Slide 1 - Fabrica de bani - Stiri

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20 Φεβ 2013 (πριν από 4 χρόνια και 10 μήνες)

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NATIONAL INSTITUTE OF RESEARCH AND
DEVELOPMENT FOR BIOLOGICAL SCIENCES

www.dbioro.eu

under the authority of

Ministry of Science and
Education of Romania

National Authority for Scientific
Research of Romania

Address:

Splaiul Independentei, no. 296, sector 6,

postal code 060031, C.P. 17
-
16

Bucharest, Romania

Phone:

+4021
-
220.77.80

Fax:

+4021
-
220.7695

E
-
mail:

office@dbio.ro


Brussels, November 2008 National Institute R&D for Biological Sciences

Brussels, November 2008 National Institute R&D for Biological Sciences

Organizational structure

The institute was founded in 1996 when the following research institutes



The Biological Research Institute
Cluj (founded 1948),




The Biological Research Institute
Iasi (founded 1956).





The Biological Research Centre
“STEJARUL” Piatra Neamt (founded
in 1956)

were brought together under the

same

umbrella.


The

main

task

of

the

institute

is

the

fundamental

and

applicative

research

in

the

vast

field

of

life

sciences
.


To

promote

excellent

quality

research

and

development,

advanced

education

and

technology

transfer,

ensuring

national

and

international

competitiveness

in

the

domains

of

Biology,

Biotechnology,

Cellular

and

Molecular

Biology,

Microbiology

and

Ecology
.


To

develop

and

transfer

technologies

in

bioproducts
.


The

Institute

works

in

close

cooperation

with

universities

from

all

over

the

country

and

abroad,

with

hospitals,

other

research

centres

and

economical

agents

working

in

the

field

of

pharmacology
.

Brussels, November 2008 National Institute R&D for Biological Sciences

Brussels, November 2008 National Institute R&D for Biological Sciences

Main activities of INCDSB




Frame Programme 7 topics


Departments of the Institute

Biology and medicine (health,
medical biotechnology);

Agriculture and food supply
(food and food safety issues,
fisheries, agricultural
biotechnology);

Environment and climate
(environmental protection);

Information and
communication technology
(key words: discrete models,
proteines, health).


-
Cellular and Molecular Biology

-
Biotechnologies

-
Biomatherials and Bioproducts

-
Bioanalysis and Bioinformatics

-
Microbiology

-
Ecotoxicology

-
Ecology, Taxonomy, Biological


Control, Resources and


Environment


The

domains

of

bio
-
,

nano
-

and

information

technology

have

an

interdisciplinary

character
.



They

contribute

to

different

industrial

sectors

and

policy

objectives,

they

are

synergic

and

sometime

complementary
.


That

is

why

our

research

themes

are

interaction

between

the

topics

from

FP
7

and

that

is

why

our

research

fields

are

referring

to
:

Brussels, November 2008 National Institute R&D for Biological Sciences

Cross
-
thematic approaches


Systems biology/bioinformatics


relevant to themes: Health and
Information and communication technology



Factors impacting health


relevant to Health



Biodiversity and its sustainable exploration for the production of
biological resources
-

relevant to Environment, which deals with the
conservation of biodiversity and natural resources



Novel biotechnology approaches and improved biotechnologies for
the production of renewable biomaterials
-

relevant to biomaterial
research under Nanosciences, Nanotechnologies, Materials and new
Production technologies


Brussels, November 2008 National Institute R&D for Biological Sciences

Cross
-
thematic approaches

Personnel

Brussels, November 2008 National Institute R&D for Biological Sciences

200 people working in the main office and in the branches.




120 researchers working in the main office and in the branches



65% having a PhD degree



2 scientific coordinators



Average researchers age
-

under 40 years

The percentage of PhDs
65%
21%
14%
Doctors
Trainers for a doctor's degree
Research workers
Where do the funds come from ?


National and international competitions

National Programme II


Partnerships


Capacities


Ideas



25 national programmes as coordinators and 100 as partners


International projects: FP6, FP7


Bilateral agreements

Brussels, November 2008 National Institute R&D for Biological Sciences

EU Projects
-

Present and Forecast

Theme:
'Food, Agriculture and Fisheries, and Biotechnology'

FP6
-
STREP Contract FOOD
-
023044/2006

Ready to eat food for breakfast and sport activity with high content of nutraceutics reducing a
disease risk and promoting public health

Coordinator CNR Italy

The

project

aims

the

realisation

of

ready
-
to
-
eat

food

with

a

high

content

of

compounds

endowed

with

functional

activity

like

carotenoids,

alliin

and

allicin,

phenolics,

rosmarinic

acid,

ferulic

acids

and

derivatives

(e
.
g
.

curcumin)
.

M
ain

objectives

of

the

Nutra
-
Snacks

project
:


Selection

of

organisms

producing

natural

biologically

active

metabolites

with

recognized

antioxidant

activity
.


Realization

of

a

bioreactor/sensors

for

innovative

plant

cell

and

in

vitro

systems

suitable

for

nutrient

production


Development

of

safety

and

quality

control

protocols

for

the

new

ready
-
to
-
eat
-
food
.


Theme:

Environment and Climate Change
'

FP6
-

SUSTDEV


2005
-

3.III.1.1

Challenges in assessing and forecasting biodiversity and ecosystem changes in EUROPE

Coordinator Universite Joseph Fourier, France


Advanced modelling approaches has been used so far to assess the impact of global change on biodiversity and ecosystems.
These approaches yield projections of the distribution of species, communities and biomass and the functioning of
ecosystems. Future goods and services are then asessed from these projections. However four main limitations remain
associated to these approaches.

Brussels, November 2008 National Institute R&D for Biological Sciences

Brussels, November 2008 National Institute R&D for Biological Sciences

FP7
-
SME
-
2008
-
1
-

Research for the benefit of specific groups

232522/2008

Biosensors and Sensors for the industrial biosynthesis process of widely used commercial
antioxidants: nutraceuticals as additives for food and aquaculture promoting public health and
safety

Coordinator BIOSENSORS Italy


The purpose of this 2
-
years project is to develop sensors and biosensors for on
-
line monitoring growth parameters of

industrial bioprocesses for the production of algal biomass and antioxidant compounds such as Xanthophylls.


EU Projects
-

Present and Forecast

Finalized International Projects

IntraBioaDiv

-

Specific Targeted Research Project

2004


2006

Title: “
Tracking surrogates for intraspecific biodiversity: towards
efficient selection strategies for the conservation of natural genetic
resources using comparative mapping and modelling approaches


Coordinator

Université Joseph Fourier
, Grenoble, France



Realisation of a Chorological Atlas for subalpine and alpine panerogam
species of the Carpathian mountains and Alpes within Gloria
Europe, INTRABIODIV international projects.


Realisation a synthesis for conservation stade of Romanian Natural
Reservation subalpines and alpines panerogam species


international projects

Brussels, November 2008 National Institute R&D for Biological Sciences

Bilateral Agreements

Universities of Montpellier, Perpignan, Lyon, Strasbourg (France),
University of Bari (Italy), University of Athens (Greece)


Unité mixte de Rechérche CNRS/USTL No 8576 Franta, Director:
Profesor Jean Claude Michalski, Pr. Emerit Jean Montreuil


Université des Science et Technologie de Lille, Laboratoire de
Glycobiologie Structurale et Fonctionnelle


Universitaté Paris 7, Laboratoire EMI
-

U 9922 INSERM


Centre
Hospitalier Bichat, France, Profesor Jean Claude Ameisen


Les Laboratoires Pharmaceutiques MacoPharma, Tourcoing, France,
Directeur General Francis Goudaliezl


Institut Pasteur Paris, Unite de Physiopathologie des Infections
Lentivirales, France, Dr.Jerome Estaquiez

Brussels, November 2008 National Institute R&D for Biological Sciences

Facilities

Brussels, November 2008 National Institute R&D for Biological Sciences

Biological Compounds Separation,
Identification & Quantification

Chromatography:


High
-
liquid chromatography


diode array detection


Bidimensional Ultra Flow Liquid Chromatography


Fluorescence detection
-
diode array detection
-

MALDI

Spectrometry
: Fourier Transformed InfraRed, UV
-
Vis,
Fluorescence

Electrochemistry:

quartz crystal microbalance,
electrochemical systems AUTOLAB, VOLTALAB

Capillary electrophoresis

Proteomics:



Matrix Assisted Laser
Desorption Ionisation
-
Time of
Flight analysis

Brussels, November 2008 National Institute R&D for Biological Sciences

Cellular and molecular biology,
biomaterial characterisation:


Flow cytometer


Cell separator


Transmission Electron Microscope


Advanced Biosafety Cabinet Class II


Laboratory CO2 incubator


Inverted microscope Zeiss

Facilities

Facilities



The Cell Culture Laboratory

set up in order to implement the specific European directives
(93/42/EEC)



Aim: to replace
in vivo

testing on laboratory animals





In vitro
cytotoxicity

assessing of medical devices;



Currently in process of accreditation according to SR EN ISO/CEI
17025:2005 standard directives.

Brussels, November 2008 National Institute R&D for Biological Sciences

Results 2007


2008




Papers

1.
Influence of polysaccharides from Viscum album L. on human dermal fibroblasts in vitro,

Craciunescu O., Balan M., Gherghina E., Moldovan L.,
Planta Medica
, 73(9), p. 900, 2007


2.
Antioxidant activity, phenol and flavonoid contents of some selected Romanian medicinal plants,

Alexandru V., Balan M., Gaspar A., Coroiu V.,
Planta Medica
, 73(9), p. 905, 2007


3.
ESEM observations on new polyurethane
-
based materials for biomedical applications: structure
and cell adhesion,

Craciunescu O., Moldovan L., Bojin D., Vasile C., Zarnescu O.,
Acta
Microscopica
, 16 (1
-
2, Suppl. 2) p.199
-
200, 2007


4.
Lipid nanostructures as carriers for targeting pharmacological active agents; formulation and in
vitro studies,
Trif M., Moisei M., Chelu F., Moldovan L., Craciunescu O., Roseanu A.,
Proceedings of
European and International Forum on Nanotechnology
, Dusseldorf, Germany, 80
-
82, 2007


5
.

Nouveaux critères d’évaluation de la viabilité des hématies destinées à la transfusion

Mitrofan
-
Oprea L., Palii C., Tissier J
-
P., Héron A., Verpoort T., Behague M. , Goudaliez F., Smagghe E.,
Schooneman, F. Huart J
-
J., Montreuil J., Bratosin D.,
Transfus. Clin. Biol.
, 14, 393
-
401, 2007


6.
Simulating FAS
-
induced apoptosis by using P systems,

S. Cheruku, A. Paun, F.J. Romero
-
Campero, M.J. Perez
-
Jimenez, O.H. Ibarra;
Progress in Natural Science
, 17(4), 424
-
431, 2007,
(ISI Impact factor : 0.531); Review: review number in MathSciNetdata base: MR2332695
(2008e:92015)

Brussels, November 2008 National Institute R&D for Biological Sciences

7.

Normal forms for spiking neural P systems
, O. H. Ibarra, A. Paun, Gh. Paun, A. Rodríguez
-
Patón,
P. Sosík, S. Woodworth;
Theoretical Computer Science

372(2
-
3), 2007, 196
-
217. (ISI Impact
factor: 0.843). Review: review number in MathSciNet data base: MR2303146 (2008a:68058)


8.
Small universal spiking neural P systems
, A. Paun, Gh. Paun,

BioSystems
, 90 (1), 2007, pp. 48
-
60. (ISI impact factor:1.080)


9.
The influence of refugial population on Lateglacial and early Holocene vegetational changes in
Romania
,

Feurdean, A., Wohlfarth, B., Bjorkman, L., Tantau, I., Bennike, O., Willis, K.J., Farcas, S.,
Robertsson, A.M., 2007,
Review of Paleobot. & Palynology
, 145, 305
-
320.
Impact factor
:
0.886


10.
Weak and variable relationships between environmental severity and small
-
scale co
-
occurrence
in alpine plant communities,

Dullinger S., Kleinbauer I., Pauli H., Gottfried M., Brooker R., Nagy L.,
Theurillat J.
-
P., Holten J.I., Abdaladze O., Benito J.
-
L., Borel J.
-
L., Coldea G., Ghosn D., Kanka R.,
Merzouki A., Klettner C., Moiseev P., Molau U., Reiter K., Rossi G., Stancisi A., Tomaselli M.,
Unterlugauer P., Vittoz P., Grabherr G., 2007,
J. Ecol.

95, 1284
-
1295, 2007. Impact factor: 2.7


11.
Cryopreservation of carnation (Dianthus caryophyllus L.) shoot tips by encapsulation
-
vitrification,

Halmagyi, A., Deliu, C., 2007
,
Scientia Horticulturae
, 133(3), 300
-
306. Impact factor: 0.697


Brussels, November 2008 National Institute R&D for Biological Sciences

Results 2007


2008




Papers

12.
The procedure to obtain an electrode with chemical modified surface using L
-
cisteine and
metallic ion determination with consequences in physiological processes

Vasilescu, I., Litescu, S.,
Penu, R., Radu, G.L.
,
2007
,
Chemistry Journal
, 58 (12), pp. 1101
-
1166


13.
Determination opf hydrosoluble vitamins content and antioxidant capacity of some yeast strains
with probiotic potential
,

Teodor, E., Birsan, C., Smarandache, D., Penu, R., Radu, G.L.
,
2007
,

Chemistry Journal
, 58 (12), pp. 1249
-
1252


14.
Composite membranes on the basis of new nanomaterials in the class MCM
-
41 modified with
metals and SAPO applied in wastewater purification
,

Roman, G.P., Parvulescu, V., Radu, G.L., Su, B.
-
L
.,
2007
,

Chemistry Journal
, 58 (1), pp. 98
-
101


15.
Stress and displacement in cantilever
-
based transducers for biosensing application
,

Bineva, I.,
Voicu, R., Esinenco, D., Dinescu, A., Muller, R., Bucur, B., Diaconu, M., Radu, L.G.

,
2007
,

Proceedings of the International Semiconductor Conference
, CAS, 1, art. no. 4063200, pp.
223
-
226


16.
Improvement of the storage stability for biosensors based on alcohol oxidase immobilized by
entrapment in a photopolymerisable matrix
,

Bucur, B., Bucur, M.P., Radu, G.L.
,

2007
,

Chemistry
Journal
, 58 (11), pp. 1145
-
1148

Brussels, November 2008 National Institute R&D for Biological Sciences

Results 2007


2008




Papers

17.
On the Hopcroft's minimization technique for DFA and DFCA,

A. Paun, M. Paun, A. Rodriguez
-
Paton,
Theoretical Computer Science
, Accepted, 0.843


18.
Discrete nondeterministic modeling of the FAS pathway,

J. Jack, A. Paun, A. Rodriguez
-
Paton,
International Journal of Foundations of Computer Science
, Accepted


19.
Computing with Cells: Membrane Systems
-

Some Complexity Issues,
O.H. Ibarra, A. Paun,
Accepted at
Journal of Cellular Automata


20.
Spiking neural P systems with extended rules: universality and languages
, Chen, H.; Ionescu,
M.; Ishdorj, TO; Păun, A.; Păun, Gh.; Pérez
-
Jiménez, M..
Nat. Comput.

7 (2008), no. 2, 147
-
166.
Review: review number in MathSciNet data base: MR2403208


21.
On spiking neural P systems and partially blind counter machines Ibarra
, Oscar H.; Woodworth,
Sara; Yu, Fang; Păun, Andrei. Nat. Comput. 7 (2008), no. 1, 3

19. Review: review number in
MathSciNet data base: MR2407929


22.
Sequentiality Induced by Spike Number in SNP Systems,
Pre
-
proceedings of Fourteenth
meeting on DNA Computing (DNA14)
, O.H. Ibarra, A. Paun, A. Rodriguez
-
Paton, June 2
-
6,
2008, Prague, Czech Republic, pp. 36
-
47


Brussels, November 2008 National Institute R&D for Biological Sciences

Results 2007


2008




Papers

23.
Hopcroft's minimization technique: queues or stacks?,
A. Paun, M. Paun, A. Rodriguez
-
Paton,
CIAA 13
, July 21
-
24, 2008, San Francisco, USA


24.

Effects of HIV
-
1 Proteins on the Fas
-
Mediated Apoptotic Signaling Cascade: A Computational
Study of Latent CD4+ T Cell Activation,

J. Jack, A. Paun, A. Rodriguez
-
Paton, accepted at
Ninth
Workshop on Molecular Computation
, WMC9, Edinburgh (UK) July 28
-
31, 2008, 20pp


25.
Determination of S
-
adenosylmethionine and S
-
adenosylhomocysteine from human blood
samples by HPLC
-
F
l, Camelia Birsan,

SC Litescu, N Cucu, GL Radu, 2008,

Analytical Letters
,
41(10), 1720
-
1731


26.
EPDM
-
HDPE blends with differentcure systems/mechanical and infra
-
red spectrometric
properties,

Moldovan Z, Ionescu F, Simona Litescu, I Vasilescu, GL Radu,
,

2008,


Journal of
Applied Sciences
8 (1), 86
-
94


27.
Genetic characterisation of some Romanian red wine grapevine varieties,

LC Ghetea, RM Motoc,
AM Niculescu, SC Litescu, VF Duma, CF Popescu
,,
2008,

Progress in Biomedical Optics and Ima
ging
-
Proceedings of SPIE 6991
, art no 699128


28.
Analysis of methanol
-
ethanol mixtures from falsified beverages using a dual biosensors
amperometric system based on alcohol dehydrogenase and alcohol oxidase
,
Bucur, B., Radu, G.L.,
Toader, C.N.
, 2008,

European Food Research and Technology
, 226 (6), pp. 1335
-
1342

Brussels, November 2008 National Institute R&D for Biological Sciences

Results 2007


2008




Papers

29.
Obtaining and caracterization of biocompatible supports as microparticles and chitosan
-
alginate
films with immobilized urease
, Roman, G.P., Neagu, E., Radu, G.L., Teodor, E.,
2008,
Chemistry
Journal
, 59 (2), pp. 208
-
211


30.
Optimization of hydroxyl radical formation using TiO2 as photocatalyst by response surface
methodology
, Eremia, S.A.V., Chevalier
-
Lucia, D., Radu, G.
-
L., Marty, J.
-
L., 2008, Talanta.
Article in Press


31.
Inhibition of Low
-

Density Lipoprotein Peroxidation by BHA use. Fluorimetric Assay
,
Sandra
Eremia, SC Litescu, JL Marty, GL Radu,
accepted 2008,

in press Analytical Letters


32.
The procedure to obtain an electrode with chemical modified surface using L
-
cisteine and
metallic ion determination with consequences in physiological processes,

Ioana Vasilescu
,
Simona Liţescu,

R. Penu,

G. L. Radu

2007,

Chemistry Journal
, 58(12), 1101
-
1106

Brussels, November 2008 National Institute R&D for Biological Sciences

Results 2007


2008




Papers



Experimental Techniques in Bioanalysis
-

ISBN 973
-
718
-
373
-
8



Bioinformatics
-

Vol I : Molecular
computing and simulating methods ISBN (10)
973
-
31
-
2299
-
8









Romanian Biological Sciences (since 1998)
-

ISSN 1584
-
0158

Brussels, November 2008 National Institute R&D for Biological Sciences

Results




Books and journals



Other over 10 books

Produced by PlantaVorel:

1.

Products with antiiflamatory and antirheumatic
actions
:

REUMA
-

solution
and

REUMA
-

cream

that
contains the phytocomplex with antiinflamatory properties and
of stimulating the circulatory system, produced from
Amoracia
rusticana



2.

Product with a detoxifying action
:
DETOX A
-

tablets

with a complex action of eliminating the residues and toxic
substances from the organism, assuring its rebalancing


3.

Products with antioxidant action
:
ANTIOXIDANT
-

capsules
and
OREGANO hydroalcoholic solution
,
preventing the formation of the free radicals by an adequate
contribution of antioxidants with the aim to maintain a
metabolic balance essential to the health state of the organism

Brussels, November 2008 National Institute R&D for Biological Sciences

Results






Products

Products based on the results of the research made in our institute

Produced by PlantaVorel:

4.

Products with immunostimulating, adaptogen,
general tonic actions
:
IMUNOSTIM A
-

tablets and
BASIL
-

glycerinated solution
with a complex, general tonic
action of the organism functions and of increasing the unspecific
defending resistance of the organism



5.

Products with sedative, cardiotonic action
:
CALMOTON
-

cardiotonic

solution with a complex action on
the central nervous system, neurovegetative and against the
functional vegetative disorders of the heart


Brussels, November 2008 National Institute R&D for Biological Sciences

Results






Products

Products based on the results of the research made in our institute

Produced by Hofigal:

Gamut of Bio
-
products based on matricial biopolymers and plant extracts used in the
treatment of tissue diseases, improving and sustaining the health of the orgamism.

These products are biocompatible, non
-
allergenic and biodegradable.

Brussels, November 2008 National Institute R&D for Biological Sciences

Results






Products

Products based on the results of the research made in our institute

1.
PLANTINTIM



The product is a gel
formula based on bioactive principles,
essential oils with an marked antiseptic
effect.

Produced by Hofigal:


2.
Bucoprotect



This gel can be used in the
treatment of painful and bleeding gums. It can be
also used in inflammatory diseases of the mouth

This bio
-
product has antiinflamatory,
antibacterians, antifungic and cicatrizing effects.




3.

Epifin

-

a formula that contains hidrosoluble
collagen, an vegetable oil rich in vitamines, and a
volatile oil with antiseptic effect.


Brussels, November 2008 National Institute R&D for Biological Sciences

Results






Products

Products based on the results of the research made in our institute

Diplomas

and

gold

medals

were

achieved

at

the

International

Inventica

Saloon



Geneva

2002
,

2003
,

2004

and

in

the

Worlds

Showroom

Eureka

in

Brussels

2003

for

bioproducts

based

on

vegetal

and

animal

extracts
.

Brussels, November 2008 National Institute R&D for Biological Sciences

Results






Patents



Methode pour stimuler la proliferation de cellules differenciees appurtenant au lignage
chrondrogenique
, French patent No. 0707113/10.10.2007. Authors: Bratosin Daniela, Buia Luminita, Heron A.
Montreuil Jean..
INTERNATIONAL PATENT



Afinity
support and obtain
proceedingd

for heparine. PATENT
No. 98
-
01052/04.06.1998, Decision No.
3/404/27.10.2005. Authors: Luminita Tcacenco, Ghiocel Radu Paul, Maria Caloianu, Eugenia
-
Dumitra Teodor, Lucia
Moldovan, Daniela Pomponiu.



Chromatographic method for polyphenols determination,
Patent application No. A/00766/30.09.2008.
Author: Gatea Florentina.



Chromatographic method for antocyanidins determination,
Patent application No.
A/00765/30.09.2008. Author: Gatea Florentina.



Characteristics improvement for simultaneous analysis of methanol and ethanol without analytes
separation by using a biosensor based on AOX extracted from
Hansenula polymorpha
”,
Patent application
No.

A696/11.09.2008

Authors:
Bucur Bogdan
,
Bucur Madălina Petruța
,
Radu Gabriel Lucian
,
Rădulescu Cristina.




Biopolymeric materials based on mixtures of polyurethane and natural polymers and preparation
method,
Patent application
No. A/00539
/
2008. Authors: Lungu Maria, Moldovan Lucia, Craciunescu Oana, Zarnescu
Otilia, Vasile Cornelia



Biocompatible materials prepared by polyurethane cover with biopolymers and preparation
method,

Patent application

No. A/00468/2008. Authors:Moldovan Lucia, Lungu Maria, Craciunescu Oana.

Brussels, November 2008 National Institute R&D for Biological Sciences

Results


Patents and patent applications


Nanostructured material based on magnetic nanoparticles and
hydrogel, and its obtain process
,

Patent application No.
A/00453/26.06.2007. Authors: Eugenia Teodor, C. Petcu, Veronica Laz
ă
r,
Mihaela Mihalache.



Obtaining method for lypase with
Yarrowia lipolitica
stem
,


Patent application No. A/001 178/08.03.2007. Authors: Luminita Tcacenco,
Diana Gabriela Groposila Constantinescu, Camelia Filofteia Diguta, Andreea
Cozea, Diana Pelinescu, Elena Sasarman.

Organizing of Scientific Meetings


"Biological Diversity


Biotechnologies


socio
-
economical

development“
-

national symposium



"Bioanalysis versus Biotechnology”
-

Workshop



"Natural Sciences“


Romanian


Austrian Symposium




"Microbiology and Biotechnology“
-

Symposium



National Congress of Biology "Emil Racovita“



"General and applied entomology“
-

National Conference



"Entomofaunistics in Central Europe“
-

International Symposium



"Medicinal Plants
-

present and perspectives“
-

National

Symposium

Brussels, November 2008 National Institute R&D for Biological Sciences

Thank You !

Brussels, November 2008 National Institute R&D for Biological Sciences