Genetic Engineering

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14 Δεκ 2012 (πριν από 4 χρόνια και 10 μήνες)

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Robin Wright

John Anderson

David Biesboer

Sehoya Cotner

Scott Gilbert

The Nature of Life Program

The Nature of Life Program

2

The
University
of
Minnesota


founded in
1851*












* (7 years before Minnesota became the 32
nd

state)

The University of Minnesota, founded in
the belief that all people are enriched by
understanding, is dedicated to the
advancement of learning and the search
for truth; to the sharing of this knowledge
through education for a diverse
community; and to the application of this
knowledge to benefit the people of the
state, the nation, and the world.

The Nature of Life Program

3

“The U”


some
relevant
facts &
figures

Large, public, land
-
grant, research
university


51,175 students (fall 2005)


28,957 undergraduate


14,107 graduate


3445 professional

Freshman admitting colleges:


Agriculture


Physical Sciences & Engineering


Business


Liberal Arts


Biological Sciences


majors in biochemistry, biology,
genetics, ecology, plant biology,
microbiology, neuroscience

The Nature of Life Program

4

College of
Biological
Sciences


some
relevant
facts &
figures

140 faculty


~450 graduate students


~1700 undergrads

average

CBS freshman

-
top 7
th

percentile of high
school class

-
ACT = 27 (10% >30)

-
more than half already
have college credits


The Nature of Life Program

5

Program
Goals


help students begin to explore biology
from molecules to ecosystems


introduce opportunities in CBS & the U


build a community of learners


increase retention & graduation rates

The Nature of Life Program

6

Program
Overview

1 credit class required for all students
entering from high school


Begins at the Lake Itasca Field
station

(in summer)


3 learning modules


evening sessions & discussions


exam

The Nature of Life Program

7

Geography
interlude:


Where the
heck is
Itasca?



http://www.nps.gov/cuva/kidstuff/pac/watersheds/images/USmaps/US_new.jpg

ver
itas ca
put

The Nature of Life Program

8

Nature of
Life:


Overview

1 credit class required for all students
entering from high school


Continues back in the Twin Cities


3 reflective essays


graduation plan


3 activities in Twin Cities


On
-
line discussion of readings
from Discover magazine

The Nature of Life Program

9

Program
logistics

350 entering freshmen


4 NOL sessions during summer

~80 students per session


1 make
-
up session second weekend
after classes begin


~40 students

Finances:


$190 course fee (covers
transportation, room, board, supplies,
s’mores)


tuition (covers faculty honoraria)


grant (covers faculty housing & board)

The Nature of Life Program

10

Overall
schedule of
activities at
the Lake
Itasca Field
Station

The Nature of Life Program

11

Emphasis
on small
group
activities


(12
-
14
students)

Check
-
in & bus trip activities

Learning modules

Round table conversations

Exam feedback


The Nature of Life Program

12

Emphasis
on small
group
activities


(12
-
14
students)

Check
-
in: assigned to groups with
names relevant to faculty in
program


karmellae; phragmoplast; bangi
-
bangi; zizania, etc.

First activity: create poster about
what word means


The Nature of Life Program

13

Emphasis
on small
group
activities


(12
-
14
students)

Check
-
in & bus trip activities

Learning modules

Round table conversations

Exam feedback


The Nature of Life Program

14

Small
group
activities:


Learning
Modules


Goals


Provide hands
-
on snapshots of
many biology disciplines


Exposure to field biology
opportunities at the Itasca
Station


Begin the transition to college
level study & expectations


Highlight opportunities in
research by relating classes to
faculty research

The Nature of Life Program

15

Small
group
activities:


Learning
Module
Topics


note: each
module is a
4 hour
session!

Field Biology


Bog Biology


Lake Ecology


Ornithology


Invertebrate
diversity


River Ecology


Laboratory Biology


Biochemical
analysis of plant
pigments


Molecular biology


Computer
modeling


Nerve function


Redox chemistry


Issues in Biology


Implications of the human genome
project


Scientific thought & philosophy


Genetic counseling


Social implications of biology

The Nature of Life Program

16

Learning
Module
example:


Science
and Bog
Biology

60 minutes

Lecture: Thinking like a scientist; discussion of the scientific
method; introduction to wetlands

10 minutes

Discussion of objectives: a comparison of a dry upland habitat
and special wetland called Iron Springs Bog.

20 minutes

Visit to a gravel pit and artesian well to explain the glacial
geology and water chemistry of the Itasca region

20 minutes

Transects and data collection on a dry upland site

10 minutes

Mini
-
field lecture about the natural history of the bog

30 minutes

Transects and data collection in the bog

30 minutes

Group discussion: comparison of data from each student
group and building of a small data base

15 minutes

Summary of data; discussion of the big questions that possible
appear on the examination.

The Nature of Life Program

17

Learning
Module
example:


hypothesis
building &
testing

15 minutes

Discussion/demo:
Pseudomonas syringae

can nucleate ice
crystal formation

20 minutes

Groups develop hypotheses, experiment, & controls to test it

15 minutes

Groups share their hypotheses & experimental design


discussion of controls, variables etc.

40 minutes

Groups complete their experiment, repeat as necessary;

Revise hypotheses if necessary

20 minutes

Groups report back their results, share ideas & hypotheses

20 minutes

Break

5 minutes

Group discussion: the nature of science

45 minutes

Provide groups with research articles from variety of biology
disciplines (microbiologists, molecular biologists,
biochemists, cell biologists, geneticists, etc.) about
Pseudomonas related to their questions


have them prepare
presentation about the kinds of questions and research
appropriate for that discipline

30 minutes

Group presentations

The Nature of Life Program

18

Plenary
Activities
with all
students


(~80 students)

Station safety

Itasca biogeography

Keys to success at the U of M

Career building strategies

University traditions

The Nature of Life Program

19

Plenary
Activities
with all
students


(~80 students)

Campfires & s’mores

The Nature of Life Program

20

Plenary
Activities
with all
students


(~80 students)

Authentic exam!

The Nature of Life Program

21

Plenary
Activities
with all
students


(~80 students)

“graduation”

The Nature of Life Program

22

Of course,
there is a
little

free
time

The Nature of Life Program

23

Does the
program
achieve its
goals?

Formal IRB
-
approved protocols to
measure attitudes


Pre
-
program questionnaire


Post
-
program questionnaire

-
part 1: repeat pre
-
program
questions

-
part 2: learning module
assessment

Informal

-
Focus groups in spring

-
Essays: reflection on NOL
experience; conversation with a
professor

Outcomes

-

graduation, retention, success

The Nature of Life Program

24

Year One

assessment
results

(goal: introduce
opportunities in
CBS & the U)

Statement

5


strongly agree

1


strongly disagree

Mean
before:

Mean
after:

“I have a good understanding of the
different majors in CBS”

3.55

3.90

“I feel confident in my chosen major
within CBS”

3.69

3.57

p<.0001 & ~.10

The Nature of Life Program

25

Year One
assessment
results

(goal: build a
community of
learners)

Statement

5


strongly agree

1


strongly disagree

Mean
before:

Mean
after:

“I feel like I know some of the faculty
in CBS”

3.09

4.09

“I am comfortable approaching CBS
faculty with questions”

3.77

4.18

p<.0001

The Nature of Life Program

26

Year One
assessment
results

(goal: increase
retention &
graduation
rates)

Statement

5


strongly agree

1


strongly disagree

Mean
before:

Mean
after:

“I am impressed by my student
peers in CBS”

3.64

4.21

“I am confident that I will make
friends among my student peers in
CBS”

4.23

4.45

p<.0001

The Nature of Life Program

27

Student
comments
from
assessment

“I thought it was an awesome experience. I
didn’t realize how many friends you could make
in three days

it rocked and gave me the
confidence for school in the fall. The whole
experience in general was definitely worth the
time and is a great program

keep it up!”

The Nature of Life Program

28

“I came to this camp
rather grudgingly. I
don’t do camping.
But now I wish it
would have been a
day or two longer.
I’ve met the coolest
people, learned a lot
about the school and
about my major

and had so much
fun!”

Student
comments
from
assessmen
t

The Nature of Life Program

29

Student
comments
from
assessmen
t

“I was able to get a
little taste of so
many different
fields of science in
just a couple of
days. Each module
had a specific
question, which was
always answered
after the
experiment or
exploration.”

The Nature of Life Program

30

Does the
exam
work?

GPA Term One
3
3.1
3.2
3.3
3.4
3.5
3.6
3.7
-2
-1
0
1
The Nature of Life Program

31

…but what
about
outcomes?

The Nature of Life Program

32

The Nature of Life Program

33



2001 NHS, 271 total

2002 NHS, 351 total

2003 NHS, 330 total

Enrollment:


in CBS

at other
U
college

not at U

in CBS

at other
U college

not at U

in
CBS

at other
U college

not at U

1 year after
admission

82.7%

4.1%

12.5%

84.3%

5.7%

9.4%

83.3%

8.2%

8.2%

2 years after
admission

66.1%

12.9%

19.6%

66.1%

16.0%

16.0%







3 years after
admission

57.6%

14.0%

21.8%













…but what
about
outcomes?

The Nature of Life Program

34

Retention Data on Fall 99 - Fall 04 Cohorts
60
65
70
75
80
85
90
95
100
Fall 2000
Fall 2001
Fall 2002
Fall 2003
Fall 2004
Fall 2005
F99 cohort
F00 cohort
F01 cohort
F02 cohort
F03 cohort
F04 cohort
Nol Cohort 1
Nol Cohort 2
The Nature of Life Program

35

GPA PROGRESSION
2.95
3
3.05
3.1
3.15
3.2
3.25
3.3
3.35
TERM 1
TERM 2
TERM 3
TERM 4
TERM 5
TERM 6
TERM 7
TERM 8
TERM
GPA
F
01
ADMITS
F
02
ADMITS
F
03
ADMITS
F
04
ADMITS
The Nature of Life Program

36

…but what
about
outcomes?

Pre
-
NOL

Post
-
NOL



NHS
1999

NHS
2000

NHS
2001

NHS
2002

NHS
2003

NHS
2004

Number of
students

219

239

269

351

329

358

Fall term
GPA

3.16

3.18

3.2

3.17

3.28

3.12

Fall term

D, F, W, I

66

61

83

111

54

121

Total # of
courses
taken

1056

1123

1300

1622

1807

1936

Courses
per student

4.8

4.7

4.8

4.6

5.5

5.4















Failing
grades per
course
taken

0.06

0.05

0.06

0.07

0.03

0.06

Failing
grades per
student

0.30

0.26

0.31

0.32

0.16

0.34

The Nature of Life Program

37

…but what
about
outcomes?

Pre
-
NOL

Post
-
NOL

NHS 1999

NHS 2000

NHS 2001

NHS 2002

NHS 2003

NHS 2004

Number of students taking
math

201

199

241

301

276

308

Number of failing grades in
math

25

20

45

46

25

66

Math failures as % of total
failing grades

37.9%

32.8%

54.2%

41.4%

46.3%

54.5%















Average math grade

2.61

2.56

2.38

1.61

2.72

2.17

Average biology grade

3.34

3.14

3.03

2.86

3.23

3.07

Average chemistry grade

2.85

2.94

3.01

2.89

3.0

3.04















# students taking Math 1271

3

10

21

45

46

182

Math 1271 D, F, W, I

0

1

4

5

3

35

Percent failing

0.0%

10.0%

19.0%

11.1%

6.5%

19.2%















# students taking Math 1281

113

122

110

85

111

73

Math 1281 D, F, W, I

6

9

20

14

11

26

Percent failing

5.3%

7.4%

18.2%

16.5%

9.9%

35.6%

The Nature of Life Program

38

Faculty
interest &
involvemen
t has
grown!

Number of Faculty Involved in Program
0
5
10
15
20
25
2003
2004
2005
The Nature of Life Program

39