Tal_USF_master_project_Aug_2011x

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2 Οκτ 2013 (πριν από 4 χρόνια και 11 μέρες)

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USF


Bioinformatics Master Project

Outline



Buck Institute




The Mooney Lab



Project Description

1

Buck Institute for Research on Aging

History

1975

1986

1987

1989

1996



1987


the Marin Superior Court selected the Institute to
receive 15% of the net income from Beryl Buck’s estate



1989


the Buck purchased a 488
-
acre parcel of undeveloped
land on Mt.
Burdell

in Novato



1996


construction began



1986


The “Buck Institute on Aging” was incorporated.



The San Francisco Foundation established
.

(at the time estimated at
$11
-

$12 million
)

1999

2010



2010


the value of the Buck Trust had grown to over
$700 million
,
generating an annual income for the Institute of approximately
$6
million per year.



1999


The buck opened

Buck Institute for Research on Aging

The Future for the Buck

3


New construction for stem
-
cell lab building
-

$41 million project

Buck Institute for Research on Aging

The Buck Today

4



Mission



To increase the healthy years of life by investigating how



normal aging contributes to the development of diseases.



Employees



200



Faculty



18 labs

Buck Institute for Research on Aging

o

Parkinson disease

o

Alzheimer

o

cancer

o

stroke

o

nutrition

o

stress

o

genetics

o

stem cells

o

bioinformatics

5

Main research focus:

The Mooney Lab

Responsibilities



Core


support other labs in the institute to:

o

handle, store, and retrieve data

o

analyze biological data

o

use tools to generate biological hypotheses



Independent research



o

identify and classify diseases causing mutations

o

analyze protein structure to estimate structure similarities,
predict catalytic and protein
-
protein interaction sites.

o

using
ontologies

to classify gene function

6

7

Lab’s Web
Tools

Plugin

-

a container for a group of related resources (software components),
embedded in a larger software application to extend its functionality.

Chimera

Pymol

LSW

Plugin

LSW

Plugin

Life Science Web Services Plug
-
ins

Integration

8

p53 Cancer Mutations

Lab’s Web Tools:



S
-
Blest



CRP



MutDB



PPI

Chimera,
Pymol
:



Analyze molecular structure



Provide: images, animations,


interactive Visualization

setuptools

SOAP

API

Easy Install

Egg files

Packages

LSW Services:

MD5

distutils

Life Science Web Services Plug
-
ins

services

WSDL

9

Contact info: tronnenoron@buckinstitute.org

USF


Bioinformatics Master Project