GSK Bioinformatics - National e-Science Centre

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2 Οκτ 2013 (πριν από 3 χρόνια και 11 μήνες)

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Systems Biology approaches to

understanding glutathione metabolism

29 September 2010

Dr Najl Valeyev

Edinburgh

University of Kent

Centre for Molecular Processing

Weather

Electronic circuits design

Aircraft flight controllers

Stock
market

Different types of Systems

Causative knockouts of “functional” parts

Lazebnik

Y, Cancer Cell. 2002 Sep;2(3):179
-
82

Linking parts with “disease” phenotypes

Family classification according to
Phenotype

Idealised Cell as a System

?

?

?

The Complexity Problem

Science or Art ?

The Complexity Problem

Major Modelling Principle

True

Object

Knowledge 1

Knowledge 2

Knowledge 3

Knowledge 4

True

Object

Model 1

Model 2

Model 3

Model 4

0.0
5.0
10.0
15.0
20.0
25.0
30.0
Comparison of experiments
with simulations

Experiments

Model predictions

Stochastic interactions between
models and experiments

should lead to deterministic
conclusions


to test and evaluate the structure of the assumed intracellular
interactions with the pathways



to identify inconsistent hypotheses and design experiments to
clarify the properties of signalling pathways



to provide advanced interpretation of the experimental data



to developed an

integrative model of
fimbriation