doc

bewilderedvoyageΒιοτεχνολογία

12 Δεκ 2012 (πριν από 4 χρόνια και 8 μήνες)

183 εμφανίσεις



Republic of Iraq

Ministry of Higher Education


and Scientific Research



University of Baghdad

Institute of
Genetic Engineering


& Biotechnology

f
or




Post G
raduate

Studies


Molecular Detection
of Some
Mutations Associated with Βe
ta
-
Thalass
a
emia in Iraq


A Thesis

Submitted

By


Zuhair Mohamme
d Ali Al
-
A
ssadi

B.V.M. & S. (1991)

M.Sc.
Theriogeno
logy (1994)


To t
he

Institute of Genetic Engineering &

Biotechnology for

Post Graduate
Studies,
University of Baghdad


In

partial fulfillment of

the requirements for the

Degree of Doctor of Philosophy
i
n

Genetic Engineering & Biotechnology


Supervised B
y

Prof.Dr.Waleed K. Al
-
Murrani

Prof.Dr.Norrya A. Ali


Tho Alhija 1427 A.H.
January
200
7 A.D
.








CERTIFICATION



We

certify that this thesis

entitled


Molecular detection

of

some mutations associated with beta


thalass
a
emia in
Iraq
” has been prepared

under our supervision as
a
partial
fulfillment of

the requirements for degree of

Doctor of
Philosophy

in
Genetic Engineering & Biotechnology

at the
Institute of the Genetic Engineering & Biotechnology

for post
graduate studies
, University of Baghdad.







Signature:

Name
:

Prof.Dr.Waleed

K. Al
-
Murrani

Da
te:

/ /



Signature:

Name
:

Prof.Dr
. Norrya A. Ali

Date:

/ /



In view of the available
recommendations, I

forward this thesis
for
debate by the examining

committee.



Signature:

Name:

Assist.prof.Dr.
Nahia A. Ali

Assistant
Dean of

the Institute of Genetic Engineering &
Biotechnology for Post Graduate

Studies

Date:

/ /


We
certify

tha
t we have read this thesis

entitled


Molecular
detection

of some mutations associated with beta


thalass
a
emia in Iraq


by


Zuhair M
ohammed Ali

J
eddoa

Al
-
Assadi


and as an examining committee
examined
the

student
in its content that
,

in our opinion, it
is adequate

for the degree of
Doctor of Philosophy

in

Genetic

Engineering &
Biotechnology
.





Signature:




Signature:



Name:

Prof.Dr.Waleed

K.
Al
-
Murrani

Name:

Prof.Dr. Norrya A. Ali





Date: / /




Date: / /







(Supervisor)



(Supervisor)


Signature:




Signature:

Name:
Prof.Dr.Nesir F.Abdullah



Name:
Assis.Prof.Dr.Nada M.
Al
-
A
nssary

Date: / /





Date: / /






(Member)





(Member)


Signature:





Signature:

Name
:

Prof.Dr.Sahib A. Mehdi


Name:
Assis.Prof.Dr.Amina
N.
Al
-
Thewani

Date: / /





Date: / /







(Member)


(Member)


Signature:

Name:

p
rof.Dr. Nahi Yosif Ya
ssee
n

Date: / /




(Chairman)


Approved for the University of Baghdad



Signature:



Name:

Assist.prof.Dr. Nahia A. Ali



Date: / /

D
ean of
the
Institute
of Genetic Engineering &
Biotechnology

for Post Graduate

Studies













Acknowledgments




First, a special gratitude and
thanks
are

due

to

ALLAH


for
his entire blessing during

the pursuit of my academic
career goal
s.


All my

thanks

go

to Baghdad University and the Institute
of
Genetic Engineering & Biotechnology for Post Graduate Studie
s
which ga
ve me this opportunity to c
omplete the requirements of my

study.




I would like to express my

deep
est

app
reciation and utmost
gratitude

to

my supervisors,

Prof.

Dr.

Waleed K. Al
-
Murrani
and
Prof.

Dr.

Norrya A. Ali for their encouragement,
continuous

guidance, effort

and interest throughout the work which contributed
to its completion.



G
reat
est

than
k also go
es

to Prof.

Dr. Ali A. Al
-
Zaag
for his
support and scientific counseling of my research.


Many

thanks and
appreciations are

due to

all the staff in
thalassaemic centers
of

Ibn

Albalady
(
Baghdad
)
,

Kerbalaa and Al
-
Dewanya pediatric hospita
ls
,

t
he

doctors and nurses,

especially Dr.
Shaymaa K.
Abbas

, Dr. Raziqa Al
-
Ebadi,

Dr. Mohammed Naji and
Dr. J
awad
Ali
,

for their
great
helpful and advisements.




Sincere thankfulness extended
to all staff members of the

medical genetic laboratory
in National Research Center for Genetic
Engineering & Biotechnology (NRCGEB) in Te
hran


Islamic
Republic of Iran,

especially

Dr.

Massoud
Houshmand,

Mr.

Redha
Mirfakhrae, Mr. Mehdi Shafa, Ms
.

G. Mo
d
daber and Ms. Maryam
Monteze
ri for their assistant and kin
d

help.


Greatest thanks also go to Ms. Nermeen Mehmmod for her
help
in
correction of the language of my dissertation.


So many thanks
are due
to my
colleagues Amer Hani, Rana
Adil,

Saad Akram and Sahar
Ahmad for

your help and support.



Heart
y respect

and sincere appreciation are
also
due to the
members of my

family

and lovely
relatives
,

especially
,

my father and
mother, and my
brothers’ Jassim and B
urair and all my sisters

for

their perm
anen
t encouragement and support
.


Finally, sincere thankfulness and Heart
y respect

are
due to my
wife and

lovely flowers
Mays
,
Ameer
, and
Safa

for their assistant
and kind support
.



Zuhair