Proteomics and Application of Mass spectrometry

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12 Φεβ 2013 (πριν από 4 χρόνια και 7 μήνες)

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Short C.V


Professor Byung
-
Gee Kim



Page
1

of 4


Byung
-
Gee K
im


Contact:

Phone
:

82
-
2
-
880
-
6774



Fax

:

82
-
2
-
883
-
6020

E
-
mail

:

byungkim@snu.ac.kr

URL

:

http://
mbbl.snu.ac.kr


Current Position:

Professor
,
School

of Chemical
and Biological
Engineering, College of Engineering
,

Institute of
M
olecular

Biology and Genetics,
and
Institute of Bioengineering
,
Seoul National University

599 Gwanangno, Gwanak
-
gu, Seoul 151
-
744, Korea


Education:

Ph.D.

in Food Science and Technology
,
Cornell University
, in Ithaca N.Y., U.S.A
, 1989

Thesis: "Population M
odel for
Escherichia coli
Containing Plasmids with ColE1 Origin of Replication".

Thesis advisor: M.L. Shuler(Dept. of Chemical Engineering)

M.S.

in Chemical Technology
, College of Engineering
,
Seoul National University
, 1982

Thesis: " The Study of the Alco
hol Production by the Immobilized
Zymomonas mobilis
Cells".

Thesis advisor: Cha
-
Yong Choi(School of Chemical Engineering)

B.S.

in Chemical Technology
, College of Engineering

,
Seoul National University
, 1980


Experience:

Professor
,
School of Chemical
and B
iological
Engineering, Seoul National University
,

Jointly appointed to Institute for Molecular Biology and Genetics, Seoul National University.

Interdisciplinary program of Biochemical Engineering and Biotechnology,Seoul National University
,
1991
-

presen
t

Head
,
Program in Engineering Biotechnology at Seoul National University
, 2011
-

present

Director
,
Korea Bio
-
Hub Center
, 2008
-
2009

Visiting Professor
,
Boston University, Biological Mass spectrometry Center, Dept. of Biochemistry

in
Medical School (with Pro
f. Catherline Costello),

2006
-
2007

Director
, Institute of Bioengineering, Seoul National University, 2005
-
2007



Head
, Graduate Program of Bioengineering, Seoul National University
, 2005
-
2006

Associate
Director
, School of Chemical and Biological Engineerin
g, Seoul National University,
2002
-
2004

Visiting Professor
, Boston University, Center for Advanced Biotechnology, (with Prof. Charles
Cantor),

1999
-
2000

Head
, Graduate Program of Bioengineering, Seoul National University
, 1997
-
1999

Short C.V


Professor Byung
-
Gee Kim



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2

of 4


Visiting Professor
, Univ
ersity of Calgary, Dept. of Biological Science, (with Prof. Sui
-
Lam Wong),
1993

Sc
ientist
,
Department of Microbiology and Fermentation, Genencor International Co.
,

S. SanFrancisco, U.S.A, 19
8
8
-
1991


Research Publications, Patents, and Special Services
:

1
9
0

Scientific research publications,
2
3

patents,
2
6
4

invited lectures and presentations



Graduate Students and Post
-
doctoral Scientists Trained and Supervised:

6
4

PhD and MS Graduate students and
22

Postdoctoral scientists and
researcher
s


Areas of Resea
rch Interest:

Biocatalysis and Enzyme Reaction Engineering


1)

Aminotransferase and its related reaction systems

-

Production of Chiral amines, amino alcohols, and specialty amino acids using
aminotransfersae

-

Combination of aminotransferse and oxido
-
reductases

-

Aminotransferase study involved in carbohydrate synthesis such as aminosugars

-

Bioinformatic study of PLP dependent enzymes


2
)
Dehydrogenase
and P450
reaction systems

-

Production of chiral alcohols and amino alcohols

-

Control of double chiral centers in diol

and amino alcohols

-

H
ydroxylation reaction
s

in alkene and flavonoids

-

Classification of oxidoreductase based upon bioinformatics


3) G
lycosyltransferase and carbohydrate synthesis

-

Production of oligosaccharides using glucosidase and glycosyltransferase

-

in v
itro

glycone unit and amino sugar synthesis using multiple enzyme reactions

-

Involved sugar nucleotide synthesis

-

C
omparison between glycosyltransferase and deoxyglycosyltransferase

-

Design of hybrid glycosyltransferase
s

for glycorandomization


Proteomics

and

Application of Mass spectrometry


1) Proteomics of Streptomyces

-

Proteomics study of Streptomyces for the secondary metabolite production

-

Proteomics of antibiotics transporters and multidrug resistance genes

-

S
creening of pathway specific regulators for an
tibiotics synthesis

-

Related
enzyme production and screening

using bioinformatics


-

Enzymatic synthesis of dTDP
-
deoxy hexoseand deoxystreptamine


Short C.V


Professor Byung
-
Gee Kim



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3

of 4


-

Quorum(i.e. gamma
-
butanolide) analysis and global regulatory system

-

Screening of q
uorum inhibitors and lactonase


2)
G
lycom
ics for xenotransplantation

-

A
nalysis
of glycans from

the membrane proteins of pig endothelial cells
for the study of
immune

reactions in xenotransplantation

-

Screening of auto
-
Ab from blood binding to the
glyc
an
-
cojugated beads


3) Biochips and
mass spectrometry

-

Protein chips using aptamers(RNA and oligopeptides) and mass spectrometry

-

Design of smart riboregulators and molecular switches

-

Protein and carbohydrate analysis using mass spectrometry

-

Development of high throughput enzyme screening syst
em
s(proteases and kinases)

using mass
spectrometry

-

Miniaturization of enzyme reactors

and aptamer affinity chromatography

and their application
in micro
-
TAS


Editorial Board Member:

Editor
,
Korean Society for Biotechnology Bioengineering

(Published by Kore
an Society
of

Biotechnology and Bioengineering),
2010
-

present


Editorial Board Member
,

Journal of Bioscience and Bioengineering

(Published by The
Society of Biotechnology, Japan), 2007
-

present

Editorial Board Member
,

Journal of Molecular Catalysis B: Enz
ymatic

(
Published by
Elsvier
Science), 2006
-

present

Editorial Board Member
,

Process Biochemistry

(
Published by
Elsvier Science), 2005
-
present

Associate/assistant Editor
, Biotechnology and Bioprocess Engineering

(Published by Korean
Society of Biotechnolog
y and Bioengineering), 1996
-

1997



Professional Societies Membership:

The National Academy of Engineering of Korea

The Korean Society

for Biotechnology an
d Bioengineering

The Korean Society

for Microbiology and Biotechnology

The Korean Society of Industrial and Engineering Chemistry

Korean Society for Biochemistry and Molecular Biology

Korean Institute of Chemical Engineers


American Institute of Chemical
Engineers

American Chemical Society

American Society of Mass spectrometry

American Society for Microbiology

Short C.V


Professor Byung
-
Gee Kim



Page
4

of 4


Society for Glycobiology


Honors and Awards:

Biocat A
ward 2010, from 5
th

International Congress on Biocatalysis,
Germany,
2010

Academic
A
ward of B
iotechnology and Bioengineering
, from
The Korean Society

for
Biotechnology and Bioengineering, 2010

Shin
-
Y
ang Academic Award,
from College of Engineering, Seoul National University,
2009

Member of the National Academy of Engineering of Korea
, 2008

Distingu
ished service award, The Korean Society of Industrial and Engineering Chemistry,
2005

Distinguished service award, The Korean Society for Microbiology and Biotechnology, 2003

Distinguished service award, The Korean Union of Chemical science and Technology
Societies,
2003


Att
achments (a
ttached

and will be provided upon further request
)

1.
List of
Scientific
Publications (
1
9
0
)

2.

List of
Invited Lectures and Presentations
(
2
6
4
)