BIO 326M 50325-50340 INTRODUCTORY MEDICAL MICROBIOLOGY & IMMUNOLOGY FALL 2013

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23 Οκτ 2013 (πριν από 3 χρόνια και 7 μήνες)

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BIO 326
M

503
2
5
-
503
4
0

INTRODUCTORY MEDICAL MICROBIOLOGY & IMMUNOLOGY

FALL 2013










Lectures:



MWF


1
1



12


FAC 21







Discussion Sessions:

503
2
5

M


8
-

9



JES A216A




503
3
0

F


8
-

9


JES A215A




503
3
5
M


9
-

10


GEA 127




503
4
0

F


9
-

10


WAG 420




Instructor:


Dr. James R. Walker

Office Hours:



NMS 1.110;
T

11
-
12; Th 1
-
2

Tel:




471
-
1692 or 471
-
5105 and leave message

Email:




jrw@mail.utexas.edu

Website:



http://www.sbs.utexas.edu/walker


TA:



Laura Geuss




lgeuss@utexas.edu



Course Content:

This course provides an overview of the structure, function, and genetics of bacteria
,
viruses and the fungi with emphasis on the interactions between microbes and human hosts.

Basic organic
chemistry and biochemistry will be introduced to permit underst
anding microbial life.

Principles of microbial
pathogenesis, host innate and adaptive immune responses to infection, epidemiology, laboratory diagnosis,
antimicrobial chemotherapy and vaccines will be covered.



Web Page:

Visit the web page for the sy
llabus, lecture schedule, a list of important bacteria and their
characteristics which must be memorized, and a study guide. This study guide includes introductions to the major
topics to be covered, outlines,
slides which will be used as the basis for the

lectures.

The study guide should be
studied before lecture to become familiar with the material. During class, you may take notes directly on the study
guide. The study guide is designed to help you prepare for class and to take notes during class; it i
s not designed
to replace attendance and note
-
taking during class.


Text

(
Optional
):

Microbiology


An Evolving Science
, 2
nd

Edition, 2010

by Slonczewski and Foster
, Norton
Publishing.

You may use
the first
edition or
even
a different text.

Students with more extensive academic
backgrounds might substitute the study guide for a text; students who need to develop their academic background
probably should use the text for basic information and as reference material.


Prerequisites:

Chem 301
,
Bio 3
11C

and
Bio 325 (or 325H)

with a grade of C
-

or better in each. Anyone without
the appropriate prerequisites will be dropped (unless your major does not require that course).


Background Knowledge:

E
veryone who has completed the required prerequisites

should

know the
following processes and be able to use the concepts indicated.

However, many students will not have taken the
prerequisites because their major does not require Bio 325
. We will, therefore, cover these topics.


A.

The nature of enzymes

and how they function

B.

Chromosome structure and replication, the concept of template
-
directed DNA synthesis

C.

Transcription and translation, use of genetic information in both

D.

Genotype/Phenotype; Mutation/Mutant

E.

Recombinant DNA and Biotechnology



Exams:

The first three exams will include multiple choice, short answer,
and
short essay

questions.

The fourth
exam will cover only the last fourth of the course. It will be all multiple choice. Anyone who misses any one of the
first three exams for
an emergency may take a make
-
up. See the instructor. Exams which remain unclaimed for
three class days after they are made available for pickup will be discarded.


Grades:

Grades will be determined by averaging all four exams
, equally,

and assigned on the

basis of 90
-
100, A; 80
-
89,B; 70
-
79, C; 60
-
69, D; less than 60, F, but a curve of 2 points is usually applied at the end of the
semester.

+/
-

grades are not assigned.

There is no other basis for grading.


Re
-
grading:

Mistakes are sometimes made in
grading. When this happens, indicate the nature of the mistake
on the front page of the exam and hand it back to the instructor by the end of the third class following the time the
graded exams are made available. Every exam handed back for re
-
grading will

be re
-
graded completely. Overall,
students might gain or lose points. Check the key before submitting for re
-
grading.


Emphasis:

The emphasis will be on concepts

and comprehension
, rather than on
memorizing
details.
However, enough facts must be learned
to be able to understand the concepts. The list
s

of bacteria

and other
microbes

must be memorized according to the instructions on the lists. The text contains too much material to be
covered in class. We choose, therefore, to lecture on, and to examine ov
er, the most important material. All exam
questions will be taken from material presented in class
,
listed on the study guide

or provided on official handouts
.


Recommended study habits:



Before Class:
Read the assigned text to familiarize yourself wit
h the material.



Use the study guide to identify the topics to be covered in lecture.



Study those topics in detail.



During Class: Attend regularly and take notes.



After Class:

Copy over the notes in good form in a permanent notebook.



Use the text

and study guide to fill in any gaps in the lecture notes.



Concentrate on the lecture notes. Use the text more
-
or
-
less as reference





material.





General:

Remember that Microbiology is, by nature, continually building on material





already

learned. You cannot hope to postpone studying because it is






necessary to know what was covered earlier to understand succeeding





lectures.




Study continually during the semester. Do not put off studying until exam time.




For exams, arrive ear
ly and put yourself together before the exam begins.


Disabilities:

The University of Texas at Austin

provides appropriate academic accommodations for qualified
students with disabilities, upon request. For more information, contact the Office of the Dean of Students at 471
-
6259, 471
-
4641


Other University policies, regulations and practices
:

See relevant University publications.



Sep

13


Last day to drop for possible refund

Nov




5

Last day to change to or from Pass/Fail
; Last day to drop
or withdraw
with Dean’s

approval, except for urgent and substantiated non
-
academic reasons.
















BIO326M

UNIQUE 50325
-
50340



TENTATIVE LECTURE SCHEDULE
-

FALL 2013 DR. WALKER



Lecture

Date



Topic







Text Chapter
*


1


AUG

28


Introduction &







Handout






Lab Methods







Chap 2, 4

2



30


Chemical Principles







Appendix I





SEP


2



LABOR DAY


3




4


Basic Biochemistry





Appendix I

4




6


Cell Structure






3



5




9


Cell Structure






3

6




11


Nutrition & Metabolism





13, 14

7



13


Nutrition & Metabolism




13, 14



8




16


Bact
erial Growth/Control




4, 5


9



18


Control/Chemotherapy





5, 27

10



20



EXAM 1

(LECTURES 1


9)



11



23


Microbial Genomics





7



12



25


Bacterial Genetics


Chromosome Replication


7

13



27


Bacterial Genetics


Chromosome Replication


7



1
4



30


Transcription






8

1
5


OCT


2


Translation






8

1
6




4



Gene Expression and Control




10 (p341
-
360)



1
7




7


Signal Transduction & Global Regulatory Mechanisms

10 (p360
-
374)

18




9


Mutations/Mutants





9 (p319
-
325)

19



11


Virology


Bacterial Viruses


Virulent



6, 11 (p385
-














394)



20



14


Virology


Bacterial Viruses


Temperate


SOS


6

2
1



16



EXAM 2

(
LECTURES

1
1
-

2
0
)

2
2



18


Microbial Genetics
-

Recombination



9 (p302
-
319)


& Transformation









23




21




Microbial Genetics


Plasmids, Mobile Genetic


9 (p331
-
340)









Elements









Microbial Genetics


Conjugation/Transduction


9 (p302
-
319)

2
4




23


Recombinant

DNA Technology




12

25




25


Animal Virology RNA & DNA
; Viral Diseases


6, 11 (p393
-














426)






26




28


Animal Virology RNA & DNA

; Viral Diseases


6, 11 (p393
-














426)

27




30


Animal Virology



Retroviruses
, Prions



26 (p
1009
-














1011)







Infectious Molecules








2
8


NOV



1


Intermediate Organisms


Chlamydia,



18 (p710
-
712)

26 (p1001
-


1002)







Rickettsia, Mycoplasma


their Diseases


18 (p701
-
702)













18 (p690
-
691)




29




4


Mycology /
Fungal Diseases




20 (p761
-
769)

30






6


Normal Flora and Infection




23

31




8



EXAM 3

(LECTURES 22


30)





3
2




11



Innate Host Resistance





23

3
3




13


Adaptive Immunity





24 (p893
-
913)

34




15


Adaptive
Immunity





24 (p893
-
913)





35




18


Adaptive Immunity





24 (p913
-
925)

36





20


Vaccines






26.9 (p1022
-














1025)

3
7




22


Immune Disorders





24 (p925
-
932)



3
8




25


Serology & Diagnosis





Study Guide



3
9




27


Epidemiology






28.5 (p1085
-














1097)








29



THANKSGIVING HOLIDAY



40


DEC


2


Bacterial Diseases





26

4
1




4


Bacterial Diseases





26

42




6



E
XAM

4

(lectures
32

-

41
)