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CURRICULUM VITAE



NAME

JACK PUYMIRAT


ADDRESS

Unit of Human Genetics


CHUL Research Center


CHUQ
-

CHUL


2705 boul. Laurier, Ste
-
Foy, Québec G1V 4G2



TITLE


Internist in medicine, Paris


Doctor in medicine (M.D.)


Neurologist


Doctor in Sciences of Par
is VI University (Ph.D.)



CURRENT

Professor, Department of Medicine, Laval University, Quebec, Canada

POSITION


Director of the Unit of Human Genetics, CHUL Research Center, Quebec,



Canada


Scientific director of the Molecular Diagnosis Laboratory, CHU
L, Quebec,


Canada


Neurologist: Clinic of neuromuscular diseases at IRDPQ and CHUL.


EDUCATION

Baccalaureat



1969 :

Série E Academy of Limoges




Medical Education


1971
-

1975 :

Faculty of Medicine Pitié
-
Salpétrière: Paris, France


1983 :


M.D. Med
icine thesis, Laureate of Faculty of Medicine of
Paris, France




Internship





1975
-

1981 :

Speciality of Neurology, Paris France


1986 :


Licence of Neurology, Paris, France



Scientific Education



1975
-

1977 :

University of Pierre and Marie Curie

-

Paris VI, Paris, France.
Licence of Biochemistry and Metabolism


1977
-
1978:

DEA in Neurobiology


1981
-

1986 :

Collège de France, University of Paris VI, Paris, France



Ph.D.


EXPERIENCE

1999
-
present :

Unit of Human Genetics, CHUL Hospital, Quebec, Ca
nada Laval




University Quebec, Canada




Professor of Medicine, University of Laval




Puymirat, J.

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ge

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1989
-

1999:

Unit of Genetic and Molecular Medicine, CHUL Hospital,
Laval University Quebec, Canada





Associated professor, University of Laval








1988
-

1989:

Laboratory of Cellular Neuroendocrinology, Collège de France,
Paris, France





Junior researcher INSERM



1986
-

1988:

Unit of Genetic and Molecular Medicine, Pr. J. Dussault, CHUL
Hospital, Quebec, Canada




Fellowship of FRSQ



Associated Professor, Uni
versity of Laval



1982
-

1986:


Sce of Neurology, Hospital Sainte
-
Anne, Paris






Associated professor of Neurology



1979
-

1986 :

Laboratory of Cellular Neuroendocrinology, Collège de France,
Paris, France





Junior researcher INSERM



1976
-

1978:

L
aboratory of Dr Y. Agid , Hospital of Salpétrière, Paris, France





Non remunerated searcher



1976:


Laboratory of Neuropharmacology of Pr J. Glowinski





Under instruction



1975
-

1976 :


Military Service, France



DIRECTION OF STUDENTS


-

Director of

DERBH diploma


Mme C. Fallet
-
Bianco, University of Paris VI, 1986
-

1989



-

Director trainees :

1994
-



: 28



-

Director master students :

1990
-



: 12


-

Director Ph.D. students :

1986
-



: 8




-

Director post
-
doctorat trainees :

1991
-



: 5





J
URY POUR THESES DE DOCTORAT


1985
-



: 12



Puymirat, J.

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TEACHING


-

Program of Neurobiology for PhD students

-

Neurological Program for MD students at University Laval.



ORGANIZING FOR MEETINGS

-

Member of the organizing committee of the XV
th

Meeting of the French S
ociety of Experimental
Neuroendocrinology, Gif/Yvette, France, 1985.

-

Responsible of the National Neurosciences expositions for the 20
-
years of INSERM, Paris,
1984.

-

Responsible of CNRS Exposition, Paris, 1984.

-

IDMC
-
05 International Myotonic Dystrophy
Consortium

Quebec City Oct 2005 Head
organizer



AWARD

-

National Dr David Green Award by Muscular Dystrophy Canada
, June 2006



SOCIETIES

-

Member of "

French Society of Experimental Neuroendocrinology
" 1986
-



-

Member of "Bureau du Cercle de neuroend
ocrinologie de L'Ile de France", (1984
-

1986)

-

Member of "Bureau scientifique du groupe d'étude sur l'involution cérébrale" (1982
-

1986)

-

Member of "The Endocrine Society", 1990
-



-

Member of " The American Thyroid Association", 1990

-

Member of "Clu
b de recherches cliniques du Québec" 1989
-





PUBLICATIONS



1.

Dupré N, Chrestian N, Bouchard JP, Rossignol E, Br
unet D, Sternberg D, Brais B,
Mathieu J, Puymirat (2008)

: J.

Clinical, electrophysiologic, and genetic study of non
-
dystrophic myotonia in French
-
Canadians.
Neuromuscul Disord. 2008 Mar 10;


2.

Bernard G
,
Poulin C
,
Puymirat J
,
Sternberg D
,

Shevell M
. (2008): Dosage Effect of a
Dominant CLCN1 Mutati
on: A Novel Syndrome.


3.

Yadava RS
,
Frenzel
-
McCardell CD
,
Yu Q
,
Srinivasan V
,
Tucker AL
,
Puymirat

J
,
Thornton CA
,
Prall OW
,
Harvey RP
,
Mahadevan MS
.
(2008) : RNA toxicity in
myotonic muscular dystrophy induces NKX2
-
5 expression
.


4.

Meijer, IA., Dion, P., Laurent, S., Dupre, N., Brais, B., Levert, A., Puymirat, J., Rioux,
MF., Sylvai
n, M., Zhu, PP., Soderblom, C.
, Stadler, J., Blasckstone, C. Rouleau,
GA.(2007) : Characterization of a novel SPG3A deletion in a French
-
Canadia
n family.
ANM Neurolo





Puymirat, J.

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5.

Pelletier, R., Caron, S.,
Puymirat, J
.

(2006)
: RNA based gene therapy for dominan
tly
inherited diseases. Current Gene Therapy

6,
131
-
146



6.


Arsenault, ME., Prévost, C., Lescault, A., Laberge, C.,
Puymirat, J.,

Mathieu, J.

(2006)
:
Génotype
-
phenotype correlation study in DM1 patients with sma
ll CTG expansions.
Neurology 66, 1248
-
125
0




7
.

Chrestian, N.,
Puymirat, J
.

JP Bouchard Dupré, N. (2006)

: Myotonia congenita, a cause
of muscle weakness and stiffness.
Neurology 2, 1
-
7



8
.

Langlois MA, Boniface C, Wang G, Alluin J, Salvaterra PM,
Puymirat J
, Rossi JJ, Lee
NS.

(2005)
Cytoplasmi
c and nuclear retained DMPK mRNAs are targets for RNAi in
myotonic dystrophy cells. J
Biol Chem. 280, 1649
-
1654


9
.

Kim, DH., Langlois, MA, Lee,
Puymirat, J.,

Riggs, AD., Rossi, JJ.
(2005)

: HnRNP H
inhibits nuclear export of mRNA containing expanded CUG r
epeats and distal branch
point sequence. N
uclear Acid Research 33,

3866
-
3874



10
.

Furling, D., Doucet, G., Langlois, M.A., Timchenko, L., Bélanger, E., Cossette.
L. and
Puymirat, J.

(2003
) Viral vector producing antisense RNA restores myotonic dystrophy
myobl
ast functions. Gene Therapy 10
, 795
-
802


11
.

Langlois, M.A., Lee, N.S., Rossi, J.J. and
Puymirat, J
.
(2003)
Hammerhead ribozyme
-
mediated destruction of nuclear foci in mu0tonic dystrophy myo
blasts. Molecular
Therapy.

7(5), 670
-
680


12
.

Cayrou, C., D
enver, R.J. and
Puymirat, J.

(2002) Suppression of BTEB in brain neuronal
cultures inhibits thyroid hormone
-
induced neurite branching. Endocrinology. 143/6,
2242
-
2249


13
. Brisson D., Tremblay M, Prévost C, Laberge C,
Puymirat J
, Mathieu J
(2002)
: Sibs
hip
stability of genotype and phenotype in myotonic dystrophy. Cli
n, Genet,

62 : 220
-
225


14
.

Martel, J., Cayrou C,
Puymirat, J
., (2002) Identification of new thyroid hormone regulated
genes in the development brain by CDNA microarray.
NeuroReport 13, 1849
-
1851



15
.

Dupré, N., Cossette, L., Hand, C.K., Bouchard, J.P., Rouleau, G.A. and
Puymirat, J.

(2001) A founder mutation of french
-
canadian families with X
-
linked hereditary
neuropathy. Can. J. Neurol. Sci. 28 : 51
-
55


16
.

Heyer, E, Zierkiewicz, E, Rochow
ski, V, Puymirat, J and Labuda, D. (2001) Phylogenetic
and familial estimates of mitochondrial substitution rates : study of control region
mutations in deep
-
rooting pedigrees.
Am. J. Hum.
Genet. 69 (5): 1113
-
1126


17
.

Furling, D., Lemieux, D., Taneja, K.
et
Puymirat, J.

(2001) Decreased levels in DMPK is
associated with a delay of human myotonic dystrophy myoblast differenciation. Neuro.
Musc. Disorders Nov ; 11 (8) : 728
-
35




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18
.

Castanotto D, Li J.R., Michienzi A, Langlois M.A., Lee N.S., Puymirat J, Ross
i, J.J.
(2001)
: Intracellular ribozyme appli
cations. Biochem Soc Trans
; 30(6), 1140
-
1145


19
.

Vilquin, J.
-
T., Guérette, B.,
Puymirat, J.
, Yaffe, D., Tomé, F. M.S., Fardeau, M. Fiszman,
M., Schwartz, K. and Tremblay, J.P. (1999) Myoblast transplantations
lead to the
expression of the laminin
2 chain in normal and dystrophic (dy/dy) mouse muscles.
Gene Therapy 6: 792
-
800.


20
.

Puymirat, J.
, Ouellet, L., Baas, D. and Sarliève, L.L. (1999) BTEB : Un facteur de
transcription qui pourrait jouer un rôle dans l’effet de la triiodothyronine (T3) sur
l’élongation neuritique.
Médecine/Sciences 15: II
-
III.


21
.

Dupré, N., Bouchard, J.
-
P., Brunet, D., Vanasse, M., Lemieux, B. and
Puymirat, J.

(1999)
Clinical and electrophysiological study in French
-
Canadian population with Charcot
-
Marie
-
Tooth disease type

1A associated with 17p11.2 duplication. Can. J. Neurol. Sci.
26: 196
-
200.


22
.

Denver, R.J., Ouellet, L., Furling, D., Kobayashi, A., Fujii
-
Kuiyama, Y. and
Puymirat, J.

(1999) Basic transcription element binding protein (BTEB) is a thyroid hormone
-
regula
ted gene in the developing central nervous system: Evidence for a role in neurite
outgrowth. J. Biol. Chem.274: 23128
-
23134.


23
.

Furling, D., Marette, A. and
Puymirat, J.

(1999) Insulin
-
like growth factor
-
I circumvents
defective insulin action in human my
otonic dystrophy skeletal muscle cells.
Endocrinology 140: 4244
-
4250.


24
.

Skuk, D., Furling, D., Bouchard, J.
-
P., Goulet, M., Roy, B., Lacroix, Y., Vilquin, J.T.,
Tremblay, J.
-
P. and
Puymirat, J.

(1999) Transplantation of human myoblasts in SCID
mice as a

potential muscular model for myotonic dystrophy. J. Neuropathol. & Exper.
Neurol. 58: 921
-
931.


2
5
.

Etongué
-
Mayer, P., Faure, R., Bouchard, J.
-
P. and
Puymirat, J.

(1998) Characterization of
a 54
-
kDa Human Protein Kinase recognized by an antiserum raised a
gainst the
myotonin kinase. Muscle & Nerve 21(1): 8
-
17.


2
6
.

Baas, D.,
Puymirat, J.

and Sarliève, L.L. (1998) Posttranscriptional regulation of
oligodendroglial thyroid hormone (T3) receptor
1 by T3. Intern. J. Develop. Neurosci.
16(6): 461
-
467.


2
7
.

Baas, D., Bourbeau, D., Sarliève, L
-
L., Ittel, M.
-
E., Dussault, J.H. and
Puymirat, J.

(1997)
Oligodendrocyte maturation and progenitor cell proliferation are independently
regulated by thyroid ho
rmone. Glia 19: 324
-
332.


2
8
.

Deschênes, I., Chahine, M., Tremblay, J., Paulin, D. and
Puymirat, J.

(1997) Increase in
the proliferative capacity of human myoblasts by using the T antigen under the
vimentin promoter control.
Muscle & Nerve 20: 437
-
445.


2
9
.

Bouchard Cl., Allard P., Mercier P., St
-
Laurent M., Dussault J.H. and
Puymirat J.

(1997)
Sensibilité et spécificité du dosage de la thyréostimuline (TSH) sur papier filtre pour le


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diagnostic d'hypothyroïdie chez la personne âgée. Annales d'Endocrinologie

58: 152
-
157.


30
.

Puymirat, J.

(1997) Are thyroid hormone receptors sufficient for transcription ?
Endocrine
News, Bulletin August.


31
.

Nobrega, J.N., Raymond, R.,
Puymirat, J.,

Belej, T. and Joffe, R.T. (1997) Regional
changes in betal thyroid hormon
e receptor immunoreactivity in rat brain after
thyroidectomy. Brain Res. 761: 161
-
164.


32
.

Heyer, E.,
Puymirat, J.
, Dieltjes, P., Bakker, E. and De Knijff, P. (1997) Estimating Y
-
chromosome
-
specific microsatellite mutation rates using deep rooting pedig
rees.
Human Mol. Gen. 6(5): 799
-
803.


33
.

Trépanier, G., Furling, D.,
Puymirat, J.

and Mirault, M
-
E. (1996) Immunocytochemical
localization of Seleno
-
glutathione peroxidase in the adult mouse brain. Neuroscience
75: 231
-
243.


3
4
.

Puymirat, J.

(1996) Thyroi
d hormone receptors are necessary but not sufficient for
transcription: an invited commentary. Eur. J. Endocrinol. 135: 651
-
652.



3
5
.

Puymirat, J.,

Étongué
-
Mayer, P. and Dussault, J.H. (1995) Thyroid hormones stabilize
acetylcholinesterase mRNA in neuro
-
2
A cells that overexpress the

1

thyroid receptor.
J. Biol. Chem. 270 (51): 30651
-
30656.


3
6
.

Guérette B., Roy R., Tremblay M., Asselin I., Kinoshita I.,
Puymirat J.

and Tremblay, J.P.
(1995) Increased granzyme B mRNA following alloincompatible myoblast
tra
nsplantation. Transplantation 60 (9): 1011
-
1016.


3
7
.

Etongué
-
Mayer, P., Faure, R., Bouchard, J.
-
P., Thibault, M.
-
C. and
Puymirat, J.

(1994)
The myotonin
-
protein kinase phosphorylates tyrosine residues in normal human
skeletal muscle. Biochem. Biophys. Re
s. Comm. 199: 89
-
92.


3
8
.

Besnard, F., Luo, M., Miehe, M., Labourdette, G., Dussault, J.H.,
Puymirat, J.

and
Sarliève, L.L. (1994) Transient expression of 3,5,3'
-
triiodothyronine nuclear receptors
in rat oligodendrocytes
in vivo
and

in vitro

immunocytochem
ical studies.
J. Neurosci.
Res. 37: 313
-
323.


39
.

Lebel, J
-
M., Dussault, J.H. and
Puymirat, J.

(1994) Overexpression of the

1

thyroid
receptor induces differentiation in neuro
-
2a cells. Proc. Natl. Acad. Sci., 91: 2644
-
2648.


40
.

Baas, D., Fressinaud, C.,

Ittel, M.E., Reeber, A., Dalençon, D.,
Puymirat, J.

and Sarliève,
L.L. (1994) Expression of thyroid hormone receptor isoforms in rat oligodendrocyte
cultures. Effect of 3,5,3'
-
triiodo
-
L
-
thyronine. Neurosci. Letters 176(1): 47
-
51.




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41
.

Baas, D., Bourbeau,
D., Carré, J.L., Sarliève, L.L., Dussault, J.H. and
Puymirat, J.

(1994)
Expression of


and


thyroid receptors during oligodendrocyte differentiation.
Neuroreport 5:1805
-
1808.


42
.

Lezoualch, F., Hassan, A., AbdelTowab, H.,
Puymirat, J.

and Demeneix, B.A.

(1994)
Precocious auto
-
induction of thyroid hormone receptors in embryonic chick
hypothalamic neurons. Neurosci Lett. 180: 197
-
202.


43
.

Puymirat, J.
, Cossette, L., Gosselin, F. and Bouchard, J.
-
P. (1994) Red blood cell Cu/Zn
superoxide dismutase activity

in sporadic amyotrophic lateral sclerosis. J. Neurol. Sci.
127:121
-
123.


44
.

Mirault, M.E., Tremblay, A., Furling, D., Trepanier, G., Dugre, F.,
Puymirat, J.

and
Pothier, F. (1994) Transgenic glutathione peroxidase mouse models for neuroprotection
studies
. Ann. N.Y. Acad. Sci. 738: 104
-
115.


4
5
.

Graff, M.N., Baas, D.,
Puymirat, J.
, Sarliève, L.L. and Delaunoy, J.P. (1993) The


and


thyroid receptors are expressed by cultured ependymal cells. Correlation with the effect
of L
-
T3 on glutamine synthetase mRN
As. Neurosciences Letters 150: 174
-
178.


4
6
.

Barakat
-
Walter, I., Duc, C. and
Puymirat, J.

(1993) Changes of nuclear 3,5,3'
-
triiodothyronine receptors expression in dorsal root ganglia and sciatic nerve during
development: comparison with regeneration. Euro
p. J. Neurosc. 5: 319
-
326.


4
7
.

Labelle, Y.,
Puymirat, J.

and Tanguay, R.M. (1993) Localization of cells in the rat brain
expressing fumarylacetoacetate hydrolase, the dificient enzyme in heredity tyrosinemia
type 1. B.B.A. 1180: 250
-
256.


4
8
.

Lebel, J.M.,

L'Héreault, S., Beaudoin, N., Dussault, J.H. and
Puymirat, J.

(1993) Thyroid
hormone up
-
regulates thyroid hormone receptor

gene expression in rat cerebral
hemisphere astrocyte cultures. Glia. 9:105
-
112.


4
9
.

Ardail, D., Lerme, F.,
Puymirat, J.

and Morel, G. (1993) Evidence for the presence of

and
-
related T3 receptors in rat liver mitochondria. Europ. J. Cell Biology 62:
105
-
113.


50
.

Puymirat, J.
, Marchand, R., Dussault and J.H. (1992) Immunocytochemical localization of


thyroid receptor in the adult rat cerebellum. Neurosc. Lett. 135: 239
-
242.


51
.

Barakat
-
Walter, I., Duc, C., Sarliève, L.L.,
Puymirat, J.
, Dussault, J.H
. and Droz, B. (1992)
The expression of nuclear 3,5,3'
-
Triiodothyronine receptors is induced in Schwann
cells by nerve transection. Exp. Neurol. 116(2): 189
-
197.


52
.

Puymirat, J.
: Thyroid receptor in the rat brain. (1992) Progress in Neurobiol. 39: 281
-
29
4.



53
.

Puymirat, J.
, L’Hérault, S. and Dussault, J.H. (1992) Expression of thyroid hormone
receptors mRNAs in cerebral hemisphere neuronal cultures. Devel. Brain Res. 69:173
-
177.



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5
4
.

Puymirat, J.
, Miehe, M., Marchand, R., Sarliève, L. and Dussault, J.H.
(1991)
Immunocytochemical localization of thyroid hormones receptors in the adult rat brain.
Thyroid 1(2): 173
-
184.


5
5
.

Puymirat, J.
, Gadbois, P., Dussault, L., Garceau, L. and Dussault, J.H. (1991) Production
of a specific polyclonal antibody against the

rat

thyroid using synthetic peptide as
antigen. Acta Endocrinologica 125: 397
-
400.


5
6
.

Garza, R.,
Puymirat, J.

and Dussault, J.H. (1990) Immunocytochemical localization of
thyroid hormone nuclear receptors in cultured acetylcholinesterase
-
positive neur
ons: a
correlation between the presence of thyroid hormone nuclear receptors and L
-
triiodothyronine morphological effects. Neuroscience 36: 473
-
483.


5
7
.

Garza, R.,
Puymirat, J.

and Dussault, J.H. (1990) Influence of soluble environmental
factors on the de
velopment of fetal brain acetylcholinesterase
-
positive neurons cultured
in a chemical defined medium: Comparison with the effects of L
-
triiodothyronine (L
-
T3). Dev. Brain Res. 56: 160
-
168.


5
8
.

Puymirat, J.
, Luo, M. and Dussault, J.H. (1989) Immunocytochem
ical localization of
thyroid hormone nuclear receptors in cultured hypothalamic dopaminergic neurones
using a monoclonal antibody against rat liver nuclear thyroid hormone receptor.
Neuroscience 30: 442
-
449.


5
9
.

Luo, M.,
Puymirat, J.

and Dussault, J.H.. (
1989) Immunocytochemical localization of
nuclear triiodothyronine receptors in astrocyte cultures.
Dev. Brain Res. 46: 131
-
136.


6
0
.

Gueguen, B.,
Puymirat, J.
, Grouselle, D., Piketty, M.L., Bleton, J.P., Bourdel, M.C. and
Rondot, P. (1988) Effets cliniques
, électrophysiologiques et endocriniens de la TRH en
perfusion à doses élevées dans la sclérose latérale amyotrophique.
Revue de Neurologie
144: 704
-
709.


61
.

Garza, R., Dussault, J.H. and
Puymirat, J.

(1988) Influence of triodothyronine on the
morphologi
cal and biochemical development of fetal brain acetylcholinesterasic
neurons cultured in a chemically defined medium. Dev. Brain Res. 43: 287
-
297.


62
.

Puymirat, J.
, Barret, A., Faivre
-
Bauman, A. and Tixier
-
Vidal, A. (1987) Biochemical
characterization of
the uptake and the release of
3
H
-
DA by hypothalamic dopaminergic
neurons cultured in serum
-
free
-
medium.
Develop. Biol. 119: 75
-
84.


63
.

Puymirat, J.

(1987) Controle hormonal de la différenciation des neurones hypothalamiques
en culture cellulaire.
Ann. End
ocrinol. 48: 352
-
355.


64
.

Gomez, S., Davous, P., Rondot, P. and
Puymirat, J.

(1986) Somatostatin like
immunoreactivity and acetylcholinesterase activity in the cerebro spinal fluid of
patients with Alzheimer disease. Psychoneuroendocrinology 1: 69
-
73.


6
5
.

Gomez, S.,
Puymirat, J.
, Valade, D., Davous, P., Rondot, P. and Cohen, P. (1986) Patients
with Alzheimer's disease show an increased content of 15KD somatostatin precursor
and lowered level of tetradecapeptide in their cerebrospinal fluid. Life Science
39: 7.



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6
6
.

Couchy, D., Faivre
-
Bauman, A.,
Puymirat, J.
, Tixier
-
Vidal, A. and Nunez, J. (1986)
Expression of microtubules
-
associated proteins during the early stages of neurites
extension by brain neuron cultures in defined medium. J. Neurochem. 47: 1255
-
1
261.


6
7
.

Puymirat, J.

and Faivre
-
Bauman, A. (1986) Evolution of triiodothyronine nuclearbinding
site in hypothalamic serum
-
free culture: evidence for their presence in neurons and
astrocytes. Neurosc. Letters 68: 299
-
304.


6
8
.

Puymirat, J.

(1985) Effect
of dysthyroidism on central catecholaminergic neurons.
Neurochem. Intern. 7: 969
-
977.


6
9
.

Koubesserian, P., Davous, P., Bianco, C.,
Puymirat, J.
, Fontaine, C., De Recondo, J. and
Rondo, P. (1985) Familial dementia of the Newmann type (subcortical gliosis)
.
Revue
de Neurologie 161: 706
-
712.


70
.

Puymirat, J.
, Faivre, A., Barret, A., Loudes, C. and Tixier
-
Vidal, A. (1985) Does
triiodothyronine influence the differentiation of fetal mouse mesencephalic
dopminergic neurons cultured in serum free medium?
Dev. B
rain. Res. 23: 315.


7
1
.

Faivre, A.,
Puymirat, J.
, Loudes, C., Barret, A. and Tixier
-
Vidal, A. (1984) Laminin
promotes attachment and neurites elongation of fetal hypothalamic neurons grown in
serum free medium.
Neurosci. Letters 44: 83
-
89.



72
.

Bourre, J
.M., Faivre
-
Bauman, A., Dumont, O., Nouvelot, A., Loudes, C.,
Puymirat, J.

and
Tixier
-
Vidal, A. (1983) Influence de la supplémentation en acides gras polyinsaturés de
milieux de culture sur la morphologie et la composition des cultures de cellules foetales

de cerveau de souris.
C.R. Acad. Sci. 296: 629.


73
.

Bourre, J.M., Faivre, A., Dumont, O., Nouvelot, A., Loudes, C.,
Puymirat, J.

and Tixier
-
Vidal, A. (1983) Effect of polyunsaturated Fatty acids on fetal mouse brain cells in
culture in a chemically defin
ed medium. J. Neurochem. 41: 1234.


7
4
.

Loudes, C., Faivre, A., Barret, A., Grouselle, D.,
Puymirat, J.

and Tixier
-
Vidal, A. (1983)
Release of immunoreactive TRH in serum free cultures of mouse hypothalamic cells.
Dev. Brain Res. 9: 231
-
240.


7
5
.

Puymirat,

J.
, Barret, A., Picart, R., Vigny, A., Loudes, C., Faivre, A. and Tixier
-
Vidal, A.
(1983) Triiodothyronine enhances the morphological maturation of dopaminergic
neurons from fetal mouse hypothalamus cultured in serum free medium. Neurosci. 10:
801
-
810.


7
6
.

Puymirat, J.
, Faivre, A., Bizzini, B. and Tixier
-
Vidal, A. (1982) Pre and post natal
ontogenesis of neurotransmitter synthetising enzymes and
125
I
-
Tetanus toxin binding
capacity in the mouse hypothalamus.
Dev. Brain Res. 3: 199
-
206.


7
7
.

Faivre, A., Ros
enbaum, E.,
Puymirat, J.
, Grouselle, D. and Tixier
-
Vidal, A. (1981)
Differentiation of fetal mouse hypothalamic cells in serum free medium.
Developmental Neurosciences 4: 118.



Puymirat, J.

CV pa
ge

10

de 30


7
8
.

Faivre, A., Rosenbaum, E.,
Puymirat, J.

and Tixier
-
Vidal, A. (1980) Mise en

évidence
d'activités neuronales dans des cultures primaires d'hypothalamus de souris foetales
maintenues en milieu sans sérum.
C.R. Acad. Sci., Paris, 290: 885
-
887.


7
9
.

Puymirat, J.
, Javoy,, F., Gaspa P., Ploska, A., Prochiantz, A. and Agid, Y. (1979) Po
st
-
mortem stability and storage in
the cold of brain enzymes.
J. Neurochem. 32: 449
-
454.




BOOK CHAPTERS


1
.

Dupré, N., Bouchard, J.
-
P., Cossette, L., Brunet, D., Vanasse, M., Lemieux, B., Mathon,
G. and
Puymirat, J.

(1999) Phenotypic manifestations in Fr
ench
-
Canadian Populations
with Charcot
-
Marie
-
Tooth Disease Type 1A Associated with 17p11.2 Duplication. In:
Annals of the New York Academy of Sciences "Charcot
-
Marie
-
Tooth Disorders". M.E.
Shy, J. Kamholz et R.E. Lovelace (Eds), 497
-
499.


2
.

Puymirat, J.

(
1997) Functions of thyroid hormone receptors in prenatal rat brain
development. In: "Recent Res. Dev. Neuroendo.
-

Thyroid Hormone and Brain
Maturation", 103
-
111.


3
.

Dussault, J.H., Glorieux, J.,
Puymirat, J.
, Van Vliet, G., Roy, J. and Doyon, J. (1994)
I
ntellectual and neurological development of children age 12 and 15 with congenital
hypothyroidism detected by neonatal screening. In: The damaged brain of iodine
deficiency. John B. Stanbury, (Ed), 149
-
151.


4
.

Puymirat, J.
, Dussault, L., Schmidt, E.D.L.S.

and Dussault, J.H. (1991)
Immunocytochemical localization of thyroid receptors in brain cell cultures, using three
different specific antibodies. In: "Progress in Thyroid Research". A. Gordon, J. Gross
and G. Hennemann (Eds), 879
-
881.


5
.

Dussault, J.H.,

L’Hérault, S. and
Puymirat, J.

(1991) Expression of

and

thyroid
hormone receptor mRNAs in cultured rat cerebral hemisphere neurons. In: "Progress in
Thyroid Research". A. Gordon, J. Gross and G. Hennemann (Eds), 883
-
885.



6
.

Sarliève, L., Besnard, C.
, Yusta, B., Pascual, A., Aranda, A., Luo, M., Dussault, J.H. and
Puymirat, J.

(1989) Investigation of myelinogenesis
in vitro
: Transient expression of L
-
Triiodothyronine nuclear receptors in secondary cultures of pure rat oligodendrocytes.
In: "Iodine and

the Brain". R. Delong and J. Robbins, (Eds) Plenum Press, New York,
113
-
130.


7.

Puymirat, J.

and Rondot, P. (1986) Study of biological markers in the cerebrospinal fluid
in Alzheimer’s disease.. "Journées de Neurologie". Dohme and Chibret, (Eds).



Puymirat, J.

CV pa
ge

11

de 30

8.

Gom
ez, S., Davous, P., Faivre, A., Rondot, P., Valade, D. and
Puymirat, J.

(1986)
Acetylcholinesterase activity and somatostatin like immunoreactivity in the cerebro
spinal fluid of demented patients. In: "Advances in behavorial Biology" Alzheimer and
Parkins
on disease: Strategies and developmental therapeutics. Fisher, A., Hanin, I. and
Lachman, S. (Eds) Plennum Press, 317
-
322.


9
.

Puymirat, J.
, Barret, A., Blanc, G., Faivre, A., Loudes, C. and Tixier
-
Vidal, A. (1985)
Effects of thyroid hormones on the develo
pment of mouse hypothalamic dopaminergic
neurons. In: "Fetal Neuroendocrinology". Ellendorff F., Gluckman, P.D. and Parvizi,
N. (Eds) Perinatalogy Press, 121
-
127.


10
.

Faivre
-
Bauman, A.,
Puymirat, J.
, Loudes, C. and Tixier
-
Vidal, A. (1984) Differentiated
m
ouse hypothalamic cells in serum free medium. In: "Cell Culture Methods for
Molecular and Cell Biology", vol.4, Methods for serum
-
free culture of neuronal and
lymphoid cells. Barnes, D.W., Sirbasku, S.A. and G. Sato, G.H., A. R. Liss, (Eds) New
York, 37
-
56
.


11.

Ziegler, M. and
Puymirat J.

(1983) Les neuropeptides.
"Confrontations psychiatriques" 22:
205
-
235.


12
.

Loudes, C., Faivre, A.,
Puymirat, J.

and Tixier
-
Vidal, A. (1983) Effects of hormones on
the development of mouse fetal hypothalamic neurons
in vi
tro
. In: "Drugs and
Hormones in Brain Development" Schlumpf, M. and Lichtensteiger W. (Eds)
Monograph in neural Sciences, Karger, Basel, 9, 43
-
49.


13
.

Puymirat, J.
, Loudes ,C., Faivre, A., Bourre
, J.M. and Tixier
-
Vidal, A. (198
2) Expression
of neuronal fu
nction by mouse fetal hypothalamic cells cultured in hormonally defined
medium. Cold Spring Harbor Conferencees on cell proliferation. In: "Growth of cells in
hormonally defined media". vol.9, D. Sirbasku and G. Sato, (Eds) 1033
-
1051.


1
4
.

Tixier
-
Vidal, A
., Faivre
-
Bauman, A.,
Puymirat, J.
, Rosembaum, E. and Grouselle, D.
(1981) Expression of neuronal activities in cultures of dissociated fetal mouse
hypothalamic cells. Effects od hormones as studied in serum
-
free medium. In: "Adv.
Physiol. Sci., vol.14, En
docrinology, Neuroendocrinology, Neuropeptides II". E. Stark,
G.B., Makara B., Halasz and Rappai, (Eds) Pergamon press, 101
-
105.



INVITED SPEAKER




1.


Congrès International de myologie 2005



Nantes , France, Mai 2005


Rn
a
-
based
gene therapy for
domina
ntly inherited diseases: the example of myotonic
dystrophy


2.


Conféren
ce, Pitié
-
Salpetière Hospital



France, June 2004



Thérapie génique pour la dystrophie myotonique





Puymirat, J.

CV pa
ge

12

de 30

3.



Conférence, Service de génétique, Hôpital de Bordeaux


France, September 2004


Dystrophy myotonique : de la clinique à la thérapie



4.


Conférence, Laboratoire Animage
-
Creatis


Lyon, France, December 2004


Evaluation pré
-
clinique d’une thérapie génique pour la dystrophie myotonique



5.


Conférence Vect Euro Train



Towards clini
cal gene therapy : pre
-
clinical gene transfer assessment




Stratagems for the development of a gene therapy for dominant hereditary



neuromuscular diseases. Barcelona 2004




6.



4
th

International Conference on Unstable Microsatellites and Human Disea
se




Potential therapeutic tools for myotonic dystrophy




Banff 2004



7
.


4th International Myotonic Dystrophy Consortium Meeting



A soluble factor produced by myotonic dystrophy myoblasts inhibits myogenic

differentiation.Glasgow 2003


8.



Annual Co
ngress of ANLLF and ANQ




Development of a clinical grid for myotonic dystrophy.




France 2002


9
.


C
lassification génétique des maladies neuromusculaires.



Département de pédiatrie, Québec, CHUQ
-
CHUL, 2001


10.

27th Meeting of European Thyr
oid Association Meeting



Suppression of BTEB in brain neuronal cultures inhibits thyroid hormone
-
induced
neurite branching. Poland 2001


11.


3rd International Myotonic Dystrophy Conference




Comparison of three methods for the e
xtraction of mutant myotonic dystrophic protein
kinase mRNAs (DMPK mRNAs).
Japan 2001


12
.

Rôle des hormones thyroïdiennes sur la prolifération et la différentiation des cellules
nerveuses. Conférence du département d’endocrinologie, Sherbrooke, March 1998
.


13
.

Dystrophie myotonique.


Département de Neurologie, Limoges, France, 1998.


14
.

Hormones thyroïdiennes et SNC.


Université Ann Arbor, Michigan, 1997.


15
.

Rôle du récepteur b1 aux hormones thyroïdiennes dans la différentiation neuronale.
CHU Sherbroo
ke, 1994.


16
.

L'expression des récepteurs aux hormones thyroïdiennes et fonction du SNC.



Puymirat, J.

CV pa
ge

13

de 30


Université McGill, Département de Pharmacologie Thérapeutique, Montréal, 1994.



17
.

Récepteurs aux hormones thyroïdiennes au cours du développement du SNC.

CHU
She
rbrooke, Québec, 1992.


18
.

Conference de
La Société

des neurosciences françaises


Implication des récepteurs b1 dans les neurones acétylcholinestérase du SNC.


Strasbourg, France, 1992.


19
.

Mécanismes d'action des hormones thyroïdiennes dans le développ
ement du SNC.
Hôtel
-
Dieu, Québec, Avril 1991


20
.

Mécanismes d'action des hormones thyroïdiennes dans le développement du SNC. CHU
Laval, Québec, Novembre 1990.


21
.

Étude des récepteurs aux hormones thyroïdiennes au cours du développement du SNC.
Laborato
ire Ben Ari U29 INSERM), Paris, 1989.


22
.

Récepteurs aux hormones thyroïdiennes au cours du développement du SNC. Collège de
France, Paris, 1989.


23
.

Étude des récepteurs aux hormones thyroïdiennes au cours du développement du SNC.
Institut Pasteur, Pari
s, France, 1989.


24
.

Étude des récepteurs aux hormones thyroïdiennes au cours du développement du SNC..
Interrelation avec les produits erbA. Centre de Neurochimie, Strasbourg, France, 1989.


25
.

Étude des récepteurs aux hormones thyroïdiennes au cours du

développement du SNC..
Club de thyroïde de Québec, Ste
-
Adèle, Québec, Octobre 1989.


26
.

Étude
in vitro

du rôle de la L
-
T3 dans la maturation neuronale. CHU Sherbrooke 1987.


27
.

Récepteurs des hormones thyroïdiennes dans le cerveau.


Département of Pro
f. Rapport, Hôpital Neker, Paris, 1986.


28
.

Intérêt de l'étude du LCR au cours du vieillissement.


The day of Neurology, Clermont
-
Ferrand, 1986.


29
.

Rôle des hormones thyroïdiennes au cours du développement du SNC.. CHU Laval,
Quebec, 1986.


30
.

Effets

de la triiodothyronine sur les neurones hypothalamiques dopaminergiques.


Université de Ulm RFA, 1985.


31
.

Influence des hormones thyroïdiennes sur la différenciation des neurones
dopaminergiques chez la souris.


Université Laval, Québec, 1985.


32
.

In
térêt des marqueurs du LCR dans la maladie d'Alzheimer.



Puymirat, J.

CV pa
ge

14

de 30


Démence du type Alzheimer, Paris, 1985.


33
.

Influences des hormones thyroïdiennes sur l'activité des systèmes monoaminergiques
centraux. Collège de France dans le cadre des tendances actuelles en
n
euroendocrinologie, 1984.


34
.

Influence des hormones thyroïdiennes sur le développement des neurones
hypothalamiques en culture.


Congrès : "Growth Factor", Paris, 1983.


35
.

Intérêt des cultures de cellules nerveuses.


Département of Neurologie, Hôpit
al Sainte
-
Anne, Paris, 1983.


3
6
.

Influence des hormones thyroïdiennes dans la différenciation des neurones
dopaminergiques de l'hypothalamus.


Institut Pierre et Marie Curie, Paris, 1983.



COMMUNICATIONS


1.

Child Neurology Society, Pittsburgh
, 18
-
21 oc
tobre 2006

Titre: Dosage effect of a dominant CLCN1 mutation: A novel syndrome

G Bernard, C Poulin, J Puymirat and M Shevell


1
11th International Congress World Muscle


Bruges, Bruxelles, Octobre 2006




RNA based gene therapy for dominantly
inherited of neuromuscular disorders


2.

European Muscle Conference


Heidelberg
, Allemagne, September

2006




Therapeutic strategies for myotonc dystrophy


3.
5
th

International Myotonic Dystrophy Consortium




Quebec, Canada, October 2005


C
haracterization of myoblast cells from myotonic dystrophy type 2 patients




4.
5
th

International Myotonic Dystrophy Consortium




Quebec, Canada, October 2005


Intergenerational contraction of the CIG repeats in large families with

myotonicd
ystrophy




5.
5
th

International Myotonic Dystrophy Consortium




Quebec, Canada
, Octobre

2005


A potential gene therapy for myotonic dystrophy type 1



6. An
nual Scientific Meeting of Canadian College of Medical Geneticists


Brom
ont, Canada
, Octob
r
e
2005


New therapeutic avenues for myotnic dystrophy




Puymirat, J.

CV pa
ge

15

de 30

7.


26
th

International Epilepsy Congress





Paris, France, Août 2005




8
.





American Society for Gene Therapy 8
th

Annual Meeting




St
-
Louis, USA, Juin 2005





A database
for managing neuromuscular disease data in the province of Quebec


9.


Congrès International de myologie 2005



Nantes , France, Mai 2005



A soluble factor produced by myotonic dystrophy myoblasts inhibits myogenic



differentiation.



10
.

Congrès Intern
ational de myologie 2005



Nantes , France, Mai 2005



A database for managing neuromuscular disease data in the province of Quebec



11
.

Congrès International de myologie 2005



Nantes , France, Mai 2005

Rna
-
based gene therapy for
dominantly inherited di
seases: the example of myotonic
dystrophy


12.

Conférence, Laboratoire Animage
-
Creatis


Lyon, France, December 2004


Evaluation pré
-
clinique d’une thérapie génique pour la dystrophie myotonique


13.


Conférence, Service de génétique, Hôpital de Bordeaux


F
rance, September 2004


Dystrophy myotonique : de la clinique à la thérapie


14.

Conférence , Genethon Institute


France, June 2004




Thérapie génique pour la dystrophie myotonique



1
5.

Conférence, Pitié
-
Salpetière Hospital



France, June 2004



Thérapie
génique pour la dystrophie myotonique


16.


Réunion scientifique
-

CHUQ

Evaluation génétique des maladies neuromusculaires en 2004


24 mars 2004


17.

Conférence Vect Euro Train, Barcelona, February 2004





Stratagème pour le dévelopment d’une théra
pie génique pour les maladies


neuromusculaires héréditaires.



Puymirat, J


18
.

Service de Neurologie, Bordeaux, France, February 2004





Traitement de la dystrophie myotonique: de la pharmacologie à la thérapie génique


Puymirat, J
.




Puymirat, J.

CV pa
ge

16

de 30


1
9
.

4
th

Internati
onal Conference on Unstable Microsatellites and Human Disease



Banff, Canada, February 2004


Potential therapeutic tools for myotonic dystrophy



20.

Rencontre du Réseau de Steinert , Paris January 2004




Puymirat, J



21.


31
st

Congress of SNE,
Paris, Septembre 2003



Puymirat, J
. : Rôle du récepteur thyroïdien

1 dans la différentiation du cervelet.



22
.

32
nd

European Muscle Conference


EMC 2003, Montpellier, 7
-
10 Septembre 2003



Puymirat J
. : Development of a therapeutical tool for myotonic
dystrophy.


23
.

CCNS 2003, June 2003, Quebec, Canada


Langlois, MA, Doucet, G, Rossi, J.J. and
Puymirat J

: Gene therapy for myotonic

dystrophy by preferential targeting of mutant myotonin protein kinase mRNA.


24
.

6
th

Annual Meeting American Society for
Gene Therapy, Juin 2003, Washington


Langlois, MA, Lee, N.S., Rossi, J.J. and
Puymirat J

: RNA
-
Based gene therapies for

myotonic dystrophy type 1.





25
.

4th International Myotonic Dystrophy Consortium Meeting, Glasgow, April 2003

Puymirat J
., Bélanger,
E., Haineault, C., Beaulieu, D., and Doucet, G: A soluble factor
produced by myotonic dystrophy myoblasts inhibits myogenic differentiation.


26
.

4th International Myotonic Dystrophy Consortium Meeting, Glasgow, April 2003

Haineault, C., Beaulieu, D., Fur
ling, D. and
Puymirat, J
. : Expression of myogenic
regulatory factors in myotonic dystrophy (DM1) myoblasts.


27
.

Congrès Neurosciences, 2003


Fournier, M, Noël, M, Cayrou, C,
Puymirat, J
, Mouginot, D and Mirault, M.E. : Thyroid
hormone
-
dependent different
iation of neuronal cells inhibited by methylmercury.


28
.

MDA
-

Conférence de presse, Jan 2003, USA



Jack Puymirat

: (S) Blocking excess genetic material
-

a new lead in NMD(T).


29
.

Xth International Congress on Neuromuscular Disease, July

2002, Vancouver, Canada


Langlois MA, Doucet G, Timchenko L, Rossi JJ et
Puymirat J

: Stratagem in vitro for

gene therapy directed to myotonic dystrophy (DM1).


30
.

Société Francophone de Thérapie Cellulaire et Génique, Juin 2002, Paris, France
Puymirat

J

et Langlois MA : Développement d'une thérapie génique pour la dystrophie
myotonique.


31.

4e Journées génétiques 2002, Montréal, May 2002 Dupré N, Bouchard J
-
P, Verreault S,
Rivest D,
Puymirat J
, Rouleau GA : A Recessive ataxia originating from the Beau
ce, a
new pure cerebellar ataxia.





Puymirat, J.

CV pa
ge

17

de 30

32
.

4e Journées génétiques 2002, Montréal, May 2002
Puymirat J

: Network for
neurogenetic diseases.



33
.

4e Journées génétiques 2002, Montréal, May 2002 Langlois MA,
Puymirat J

:
Développement d'une thérapie génique pou
r la dystrophie myotonique.


34
.


7e Annual Meeting of RNA Society, May 28th
-
June 2nd 2002, Wisconcin, USA Kim D,


Langlois MA,
Puymirat J

et Rossi J : Binding of hnRNP H (CUG)n expansions

associated with myotonic dystrophy.


35
.


Annual Congress of A
NLLF and ANQ, 2002, Cannes, France



Jack Puymirat
. Development of a clinical grid for myotonic dystrophy


36
.

Réunion des membres du Département des sciences neurologiques, Nov 2002, Qc


L'investigation des myopathies en 2002.


37
.

73rd American Thyroid
Association Meeting, Washington, USA, November 2001
Puymirat J
. Cayrou C, Grouselle D, Martel J : A transgenic mouse expressing a mutant
(beta) thyroid hormone receptor show delay in cerebellar development.



38
.


3rd International Myotonic Dystrophy Confe
rence, Kyoto, Japan, October 2001




Cossette L, Doucet G and
Puymirat J
. Comparison of three methods for the extraction of
mutant myotonic dystrophic protein kinase mRNAs (DMPK mRNAs)


39
.


3rd International Myotonic Dystrophy Conference, Kyoto, Japan, O
ctober 2001

Puymirat J
, Doucet G, Cossette L and Timchenko L. The use of RNA antisense as a
potential gene therapy for myotonic dystrophy (DM).


40
.

3rd International Myotonic Dystrophy Conference, Kyoto, Japon, Octobre 2001

Kim D, Langlois MA,
Puymirat J

and Rossi JJ.
Identification of the CUG repeats
binding proteins in HeLa and myoblast.


41
.



27th Meeting of European Thy
roid Association Meeting, Août

2001, Warsaw, Poland




Puymirat J
., Cayrou C and Martel J. : Mice with a targeted mutation in the th
yroid


receptor gene exhibit delayed development in the cerebellum.



42
.


27th Meeting of European Thy
roid Association Meeting, Août

2001, Warsaw, Poland




Puymirat J
., Cayrou C and Martel J. : Suppression of BTEB in brain neuronal cultures
inhibits th
yroid hormone
-
induced neurite branching.



43
.

Journée de la Recherche, Faculté de Médecine
, Université Laval, Québec, Juin

2001.




Puymirat, J
. et Cayrou C. : Development of transgenic mice which reproduce brain
abnormalities observed in the hypothyroi
d state.


44
.



Journée de la Recherche, Faculté de Médecine
, Université Laval, Québec, Juin

2001.




Puymirat, J
. et Martel J. : Identification of thyroid hormones target genes by microarray.


45
.



4e colloque de l'Association de thérapie g
énique du Qu
ébec, Montréal, Juin

2001
,




Puymirat J
. : Gene therapy for myotonic dystrophy.



Puymirat, J.

CV pa
ge

18

de 30


46
.


Journée de la Recherche, Faculté de Médecine, Univer
sité Laval, Québec, Mai

2000.



Dupré, N., Cossette, L., Bouchard, J.
-
P. and
Puymirat, J.
: Molecular diagnosis of th
e
Charcot
-
Marie
-
Tooth type 1A by PCR.


47
.


Journée de la Recherche, Faculté de Médecin
e, Université Laval, Québec, Mai

2000.



Cayrou, C., Ouellet, L., Martel, J. and
Puymirat, J.
: Identification of thyroid hormones
target genes in the brain.


48
.


Journ
ée de la Recherche, Faculté de Médecin
e, Université Laval, Québec, Mai

2000.



Puymirat, J.

and Furling, D.: Development of a gene therapy for myotonic dystrophy.


49
.


International Congress of Myology (AFM), Acropolis, Nice, France
, Mars

2000.



Furling
, D. and
Puymirat, J.
: Differentiation of human myotonic dystrophy muscle cells
in vitro et in vivo.


5
0.


Fourth International Congress of the World Muscle Society, Talya Convention Centre,
Antalya, Turkey
, Octobre

1999.



Skuk, D., Furling, D., Bouchard,

J.
-
P., Vilquin, J.
-
T., Tremblay, J.P. and
Puymirat, J.
:
Human myoblast transplantation in SCID mice as a potential tool for studies in myotonic
dystrophy.


51
.


68
th

Assemblée Annuelle
-

Collège Royal des Médecins et Chirurgien
s du Canada,
Montreal, Septe
mbre

1999.



Dupré, N., Cossette, L., Bouchard, J.
-
P. and
Puymirat, J.
: Comparison of tthree methods
for the molecular diagnosis of 1,5 MB duplication on chromosome 17 associated with the
Charcot
-
Marie
-
Tooth disease type 1A.


52
.


72
nd

Annual Meeting of th
e American Thyroid Association, Palm Beach, Florida
,
Septembre

1999.



Puymirat, J.

and Denver, R.: Basic transcription element binding protein (BTEB) is a
thyroid hormone regulated gene in the developing brain: evidence for a role in neurite
outgrowth.


5
3.


Journée de la Recherche, Faculté de Médecine, Universit
é Laval, Quebec, Mai

1999.



Furling, D., Marette, A. and
Puymirat, J.
: Effect of l’IGF
-
1 (Insulin
-
like growth factor
-
1)
on myotonic dystrophy skeletal muscle cells.


54
.


Journée de la Recherche,
Faculté de Médecin
e, Université Laval, Quebec, Mai

1999.



Cayrou, C., Ouellet, L. and
Puymirat, J.
: BTEB: a transcription factor involves in T3
-
induces neurite outgrowth.


55
.


Journée de la Recherche, Faculté de Médecin
e, Université Laval, Quebec, Mai

19
99.



Dupré, N., Bouchard, J.
-
P. and
Puymirat, J.
: Hereditary neuropathies in Quebec.


56.


Club Thyroidien du Québec, Montreal, Mai 1999.



Cayrou, C. and
Puymirat, J.
: BTEB: a transcription factor involves in T3
-
induces neurite
outgrowth.



Puymirat, J.

CV pa
ge

19

de 30


57
.


XXVIII
rd

Colloque de la Société de Neuroendocrinologie, Marseille,
Mai

1999.



Puymirat, J.
, Baas, D., Ouellet, L., Cayrou, C. and Sarliève, L.: Thyroid hormones and
brain development.


58
.


Second International Myotonic Dystrophy Consortium (IDMC)
Conference, No
rth
Carolina, Avril

1999.



Furling, D., Marette, A. and
Puymirat, J.
: Insulin
-
like growth factor
-
I overcomes insulin
defective action in human myotonic dystrophy skeletal muscle cells.


59
.


Second International Myotonic Dystrophy Consortium (IDMC) Confer
ence, North
Carolina
, Av
ril 1999.



Furling, D., Skuk, D., Bouchard, J.
-
P., Vilquin, J.
-
T., Tremblay, J.P. and
Puymirat, J.
:
Transplantation of myotonic dystrophy human myoblasts in SCID mice: a new potential
muscular model.


60
.


Second International Myot
onic Dystrophy Consortium (IDMC) Conference, North
Carolina
, Av
ril 1999.



Furling, D. and
Puymirat, J.
: Myotonic dystrophy protein kinase (DMPK) expression in
primary skeletal muscle cell cultures derived from normal and DM patients.



61
.


122
rd

Annual M
eeting of the A
merican Neurological Ass
, Montreal
, Octobre

1998.



Dupré, N., Bouchard, J.
-
P., Brunet, D., Vanasse, M., Lemieux, B. and
Puymirat, J.
:
Clinical and electrophysiologic study in french
-
canadian families with Charcot
-
Marie
-
Tooth disease type 1A

associated with 17p11.2 duplication.


62
.


122
rd

Annual Meeting of the A
merican Neurological Ass
, Montreal
, Octobre

1998.



Furling, D., Bouchard, J.
-
P. and
Puymirat, J.
: Decrease levels in myotonin protein kinase
is associated with a delay in human myoto
nic dystrophy myoblast differentiation.


63
.


40
e
Réun
ion Annue. du Club de Rech.

Cliniq
ues du Québec, Montreal, Octobre

1998.



Dupré, N., Bouchard, J
-
P., Brunet, D., Vanasse, M., Lemieux, B. and
Puymirat, J.
:
Genetics aspects of hereditary neuropathies
in French
-
Canadian population.


64
.


40
e
Réun
ion Annue. du Club de Rech.

Clinique
s du Québec, Montreal, Octobre

1998.



Furling, D., Lemieux, D., Bouchard, J.
-
P. and
Puymirat, J.
: Effects de l’IGF
-
1 (Insulin
-
like Growth Factor
-
1) on myotonic dystrophy hu
man myoblast differentiation.


65
.


40
e
Réunio
n Annuelle du Club de Rech.

Cliniq
ues du Québec, Montreal, Octobre

1998.



Bouchard, J.
-
P. and
Puymirat, J.
: Development of a data base for neuromuscular diseases
in Quiebec.


66
.


Third International Conf. o
n Charcot
-
Marie
-
Tooth Disorders, Montreal
, Octobre

1998.



Dupré, N., Bouchard, J.
-
P. and
Puymirat, J.
: A new mutation in the connexin gene on
chromosome X in the three french
-
canadian families with X
-
linked hereditary
neuropathy: phenotypic study.




Puymirat, J.

CV pa
ge

20

de 30

67
.


4
8
th

Annual Meeting of the American Society of Human Genetics (ASHG), Denver,
Colorado
, Octobre

1998.




Furling, D., Bérubé, D., Bouchard, J.
-
P. and
Puymirat, J.
: Beneficial effect of insulin
-
like
growth factor
-
I (IGF
-
I) on myotonic dystrophy skeletal musc
le cells.


68
.


9

e

Journée Hospitalo
-
Universitaire
, Manoir St
-
Castin, Quebec, Juin

1998.



Dupré, N., Bouchard, J.
-
P., Brunet, D., Vanasse, M., Lemieux, B. and
Puymirat, J.
:
Clinical and Genetics aspects of hereditary neuropathies in Quebec.


69
.


33
rd

Me
eting of the Canadian Congress of Neurogical Sciences, Montreal
, Juin

1998.



Dupré, N.,
Puymirat, J.
, Bouchard, J.
-
P., Brunet, D., Vanasse, M. and Lemieux, B.:
Genetic aspects of Charcot
-
Marie
-
Tooth neuropathies in the French
-
Canadian
Population.


70
.


XX
V
e

Forum de
s Jeunes Chercheurs, Quebec, Mai

1998.



Furling, D., Lemieux, D., Bouchard, J.
-
P. and
Puymirat, J.
: Decrease levels in myotonin
protein kinase is associated with a delay in myotonic dystrophy myoblast differentiation.


71
.


ACFAS, Quebec
, Mai

1998.



Dupré, N., Bouchard, J.
-
P., Brunet, D., Vanasse, Michel, Lemieux, B. and
Puymirat, J.
:
Genetics of hereditary neuropathiesin the french
-
canadian population.


72
.


Journées Gén
étiques au Québec, Montreal, Mai
1998.



Dupré, N., Bouchard, J
-
P., Bru
net, D., Vanasse, M., Lemieux, B. and
Puymirat, J.
:
Hereditary neuropathies in Quebec.


73
.


Journées Gén
étiques au Québec, Montreal, Mai

1998.



Bouchard, J.
-
P. and
Puymirat, J.
: Development of a data base for neuromuscular diseases.


74
.


Annual Meetin
g of the Society for Neuroscie
nce, Nouvelle
-
Orléans, Novembre

1997.



Denver, R.J. and
Puymirat, J.
: The basic transcription element binding protein (BTEB) is
a developmentally
-
regulated thyroid hormone
-
responsive gene in the central nervous
system of
xe
nopus

and rat.


75
.


6
e

Congrès Conjoint Annuel des Sciences Neurologiques du Québec, Châ
teau
Montebello, Quebec, Octobre

1997.



Puymirat, J.
: Classification of neuromuscular diseases.


76
.


XXVI
e

Colloque de la Société de Neuroendocrinologie Expérimental
e
, Marseille,
Septembere

1997.



Puymirat, J.

and Denver, R.: Identification of new thyroid hormone
-
regulated genes
expressed in the developing rat brain by cross
-
species hybridizations.


77
.

ISN Satellite and UCON
-
Kroc Symposium, Frontiers of myelin biol
ogy and
demyelinating disease, Mystic, Connecticut
, Juillet

1997.



Baas, D., Bourbeau, D., Ittel, M.E., Dussault, J.H.,
Puymirat, J.

and Sarliève, L.L.:
Oligodendrocyte maturation and progenitor cell proliferation are independently regulated
by thyroid ho
rmone.




Puymirat, J.

CV pa
ge

21

de 30

78
.

First Conference Internationale du Consortium sur la dystrophie myo
tonique de Steinert,
Paris, Juillet

1997.



Puymirat, J.
: A data base for myotonic dystrophy.


79
.



First Conference Internationale du Consortium sur la Dystrophie Myotonique

de Steinert,
Paris, Juillet

1997.



Puymirat, J.
: Charactérisation of a 54
-
kDA protein kinase recognized by an anti
-
myotonin kinase antibody.




80
.


First Conference Internationale du Consortium sur la Dystrophie Myotonique

de Steinert,
Paris, Juillet

199
7.



Puymirat, J.
, Vilquin, J.
-
T. and Tremblay, J.: Transplantation de DM myoblasts as a
model for myotonic dystrophy.


81
.


79
th

Annual Meeting of the Endocrine Society, Minneapolis
, Juin

1997.



R.J. Denver and
Puymirat, J.
: The basic transcription elem
ent binding protein (BTEB) is
a developmentally
-
regulated thyroid hormone
-
responsive gene in the central nervous
system of
xenopus

and rat.


82
.


40
th

Congrès Annuel de la Fédération Canadienne des Sociétés de Biolo
gie (FCSB),
Hilton
-
Quebec, Juin

1997.



Deschênes, I., Tremblay, J.,
Puymirat, J.

and Chahine, M.: Immunocytochemical and
electrophysiological characterization of conditionally immortal human skeletal muscle
cells.


83
.


40
th

Congrès Annuel de la Fédération Canadienne des Sociétés de Biolo
gie (F
CSB),
Hilton
-

Quebec, Juin

1997.



Furling, D., Bouchard, J.
-
P. and
Puymirat, J.
: Characterization of a 54
-
kDa human
protein kinase recognized by an antiserum raised against the myotonin kinase.



84
.


69
th

Annual Meeting of American Thyroid Association, S
an Diego,

Novembre

1996.



Puymirat, J.

and Dussault, J.H.: Oligodendrocyte maturation and progenitor cell
proliferation are independently regulated by thyroid hormones.


85
.


Annual Meeting of the Society for Neuroscience, Washington
, Novembre

1996.



Des
chênes, I.,
Puymirat, J.

and Chahine, M.: Immunocytochemical and electro
-
physiological characterization of conditionnally immortal human skeletal muscle cells.


86
.


6
th

Conference on : «Les maladies neuromusculaires», Versailles, France
, Octobre

1996.



P
uymirat, J.

and Etongué
-
Mayer, P.E.: Charactérisation of a 54
-
kDa protein kinase
recognized by an anti
-
myotonin kinase antibody.


87
.


6
th

Conference on : «Les maladies neuromusculair
es», Versailles, France, Octobre

1996.



Puymirat, J.,

Deschênes, I., Cha
hine, M., Tremblay, J. and Paulin, D.: Increase
proliferative capacity of human myoblasts overexpressing the antigen T.


88
.


XXXVIII
rd

Annual Meeting of Club de recherche clinique du Quebec, Mont
-
Ste
-
Anne,
Quebec, Octobre 1996.



Puymirat, J.
: Thyroid ho
rmones and myelination.



Puymirat, J.

CV pa
ge

22

de 30


89
.


Les Journées de la Génétique Humaine
, Montreal, Juin

1996.



Puymirat, J.
, Faure, R., Chahine, M., Tremblay, J. and Bouchard, J.P.: Study of the
pathogenesis of myotonic dystrophy.


90
.


25
th

Annual Meeting of the Soc for Neu
roscience,
San Diego, California
, Novembre

1995



Trépanier G., Furling D. and
Puymirat, J.
: "Immunocytochemical localization of Se
-
glutathione peroxidase in the adult mouse brain".


91
.


45
th

Annual Meeting of the American So
ciety of Human Genetics, Octobr
e

1995.



Puymirat, J.
, Etongue
-
Mayer, P., Chahine, M., Tremblay, J. and Bouchard, J.P.
Immortalization of human muscle cells: a model system for the derivation of dystrophic
human muscle cells.



92
.


45
th

Annual Meeting of the Ame

Society of Hum
an Genet
ics, Mineapolis, Octobre

1995.



Puymirat, J.
, Etongué
-
Mayer, P.E., Baas, D. and Bouchard, J.P.: "Differential expression
of myotonic dystrophy mRNA in rat brain cells".


93
.


37
th

Ann
ual Meeting of Club de Rech

Cl
inique du Québec, Bromont, Septembre

1995.



Furling, D.,
Puymirat, J.

and Mirault, M.
-
E. Overexpression of glutathion peroxydase
and resistance to dopaminergic neurotoxins.


94
.


11
th

International Thyroid Congress, Toronto
, Septembre

1995.



Puymirat, J.

and Dussault, J.H.: Differential regulat
ion of gene expression in the same
cell by the interaction of thyroid hormones with the thyroid receptor

1

(TR

1
).


95
.


American Society of Human Genetics, Montreal, Canada, 1994.



Puymirat, J.
, Etongué
-
Mayer, P., Faure, R., Bouchard, J.
-
P., Laframbois
e, R. and
Thibault, M.
-
C.: The myotonic dystrophy gene product is a tyrosine/serine kinase:
Decreased levels of M
-
PK activity are associated with the congenital and adult forms of
myotonic dystrophy.


96
.


Canadian Congress of Neurological Sciences, Terre
-
Neuve, Canada, 1994.



Bouchard, J.
-
P., Etongué
-
Mayer, P., Faure, R., Thibault, M.C. and
Puymirat, J.
:

Decreased levels of myotonic dystrophy activity in congenital and adult forms of
myotonic dystrophy.


97
.


76
th

Annual Meeting of the Endocrine Society,

Anaheim, CA, USA, 1994.



Dussault, J.H. et
Puymirat, J.
: Thyroid hormone regulates c
-
jun gene expression in
neuro
-
2a cells which overexpress the

1

thyroid receptor.


98
.


XXI
st

Meeting des jeunes chercheurs, Reims, France, 1994.



Baas, D., Ittel., M.E.
, Hauw, J.J.,
Puymirat, J.

and Sarlieve, L.L.: Expression of thyroid
hormone receptor mRNA in Schwann cells.


99
.


Annual Meeting of the American Thyroid Association, Chicago, USA, 1994.



Puymirat, J.

CV pa
ge

23

de 30



Puymirat, J.

and Dussault, J.H.: Protein kinase inhibitor (H7) bloc
ks the effect of
triiodothyronine on acetylcholinesterase activity and its mRNAs, in neuroblastoma cells
that overexpress the thyroid receptor

1
.


100.

XXIII
rd

Colloque de la Société de neuroendocrinologie expérimentale, Sophia Antipolis,
France, 1994.



Puymirat, J.
, Cossette, L. and Dussault, J.H.: Regulation of brain acetylcholinesterase
by thyroid hormone

: Evidence for the involvement of a protein kinase.


101
.


XXII
nd

Annual Meeting of the European Thyroid Association, Vienna, Austria, 1994.



Dus
sault, J.H. and
Puymirat, J.
: Thyroid hormone regulates immediate
-
early gene
expression in neuro
-
2a cells which overexpress the

1

thyroid receptor.


102
.


63
rd

Annual Meeting of the Royal College of Physicians and Surgeons of Canada,
Toronto, Canada, 1994
.



Bourbeau, D., Baas, D., Carré J.L., Louis, J.C., Sarliève, L.L., Dussault, J.H. and
Puymirat, J.
: Expression différentielle des récepteurs de l'hormone thyroïdienne

1

et

1

durant la différenciation oligodendrocytaire.


103
.


17
th

Annual Meeting of th
e Canadian College of Neuropsychopharmacology, Québec,
Canada, 1994.



Furling, D.,
Puymirat, J.

and Mirault, M.E.: The overexpression of glutathione
peroxydase by human catecholaminergic neuroblastoma cells increased their resistance
to 6
-
OHDA toxicity.


104
.


37
th

Annual Meeting of the Canadian Federation of Biological Societies, Montréal, 1994.



Furling, D.,
Puymirat, J.

and Mirault, M.E.: Characterization of human
catecholaminergic neuroblastoma cell transfectants overexpressing glutathione
peroxydase.


105
.


Annual Meeting of the Society for Neuroscience, Miami Beach, Florida, U.S.A, 1994.



Furling, D., Barden, N.,
Puymirat, J.

and Mirault, M.E.: Positive effects of glutathione
peroxidase overexpression on the responses of human catecholaminergic neur
oblastoma
cells to free radicals generating agents.


106
.


44
th

Annual Meeting of the Amer. Society of Human Genetics, Montréal, 1994.



Puymirat, J., Etongué
-
Mayer, P., Faure, R., Bouchard, J.
-
P., Laframboise, R. and
Thibault, M.C.: The myotonic dystrophy

gene product is a tyrosine/serine kinase:
Decreased levels of M
-
PK activity are associated with the congenital and adult forms of
myotonic dystrophy.


107
.


Collomed Symposium. Molecular and Cell Biology of Myelin diseases. Lausanne,
Switzerland, 1994.



Baas, D., Ittel, M.E., Hauw, J.J.,
Puymirat, J
. and Sarliève., L.L.: Expression of thyroid
hormone receptor mRNA in Schwann cell line.


108
.


Club des Cellules Gliales, Paris, France, 1994.



Puymirat, J.

CV pa
ge

24

de 30



Baas, D., Ittel, M.E., Bourbeau, D., Hauw, J.J., Expression of t
hyroid hormone receptor
mRNA in Schwann cells.


109
.


37
th

Meeting of the Canadian Federation of Biological Societies, Mont, Quebec
,
1994.



Trépanier, G., Tremblay, A.,
Puymirat, J.

and Mirault, M.E. Immunocytochemical
localization of glutathione peroxida
se in brain of transgenic GPx mice.


110
.


Fourth Joint LWPES/ESPE Meeting, San Francisco, USA, 1993.



Roy, J.,
Puymirat, J.,

Van Vliet, G., Doyon, J. and Dussault, J.H.: Neurological,
neuroradiological and neuropsychological evaluation of patients with
congenital
hypothyroidism (CH) at 15
-
years.


111
.


Thyroid and the brain.



New England Regional Newborn Screening Program, Boston, 1993.


112
.


International Council for Control of Iodine Difficiency Disorders Symposium,
Philadelphia, USA, 1993.



Dussa
ult, J.H., Glorieux, J.,
Puymirat, J.
, Van Vliet, G., Roy, J. and Doyon, J.:
Intellectual and neurological development at age 12 and 15 years of children with
congenital hypothyroidism (CH) detected by neonatal screening.


113
.


75
th

Annual Meeting of the
Endocrine Society, Las Vegas, USA, 1993.



Lebel, J.M., Cossette, L., Beaudoin, N., Garceau, L., Dussault, J.H. and
Puymirat, J.:

Overexpression of the thyroid receptors b1 and a1 in neuronal (neuro
-
2a) and glial (C6)
cell lines: the effect of L
-
Triiodothy
ronine (L
-
T3) on nerve cells proliferation is
mediated by the

1

receptors and specific to neurones.


114
.


Club de recherches cliniques du Québec, Pointe
-
au
-
Pic, Canada, 1993.



Etongué
-
Mayer, P., Faure, R., Thibault, M.
-
C., Bouchard, J.
-
P. and
Puymirat,
J.
:
Caractérisation d’un anticorps dirigé contre la myotonine protéine kinase (MK):
Démonstration de l’activité kinase.


115
.


Society for Neuroscience, Washington, USA, 1993.



Mirault, M.
-
E., Tremblay, A., Trépanier, G., Furling, D., Di Paolo, T. and
Puy
mirat, J.
:
Overexpression of glutathion peroxidase in the brain of transgenic mice increases their
resistance to MPTP
-
mediated neurotoxicity.


11
6.


Keystone Symposia on Molecular & Cellular Biology, Lake Tahoe, CA, USA, 1993.



Mirault, M.
-
E., Tremblay, A
., Trépanier, G., Furling, D., Di Paolo, T. and
Puymirat
,

J.
:
Transgenic mice overexpressing SE
-
glutathione peroxidase in the brain: differential
resistance to MPTP
-
mediated neurotoxicity.


11
7.


Genetic Society of Canada Meeting, Lac Delage, Quebec, 1993.



Etongué
-
Mayer, P., Faure, R., Thibault, M.
-
C. and
Puymirat, J.
: The myotonin protein
kinase: Characterization of the catalytic activity i
n vivo.


11
8.


American Society of Human Genetics, 1993.



Puymirat, J.

CV pa
ge

25

de 30



Sabourin, L.A., Tsilfidis, C.T., Etongué
-
Mayer, P.,
Puymi
rat, J.,

Karpati, G. and
Korneluk, R.G.: Investigation of the role of the myotonic dystrohpy kinase (DMK) in the
differentiation of cultured myoblasts.


119.

67
th

Annual Meeting of the American Thyroid Association, Tampa, USA, 1993.



Puymirat, J.
, Lebel,

J.M. and Dussault, J.H.: Overexpression of the thyroid receptor

1

induces differentiation in neuro
-
2a cells.


120
.


67
th

Annual Meeting of the American Thyroid Association, Tampa, USA, 1993.



Baas, D., Sarliève, L.L. and
Puymirat, J.
: Temporal expressio
n of the
1

and
1

thyroid
receptor during oligodendrocyte differentiation.




12
1.


Congrès Annuel de la Société d'Endocrinologie, San Antonio, Texas, USA, 1992.

Lebel, J.M., Dussault, J.H. and
Puymirat, J.
: Preferential localization of the

1

and

1

thyr
oid receptor mRNAs in proliferative and non proliferative astrocytes respectively.


12
2.


Conference of «La Société des neurosciences françaises», Strasbourg, France, 1992.

Sarliève, L., Beaudoin, N., Dalençon, D., Furling, D., Dussault, J.H. and
Puymirat
J.
:
Expresion of thyroid hormone receptors in oligodendrocyte in culture.


12
3.


9
e

Congrès International d'Endocrinologie, Nice, France, 1992.

Lebel, J.M., Dussault, J.H. and
Puymirat, J.
:
In vivo

localization of the
1

and
1

thyroid
receptor mRNAs in proliferative and non proliferative astrocytes.


12
4.


66
e

Congrès Annuel de l'Association Américaine de la Thyroïde, Rochester, Minnesota,
USA, 1992.



Maillette, A., Sarliève, L., Lebel, J.M., Dussault, J.H. and
Puymir
at, J.
: Influence of
triiodothyronine on the differentiation of oligodendrocytes.


12
5.


XXXIV
e

Congrès Annuel du Club de recherches cliniques du Québec, Montébello,
Canada, 1992.



Lebel, J.M., Sarliève, L.L., Dussault, J.H. and
Puymirat, J.
: Expression o
f thyroid
hormone receptor mRNA in astrocytes and oligodendrocytes: Effect of T3.


12
6.


83
e

Congrès Annuel de l'Association Américaine pour la recherche sur le Cancer, San
Diego, U.S.A, 1992.



Mirault, M.E., Trembaly, A., Pothier, F., Piguet, P.F., Sure
tte, M., Julien, P. Moorjani,
S.,
Puymirat, J.

and Borgeat, P.: Phenotypes of transgenic mice overexpressing
glutathione perixodase.


12
7.


Intellectual and neurological development at age 15 years of children with congenita
l
hypothyroidism. Québec,
1992.


12
8.


15
th

Annual Meeting of the European Neuroscience Association, Munich, 1992.



Sarliève, L.L, Beaudoin, N., Dussault, J.H. and
Puymirat, J.:

Expression of L
-
3,5,3'
-
triiodothyronine of nuclear receptor mRNAs in pure oligodendrocyte secondary cultures.





Puymirat, J.

CV pa
ge

26

de 30

12
9.


XXI
st

Colloque de la Société de neuroendocrinologie expérimentale, Nancy, France,
1992.



Graff, M.N., Baas, D.,
Puymirat, J.,

Sarliève, L.L. and Delaunoy, J.P.: Expresion of
thyroid hormone receptors and modulation of glutamine synthétase activit
y in primary
ependymal cell culture.


130
.


10
e

Congrès Internationale de Thyroïde, La Haye, Pays
-
Bas, 1991.



Dussault, J .H., L’Héreault, S. and
Puymirat, J.
: Expression of


and


thyroid hormone
receptor mRNAs in cultured rat cerebral hemisphere neur
ons.


131
.


10
th

Congrès Internationale de Thyroïde, La Haye, Pays
-
Bas, 1991.



Puymirat, J.
, Dussault, J.H., Schmidt, E.D.L. and Dussault, L.: Immunocytochemical
localization of the

and

forms of thyroid receptors in brain cell cultures.


132
.


Symposi
um Keystone, Tamarron, U.S.A, 1991.

Puymirat, J.
, L’Héreault, S., Turgeon, C. and Dussault, J.H.: Differential expression and
regulation of


and


thyroid hormone receptor mRNAs in brain cell cultures.


133
.


73
e

Congrès Annuel de la Société d'Endocrinol
ogie, Washington, U.S.A, 1991.

Puymirat, J.
, Turgeon, C., L’Hérault, S. and Dussault, J.H.: Expression of


and


thyroid hormone mRNAs in the developing rat cerebral hemispheres:
in vivo

and
in vitro
study.


134
.


20
e

Congrès de la Société de Neuroendocr
inologie, Geneva, Switzerland, 1991.

Puymirat, J.,

L’Héreault, S., Turgeon, C. and Dussault, J.H.: Expression of thyroid
hormone receptors mRNAs in the developing brain:
in vivo
et
in vitro

study


135
.


65
e

Congrès Annuel de l'Association Américaine de la

Thyroïde, Boston , U.S.A, 1991.

Puymirat, J.

and Dussault, J.H.: Influence of triiodothyronine (L
-
T3) on the expression
of TR


mRNAs in astrocyte cultures.


136
.


New England Regional Newborn Screening Program, Neurological Follow
-
up.

Portland, 1991.


13
7
.


8
e

Congrès International de Génétique humaine, Washington, U.S.A, 1991.

Labelle, Y., Phaneuf, D.,
Puymirat, J.

and Tanguay, R.M.: Expression analysis of
fumarylacetoacetate hydrolase, the enzyme dificient in hereditary tyrosimemia.


138
.


2
e

Congrès In
ternational de Neuroendocrinologie, Bordeaux, France, 1990.



Puymirat, J.
, Marchand, R., Sarliève, L. et Dussault, J.H.: Mapping of thyroid receptors
in the adult rat brain.


139
.


XXXII
e

Réunion annuelle du Club de recherches cliniques du Québec, La Malb
aie,
Canada, 1990.



Puymirat, J.
, L’Héreault, S. and Dussault, J.H.: Expression of thyroid hormones mRNA
in primary neuronal cultures.



140
.


XXXII
e

Réunion annuelle du Club de recherches cliniques du Québec, La Malbaie,
Canada, 1990.



Puymirat, J.

CV pa
ge

27

de 30



Turgeon, C.,
Puym
irat, J.

and Dussault, J.H.: Expression of thyroid hormone receptors in
the developing cerebellum and cerebral hemispheres.


14
1.


Conférence Neurosciences , Montpellier, France, 1989.



Peyrin, L., Fallet
-
Bianco, C.,
Puymirat, J.
, Jeannin, Ch., Valade, D
., Mas, J.L. and
Rondot, P.: levels of noradrenergic activity in dementia of the Alzheimer type.


14
2.


Conférence Neurosciences, Montpellier, France, 1989.



Fallet
-
Bianco, C., Jeannin, Ch., Valade, D., Peyrin, L., Mas, J.L., Rondot, P. and
Puymirat, J.
: Value of the levels of acetylcholinesterase activity in the cerebrospinal
fluid in dementia: a 5 years longitudinal study.


14
3.


Conférence IPSEN, Toulouse, France, 1989.



Fallet
-
Bianco, C., Jeannin, Ch., Valade, D., Peyrin, L., Mas. J.L., Rondot, P.

and
Puymirat, J.
: Is acetylcholinesterase activity of cerebrospinal fluid, a useful diagnostic
marker of dementia of Alzheimer type? A longitudinal study over a five
-
year span.


14
4.


Conférence IPSEN, Toulouse, France, 1989.



Peyrin, L., Fallet
-
Bianco,
C.,
Puymirat, J.
, Jeannin, Ch., Valade, D., Mas, J.L., Fredy, D.
and Rondot, P.: Norepinephrine and 3
-
methoxy
-

hydroxyphenylglycol assays in
cerebrospinal fluid show alterations of brain noradrenergic neurons in demented patients.


14
5.


12
e

Congrès de l
a Société Internationale de Neurochimie, Algrave, Portugal, 1989.



Besnard, F., Luo, M., Janet, T., Labourdette, J.,
Puymirat, J.

and Dussault, J.H.: Pure
cultured rat oligodendrocytes express high level of an erbA protooncogene transcript.


14
6.


3
e

Col
loque national des neurosciences, Montpellier, France, 1989.



Sarliève, L.L., Besnard, F., Janet, T., Luo, M.,
Puymirat, J.

and Dussault, J.H.:
Expression of thyroid recptors in oligodendrocyte cultures.


14
7.


Society d'Endocrinologie, Seattle, USA, 19
89.



Garza, R.,
Puymirat, J.

and Dussault, J.H.: Immunocytochemical localisation of thyroid
hormone nuclear receptors in cultured cholinergic neurons using a monoclonal antibody
against rat liver thyroid hormone receptor.


14
8.


Association Américaine de

Thyroïde, San Francisco, USA, 1989.



Garza, R.,
Puymirat, J.

and Dussault, J.H.: The presence of thyroid hormone receptors in
cultured cholinergic neurons is correlated with a triiodothyronine morphological effect.


14
9.


Club de recherches cliniques du
Québec, Sainte
-
Adele, Canada, 1989.



Garza, R.,
Puymirat, J.

and Dussault, J.H.: The presence of thyroid hormone receptors in
cultured cholinergic neurons is correlated with a triiodothyronine morphological effect.


150
.


"Iodine and the Brain", Institut

National de Santé, Béthesda, U.S.A., 1988.



Puymirat, J.
, Garza, R. and Dussault, J.H.: Influence of triiodothyronine on the
development of fetal brain cholinergic neurons cultured in a chemically defined medium.


151
.


XIX
e

Congrès de la Société Améric
aine

de Neurochimie, N
-
Orléans, U.S.A., 1988.



Puymirat, J.

CV pa
ge

28

de 30



Puymirat, J.
, Luo, M. and Dussault J.H.: Immunocytochemical localization of L
-
Triiodothyronine nuclear receptor in astroglial cell cultures.


152
.


XIX
e

Congrès de la Société Américaine

de Neurochimie, N
-
Orl
éans, U.S.A., 1988.



Besnard, F., Luo, M.,
Puymirat, J.
, Labourdette, G. and Sarliève, L.:
Immunocytochemical localization of T3 receptors in rat oligodendrocytes.


153
.


VIII
e

Séminaire hivernal des neurosciences européennes, Tignes, France, 1988.



Bes
nard, F., Luo, M.,
Puymirat, J.
, Labourdette, G. and Sarliève, L.:
Immunocytochemical localization of T3 nuclear receptors in pure rat oligodendrocytes
producing myelin
-
related membranes.


154
.


XXIV
e

Symposium des Modèles Biologique.
Prague, Tchécoslovaqu
ie, 1988.



Sarliève, L., Besnard, F., Yusta, B., Aranda, A., Luo, M., Dussault, J.H. and
Puymirat,
J.
: Hormonal factors in regulation of nervous tissue differentiation in tissue culture with
emphasis upon nuclear triiodothyronine receptors.


155
.


Congr
ès Annuel de l'Association Américaine de Thyroïde, Montréal, Canada, 1988.



Garza, R., Dussault, J.H. and
Puymirat, J.
: Évidence of a direct effect of triiodothyronine
on the development of fetal brain cholinergic neurons cultured in a chemically defined

medium.


156
.


XXIII
e

Congrès Canadien des Sciences Neurologiques, 1988.



Puymirat, J.
, Gueguen, B. and Rondot, P.: clinical and electrophysiological effects of
TRH administry in amyotrophic lateral scelrosis.


157
.


XXIII
e

Congrès Canadien des Scien
ces neurologiques, 1988.



Puymirat, J.
, Gomez, S., Bianco, C. and Rondot, P.: Levels of acetylcholinesterase and
somatostatin in the cerebrospinal fluid in dementia of the Alzheimer type.


158
.


Club de recherches cliniques, Charlevoix, Canada, 1988.



Garza, R. Dussault, J.H. and
Puymirat, J.
: Direct effect of thyroid hormones on the
development of brain cholinergic neurons in vitro.


159
.


Congrès annuel de l'Association Américaine de la Thyroïde, Washington, USA, 1987.



Puymirat, J.
, Garza, R. and D
ussault, J.H.: Influence of triiodothyronine on the
development of fetal brain cholinergic neurons cultured in chemically defined medium.


160
.


XVII
e

Congrès de «Soc. de neuroendocrinologie expérimentale», Lyon, France, 1987.



Puymirat, J.
, Luo, M. and

Dussault, J.H.: Immunocytochemical localisation of thyroid
hormone receptors in primary astrocyte cultures.


161
.


Congrès de «Union médicale du Canada», Montébello, Canada, 1987.



Garza, R., Dussault, J.H. and
Puymirat, J.
: Influence of triiodothyronin
e (T3) on the
maturation of brain cholinergic neurons in cultures.


162
.


Club français de neuropathologie, Paris, France, 1987.



Sarliève, L.L., Besnard, F., Luo, M. and
Puymirat J.
: Immunocytochemical localisation
of thyroid hormone receptors in primar
y oligodendrocyte cultures.



Puymirat, J.

CV pa
ge

29

de 30


16
3


XVI
e

Conférence
Soc. de neuroendocrinologie expérimentale», Marseille, France, 1986.



Puymirat, J.
, Barret, A., Faivre
-
Bauman, A. and Tixier
-
Vidal, A.: Hormonal control of
neuronal differentiation.


164
.


Conférence sur

: «Les investigations de la maladie d'Alzheimer: Génétique et
Epidémiologie», Cascapedia, 1986.



Puymirat, J.
: Rôle des facteurs de croissance dans la maladie d'Alzheimer.


165
.


XV
e

Colloque de la Soc. neuroendocrinologie expérimentale Gif/Yvette, Fra
nce, 1985.



Puymirat, J.
, Faivre
-
Bauman, A., Barret, A. and Tixier
-
Vidal, A.: Rôle de la
triiodothyronine sur la différentiation des neurones dopaminergiques de l'hypothalamus
de souris foetales cultivés en milieu défini.


166
.


XX
e

OHOLO Conférence, Ei
lat, Israël, 1985.



Puymirat, J.
, Davous, P., Valade, D., Gomez, S. and Rondot, P.: Acetylcholinesterase
activity and somatostatin like immunoreactivity in the CSF of demented patients.


167
.



7
e

Congrès International d'Endocrinologie, Quebec, Canada, 1
984.



Puymirat, J.
, Loudes, C., Faivre
-
Bauman, A., Lassare ,C., Binoux, M. and Tixier
-
Vidal,
A.: Effect of triodothyronine on development
in vitro

of dopaminergic and thyroliberin
hypothalamic neurons.


168
.


Neuroendocrinologie Feotale, Mariensee, RFA,
1984.



Puymirat, J.
, Barret, A. and Tixier
-
Vidal, A.: Effects of thyroid hormones on the
development of mouse hypothalamic dopaminergic neurons.


169
.


XV
e
Congrès de psychoneuroendocrinologie, Vienne, Autriche, 1984.



Puymirat, J.
, Gomez, S., Davous,
P., Valade, D. and Rondot, P.: Somatostatin like
immunoreactivity and acetylcholinesterase activity in the CSF of patients with Azheimer
disease.


170
.


V
e

Symposium sur les «Cathécholamines», Göteborg, Sweden, 1983.



Puymirat, J.
, Barret, A., Loudes, C.
, Faivre
-
Bauman, A. and Tixier
-
Vidal, A.:
Morphological effect of triiodothyronine on dopaminergic neurons from fetal mouse
hypothalamic and mesencephalic cells cultured in serum free medium.


171
.


1
ère

Conférence Annuelle «Société française de biologie
cellulaire», Paris, France, 1983.



Faivre
-
Bauman, A.,
Puymirat, J.
, Loudes, C., Barret, A. and Tixier
-
vidal, A.: Factors
involved in attachment and migration of hypothalamic neurons
in vitro
.


172
.


30
e

Congrès of " Société Européenne de Cu
lture de Tissu ", Paris, France, 1982.



Faivre
-
Bauman, A., Loudes, C.,
Puymirat, J.
, Tixier
-
Vidal, A. and Bourre, J.M.: Role of
hormones and fatty acids on the development of hypothalamic neurons in the absence of
serum.


173
.


E.M.B.O. Atelier de travail

“Les mécanismes moléculaires dans le développement du
système nerveux”, Strasbourg, France, 1982.



Puymirat, J.

CV pa
ge

30

de 30



Puymirat, J.
, Barret, A., Faivre
-
Bauman, A., Loudes, C. and Tixier
-
Vidal, A.: Effects of
triiodothyronine on the development of mouse fetal hypothalamic c
ells
in vitro.


174
.


3
e

Congrès " de la Société de Neurosciences Développementales ", Patras, Grèce, 1982.



Loudes, C., Faivre
-
Bauman, A., Grouselle, D.,
Puymirat, J.

and Tixier
-
Vidal, A:
In vitro

differentiation of hypothalamic neurons in serum
-
free me
dium.


175
.


3
e

Congrès de la Société de Neurosciences Développementales, Patras, Greece 1982.
Puymirat, J.
, Loudes, C., Faivre
-
Bauman, A., Lassare, C., Binoux, M. and Tixier
-
Vidal,
A.: Effect of triodothyronine on development
in vitro

of dopaminergic and

thyroliberin
hypothalamic neurons.


176
.


29
e

C
ongrès de la "Société Euro

de Culture de Tissu", Noorwijkerhout, Pays
-
Bas, 1981.



Faivre
-
Bauman, A.,
Puymirat, J.
, Rosembaum, E., Grouselle, D. and Tixier
-
Vidal, A.:
Expression of neuronal activities in ser
um
-
free medium culture of fetal mouse brain
cells.


1
77
.


1
er

Congrès International de la Société de Neurosciences Développementales,
Strasbourg, France, 1980.



Puymirat, J.
, Faivre
-
Bauman, A. and Tixier
-
Vidal, A.: Pre
-
natal and post
-
natal
ontogenesis
of neurotransmetter synthetising enzymes and tetanus toxin binding capacity
in the mouse hypothalamus.


178
.


1
st

Congrès International de la Société de Neurosciences Développementales Strasbourg,
France, 1980.



Faivre
-
Bauman, A.,
Puymirat, J.
, Rosembaum,

E. and Tixier
-
Vidal, A.: Evidence for
neuronal activities in primary cultures from fetal mouse brain cells grown in serum
-
free
medium.
Modulation by different hormones.


179
.


Conférence Nationale de Neurosciences: "Bilan et perspectives des Neuroscience
s",
Touquet, France, 1980.



Faivre
-
Bauman, A.,
Puymirat, J.
, Rosenbaum, E. and Tixier
-
Vidal, A.: Expression of
neuronal activities in primary neuronal cultures grown in serum
-
free medium.: Role of
thyroid hormones.