A near real-time surveillance program for PRRS in Iowa, United States

cathamΤεχνίτη Νοημοσύνη και Ρομποτική

23 Οκτ 2013 (πριν από 3 χρόνια και 10 μήνες)

78 εμφανίσεις

A near real
-
time

surveillance
program
for
PRRS

in
Iowa, United States

Perez

AM,
Polson

D,
Mueller

K, Cano JP, Brito B,
Mondaca

E,
Whedbee

Z,
Main

R

University of California in Davis (Perez, Brito, Whedbee
)

Iowa
State University (Mueller, Main
)

Boehringer

Ingelheim

Vetmedica

Inc (Polson, Cano,
Mondaca
)

University of California, Davis

GEOVET Conference 2013

21
-
23 August

London, UK


Relevant Context


Prerequisite Culture


Necessary
Collaborations


Required Tools


A near real
-
time surveillance program for PRRS in Iowa, United States


Relevant Context


Prerequisite Culture


Necessary
Collaborations


Required Tools


A near real
-
time surveillance program for PRRS in Iowa, United States

Porcine Reproductive and Respiratory
Syndrome (PRRS) virus


Enveloped RNA virus
-

order
Nidovirus
, family
Arteriviridae
, genus
Arterivirus
.



Causes reproductive failure of sows and respiratory problems of
piglets and growing pigs



The single most important swine disease in North America



Cost for the US swine industry
:
$664 million USD/year*



Difficult to control


TRANSMISSION


PERSISTENCE


GENETIC DIVERSITY
-

heterologous

protection


MULTIPLE CLINICAL PRESENTATIONS



Swine industry efforts to control PRRS:
ARC&E projects


PRRS is
wicked.

A near real
-
time surveillance program for PRRS in Iowa, United States

A near real
-
time surveillance program for PRRS in Iowa, United States

What makes a problem “wicked”?

“The kinds of problems that
planners deal with…are
inherently different from the
problems that scientists and
perhaps some classes of
engineers deal with.
Planning
problems are inherently
wicked
.”


Rittel & Webber (1973)

Context:


Science is good…


…and
institutional
-
scale science has & continues
to make very valuable contributions to its
business & professional constituencies


…but institutional
-
scale science has limitations…


Institutional
-
scale science can tell us:


What
HAS

happened (retrospective, observational)


What
CAN

happen, given a specific and defined
condition set (experimental)

A near real
-
time surveillance program for PRRS in Iowa, United States

Context:


We need to
complement

institutional
-
scale
(cross
-
sectional/static) science with
i
ndustrial
-
scale (operational/dynamic)
science…

…science that can tell us what
DOES

happen…

…every time
it happens…

…that helps us understand
why

it happens…


what
we can do about it…

…and
measure

if what we did was valuable.

A near real
-
time surveillance program for PRRS in Iowa, United States

Key target questions:


Am I negative or positive?


Am I stable or unstable?


Is this resident or non
-
resident virus?


How did it get here?


Where did it come from?


Is this a previously existing or a new variant?


Where did it start?


When did it start?


How did it start?

A near real
-
time surveillance program for PRRS in Iowa, United States

Key target questions:


Is what I’ve been doing working?


Would something else work better?


Am I at lower/same/higher risk today compared
to yesterday?


Am I progressing towards or away from my
goals of [_____]?


Why am I progressing towards or away from my
goal(s)?


What can I do to fix/improve what I’m doing
today?

A near real
-
time surveillance program for PRRS in Iowa, United States

If PRRSv
really

costs us
“$664,000,000”

per year,
maybe

it’s well worth it to us
all to
actively work together

using
all the tools &
weapons

we have available
today to manage it in a
coordinated collaborative

effort.

A near real
-
time surveillance program for PRRS in Iowa, United States

2009:

10+1 total projects

A near real
-
time surveillance program for PRRS in Iowa, United States

2013:

25+4 total projects

A near real
-
time surveillance program for PRRS in Iowa, United States


Relevant Context


Prerequisite Culture


Necessary
Collaborations


Required Tools


A near real
-
time surveillance program for PRRS in Iowa, United States

Area
-
Regional Control & Elimination
(ARC&E) is…

…producers & veterinarians
working
together

with their neighbors and
business partners

so that
together

they
achieve greater sustained
improvement in health and
productivity in their neighborhood
than any one can achieve on their own.

A near real
-
time surveillance program for PRRS in Iowa, United States

The Golden
(PRRS) Rule


Do

TRANSMIT

unto

your neighbor

as you would have

your neighbor

do

TRANSMIT

unto you.”

Be
Better

Together

Better

Together

A near real
-
time surveillance program for PRRS in Iowa, United States


Relevant Context


Prerequisite Culture


Necessary
Collaborations


Required Tools


A near real
-
time surveillance program for PRRS in Iowa, United States

Veterinarians Across U.S. Submitting Cases to their VDL Service Providers

Submi tters
i ndicate the i nclusion of a submission (case) in a specific regional disease monitoring effort (project) on the diagnostic l a
bor
atory submission form

VDL LIMS (e.g. ISU)

VDL LIMS (e.g. SDSU)

VDL LIMS (e.g. UMN)

Secure Animal Health
Diagnostic Database

(SAHDD)


Based on: HIMS® Platform

(Web
-
Based, Password Protected,
Viewable,
Sortable
)

Disease
Bio
Portal
®

Real
-
time disease analysis and mapping

(Web
-
based & Password Protected)

Permissioned

Bio
Portal
® Users

Pathogen
Specific

Dx

Data Only

Case
Submission

Rules
-
based decisions used to update

Initially = System Administrator

G
oal =

Automation

View only

All
Dx

Results

Rhapsody

(
Pushed
)

Permissioned


Animal
Health

Officials

AgConnect
®

View

only

Primary
Collaborators:

ISU,

UC
-
Davis,

FAZD
-
DHS,

CFSPH,
Progressus

Ltd,

BIVI

Dynamic Risk Data

PADRAP Data

Sequence Data

Cartographs

Case
Submission

All
Dx

Results

Case
Submission

All
Dx

Results

Antigenic
Cartography
Analysis

System

(Pushed)

Interpreted
Diagnostic Data

PADRAP®


(Web
-
based & Password Protected)

Permissioned


PADRAP

Users

Input Surveys

View Data/Reports


Relevant Context


Prerequisite Culture


Necessary
Collaborations


Required Tools


A near real
-
time surveillance program for PRRS in Iowa, United States

Design Specifications:


Operations (transactions) user funded


Sampling, logistics, testing, data
-
management, analytics


Cost
-
efficient to implement & inexpensive to
operate


Convenient & easy to do perpetually


Standardized materials, tools, methods &
processes , definitions & metrics, analytics &
interpretation

A near real
-
time surveillance program for PRRS in Iowa, United States

Design Specifications:


Automated everywhere possible


Interfaced / integrated with all best
-
in
-
class tools and methods


Near
-
real
-
time results &
interpretation


Pre
-
defined “best
-
practice”
contingencies

A near real
-
time surveillance program for PRRS in Iowa, United States

Design Specifications:


Supports well
-
informed decision
-
making


Intra
-
Enterprise


in
-
process / execution
-
level


Management oversight / process
-
level


Inter
-
Enterprise


Within Areas & Regions


Among Areas & Regions



Policymakers


Supports rigorous research & effective learning


Effective training/education & support structure


Broad & deep support by served constituents and leaders

A near real
-
time surveillance program for PRRS in Iowa, United States

The
BioPortal


C
ollect


C
ompile


O
rganize


Analyze


S
hare


U
se data

Objectives


To
support “local” decision
-
making for PRRS
management and contingent action execution
by veterinary practitioners and
farmers



To support
“regional” monitoring of progress
towards area
-

and network
-
based PRRS
management


Web
-
based health
management system

January 2010



CADMS/UC
-
Davis &
Boehringer

Ingelheim

collaboration agreement






Phases:

Adapt
Disease
BioPortal

platform to manage PRRS cases and
become
adopted as
a
standard
tool for PRRS
ARC&E project use and epidemiological
analysis in the U.S. swine
industry

Increase capabilities of Disease
BioPortal

to be employed as a surveillance and
epidemiological analysis tool for swine diseases

Collaborators


Center for Animal
D
isease
M
odeling and Surveillance
-
University of California
-
Davis (CADMS)



Boehringer

Ingelheim

Vetmedica



Iowa State University Veterinary Diagnostic
Laboratory (ISU
-
VDL)



Production Animal Disease Risk Assessment Program
(PADRAP)



SE IA PRRS ARC Project Coordinator


http://fmdbioportal.ucdavis.edu/

BioPortal

Tools
-

PRRS site

Space
-
time genetic
visualizer

Is it a new isolate to the herd or system?

Where did it most likely come from?

New isolate to
the system (3%)

Changes in prevalence and incidence

Current work in progress


The system is being piloted by participating farms in
a South
-
East Iowa PRRS Area Control Project


45 producers
-
large and small


410 sites enrolled ~1,000,000 pigs


L
ocal and regional consulting veterinarians



Development and improvement of the PRRS
BioPortal

tailored to PRRS and the swine industry



Platform for data transfer ISU
-
VDL

to
-

BioPortal




Definitions and standards for data management


What’s next?


Interpretation algorithms development & automation


Case result


Site status


Site classification


Development phases


Bioportal enhancements (e.g., producer/veterinarian
operational health management tools)


Interfaces with other systems (e.g., VDL LIMS, PADRAP)


Broad adoption


Systems


Practices


ARC&E projects


VDL’s


Research leverage

Veterinarians Across U.S. Submitting Cases to their VDL Service Providers

Submi tters
i ndicate the i nclusion of a submission (case) in a specific regional disease monitoring effort (project) on the diagnostic l a
bor
atory submission form

VDL LIMS (e.g. ISU)

VDL LIMS (e.g. SDSU)

VDL LIMS (e.g. UMN)

Secure Animal Health
Diagnostic Database

(SAHDD)


Based on: HIMS® Platform

(Web
-
Based, Password Protected,
Viewable,
Sortable
)

Disease
Bio
Portal
®

Real
-
time disease analysis and mapping

(Web
-
based & Password Protected)

Permissioned

Bio
Portal
® Users

Pathogen
Specific

Dx

Data Only

Case
Submission

Rules
-
based decisions used to update

Initially = System Administrator

G
oal =

Automation

View only

All
Dx

Results

Rhapsody

(
Pushed
)

Permissioned


Animal
Health

Officials

AgConnect
®

View

only

Primary
Collaborators:

ISU,

UC
-
Davis,

FAZD
-
DHS,

CFSPH,
Progressus

Ltd,

BIVI

Dynamic Risk Data

PADRAP Data

Sequence Data

Cartographs

Case
Submission

All
Dx

Results

Case
Submission

All
Dx

Results

Antigenic
Cartography
Analysis

System

(Pushed)

Interpreted
Diagnostic Data

PADRAP®


(Web
-
based & Password Protected)

Permissioned


PADRAP

Users

Input Surveys

View Data/Reports

A near real
-
time surveillance program for PRRS in Iowa, United States

A near real
-
time surveillance program for PRRS in Iowa, United States

A near real
-
time surveillance program for PRRS in Iowa, United States

Veterinarians Across U.S. Submitting Cases to their VDL Service Providers

Submi tters
i ndicate the i nclusion of a submission (case) in a specific regional disease monitoring effort (project) on the diagnostic l a
bor
atory submission form

VDL LIMS (e.g. ISU)

VDL LIMS (e.g. SDSU)

VDL LIMS (e.g. UMN)

Secure Animal Health
Diagnostic Database

(SAHDD)


Based on: HIMS® Platform

(Web
-
Based, Password Protected,
Viewable,
Sortable
)

Disease
Bio
Portal
®

Real
-
time disease analysis and mapping

(Web
-
based & Password Protected)

Permissioned

Bio
Portal
® Users

Pathogen
Specific

Dx

Data Only

Case
Submission

Rules
-
based decisions used to update

Initially = System Administrator

G
oal =

Automation

View only

All
Dx

Results

Rhapsody

(
Pushed
)

Permissioned


Animal
Health

Officials

AgConnect
®

View

only

Primary
Collaborators:

ISU,

UC
-
Davis,

FAZD
-
DHS,

CFSPH,
Progressus

Ltd,

BIVI

Dynamic Risk Data

PADRAP Data

Sequence Data

Cartographs

Case
Submission

All
Dx

Results

Case
Submission

All
Dx

Results

Antigenic
Cartography
Analysis

System

(Pushed)

Interpreted
Diagnostic Data

PADRAP®


(Web
-
based & Password Protected)

Permissioned


PADRAP

Users

Input Surveys

View Data/Reports

A near real
-
time surveillance program for PRRS in Iowa, United States

A near real
-
time surveillance program for PRRS in Iowa, United States

A near real
-
time surveillance program for PRRS in Iowa, United States

Veterinarians Across U.S. Submitting Cases to their VDL Service Providers

Submi tters
i ndicate the i nclusion of a submission (case) in a specific regional disease monitoring effort (project) on the diagnostic l a
bor
atory submission form

VDL LIMS (e.g. ISU)

VDL LIMS (e.g. SDSU)

VDL LIMS (e.g. UMN)

Secure Animal Health
Diagnostic Database

(SAHDD)


Based on: HIMS® Platform

(Web
-
Based, Password Protected,
Viewable,
Sortable
)

Disease
Bio
Portal
®

Real
-
time disease analysis and mapping

(Web
-
based & Password Protected)

Permissioned

Bio
Portal
® Users

Pathogen
Specific

Dx

Data Only

Case
Submission

Rules
-
based decisions used to update

Initially = System Administrator

G
oal =

Automation

View only

All
Dx

Results

Rhapsody

(
Pushed
)

Permissioned


Animal
Health

Officials

AgConnect
®

View

only

Primary
Collaborators:

ISU,

UC
-
Davis,

FAZD
-
DHS,

CFSPH,
Progressus

Ltd,

BIVI

Dynamic Risk Data

PADRAP Data

Sequence Data

Cartographs

Case
Submission

All
Dx

Results

Case
Submission

All
Dx

Results

Antigenic
Cartography
Analysis

System

(Pushed)

Interpreted
Diagnostic Data

PADRAP®


(Web
-
based & Password Protected)

Permissioned


PADRAP

Users

Input Surveys

View Data/Reports

ATP

Reference

System

A near real
-
time surveillance program for PRRS in Iowa, United States

MLV

ATP

WT

A near real
-
time surveillance program for PRRS in Iowa, United States

A near real
-
time surveillance program for PRRS in Iowa, United States

A near real
-
time surveillance program for PRRS in Iowa, United States

A near real
-
time surveillance program for PRRS in Iowa, United States

Conclusions


The approach here represents a multi
-
institutional
effort with direct impact in the control of, arguably,
the most important disease of swine in the United
States. The project may be easily scaled
-
up to include
larger areas as well as other diseases.



Data collection and organization is the most
significant challenge. It can be overcome by
automating processes and strategizing resources



This tool will demonstrate its value when applied in
control interventions, reducing incidence/prevalence

Acknowledgments

-
Swine practitioners and producers


-
ISU Veterinary Diagnostic Laboratory


-
BIVI Health Management Center


-
PADRAP


-
SE IA PRRS ARC Project Coordinator


Thank you.

A near real
-
time surveillance program for PRRS in Iowa, United States