Information

crunchkingofprussiaΒιοτεχνολογία

6 Δεκ 2012 (πριν από 4 χρόνια και 8 μήνες)

210 εμφανίσεις

Department of Life Sciences


Biological Sciences


Botany, Zoology, Marine Biology, Microbiology, Biochemistry,


Molecular and Cell Biology, etc
.


Agricultural Sciences


Agronomy, Horticulture, Forestry, Fishery, Animal Husbandry,


Veterinary Science, Agricultural Chemistry, Food Science, etc
.


Medical Sciences


Basic Medical Sciences: Anatomy, Physiology, Pharmacology,
Biochemistry, Microbiology and Immunology, Molecular Medicine,
Epidemiology, Public Health and Occupational Medicine, Legal
Medicine and Forensic Science, etc.


Clinical Sciences: Internal Medicine, Surgery, Radiology, Nuclear
Medicine, Gynecology and Obstetrics, Pediatrics, Dentistry, etc.


National Science and Technology Programs


Agricultural Biotechnology,


Genomics Medicine,


Pharmaceutical Biotechnology.


1996
-
2005
Annual Budget, Dept. of Life Sciences

49,588
57,028
66,437
77,431
77,960
87,918
90,533
108,101
108,477
115,264
0
50,000
100,000
150,000
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
(
Thousand USD)

2,820
4,798
4,719
4,590
4,348
3,162
2,944
2,786
4,157
4,900
3,684
2,246
2,853
2,936
2,790
2,201
2,069
2,016
2,601
3,123
2,842
1,467
65%
72%
70%
68%
64%
64%
70%
71%
58%
65%
60%
0
1000
2000
3000
4000
5000
6000
`96
`97
`98
`99
`00(1)
`00(2)
`01
`02
`03
`04
`05
Year
(Grant Number)
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Application Numbers
Funding Numbers
Funding Rate ( % )
Life Sciences Grant Applications and Funding

Department of Life Sciences

Funding Policy




Individual Grant



偲潧牡o 偲潪o捴c



䙲潮瑩敲 卣楥湣攠偲潧牡o



T敡e映 硣敬汥湣l 偲潧牡o



䥮瑥I
-
浩湩獴敲楡氠䡥慬瑨t䙯潤⁒ ☠& 偲潧牡o



䥮瑥I
-
摩獣d灬楮慲礠䥮瑥杲慴a潮o偲潧牡o



International(Bilateral) Collaboration Program


Industrial
-
University Collaboration R & D Program


Biotechnology Successful Investment Program



乡瑩潮慬⁓捩c湣攠慮搠T散桮潬潧礠剥獥慲捨⁐c潧牡o


Genomic Medicine S & T Research Program


Biotechnology Pharmaceuticals S & T Research Program


Agriculture Biotechnology S & T Research Program


Bioengineering Program Project


To focus on research fields with integrated efforts
of inter
-
departments, inter
-
institutes, and inter
-
universities.


To promote international collaboration


Major research areas:

1.
Functional tissue/molecular imaging

2.
Mobile monitoring and distributing wireless
integrated sensors system

3.
Biomedical optics and biophotonic monitoring
systems

4.
New biomechanics of tissues, cells, and genes

5.
Tissue and cell engineering and new
biomaterials

Bioinformatics


Multidisciplinary Research Programs


Genome annotation and development
of its tools


Microarray and proteomic data
analysis and value
-
added data bank


Macromolecular sequencing and
structural data analysis


Phylogenetic data analysis


Industry
-
University Cooperative

Research Program

To promote advanced and applied
technology research by the academic
community, and also to encourage
enterprises to actively participate in
applied academic research, and thereby to
enhance the R&D capabilities and skilled
manpower of private sectors.


The Budget for the

National Science
and Technology Program

million USD

NSTPAB

乡瑩N湡氠卣楥湣攠慮n T散桮潬o杹 偲潧牡洠景爠A杲楣畬瑵牡氠䉩潴散桮潬ogy

乓呐䉐

National Science and Technology Program for Biotechnology and Pharmaceuticals

NRPGM

乡N楯渠剥獥R牣栠偲潧牡洠景爠G敮潭楣i䵥M楣楮e

SARS

十剓R剥獥慲捨⁐牯橥捴

Year
2000
2001
2002
2003
2004
2005
2006
NSTPAB
5.31


3.85


4.57


9.47


10.97

6.67


6.81


NSTPBP
4.29


3.10


6.58


4.48


6.25


8.14


7.50


NRPGM
-
-
56.49

53.40

36.00

36.80

31.25

SARS
2.35



Agricultural Biotechnology National Program


Fifteen Research Teams


Development

and

integration

of

floral

(Chrysanthemum

and

orchids)

production

and

marketing

systems
.


Integration

and

industrial

application

of

conventional

and

genetic
-
engineered

post
-
harvest

technology

for

vegetables

and

fruits
.


Integration

of

key

techniques

for

organic

farming

(e
.
g
.

stress

tolerant

varieties,

bioprotectants

and

biofertilizers)
.


Promotion

and

establishment

of

production

systems

for

high

quality

Chinese

herbs

and

health

foods
.


Development

of

fry

production

systems

with

quality

assurance

(shrimp

and

grouper)

and

related

transportation

and

marketing

technology
.


Biotechnology

applications

in

the

production

of

Taiwan

tilapia

for

international

market
.


Application

of

biotechnology

in

the

improvement

of

cage
-
culture

and

processing

technology

for

Cobia
.


Agricultural Biotechnology National Program

Fifteen Research Teams


Agricultural waste treatments in generating value
-
added by
-
products.


Inventing and improving production systems for high quality
swine and chicken.


Developing biological agents (vaccines and adjuvants) for
plant
-

and animal
-
related applications.


Application of transgenic technology for ornamental plants
and fishes, and for medical and feed industries.


Development of molecular techniques for diagnostic systems
and marker
-
assisted breeding.


Development of bioreactor technologies for producing
industrial and medical materials.


Establishment of GMO assessment and accrediting systems.


Research and development of novel functional genomics
based technologies for biotechnological industries.

D.C.N. Chang

SWEET RICE

transgenic rice seeds expressing


an amylopullulanase (
APU
) gene

S.M. Yu and J.F. Shaw

National Program in Biotechnology
and Pharmaceuticals
(1999
-
2006)


Natural Products


Synthetic Chemicals


Protein Drugs


Protein Chips


Drug Screening and Evalulation


Clinical Trials


Industrial Applications and Technology
Transfer

R&D on YC
-
1 and its Derivatives Project

Academics

C桩湡 䵥M楣慬i啮楶敲獩瑹

卨敮g
-
䍨C
䭵o
),
N慴楯湡氠T慩a慮⁕a楶敲獩瑹⁃潬汥来 潦o
Medicine

Che
-
M楮i⁔敮e


Enterprise

H敡汴l⁂楯堠䉩潴散栮h䍯.

䙡Fg
-
Y甠䱥e


乩捨e

偃吠灡瑥湴猠w楴栠浵汴m
-
楮摩捡瑩潮猬t潶敲‱㜰
international SCI papers acknowledgements

Challenge

C潭灥o攠w楴栠潴桥爠灨慲浡a敵瑩捡氠
捯浰m湩敳 獵捨 慳 A癥湴楳n慮搠䉡y敲e整挮

T慲来瑳

ㄮ1

-
ㄠ⁣汩湩捡氠瑲楡氠⡕匠慮搠T慩a慮a




2
.
R&D on follow
-
up YC
-
1 derivatives


3
.
Establishment of a R&D Center

Project for Development of Microfluidic
Biochip Systems

Academy

乡瑩t湡氠䍨C湧 䭵湧K啮楶e牳楴i


Gwo
-
䉩渠䱥LⰠ卨S
-
䡵椠䍨C測


Jiunn
-
Jong Wu
,
Ching
-
Hsing Luo
,
Mei
-
Ling Tsai
,
Jyh
-
Ming Ting
,


Chih
-
Ching Chang


䕮瑥牰物Ee

偲P獩摥湴s䉩潳B獴s洠䥮挮

乩捨N

7

灡瑥湴猠
⠱(

楮 灡瑥湴p慰灬楣i瑩t渠灲潣n獳


䍨慬汥湧e

䍯浰整楴C潮 w楴栠潶敲獥慳 捯浰慮楥c

Targets

1⸠
䑥ve汯瀠a⁳ 物rs 潦oa摶a湣n搠扩潣桩瀠sys瑥浳


2.

Development of biochips for early detection of virus/bacteria





related diseases.

The

developed

microfluidic

biochip

systems

have

successfully

demonstrated

their

capability

for

fast

diagnosis

of

virus/bacteria
-
related

diseases
.

This

project

will

collaborate

several

local

companies

to

start

up

a

competitive

bio
-
MEMS

company
.

Sensor
Heaters
可攜式細胞前處理及
PCR
模組

PCR
溫度控制元件照片

Portable apparatus for cell pretreatment and PCR chips.



National Science and Technology Program

on Genomic Medicine
(2002
-

2009)

CANCER


LIVER

LUNG

ELSI

INFECTIOUS

DISEASES

HIGHLY HERITABLE

DISEASES

INNOVATIVE

RESEARCH

Industrial

Cooperation

Interanational

Cooperation



Core facilities

The National Program attempts to coordinate
national resources and to fund projects that are in
line with Taiwan’s strategic development.
Comprehensive cores have been established to
support various scientific programs.


Six major core facilities:


Mutant Mouse Facility and Disease Models


Clinical Tissues Bank


High Throughput Genomics Facilities


Proteomics and Structural Biology Facilities


Bioinformatics


Innovation and Key Technology Development

Result in Lung Cancer

1.
Many tumor suppressor genes (TSGs) had 5’CpG hypermethylation
in their promoter and/or exon1 regions in lung cancer.

2.
These TSGs are: hMLH1 and hMSH2, p16INK4a), p14ARF, FHIT,
BLU, RASSF1A, RARβ, HIF, SLIT2, BRCA1/2.

3.
Overexpression of DNA methyltransfer enzymes (DNMTs)
contributes to NSCLC tumorigenesis and associate with 5’CpG
hypermethylation in their target TSGs.


The mRNA and protein of DNMTs were highly expressed in tumor tissue.

ENU mutagenesis established mice with mitochondrial
branched
-
chain aminotransferase deficiency resembling
human maple syrup urine disease. (
J. Clin. Invest. 2004
)

ENU mutagenesis mouse models of

human metabolic disease