Supramoleuclar chemistry and Nanobiotechnologyx - IIT Roorkee

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27 Οκτ 2013 (πριν από 3 χρόνια και 11 μήνες)

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1



Supramolecular Chemistry

Details of C
ourse:


S.No.



Particulars

Contact

Hours

1.

Introduction to supramolecular Chemistry
-

Inspiration, history and definition. Molecular
forces: role of non
-
covalent interactions in
supramolecular chemistry


differences wi瑨
浯lecular and supra浯lecular sys瑥洬 kine瑩cs and 瑨er浯dyna浩cs of supra浯lecular
asse浢lies.

5



Molecular Structure
s
-

Natural and artificial ionophores and receptors
-

cyclodextrins,
zeolites,cucurbiturils
, crown ethers, calixarenes and porphyrins based system. Synthesis of
receptors

for cation, anion and neutral molecules; non covalent synthesis


syn瑨esis of
浯lecules 㬠浥瑡l con瑡ining 浯lecular geo浥瑲ies.

Molecular recogni瑩on


bio 浡瑥rials and bioi
nspirs瑩on (pro瑥in folding, asse浢ly and
s瑲uc瑵re , pro瑥in 浩sfolding and diseases), biomeme瑩es and nano瑥chnology.





Synthesis and Fabrication
-

Top down vs. bottom up approaches, self
-
assembly and core
-
shell system, microspheres
-

colors from the beaker, microporous and mesoporous
materials.

8

4.

Application of self
-
assembled Nanomaterials



Self
-
asse浢led 浯lecular s瑲uc瑵res

(
浯lecular con瑡in
ers, 浥瑡lla
-
cages and capsules), 浯lecular scale 浡chines
-

浥chanical
ro瑯rs, gears, breaks, and 浯lecular swi瑣hes. Self asse浢ling blocks, nanorods, nano瑵bes
and nanowires. Nano
-
i浡ging and nano
-
drugs.









Total


42



11. Suggested books:

S.No.

Name of the Authors/Books/Publisher

Year of
publication

1.

T.pradeep, Nano: The Essentials, Tata McGrawHill, New Delhi

2007

2


2.

G. Ozin, A. Arsenault, Nanochemistry. A Chemical Approach to Nanomaterials, RSC, London

2005

3.

Z.L. Wang, Z. Zhang, Y. Liu, Handbook of Nanophase and Nanostructured Materials, Kluwer

Academic, New York.

2002

4.

G. Cao, Nanostructurs and Nanomaterials. Synthesis, Properties and Application, Imperial
College Press, London

2004

5.

P. Gomez
-
Romero, C. Sanchez, Functional Hybrid Materials, Wiley
-
VCH, Weinheim

2004

6.

V. Balzani, M.
Venturi, A. Credi, Molecular Devices and Machines

A Journey in瑯 瑨e
Nanoworld, Wiley
-

V䍈
, Weinheim

㈰〳



J.W. S瑥ed, J.L. A瑷ood, Supera浯lecular 䍨e浩s瑲y, John Wiley & Sons, England.

㈰〰



J. 娮 婨ang, 娮L. Wang, J. liu, S.W. 䍨en, G.Y. Liu, Sel
f
-

asse浢led Nanos瑲uc瑵res, Kluwer
Acade浩c Publisher, New York.

㈰〲

9.

V. Anslyn, D.A. Dougher瑹, Modern Physical Organic 䍨e浩s瑲y , Universi瑹 Science
Books,Sausalito, 䍁.

㈰〶

㄰1

J.W. S瑥ed, D.R. Turner, K.J. Wallace, 䍯re 䍯ncep瑳 in
SUpra浯lecular 䍨e浩s瑲y and
Nanoche浩s瑲y, John Wiley & Sons L瑤., England

㈰〷







INDIAN INSTITUTE OF TECHNOLOGY ROORKEE


NAME OD DEPTT./CENTER:

Center of Nanotechnology

1. Subject code
: NT
-
542

Course title
: Nan
obiotechnology

2. Contact Hours: L
: 3

T:
1

P:
0

3. Examination Duration (Hours): Theory:
03

Practicals
: 00

4. Relative Weightage: CWS:
25

PRS:
00

MTE:
25

ETE:
50

5. Credits
: 04

6. Semester
: Autumn/ Spring

7. Pre
-
requisite: None.

8. Subject Area: PG
-
14

9.
Objective of course
: This course is intended to impart the knowledge of nanoscale biological
molecules, their methods of analysis, integration to macromolecules, and providing an
underst
anding of various nanobiotechnological applications.

3


10.
Details of Course
:

S.No.

Particulars

Contact
Hours

1

Overview of Nanobiotechnology

Historical perspective of integration of biology, chemistry, and
material science, Opportunities and promises of
nanobiotechnology

2

2

Biology Molecules and their Analysis

Complexity and size of biology molecules
-
DNA,RNA,proteins
and carbohydrates.

Techniques
-
Biochemical analyses, Electrophoretic and
chromatographic analyses
-

basic principles and applications.

6

3

Single molecules Approaches in Biotechnology

Fluorescence spectroscopy
-

Fluorescent probes for analysis of
proteins and nucleic acids. Labeling of proteins and nucleic acids
bu various fluorescent dyes. Molecular beacons and applications.

4

4

Microbiology

and nanotechnology
-

Bacteria and Viruses
-

Prokarotic complexity and size
distribution. Bacterial cell


-
cell c潭municati潮Ⱐ 煵漠 rum
sensingⰠ chem潴axis⸠ Micr潢oal 灲潤octi潮 潦 in潲ganic
nan潰orticles⸠ G潬摮an潰orticles f潲 ima杩湧 an搠thera灹.

8

5

Mini
aturised devices
-

nanotechnology and medical devices
-

Overview of smart devices for medical field, mimiaturised
devices for drug delivery, advantages of miniaturised devices
-

lab on chip concept,
-
epipen, intelligent pill, wobbling gels.

6

6

Nanomaterials

used in Biotechnology

Nanopaticles, carbon nanotubes, fullerenes, nanofibres, quantum
dots and buckyballs interface with biological macromolecules.
Biological perspectives of nanomaterials
-

impact of
nanomaterials in biological processes
-

tolerance by imm
une
systems and toxicity.

Nucleic acid Engineering
-

Modifications of DNA for nano
-
technological applicatios. Nanostructure assembly using DNA.

7

7

Applications of Nanobiotechnology
-

Nano
-
Biosensing
-

Biosensors and nanobiosensors



扡sics⸠
Design an搠 ty灥s 潦 nano
-
扩潳ens潲s⸠ DNA a灴amers f潲 nano
-
扩潳ensi湧 an搠摲ug 摩sc潶ery.

Nano
-
Medicine
-

Impact of nanotechnology in health and
medicine
-

overview. Promising applications of nanomedicine
-
recent concepts
-

implantable devices, dend
rimers
-
polymers for
drug delivery, targeted drug delivery for cancer and other
diseases.

Synthetic Biology
-

Self assembly of nucleic acids into
nanostructures, nanomotors and nanoengines based on nucleic
acids.

6

4




8

Chemical Biology and Systems biology

Small molecules as antibiotics
-

mode of action, chemical
genetics, nanotechnology and high throughput screening for
drug discovery.

3


Total

42



11.
Suggested Books
:

S.No.

Name of Books/Authors

Years of
publication

1

J.M.Breg, J.L. Tymoczko and L.
Stryer, Biochemistry,6
th

Ed.


W⹈⸠.reeman an搠C潭灡nyⰠ New⁹潲k

㈰〶

2

D⹓⸠ G潯摳ellⰠ Bi潮an潴echn潬潧y: Less潮s fr潭 NatureⰠ
Wiley Press

㈰〴

3

C⹍⸠ Niemeyer an搠 C⹁⸠ Mir歩n
-

(E摩t潲)Ⱐ
Nan潢o潴echn潬潧y: C潮ce灴sⰠ A灰picati潮s an搠
Pers灥ctivesⰠ Wiley
Press

㈰〴

4

C⸠.aish Anti扩潴ics: Acti潮sⰠ OriginsⰠ an搠Resistance,

㈰〳

5

D⹐⸠ AryaⰠ Amin潧lyc潳i摥 Anti扩潴ics: Fr潭 Chemical
Bi潬潧o t漠orug Disc潶ery


Wiley Press

㈰〷

6

V⸠ La扨asehwar an搠 D⹌⸠ Lesile
-
Pelec歹(E摩t潲)Ⱐ
扩潭e摩cal A灰pications 潦
Nan潴echn潬o杹Ⱐ Wiley Press

㈰〷

7

S⸠.lussman⸠ The A灴amer Han摢潯欺 Functi潮al

Olig潮畣leoti摥s an搠their A灰picationⰠ Wiley VCH⁐ress

㈰〶

8

R⹌⹐潵lterⰠ I⸠ A摡msⰠ I⹋n潷ler an搠 D⹐⹌ea摥r⸠ The
Bi潣hemistry 潦 Nucleic Aci摳⸠ S灲inger
-

Verlag Gm扈

㈰〷




11