroscopic
Studies of the Rp
-
Rp and Sp
-
Sp Methylphosphonate (Me) Modified Dup
lexes:
[d(GG(Me)AATTCC)]
2
, [d(GGAA(Me)TTCC)]
2
, [d(GGAATT(Me)CC)]
2,
"
Nucl. Acids
Res
.,
15
, 4915 (1987).

28.


Bower, M., Summers, M.F., Kell, B., Hoskins, J., Zon, G., Wilson, W.D. "Synthesis and
Characterization of Oligodeoxyribonucleotides Containing Termi
nal Phosphates. NMR,
UV Spectroscopic and Thermodynamic Analysis of Duplex Formation of
[d(pGGAATTCC)]
2
, [d(GGAATTCCp)]
2

and [d(pGGAATTCCp)]
2,
"
Nucl. Acids Res
.,
15
, 3531 (1987).

29.

Byrd, R.A., Egan, W., Summers, M.F., Bax, A. "New NMR Methods, for Struct
ural
Studies of Polysaccharides: Application to the Haemophilus Influenzae Type A Capsular
Polysaccharide,"
J. Carbohydr. Res
.,
166
, 47, (1987).


Michael F. Summers

December 14, 2013


Page
4


30.

Marzilli, L.G., Bayo, F., Summers, M.F., Thomas, L.B., Zangrando, E., Bresciani
-
Pahor,
N., Randaccio, L. "T
ransfer to Organometallic Chemistry of Substituent Constants from
Organic Chemistry. Resolution of Long Standing Anomalies in the Chemistry of
Organocobalt B12 Models and Organocobalamins,"
J. Am. Chem. Soc
.,
109
, 6045 (1987).

31.

Fouts, C.S., Marzilli, L
.G., Byrd, R.A., Summers, M.F., Zon, G., Shinozuka, K. "HMQC,
1
H and
31
P NMR Studies of Pt Amine Adducts of Tetradeoxyribonucleotides.
Relationship Between
31
P Shift and Potential H
-
Bonding Interactions in pGpG Moieties
Crosslinked by Pt,"
Inorg. Chem
.,
27
, 366 (1988).

32.

Bax, A., Summers, M.F., Guirgis, N., Schneerson, R., Robbins, J.B., Orskov, F., Orskov,
I., Vann, W.F. "Structural and Immunological Studies of the Escerichia coli K93 and K53
Capsular Polysaccharides,"
Carbohydrate Research
,
173
, 53 (198
8).

33.

Tsui, F.
-
P., Egan, W., Summers, M.F., Byrd, R.A., Schneerson, R., Robbins, J.B.
"Structure Determination of the Escherichia Coli K100 Capsular Polysaccharide, Cross
-
Reactive with the Capsule from Type B Haemophilus Influenzae,"
Carbohydrate Res
.,
1
73
, 65 (1988).

34
.

Summers, M.F. "
113
Cd NMR Spectroscopy of Coordination Compounds and Proteins,"
Coord. Chem. Revs
.,
86
, 43 (1988).

35.

Hosmane, R.S., Lim, B.B., Summers, M.F., Siriwardane, U., Hosmane, N.S., Chu, S.S.C.
Rearrangements in Heterocyclic Syn
thesis. 2. Novel transformations of 2
-
Aminonicotinonitrile and Anthranilonitrile,
J. Org. Chem
.,
53
, 5309 (1988).


36
.

South, T.L., Kim, B.
, Summers, M.F. "
113
Cd NMR Studies of a 1:1 Cd Adduct with an
18
-
Residue Zinc Finger Peptide from HIV
-
1 Nucleic Ac
id Binding Protein, p7,"
J. Am.
Chem. Soc
.,
111
, 395 (1989).

37.


Zeng, B., Pollack, R.M., Summers, M.F. "Conformational Analysis via Heteronuclear
Correlation NMR Spectroscopy,"
J. Org. Chem
.
55
, 2534 (1990).

38.

Summers, M.F., South, T.L., Kim, B., Hare
, D.R.
in "Frontiers of NMR in Molecular
Biology,"

UCLA Symposia on Cellular and Molecular Biology, Vol. 109, D. Live, I.
Armitage, D. Patel, eds., Alan R. Liss, Inc., N.Y. p. 37. (1990).

39.

Summers, M.F., South, T.L., Kim, B., Hare, D.R. "Structure of a
n HIV Zinc Finger
-
Like
Domain via a New NMR
-
Based Distance Geometry Approach,"
Biochemistry

29
, 329
(1990).

40.

Blake, P.R., Summers, M.F. "NOESY
-
1
-
1
-
Echo Spectroscopy with Eliminated Radiation
Damping,"
J. Magn. Reson
.
86
, 622 (1990).

41.

Won, H., Summers
, M.F., Olson, K., Wolfe, R. "Two
-
Dimensional NMR Studies of Native
Coenzyme F430,"
J. Am. Chem. Soc
.
112
, 2178 (1990).


Michael F. Summers

December 14, 2013


Page
5


42.

South, T.L.,
Kim, B.
, Hare, D.R., Summers, M.F. "Zinc Fingers and Molecular
Recognition: Structure and Nucleic Acid Binding Studies
of an HIV Zinc Finger
-
Like
Domain,"
Biochemical Pharmacology

40
, 123 (1990).

43.

South, T.L., Summers, M.F. "Zinc Fingers,"
in Metal
-
Ion Induced Regulation of Gene
Expression; Adv. Inorg. Biochem
., Vol. 8, L.G. Marzilli, G. Eichhorn, eds., Elsevier, N.Y.,

pp. 199
-
248 (1990).

44.

Olson, K.D., Won, H., Wolfe, R.S., Hare, D.R., Summers, M.F. "Stereochemical Studies
of Coenzyme F430 based on 2D NOESY Back
-
Calculations,"
J. Am. Chem. Soc
.,
112
,
5884 (1990).

45.

South, T.L., Blake, P.R., Sowder, R., Arthur, L.O.
, Henderson, L.E., Summers, M.F. "The
Nucleocapsid Protein Isolated from HIV
-
I Particles Binds Zinc and Form Retroviral
-
Type
Zinc Fingers,"
Biochemistry
-

Accelerated Publication
,
29
, 7786
-
7789 (1990).

46.

Summers, M.F. "Zinc Finger Motif for Single
-
Strand
ed Nucleic Acids? Investigations by
Nuclear Magnetic Resonance,"
Prospects
-

J. Cell. Biochem.
,
45
, 41 (1991).

47.

Blake, P.R., Hare, D.R., Summers, M.F. "Is 2D NOESY Back
-
calculation Necessary for
NMR
-
Based Structure Determination? A Systematic Study I
nvolving a Retroviral
-
Type
Zinc Finger Peptide," in
"Techniques in Protein Chemistry",
Vol. II, J. J. Villafranca, Ed.,
Academic Press, N.Y., pp. 357
-
370 (1991).


48.

South, T.L., Blake, P.R., Hare, D.R., Summers, M.F. "The C
-
Terminal Retroviral
-
Type
Zinc
Finger Domain from the HIV
-
1 Nucleocapsid Protein is Structurally Similar to the N
-
Terminal Zinc Finger Domain,"
Biochemistry
,
30

(1991), 6342.

49.

Blake, P.R., Park, J.
-
B., Bryant, F.O., Aono, S., Magnuson, J.K., Eculston, E., Howard,
J.B., Summers, M.F.,

Adams, M.W.W. "Determinants of Protein Hyperthermostability:
Purification, Amino Acid Sequence, and Secondary Structure by NMR of the Zinc Adduct
of Rubredoxin from the Hyperthermophilic Archaebacterium,
Pyrococcus furiosus
,"
Biochemistry
,
30
, 10885 (1991
).


50
.

Summers, M.F., Henderson, L.E., Chance, M.R., Bess, Jr., J.W., South, T.L., Blake, P.R.,
Sagi, I., Perez
-
Alvarado, G., Sowder, III, R.C., Arthur, L.O. "Nucleocapsid Zinc Fingers
Detected in Retroviruses: EXAFS Studies of Intact Viruses and the Solu
tion
-
State
Structure of the Nucleocapsid Protein from HIV
-
1,"
Protein Science

1
, 563
-
574 (1992).

51
.

Blake, P.R., Park, J.B., Adams, M.W.W., Summers, M.F. "Novel Observation of NH
--
S(Cys) Hydrogen Bond
-
Mediated Scalar Coupling in
113
Cd
-
Substituted Rubredox
in from
Pyrococcus furiosus,"
J. Am. Chem. Soc
.
114
, 4931 (1992).

52.

Kyle, K.J., Green, L.M., Blake, P.R.,
Smithwick, D
., Summers, M.F. "A Novel Beta Turn
Mimic Useful for Mapping the Unknown Topology of Peptide Receptors,"
Peptide
Research

5
, 206
-
209 (19
92).


Michael F. Summers

December 14, 2013


Page
6


53.

Delahunty, M.D., South, T.L., Summers, M.F., Karpel, R.L. "Nucleic Acid Interactive
Properties of a Peptide Corresponding to the N
-
Terminal Zinc Finger Domain of HIV
-
1
Nucleocapsid Protein,"
Biochemistry

31
, 6461 (1992).

54.

Won, H., Olson, K.D.,

Hare, D.R., Wolfe, R.S., Kratky, C., Summers, M.F. "Structural
Modeling of Small Molecules by NMR: Solution
-
State Structure of 12,13
-
Diepimeric
Coenzyme F430 and Comparison with the X
-
ray Structure of the Pentamethylester
Derivative,"
J. Am. Chem. Soc.

11
4
, 6880 (1992).

55.

Blake, P.R., Lee, B., Summers, M.F., Adams, M.W.W., Park, J.
-
B., Zhou, Z.H., Bax, A.
"Quantitative Measurement of Small Through
-
Hydrogen
-
Bond and "Through
-
Space"
1
H
-
113
Cd and
1
H
-
199
Hg J Couplings in Metal
-
Substituted Rubredoxin from Pyr
ococcus
Furiosus,"
J. Biomol. NMR

2
, 527
-
533 (1992).

56.

Chance, M.R., Sagi, I., Wirt, M.D., Frisbie, S.M., Scheuring, E., Chen, E., Bess Jr., J.W.,
Henderson, L.E., Arthur, L.O., South, T.L.,
Perez
-
Alvarado, G
., Summers, M.F. "EXAFS
Studies of a Retroviru
s: Equine Infectious Anemia Virus Cysteine Arrays are Coordinated
to Zinc,"
Proc. Natl. Acad. Sci. U.S.A
.
89
, 10124
-
10128 (1992).

57.

Blake, P.R., Park, J.
-
B., Zhou, Z.H., Hare, D.R., Adams, M.W.W., Summers, M.F.
"Solution
-
State Structure by NMR of the Zi
nc
-
Substituted Rubredoxin from the Marine
Hyperthermophilic Archaebacterium, Pyrococcus furiosus,"
Protein Science

1
, 1508
-
1521
(1992).

58.

Blake, P.R., Day, M.W., Hsu, B.T., Joshua
-
Tor, L., Park, J.
-
B., Hare, D.R., Adams,
M.W.W., Rees, D.C., Summers, M.
F. "Comparison of the X
-
ray Structure of Native
Rubredoxin from Pyrococcus furiosus with the NMR Structure of the Zinc
-
Substituted
Protein,"
Protein Science

1
, 1522
-
1525 (1992).

59.

Nickon, A., Ilao, M.C., Stern, A.G., Summers, M.F. "Hydrogen Trajectories

in Alkene to
Carbene Rearrangements. Unequal Deuterium Isotope Effects for the Axial and Equatorial
Paths,"
J. Am. Chem. Soc.

114
, 9230
-
9232 (1992).

60.

Kyle, D.J., Blake, P.R.,

Smithwick, D.
, Green, L.M., Martin, J. A., Sinsko, J.A., Summers,
M.F. “NM
R and Computational Evidence that High Affinity Bradykinin Receptor
Antagonists Adopt C
-
Terminal

-
Turns,”

J. Med. Chem
.
36
, 1450
-
1460 (1993).

61.

South, T.L., Summers, M.F. "Zinc
-

and Sequence
-
Dependent Binding to Nucleic Acids by
the N
-
Terminal Zinc Finger Domain of the HIV
-
1 Nucleocapsid Protein: Structure of the
Complex with the Psi
-
Site Analog,
d(ACGCC),"
Protein Science

2
, 3
-
19 (1993).

62.

Rice, W.G., Schaeffer, C.A., Harten, B., Villinger, F., South, T.L., Summers, M.F.,
Henderson, L.E., Bess, Jr., J.W., Arthur, L.O., McDougal, J.S., Orloff, S.L., Mendeleyev,
J., Kun, E. “Inhibition of HIV
-
1 i
nfectivity by zinc
-
ejecting aromatic C
-
nitroso
compounds,”
Nature

361
, 473
-
475 (1993).


Michael F. Summers

December 14, 2013


Page
7


63.

H. Won, Olson, K.D., Wolfe, R.W., Summers, M.F., Wolfe, R.S. “F430
-
Dependent
Biocatalysis in Methanogenic Archaebacteria.,”
Comments Inorg. Chem

15
, 1
-
26 (1993).

6
4.

Blake, P. R., Lee, B., Park, J.
-
B., Zhou, Z. H., Adams, M. W. W., Summers, M. F.,
“Heteronuclear Magnetic Resonance Studies of Zn
-
,
113
Cd
-
, and
199
Hg
-
Substituted
P.
furiosus

Rubredoxin: Implications for Biological Electron Transfer,”
New J. Chem.

18
,
387
-
395 (1994).

65.

Blake, P. R., Summers, M. F., Insights into the structural and electronic properties of
metalloproteins by heteronuclear magnetic resonance,
Adv. Inorg. Biochem.
Vol. 10
,
L.G.
Marzilli, G. Eichhorn, Eds., Elsevier, N.Y., pp. 201
-
228,
(1994).

66.

Perez
-
Alvarado, G. C.,

Miles, C., Michelsen, J. W., Louis, H. A., Winge, D. R., Beckerle,
M. C., Summers, M. F., “Structure of the C
-
terminal LIM domain from the cysteine rich
protein CRP,”
Nature Structural Biology

1
, 388
-
398 (1994).

67.

Massi
ah, M
., Starich, M. R.,
Paschall, C. M
., Summers, M. F., Christensen, A. M.,
Sunduist, W. I., “Three Dimensional Structure of the Human Immunodeficiency Virus
Type
-
1 Matrix Protein.”
J. Mol. Biol.

244
, 198
-
223 (1994).

68.

Blake, P.R. & Summers, M.F. "Prob
ing the Unusually Similar Metal Binding Sites of
Retroviral Zinc Fingers and Iron
-
Sulfur Proteins by Nuclear Magnetic Resonance,"
Adv.
Biophys. Chem.

Vol 4, C. A. Bush, Ed., JAI Press, Inc., pp. 1
-
30 (1994).

69.

Won, H., Olson, K. D., Park, J., Wolfe, R.
S., Hare, D. R., Summers, M. F., “Solution
-
State Structure of Native Coenzyme F430 by NMR Methods,”
Bull. Korean Chem. Soc
.
16
, 649
-
653 (1995).

70.

Starich, M. R., Sandman, K., Reeve, John N., Summers, M. F.. “NMR Structure of HMfB
from the Hyperthermophi
le,
Methanothermus fervidus,

Confirms that this Archaeal Protein
is a Histone,”
J. Mol. Biol.

255
, 187
-
203 (1996).

71.

Zhu, W., Zeng, Q., Colangelo, C. M., Michelle Lewis, L., Summers, M. F., Scott, R. A.
“The N
-
Terminal Domain of TFIIB from Pyrococcus fu
riosus forms a Zinc Ribbon,”
Nature Structural Biology

3
, 122
-
124 (1996).

72.

Perez
-
Alvarado, G. C
., Kosa, J. L., Louis, H. A., Beckerle, M. C., Winge, D. R., Summers,
M. F. “Structure of the Cysteine Rich Intestinal Protein, CRIP,”

J. Mol. Biol.

257
, 15
3
-
174 (1996).

73.

Summers, M. F. “NMR Studies of Zinc Fingers,” in
Encyclopedia of NMR
,, Vol. 8, D. M.
Grant and R. K. Harris, eds., John Wiley & Sons, Ltd., Sussex, England pp. 5063
-
5071
(1996).

74.

Rice, W. G., Turpin, J. A., Schaeffer, C. A., Graham, L.
, Clanton, D., Buckheit, R. W.,
Zaharavetz, D., Summers, M. F., Wallqvist, A., Covell, D. G., “Evaluation of Selected
Chemotypes in coupled Cellular and Molecular Target
-
Based Screens Identifies Novel
HIV
-
1 Zinc Finger Inhibitors,”
J. Med. Chem
.
39
, 3606
-
3
616 (1996).


Michael F. Summers

December 14, 2013


Page
8


75.

Gitti, R.K., Lee, B.M.,
Walker, J
., Summers, M.F., Yoo, S., Sundquist, W.I. “Structure of
the Amino
-
Terminal Core Domain of the HIV
-
1 Capsid Protein,”
Science

273
, 231
-
235
(1996).

76.

Momany, C., Kovari, L. C., Prongay, A. J., Keller, W., G
itti, R. K., Lee, B. M.,
Gorbalenya, A. E., Tong, L., McClure, J., Ehrlich, L. S., Summers, M. F., Carter, C.,
Rossmann, M. G., “Crystal Structure of Dimeric HIV
-
1 Capsid Protein,”
Nature Structural
Biology

3
, 763
-
770 (1996).

77
.

Christensen, A. M.,
Massia
h, M. A.
,
Turner, B. G.,

Sundquist, W. I., Summers, M. F.
“Structure of the HTLV
-
II Matrix Protein and Comparison of Matrix Protein Structures
from the Two Classes of Pathogenic Human Retroviruses,”
J. Mol. Biol
.
264
, 1117
-
1131
(1996).

78
.

Massiah, M. A
.,
Worthylake, D., Christensen, A. M., Sundquist, W. I., Hill, C. P.,
Summers, M. F. “Comparison of the NMR and X
-
ray Structures of the HIV
-
1 Matrix
Protein: Evidence for Conformational Changes During Viral Assembly,”
Protein Science

5
, 2391
-
2398 (1996).

7
9.

Wu, Z. R., Ebrahimian, S., Zawrotny, M. E., Thornburg, L. D.,
Perez
-
Alvarado, G. C
.,
Brothers, P., Pollack, R. M., Summers, M. F. “Solution Structure of 3
-
Oxo
-

5
-
Steroid
Isomerase,”
Science

276
, 415
-
418 (1997).

80.

Rice, W. G., Turpin, JU. A., Clanton,

D., Buckheit, Jr., R. W., Summers, M. F.,
McDonnell, N. B., De Guzman, R. N., Covell, D. G., Wallquist, A., Zalkow, L., Bader, J.
P., Haugwitz, R. D., Sausville, E. A. “Azodicarbonamide inhibits HIV
-
1 replication by
targeting the nucleocapsid protein,”
Nature Medicine

3
, 341
-
345 (1997).

81.

McDonnell, N. B., Rice, W. G., Summers, M. F. “Zinc
-
Ejection as a New Rationale for
the use of Cystamine and Thiamine Disulfide in the Treatment of AIDS,”
J. Med. Chem
.
40
, 1969
-
1976 (1997).

82.

Yao, X., Wei, D.,
S
oden, Jr., C.
, Summers, M. F., Beckett, D. “Structure of the Carboxyl
-
Terminal Fragment of the Apo
-
Biotin Carboxyl Carrier Subunit of
Escherichia coli

Acetyl
-
CoA Carboxylase,”
Biochemistry

36
, 15089
-
15100 (1997).

83.

De Guzman, R. N., Wu, Z. R.,
Stalling
, C. C.
, Pappalardo, L., Borer, P. N., Summers, M.
F. “Structure of the HIV
-
1 Nucleocapsid Protein Bound to the SL3

-
RNA Recognition
Element,”
Science

279
, 384
-
388 (1998).

84.

Won, H., Summers, M. F. “Highly Overlapping
1
H NMR Signal Assignments of 12,13
-
Diepimeric Coenzyme F430 by the Compensated ROESY Experiment,”
Bull. Korean
Chem. Soc.

19
, 379
-
383 (1998).

85.

Lee,

B. M., De Guzman, R. N.,
Turner, B. G.
, Tjandra, N., Summers, M. F. “Dynamical
Behavior of the HIV
-
1 Nucleocapsid Protein,”
J. Mol. Biol
.
279
, 633
-
649 (1998).


Michael F. Summers

December 14, 2013


Page
9


86.

Turner, R. B., Smith, D. L
., Zawrotny, M. E., Summers, M. F., Posewitz, M. C., Winge, D.
R.

“Solution Structure of a Zinc Domain Conserved in Yeast Copper
-
Regulated
Transcription Factors,”
Nature Struct. Biol
.
5
, 551
-
555 (1998).

87.

Zhu, W., Sandman, K., Lee, G. E., Reeve, J. N., Summers, M. F. “NMR Structure and
Comparison of the Archaeal Histo
ne HFoB from the Mesophile Methanobacterium
formicicum, with HMfB from the Hyperthermophile Methanothermus fervidus,”
Biochemistry

37
, 10573
-
10580 (1998).

88.

Sandman, K., Zhu, W., Summers, M. F., Reeve, J. N. “Evolution of the histone fold,” in
Thermophil
es


The keys to molecular evolution and the origin of life?
, M. W. W. Adams
and J. Wiegel, Eds., Taylor & Francis Inc., PA pp. 243
-
253 (1998).

89.

Massiah, M.A
., Blake, P.R., Summers, M.F. “Nucleic Acid Interactive Protein Domains
That Require Zinc” in
Bi
oorganic Chemistry: Peptides and Proteins
, S.M. Hecht, ed.,
Oxford University Press, NY pp. 258
-
278 (1998).

90.

Turner, B. G.
, Summers, M. F. “Structural Biology of HIV
-
1,”
J. Mol. Biol

285
, 1
-
31
(1999).

91.

Yao, X.,
Perez
-
Alvarado, G. C
., Louis, H. A., P
omies, P., Hatt, C., Summers, M. F.,
Beckerle, M. C. “Solution structure of the chicken cysteine
-
rich protein, CRP1, a double
-
LIM protein implicated in muscle differentiation,”
Biochemistry

38
, 5701
-
5713 (1999).

92.

De Guzman, R. N.,
Turner, R. B.,

Summers
, M. F. “Protein
-
RNA Recognition,” in
Biopolymers

48
, 181
-
195 (1999).

93.

Khorasanizadeh, S., Campos
-
Olivas, R.,
Clark, C. A.
, Summers, M. F. “Sequence
-
specific
1
H,
13
C and
15
N chemical shift assignment and secondary structure of the HTLV
-
I capsid
protein,

J. Biomol. NMR

14
, 199
-
200 (1999).

94.

Yao, X.,
Soden Jr., C.
, Summers, M. F., Beckett, D. “Comparison of the Backbone
Dynamcis of the Apo
-

and Holo
-
Carboxyl
-
terminal Domain of the Biotin Carboxyl Carrier
Subunit of Escherichia coli Acetyl
-
CoA Carboxylas
e,”
Protein Science

8
, 307
-
317 (1999).

95.

Khorasanizadeh, S., Campos
-
Olivas, R., Summers, M. F. “Solution Structure of the Capsid
Protein from the Human T
-
Cell Leukemia Virus Type
-
I,”
J. Mol. Biol
.
291
, 491
-
505
(1999).

96.

Jabet, C., Gitti, R., Summers,
M. F., Wolberger, C. “NMR Studies of the Pbx1 TALE
Homeodomain Protein Free in Solution and Bound to DNA: Proposal for a Mechanism of
HoxB1
-
Pbx1
-
DNA Complex Assembly,”

J. Mol. Biol
.
291
, 521
-
530 (1999).

97.

Campos
-
Olivas, R., Summers, M. F. “Backbone Dyna
mics of the N
-
Terminal Domain of
the HIV
-
1 Capsid Protein and Comparison with the G94D Mutant Conferring Cyclosporin
Resistance/Dependence,”
Biochemistry

38
, 10262
-
10271 (1999).


Michael F. Summers

December 14, 2013


Page
10


98.

Pollack, R. M., Thornburg, L. D., Wu, Z. R., Summers, M. F. “Mechanistic I
nsights from
the Three
-
Dimensional Structure of 3
-
Oxo
-

5
-
Steroid Isomerase,”
Arch. Biochem.
Biophys
.
370
, 9
-
15 (1999).

99.

Campos
-
Olivas, R., Newman, J. L.,
Ndassa, Y
., Summers, M. F. “
1
H,
13
C and
15
N chemical
shift assignments of the capsid protein from Rous sarcoma virus,”
J. Biomol. NMR

15
,
267
-
268 (1999).

100.

Klein, D. J.,

Johnson, P. E.,
Zollars, E. S.
, De Guzman, R. N., Summers, M. F. “Structure
of the Nucleocapsid Protein from the Mouse Mammary Tumor Virus Reveals Unusual
Folding of the C
-
terminal Zinc Finger,”
Biochemistry

39
, 1604
-
1612 (2000).

101.

C
ampos
-
Olivas, R., Newman, J. L., Summers, M. F. “Solution Structure and Dynamics of
the Rous Sarcoma Virus Capsid Protein and Comparison with Capsid Proteins of other
Retroviruses,”
J. Mol. Biol.

296
, 633
-
649 (2000).

102.

Amarasinghe, G. K., De Guzman, R.
N.,
Turner, R. B
., Summers, M. F. “NMR Structure
for Stem Loop
SL2 of the HIV
-
1


RNA Packaging Signal Reveals a Novel A
-
U
-
A Base
Triple Platform,”
J. Mol. Biol.

299
, 145
-
156 (2000).

103.

Johnson, P. E.,
Turner, R. B.,

Wu, Z. R.,
Hairston, L
., Guo, J., Lev
in, J. G., Summers, M.
F. “A Mechanism for (+) Strand Transfer Enhancement by the HIV
-
1 Nucleocapsid
Protein During Reverse Transcription,”
Biochemistry

39
, 9084
-
9091(2000).

104
.

Amarasinghe, G. K., De Guzman, R. N.,
Turner, R. B.
,
Chancellor, K.
, Wu, Z.
-
R.,
Summers, M. F. “
NMR Structure of the HIV
-
1 Nucleocapsid Protein Bound to Stem
-
Loop
SL2 of the

-
RNA Packaging Signal. Implications for Genome Recognition,”
J. Mol.
Biol
.
301
, 491
-
511 (2000).

105
.

D'Souza, V.,
Melamed, J.,

Habib, D.
,
Pullen, K., Wallace, K.
, Summers, M. F.,
"Identification of a High
-
Affinity Nucleocapsid Protein Binding Site within

the Moloney
Murine Leukemia Virus

-
RNA Packaging Signal. Implications for Genome
Recognition,"
J. Mol. Biol.

314
, 217
-
232 (2001).

106
.

Amarasinghe, G. K., Zhou, J.,
Miskimon, M.
,
Chancellor, K. J.
,
McDonald, J. A.,
Matthews, A. G., Miller, R. R., Rouse,
M. D
., Summers, M. F., "Stem
-
loop SL4 of the
HIV
-
1

-
RNA Packaging Signal Exhibits Weak Affinity for the Nucleocapsid Protein.
Structural Studies and Implications for Genome Recognition,"
J. Mol. Biol.

314
, 961
-
969
(2001).

107
.

Gatanaga, H., Suzuki, Y., T
sang, H., Yoshimura, K., Kavlick, M. F., Nagashima, K.,
Gorelick, R. J., Mardy, S., Tang, C., Summers, M. F., Mitsuya, H. “Amino acid
substitutions in Gag protein at non
-
cleavage sites are indispensable for the development of
a high multitude of HIV
-
1 resi
stance against protease inhibitors,”
J. Biol. Chem
.
277
,
5952
-
5961 (2002).

108
.

Tang, C.,
Ndassa, Y.
, Summers, M. F., “Structure of the N
-
terminal 283
-
residue fragment
of the immature HIV
-
1 Gag polyprotein,”
Nature Struct. Biol
.
9
, 537
-
543 (2002).


Michael F. Summers

December 14, 2013


Page
11


109
.

Law
rence, D. C.,
Stover, C. C.
,
Noznitsky, J.
, Wu, Z.
-
R., Summers, M. F. “Structure of the
intact stem and bulge of the HIV
-
1

-
RNA

stem loop SL1,”
J. Mol. Biol
.
326
, 529
-
542
(2003).

110
.

Tang, C.,
Loeliger, E
.,
Kinde, I
.,
Kyere, S
., Mayo, K., Barklis, E., S
un, Y., Huang, M.,
Summers, M. F. “Antiviral inhibition of HIV
-
1 capsid assembly,”
J. Mol. Biol
.
327
, 1013
-
1020 (2003).

111
.

Tang, C.,
Loeliger, E
.,
Luncsford, P
.,
Kinde, I
., Beckett, D., Summers, M. F., “Entropic
switch regulates myristate exposure in the

HIV
-
1 Matrix protein,”
Proc. Natl. Acad. Sci.
U.S.A.

101
, 517
-
522 (2004).

112
.

D’Souza, V., Dey, A.,
Habib, D
., Summers, M. F., “NMR structure of the 101
-
nucleotide
core encapsidation signal of the Moloney Murine Leukemia Virus,
J. Mol. Biol.

337
, 427
-
442

(2004).

113
.

Newman, J. L., Butcher, E. W.,
Patel, D. T.
,
Makhaylenko, Y
. & Summers, M. F.,
“Flexibility in the P2 domain of the HIV
-
1 Gag polyprotein,”
Protein Science
13
, 2101
-
2107 (2004).

114
.

D'Souza, V. D., Summers, M. F., "Structural Basis for Packa
ging the Dimeric Genome of
Moloney Murine Leukemia Virus,"
Nature

431
, 586
-
590 (2004).

115.

Dey, A.,
York, D.
,
Smalls
-
Mantey, A.
, Summers, M. F., “Composition and sequence
dependent binding of RNA to the nucleocapsid protein of Moloney Murine Leukemia
Viru
s,”
Biochemistry

44
, 3735
-
3744 (2005).

116
.

Zhou, J.,
McAllen, K., Tailor, Y.
, Summers, M. F. “High affinity nucleocapsid protein
binding to the


RNA packaging signal of Rous sarcoma virus,”
J. Mol. Biol.

349
, 976
-
988 (2005).

117
.

D’Souza, V., Summers, M
. F. “How retroviruses recognize and package their RNA
genomes,”
Nature Reviews Microbiology

3
, 643
-
655 (2005).

118.

Summers, M. F., Hrabowski, F. A. III, “Preparing minority scientists and engineers,”
Science

311
, 1870
-
1871 (2006).

119
.

Saad, J. S.,
Mille
r, J., Tai, J., Kim, A., Ghanam, R. H.
, Summers, M. F. “Structural basis
for targeting HIV
-
1 Gag proteins to the plasma membrane for virus assembly,”
Proc. Natl.
Acad. Sci. U.S.A
.,
103
, 11364
-
11369 (2006).

120
.

Zhou, J.,
Bean, Rebecca L.
, Vogt, V. M., Summ
ers, M. F. “Solution Structure of the Rous
Sarcoma Virus Nucleocapsid Protein:


RNA Packaging Signal Complex”,
J. Mol. Biol.

365
, 453
-
467 (2006).

121
.

Saad, J. S.,
Loeliger, E.
,
Luncsford, P.
,
Liriano, M.
,
Tai, J.
,
Kim, A.
,
Miller, J.
, Joshi, A.,
Freed, E
. O., Summers, M. F. “Point mutations in the HIV
-
1 matrix protein turn off the
myristyl switch”,
J. Mol. Biol.

366
, 574
-
585 (2007).